Insulin receptors in the kidneys in health and disease
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摘要
Insulin is an important hormone that affects various metabolic processes,including kidney function.Impairment in insulin's action leads to insulin resistance in the target tissue.Besides defects in post-receptor insulin signaling,impairment at the receptor level could significantly affect insulin sensitivity of the target tissue.The kidney is a known target of insulin;however,whether the kidney develops "insulin resistance" is debatable.Regulation of the insulin receptor(IR) expression and its function is very well studied in major metabolic tissues like liver,skeletal muscles,and adipose tissue.The physiological relevance of IRs in the kidney has recently begun to be clarified.The credit goes to studies that showed a wide distribution of IR throughout the nephron segments and their reduced expression in the insulin resistance state.Moreover,altered renal and systemic metabolism observed in mice with targeted deletion of the IR from various epithelial cells of the kidney has strengthened this proposition.In this review,we recapitulate the crucial findings from literature that have expanded our knowledge regarding the significance of the renal IR in normal-and insulin-resistance states.
Insulin is an important hormone that affects various metabolic processes,including kidney function.Impairment in insulin's action leads to insulin resistance in the target tissue.Besides defects in post-receptor insulin signaling,impairment at the receptor level could significantly affect insulin sensitivity of the target tissue.The kidney is a known target of insulin;however,whether the kidney develops "insulin resistance" is debatable.Regulation of the insulin receptor(IR) expression and its function is very well studied in major metabolic tissues like liver,skeletal muscles,and adipose tissue.The physiological relevance of IRs in the kidney has recently begun to be clarified.The credit goes to studies that showed a wide distribution of IR throughout the nephron segments and their reduced expression in the insulin resistance state.Moreover,altered renal and systemic metabolism observed in mice with targeted deletion of the IR from various epithelial cells of the kidney has strengthened this proposition.In this review,we recapitulate the crucial findings from literature that have expanded our knowledge regarding the significance of the renal IR in normal-and insulin-resistance states.
Insulin is an important hormone that affects various metabolic processes,including kidney function.Impairment in insulin's action leads to insulin resistance in the target tissue.Besides defects in post-receptor insulin signaling,impairment at the receptor level could significantly affect insulin sensitivity of the target tissue.The kidney is a known target of insulin;however,whether the kidney develops "insulin resistance" is debatable.Regulation of the insulin receptor(IR) expression and its function is very well studied in major metabolic tissues like liver,skeletal muscles,and adipose tissue.The physiological relevance of IRs in the kidney has recently begun to be clarified.The credit goes to studies that showed a wide distribution of IR throughout the nephron segments and their reduced expression in the insulin resistance state.Moreover,altered renal and systemic metabolism observed in mice with targeted deletion of the IR from various epithelial cells of the kidney has strengthened this proposition.In this review,we recapitulate the crucial findings from literature that have expanded our knowledge regarding the significance of the renal IR in normal-and insulin-resistance states.
引文
1 Gavin JR,Roth J,Neville DM Jr,de Meyts P,Buell DN.Insulin-dependent regulation of insulin receptor concentrations:a direct demonstration in cell culture.Proc Natl Acad Sci USA 1974;71:84-88[PMID:4359334 DOI:10.1073/pnas.71.1.84]
2 Giorgino F,Almahfouz A,Goodyear LJ,Smith RJ.Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo.J Clin Invest 1993;91:2020-2030[PMID:7683695 DOI:10.1172/JCI116424]
3 Grote CW,Groover AL,Ryals JM,Geiger PC,Feldman EL,Wright DE.Peripheral nervous system insulin resistance in ob/ob mice.Acta Neuropathol Commun 2013;1:15[PMID:24252636DOI:10.1186/2051-5960-1-15]
4 Sechi LA,De Carli S,Bartoli E.In situ characterization of renal insulin receptors in the rat.JRecept Res 1994;14:347-356[PMID:7877134 DOI:10.3109/10799899409101509]
5 Nakamura R,Emmanouel DS,Katz AI.Insulin binding sites in various segments of the rabbit nephron.J Clin Invest 1983;72:388-392[PMID:6348088 DOI:10.1172/JCI110979]
6 Gatica R,Bertinat R,Silva P,Carpio D,Ramírez MJ,Slebe JC,San Martín R,Nualart F,Campistol JM,Caelles C,Yá?ez AJ.Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney.J Cell Biochem 2013;114:639-649[PMID:23059533 DOI:10.1002/jcb.24406]
7 Tiwari S,Halagappa VK,Riazi S,Hu X,Ecelbarger CA.Reduced expression of insulin receptors in the kidneys of insulin-resistant rats.J Am Soc Nephrol 2007;18:2661-2671[PMID:17855644DOI:10.1681/ASN.2006121410]
8 De Meyts P.In:De Groot LJ,Chrousos G,Dungan K,Feingold KR,Grossman A,Hershman JM,Koch C,Korbonits M,McLachlan R,New M,Purnell J,Rebar R,Singer F,Vinik A,editors.SourceEndotext[Internet]..South Dartmouth(MA):MDText.com,Inc.;2000-2016 Apr 27;[PMID:27512793]
9 Hale LJ,Coward RJ.Insulin signalling to the kidney in health and disease.Clin Sci(Lond)2013;124:351-370[PMID:23190266 DOI:10.1042/CS20120378]
10 Ullrich A,Bell JR,Chen EY,Herrera R,Petruzzelli LM,Dull TJ,Gray A,Coussens L,Liao YC,Tsubokawa M.Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.Nature 1985;313:756-761[PMID:2983222 DOI:10.1038/313756a0]
11 Ebina Y,Ellis L,Jarnagin K,Edery M,Graf L,Clauser E,Ou JH,Masiarz F,Kan YW,Goldfine ID.The human insulin receptor cDNA:the structural basis for hormone-activated transmembrane signalling.Cell 1985;40:747-758[PMID:2859121 DOI:10.1016/0092-8674(85)90334-4]
12 Seino S,Seino M,Nishi S,Bell GI.Structure of the human insulin receptor gene and characterization of its promoter.Proc Natl Acad Sci USA 1989;86:114-118[PMID:2911561 DOI:10.1073/pnas.86.1.114]
13 Hubbard SR.Structure and Mechanism of the Insulin Receptor Tyrosine Kinase..Handbook of Cell Signaling(Second Edition):Elsevier;2009;307-313
14 Bisbis S,Derouet M,Simon J.Characterization of insulin receptors in chicken kidneys:effect of nutritional status.Gen Comp Endocrinol 1994;96:37-49[PMID:7843566 DOI:10.1006/gcen.1994.1157]
15 Butlen D,Vadrot S,Roseau S,Morel F.Insulin receptors along the rat nephron:[125I]insulin binding in microdissected glomeruli and tubules.Pflugers Arch 1988;412:604-612[PMID:3211711 DOI:10.1007/BF00583761]
16 Tiwari S,Wade JB,Ecelbarger CA.Insulin receptor localization and regulation in rat kidney(Abstract).FASEB J 2006;20:A1169[DOI:10.1096/fasebj.20.5.a1169]
17 Bates CM,Merenmies JM,Kelly-Spratt KS,Parada LF.Insulin receptor-related receptor expression in non-A intercalated cells in the kidney.Kidney Int 1997;52:674-681[PMID:9291186DOI:10.1038/ki.1997.381]
18 Ozaki K,Takada N,Tsujimoto K,Tsuji N,Kawamura T,Muso E,Ohta M,Itoh N.Localization of insulin receptor-related receptor in the rat kidney.Kidney Int 1997;52:694-698[PMID:9291189DOI:10.1038/ki.1997.384]
19 Tiwari S,Sharma N,Gill PS,Igarashi P,Kahn CR,Wade JB,Ecelbarger CM.Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.Proc Natl Acad Sci USA 2008;105:6469-6474[PMID:18424559 DOI:10.1073/pnas.0711283105]
20 Tiwari S,Singh RS,Li L,Tsukerman S,Godbole M,Pandey G,Ecelbarger CM.Deletion of the insulin receptor in the proximal tubule promotes hyperglycemia.J Am Soc Nephrol 2013;24:1209-1214[PMID:23723425 DOI:10.1681/ASN.2012060628]
21 Whelton PK,Appel LJ,Sacco RL,Anderson CA,Antman EM,Campbell N,Dunbar SB,Frohlich ED,Hall JE,Jessup M,Labarthe DR,MacGregor GA,Sacks FM,Stamler J,Vafiadis DK,Van Horn LV.Sodium,blood pressure,and cardiovascular disease:further evidence supporting the American Heart Association sodium reduction recommendations.Circulation 2012;126:2880-2889[PMID:23124030 DOI:10.1161/CIR.0b013e318279acbf]
22 Lambers Heerspink HJ,Holtkamp FA,Parving HH,Navis GJ,Lewis JB,Ritz E,de Graeff PA,de Zeeuw D.Moderation of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers.Kidney Int 2012;82:330-337[PMID:22437412 DOI:10.1038/ki.2012.74]
23 Graudal NA,Hubeck-Graudal T,Jurgens G.Effects of low sodium diet versus high sodium diet on blood pressure,renin,aldosterone,catecholamines,cholesterol,and triglyceride.Cochrane Database Syst Rev 2017;4:CD004022[PMID:28391629 DOI:10.1002/14651858.CD004022.pub4]
24 Wang X,Armando I,Upadhyay K,Pascua A,Jose PA.The regulation of proximal tubular salt transport in hypertension:an update.Curr Opin Nephrol Hypertens 2009;18:412-420[PMID:19654544 DOI:10.1097/MNH.0b013e32832f5775]
25 Doris PA.Renal proximal tubule sodium transport and genetic mechanisms of essential hypertension.J Hypertens 2000;18:509-519[PMID:10826552 DOI:10.1097/00004872-200018050-00002]
26 Capasso G,Rizzo M,Garavaglia ML,Trepiccione F,Zacchia M,Mugione A,Ferrari P,Paulmichl M,Lang F,Loffing J,Carrel M,Damiano S,Wagner CA,Bianchi G,Meyer G.Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension.Am J Physiol Renal Physiol 2008;295:F556-F567[PMID:18480177 DOI:10.1152/ajprenal.00340.2007]
27 Horita S,Seki G,Yamada H,Suzuki M,Koike K,Fujita T.Insulin resistance,obesity,hypertension,and renal sodium transport.Int J Hypertens 2011;2011:391762[PMID:21629870DOI:10.4061/2011/391762]
28 Sechi LA,Griffin CA,Schambelan M.Effect of dietary sodium chloride on insulin receptor number and mRNA levels in rat kidney.Am J Physiol 1994;266:F31-F38[PMID:8304482 DOI:10.1152/ajprenal.1994.266.1.F31]
29 Catena C,Cavarape A,Novello M,Giacchetti G,Sechi LA.Insulin receptors and renal sodium handling in hypertensive fructose-fed rats.Kidney Int 2003;64:2163-2171[PMID:14633139 DOI:10.1046/j.1523-1755.2003.00313.x]
30 Blazer-Yost BL,Esterman MA,Vlahos CJ.Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity.Am J Physiol Cell Physiol 2003;284:C1645-C1653[PMID:12606308DOI:10.1152/ajpcell.00372.2002]
31 Féraille E,Carranza ML,Gonin S,Béguin P,Pedemonte C,Rousselot M,Caverzasio J,Geering K,Martin PY,Favre H.Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10.Mol Biol Cell1999;10:2847-2859[PMID:10473631 DOI:10.1091/mbc.10.9.2847]
32 Fuster DG,Bobulescu IA,Zhang J,Wade J,Moe OW.Characterization of the regulation of renal Na+/H+exchanger NHE3 by insulin.Am J Physiol Renal Physiol 2007;292:F577-F585[PMID:17018843 DOI:10.1152/ajprenal.00240.2006]
33 Salvetti A,Brogi G,Di Legge V,Bernini GP.The inter-relationship between insulin resistance and hypertension.Drugs 1993;46 Suppl 2:149-159[PMID:7512468 DOI:10.2165/00003495-199300462-00024]
34 Hall JE.Mechanisms of abnormal renal sodium handling in obesity hypertension.Am JHypertens 1997;10:49S-55S[PMID:9160781 DOI:10.1016/S0895-7061(97)00075-7]
35 Hall JE,do Carmo JM,da Silva AA,Wang Z,Hall ME.Obesity-induced hypertension:interaction of neurohumoral and renal mechanisms.Circ Res 2015;116:991-1006[PMID:25767285 DOI:10.1161/CIRCRESAHA.116.305697]
36 Soleimani M.Insulin resistance and hypertension:new insights.Kidney Int 2015;87:497-499[PMID:25723632 DOI:10.1038/ki.2014.392]
37 Nizar JM,Walczak EM,Dong W,Bankir L,Bhalla V.Inducible Renal Tubule-specific Insulin Receptor Knockout Mice Have Decreased NCC-mediated Sodium Reabsorption and Reduced Sensitivity to Mineralocorticoid-induced Hypertension in Obesity and Insulin Resistance(Abstract).FASEB J 2016;30:968
38 Hayashi K,Fujiwara K,Oka K,Nagahama T,Matsuda H,Saruta T.Effects of insulin on rat renal microvessels:studies in the isolated perfused hydronephrotic kidney.Kidney Int 1997;51:1507-1513[PMID:9150466 DOI:10.1038/ki.1997.207]
39 Schmetterer L,Müller M,Fasching P,Diepolder C,Gallenkamp A,Zanaschka G,Findl O,Strenn K,Mensik C,Tschernko E,Eichler HG,Wolzt M.Renal and ocular hemodynamic effects of insulin.Diabetes 1997;46:1868-1874[PMID:9356038 DOI:10.2337/diab.46.11.1868]
40 Ter Maaten JC,Bakker SJ,SernéEH,Moshage HJ,Donker AJ,Gans RO.Insulin-mediated increases in renal plasma flow are impaired in insulin-resistant normal subjects.Eur J Clin Invest2000;30:1090-1098[PMID:11122324 DOI:10.1046/j.1365-2362.2000.00749.x]
41 Scherrer U,Sartori C.Insulin as a vascular and sympathoexcitatory hormone:implications for blood pressure regulation,insulin sensitivity,and cardiovascular morbidity.Circulation 1997;96:4104-4113[PMID:9403636 DOI:10.1161/01.CIR.96.11.4104]
42 Erdely A,Freshour G,Maddox DA,Olson JL,Samsell L,Baylis C.Renal disease in rats with type 2 diabetes is associated with decreased renal nitric oxide production.Diabetologia 2004;47:1672-1676[PMID:15490111 DOI:10.1007/s00125-004-1509-1]
43 Elkayam U,Cohen G,Gogia H,Mehra A,Johnson JV,Chandraratna PA.Renal vasodilatory effect of endothelial stimulation in patients with chronic congestive heart failure.J Am Coll Cardiol 1996;28:176-182[PMID:8752811 DOI:10.1016/0735-1097(96)00092-7]
44 Ortiz PA,Hong NJ,Garvin JL.NO decreases thick ascending limb chloride absorption by reducing Na(+)-K(+)-2Cl(-)cotransporter activity.Am J Physiol Renal Physiol 2001;281:F819-F825[PMID:11592939 DOI:10.1152/ajprenal.2001.281.5.F819]
45 Stoos BA,Garcia NH,Garvin JL.Nitric oxide inhibits sodium reabsorption in the isolated perfused cortical collecting duct.J Am Soc Nephrol 1995;6:89-94[PMID:7579075 DOI:10.1111/j.1464-410X.1995.tb07860.x]
46 Li L,Garikepati RM,Tsukerman S,Tiwari S,Ecelbarger CM.Salt sensitivity of nitric oxide generation and blood pressure in mice with targeted knockout of the insulin receptor from the renal tubule.Am J Physiol Regul Integr Comp Physiol 2012;303:R505-R512[PMID:22814664 DOI:10.1152/ajpregu.00033.2012]
47 Cowley AW Jr,Mattson DL,Lu S,Roman RJ.The renal medulla and hypertension.Hypertension1995;25:663-673[PMID:7721413 DOI:10.1161/01.HYP.25.4.663]
48 Cowley AW Jr,Mori T,Mattson D,Zou AP.Role of renal NO production in the regulation of medullary blood flow.Am J Physiol Regul Integr Comp Physiol 2003;284:R1355-R1369[PMID:12736168 DOI:10.1152/ajpregu.00701.2002]
49 Wu F,Park F,Cowley AW Jr,Mattson DL.Quantification of nitric oxide synthase activity in microdissected segments of the rat kidney.Am J Physiol 1999;276:F874-F881[PMID:10362776DOI:10.1152/ajprenal.1999.276.6.F874]
50 Pandey G,Makhija E,George N,Chakravarti B,Godbole MM,Ecelbarger CM,Tiwari S.Insulin regulates nitric oxide production in the kidney collecting duct cells.J Biol Chem 2015;290:5582-5591[PMID:25533472 DOI:10.1074/jbc.M114.592741]
51 Underwood PC,Adler GK.The renin angiotensin aldosterone system and insulin resistance in humans.Curr Hypertens Rep 2013;15:59-70[PMID:23242734 DOI:10.1007/s11906-012-0323-2]
52 Csibi A,Communi D,Müller N,Bottari SP.Angiotensin II inhibits insulin-stimulated GLUT4translocation and Akt activation through tyrosine nitration-dependent mechanisms.PLoS One2010;5:e10070[PMID:20383279 DOI:10.1371/journal.pone.0010070]
53 Yavuz D,Ko?M,Toprak A,Akpinar I,Velio?lu A,Deyneli O,Haklar G,Akalin S.Effects of ACEinhibition and AT1-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients.J Renin Angiotensin Aldosterone Syst 2003;4:197-203[PMID:14608527 DOI:10.3317/jraas.2003.032]
54 Andreozzi F,Laratta E,Sciacqua A,Perticone F,Sesti G.Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells.Circ Res2004;94:1211-1218[PMID:15044323 DOI:10.1161/01.RES.0000126501.34994.96]
55 Stumvoll M,Meyer C,Mitrakou A,Nadkarni V,Gerich JE.Renal glucose production and utilization:new aspects in humans.Diabetologia 1997;40:749-757[PMID:9243094 DOI:10.1007/s001250050745]
56 Stumvoll M,Meyer C,Mitrakou A,Gerich JE.Important role of the kidney in human carbohydrate metabolism.Med Hypotheses 1999;52:363-366[PMID:10416940 DOI:10.1054/mehy.1997.0655]
57 Cano N.Bench-to-bedside review:glucose production from the kidney.Crit Care 2002;6:317-321[PMID:12225606 DOI:10.1186/cc1517]
58 Meyer C,Stumvoll M,Nadkarni V,Dostou J,Mitrakou A,Gerich J.Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus.J Clin Invest 1998;102:619-624[PMID:9691098DOI:10.1172/JCI2415]
59 Stumvoll M,Meyer C,Kreider M,Perriello G,Gerich J.Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans.Metabolism 1998;47:1227-1232[PMID:9781626 DOI:10.1016/S0026-0495(98)90328-6]
60 Cersosimo E,Judd RL,Miles JM.Insulin regulation of renal glucose metabolism in conscious dogs.J Clin Invest 1994;93:2584-2589[PMID:8200996 DOI:10.1172/JCI117270]
61 Bergman H,Drury DR.The relationship of kidney function to the glucose utilization of the extra abdominal tissues.Am J Physiol(legacy content)1938;124:279-284[DOI:10.1152/ajplegacy.1938.124.2.279]
62 Wilding JP.The role of the kidneys in glucose homeostasis in type 2 diabetes:clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors.Metabolism 2014;63:1228-1237[PMID:25104103 DOI:10.1016/j.metabol.2014.06.018]
63 Krebs HA,Bennett DA,DE Gasquet P,Gasquet P,Gascoyne T,Yoshida T.Renal gluconeogenesis.The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices.Biochem J 1963;86:22-27[PMID:14035641 DOI:10.1042/bj0860022]
64 Peres LA,Bredt LC,Cipriani RF.Acute renal injury after partial hepatectomy.World J Hepatol2016;8:891-901[PMID:27478539 DOI:10.4254/wjh.v8.i21.891]
65 Coward RJ,Welsh GI,Yang J,Tasman C,Lennon R,Koziell A,Satchell S,Holman GD,Kerjaschki D,TavaréJM,Mathieson PW,Saleem MA.The human glomerular podocyte is a novel target for insulin action.Diabetes 2005;54:3095-3102[PMID:16249431 DOI:10.2337/diabetes.54.11.3095]
66 Cersosimo E,Garlick P,Ferretti J.Insulin regulation of renal glucose metabolism in humans.Am J Physiol 1999;276:E78-E84[PMID:9886953 DOI:10.1016/S0303-7207(98)00201-9]
67 Meyer C,Dostou J,Nadkarni V,Gerich J.Effects of physiological hyperinsulinemia on systemic,renal,and hepatic substrate metabolism.Am J Physiol 1998;275:F915-F921[PMID:9843908 DOI:10.1152/ajprenal.1998.275.6.f915]
68 McGivan JD,Pastor-Anglada M.Regulatory and molecular aspects of mammalian amino acid transport.Biochem J 1994;299:321-334[PMID:8172590 DOI:10.1042/bj2990321]
69 Eid A,Bodin S,Ferrier B,Delage H,Boghossian M,Martin M,Baverel G,Conjard A.Intrinsic gluconeogenesis is enhanced in renal proximal tubules of Zucker diabetic fatty rats.J Am Soc Nephrol 2006;17:398-405[PMID:16396963 DOI:10.1681/ASN.2005070742]
70 Tejada T,Catanuto P,Ijaz A,Santos JV,Xia X,Sanchez P,Sanabria N,Lenz O,Elliot SJ,Fornoni A.Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death.Kidney Int 2008;73:1385-1393[PMID:18385666 DOI:10.1038/ki.2008.109]
71 Barthel A,Schmoll D.Novel concepts in insulin regulation of hepatic gluconeogenesis.Am JPhysiol Endocrinol Metab 2003;285:E685-E692[PMID:12959935 DOI:10.1152/ajpendo.00253.2003]
72 Valenti L,Rametta R,Dongiovanni P,Maggioni M,Fracanzani AL,Zappa M,Lattuada E,Roviaro G,Fargion S.Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis.Diabetes 2008;57:1355-1362[PMID:18316359 DOI:10.2337/db07-0714]
73 Michael MD,Kulkarni RN,Postic C,Previs SF,Shulman GI,Magnuson MA,Kahn CR.Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.Mol Cell 2000;6:87-97[PMID:10949030 DOI:10.1016/S1097-2765(05)00015-8]
74 DeFronzo RA,Davidson JA,Del Prato S.The role of the kidneys in glucose homeostasis:a new path towards normalizing glycaemia.Diabetes Obes Metab 2012;14:5-14[PMID:21955459 DOI:10.1111/j.1463-1326.2011.01511.x]
75 Winzell MS,Ahrén B.The high-fat diet-fed mouse:a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes.Diabetes 2004;53 Suppl 3:S215-S219[PMID:15561913 DOI:10.2337/diabetes.53.suppl_3.S215]
76 Radziuk J,Pye S.Hepatic glucose uptake,gluconeogenesis and the regulation of glycogen synthesis.Diabetes Metab Res Rev 2001;17:250-272[PMID:11544610 DOI:10.1002/dmrr.217]
77 Pandey G,Shankar K,Makhija E,Gaikwad A,Ecelbarger C,Mandhani A,Srivastava A,Tiwari S.Reduced Insulin Receptor Expression Enhances Proximal Tubule Gluconeogenesis.J Cell Biochem 2017;118:276-285[PMID:27322100 DOI:10.1002/jcb.25632]
78 Horita S,Nakamura M,Suzuki M,Satoh N,Suzuki A,Seki G.Selective Insulin Resistance in the Kidney.Biomed Res Int 2016;2016:5825170[PMID:27247938 DOI:10.1155/2016/5825170]
79 Biddinger SB,Hernandez-Ono A,Rask-Madsen C,Haas JT,Alemán JO,Suzuki R,Scapa EF,Agarwal C,Carey MC,Stephanopoulos G,Cohen DE,King GL,Ginsberg HN,Kahn CR.Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.Cell Metab 2008;7:125-134[PMID:18249172 DOI:10.1016/j.cmet.2007.11.013]
80 Brown MS,Goldstein JL.Selective versus total insulin resistance:a pathogenic paradox.Cell Metab 2008;7:95-96[PMID:18249166 DOI:10.1016/j.cmet.2007.12.009]
81 Laplante M,Sabatini DM.mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.Proc Natl Acad Sci USA 2010;107:3281-3282[PMID:20167806 DOI:10.1073/pnas.1000323107]
82 Sasaki M,Sasako T,Kubota N,Sakurai Y,Takamoto I,Kubota T,Inagi R,Seki G,Goto M,Ueki K,Nangaku M,Jomori T,Kadowaki T.Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney.Diabetes 2017;66:2339-2350[PMID:28630133DOI:10.2337/db16-1602]
83 Ya?ez AJ,Ludwig HC,Bertinat R,Spichiger C,Gatica R,Berlien G,Leon O,Brito M,Concha II,Slebe JC.Different involvement for aldolase isoenzymes in kidney glucose metabolism:aldolase B but not aldolase A colocalizes and forms a complex with FBPase.J Cell Physiol 2005;202:743-753[PMID:15389646 DOI:10.1002/jcp.20183]
84 Mitrakou A.Kidney:its impact on glucose homeostasis and hormonal regulation.Diabetes Res Clin Pract 2011;93 Suppl 1:S66-S72[PMID:21864754 DOI:10.1016/S0168-8227(11)70016-X]
85 Wang Q,Guo T,Portas J,McPherron AC.A soluble activin receptor type IIB does not improve blood glucose in streptozotocin-treated mice.Int J Biol Sci 2015;11:199-208[PMID:25561902DOI:10.7150/ijbs.10430]
86 Tesch GH.Review:Serum and urine biomarkers of kidney disease:A pathophysiological perspective.Nephrology(Carlton)2010;15:609-616[PMID:20883281 DOI:10.1111/j.1440-1797.2010.01361.x]
87 Mogensen CE,Christensen CK.Predicting diabetic nephropathy in insulin-dependent patients.N Engl J Med 1984;311:89-93[PMID:6738599 DOI:10.1056/NEJM198407123110204]
88 Russo LM,Sandoval RM,Campos SB,Molitoris BA,Comper WD,Brown D.Impaired tubular uptake explains albuminuria in early diabetic nephropathy.J Am Soc Nephrol 2009;20:489-494[PMID:19118149 DOI:10.1681/ASN.2008050503]
89 Tojo A,Onozato ML,Ha H,Kurihara H,Sakai T,Goto A,Fujita T,Endou H.Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats.Histochem Cell Biol 2001;116:269-276[PMID:11685557 DOI:10.1007/s004180100317]
90 Dickson LE,Wagner MC,Sandoval RM,Molitoris BA.The proximal tubule and albuminuria:really!J Am Soc Nephrol 2014;25:443-453[PMID:24408874 DOI:10.1681/ASN.2013090950]
91 Christensen EI,Birn H.Megalin and cubilin:synergistic endocytic receptors in renal proximal tubule.Am J Physiol Renal Physiol 2001;280:F562-F573[PMID:11249847 DOI:10.1152/ajprenal.2001.280.4.F562]
92 Pilz S,Rutters F,Nijpels G,Stehouwer CD,H?jlund K,Nolan JJ,Balkau B,Dekker JM;RISCInvestigators.Insulin sensitivity and albuminuria:the RISC study.Diabetes Care 2014;37:1597-1603[PMID:24623021 DOI:10.2337/dc13-2573]
93 Coffey S,Costacou T,Orchard T,Erkan E.Akt Links Insulin Signaling to Albumin Endocytosis in Proximal Tubule Epithelial Cells.PLoS One 2015;10:e0140417[PMID:26465605 DOI:10.1371/journal.pone.0140417]
94 Zeng B,Chen GL,Garcia-Vaz E,Bhandari S,Daskoulidou N,Berglund LM,Jiang H,Hallett T,Zhou LP,Huang L,Xu ZH,Nair V,Nelson RG,Ju W,Kretzler M,Atkin SL,Gomez MF,Xu SZ.ORAI channels are critical for receptor-mediated endocytosis of albumin.Nat Commun 2017;8:1920[PMID:29203863 DOI:10.1038/s41467-017-02094-y]
95 Mottl AK,Divers J,Dabelea D,Maahs DM,Dolan L,Pettitt D,Marcovina S,Imperatore G,Pihoker C,Mauer M,Mayer-Davis EJ;SEARCH for Diabetes in Youth Study.The dose-response effect of insulin sensitivity on albuminuria in children according to diabetes type.Pediatr Nephrol2016;31:933-940[PMID:26754041 DOI:10.1007/s00467-015-3276-2]
96 Bryniarski MA,Yee BM,Jaffri I,Chaves LD,Yu JA,Guan X,Ghavam N,Yacoub R,Morris ME.Increased Megalin Expression in Early Type 2 Diabetes:Role of Insulin Signaling Pathways.Am JPhysiol Renal Physiol 2018[PMID:29949391 DOI:10.1152/ajprenal.00210.2018]
97 Salem ES,Grobe N,Elased KM.Insulin treatment attenuates renal ADAM17 and ACE2shedding in diabetic Akita mice.Am J Physiol Renal Physiol 2014;306:F629-F639[PMID:24452639DOI:10.1152/ajprenal.00516.2013]
2 Giorgino F,Almahfouz A,Goodyear LJ,Smith RJ.Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo.J Clin Invest 1993;91:2020-2030[PMID:7683695 DOI:10.1172/JCI116424]
3 Grote CW,Groover AL,Ryals JM,Geiger PC,Feldman EL,Wright DE.Peripheral nervous system insulin resistance in ob/ob mice.Acta Neuropathol Commun 2013;1:15[PMID:24252636DOI:10.1186/2051-5960-1-15]
4 Sechi LA,De Carli S,Bartoli E.In situ characterization of renal insulin receptors in the rat.JRecept Res 1994;14:347-356[PMID:7877134 DOI:10.3109/10799899409101509]
5 Nakamura R,Emmanouel DS,Katz AI.Insulin binding sites in various segments of the rabbit nephron.J Clin Invest 1983;72:388-392[PMID:6348088 DOI:10.1172/JCI110979]
6 Gatica R,Bertinat R,Silva P,Carpio D,Ramírez MJ,Slebe JC,San Martín R,Nualart F,Campistol JM,Caelles C,Yá?ez AJ.Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney.J Cell Biochem 2013;114:639-649[PMID:23059533 DOI:10.1002/jcb.24406]
7 Tiwari S,Halagappa VK,Riazi S,Hu X,Ecelbarger CA.Reduced expression of insulin receptors in the kidneys of insulin-resistant rats.J Am Soc Nephrol 2007;18:2661-2671[PMID:17855644DOI:10.1681/ASN.2006121410]
8 De Meyts P.In:De Groot LJ,Chrousos G,Dungan K,Feingold KR,Grossman A,Hershman JM,Koch C,Korbonits M,McLachlan R,New M,Purnell J,Rebar R,Singer F,Vinik A,editors.SourceEndotext[Internet]..South Dartmouth(MA):MDText.com,Inc.;2000-2016 Apr 27;[PMID:27512793]
9 Hale LJ,Coward RJ.Insulin signalling to the kidney in health and disease.Clin Sci(Lond)2013;124:351-370[PMID:23190266 DOI:10.1042/CS20120378]
10 Ullrich A,Bell JR,Chen EY,Herrera R,Petruzzelli LM,Dull TJ,Gray A,Coussens L,Liao YC,Tsubokawa M.Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.Nature 1985;313:756-761[PMID:2983222 DOI:10.1038/313756a0]
11 Ebina Y,Ellis L,Jarnagin K,Edery M,Graf L,Clauser E,Ou JH,Masiarz F,Kan YW,Goldfine ID.The human insulin receptor cDNA:the structural basis for hormone-activated transmembrane signalling.Cell 1985;40:747-758[PMID:2859121 DOI:10.1016/0092-8674(85)90334-4]
12 Seino S,Seino M,Nishi S,Bell GI.Structure of the human insulin receptor gene and characterization of its promoter.Proc Natl Acad Sci USA 1989;86:114-118[PMID:2911561 DOI:10.1073/pnas.86.1.114]
13 Hubbard SR.Structure and Mechanism of the Insulin Receptor Tyrosine Kinase..Handbook of Cell Signaling(Second Edition):Elsevier;2009;307-313
14 Bisbis S,Derouet M,Simon J.Characterization of insulin receptors in chicken kidneys:effect of nutritional status.Gen Comp Endocrinol 1994;96:37-49[PMID:7843566 DOI:10.1006/gcen.1994.1157]
15 Butlen D,Vadrot S,Roseau S,Morel F.Insulin receptors along the rat nephron:[125I]insulin binding in microdissected glomeruli and tubules.Pflugers Arch 1988;412:604-612[PMID:3211711 DOI:10.1007/BF00583761]
16 Tiwari S,Wade JB,Ecelbarger CA.Insulin receptor localization and regulation in rat kidney(Abstract).FASEB J 2006;20:A1169[DOI:10.1096/fasebj.20.5.a1169]
17 Bates CM,Merenmies JM,Kelly-Spratt KS,Parada LF.Insulin receptor-related receptor expression in non-A intercalated cells in the kidney.Kidney Int 1997;52:674-681[PMID:9291186DOI:10.1038/ki.1997.381]
18 Ozaki K,Takada N,Tsujimoto K,Tsuji N,Kawamura T,Muso E,Ohta M,Itoh N.Localization of insulin receptor-related receptor in the rat kidney.Kidney Int 1997;52:694-698[PMID:9291189DOI:10.1038/ki.1997.384]
19 Tiwari S,Sharma N,Gill PS,Igarashi P,Kahn CR,Wade JB,Ecelbarger CM.Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.Proc Natl Acad Sci USA 2008;105:6469-6474[PMID:18424559 DOI:10.1073/pnas.0711283105]
20 Tiwari S,Singh RS,Li L,Tsukerman S,Godbole M,Pandey G,Ecelbarger CM.Deletion of the insulin receptor in the proximal tubule promotes hyperglycemia.J Am Soc Nephrol 2013;24:1209-1214[PMID:23723425 DOI:10.1681/ASN.2012060628]
21 Whelton PK,Appel LJ,Sacco RL,Anderson CA,Antman EM,Campbell N,Dunbar SB,Frohlich ED,Hall JE,Jessup M,Labarthe DR,MacGregor GA,Sacks FM,Stamler J,Vafiadis DK,Van Horn LV.Sodium,blood pressure,and cardiovascular disease:further evidence supporting the American Heart Association sodium reduction recommendations.Circulation 2012;126:2880-2889[PMID:23124030 DOI:10.1161/CIR.0b013e318279acbf]
22 Lambers Heerspink HJ,Holtkamp FA,Parving HH,Navis GJ,Lewis JB,Ritz E,de Graeff PA,de Zeeuw D.Moderation of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers.Kidney Int 2012;82:330-337[PMID:22437412 DOI:10.1038/ki.2012.74]
23 Graudal NA,Hubeck-Graudal T,Jurgens G.Effects of low sodium diet versus high sodium diet on blood pressure,renin,aldosterone,catecholamines,cholesterol,and triglyceride.Cochrane Database Syst Rev 2017;4:CD004022[PMID:28391629 DOI:10.1002/14651858.CD004022.pub4]
24 Wang X,Armando I,Upadhyay K,Pascua A,Jose PA.The regulation of proximal tubular salt transport in hypertension:an update.Curr Opin Nephrol Hypertens 2009;18:412-420[PMID:19654544 DOI:10.1097/MNH.0b013e32832f5775]
25 Doris PA.Renal proximal tubule sodium transport and genetic mechanisms of essential hypertension.J Hypertens 2000;18:509-519[PMID:10826552 DOI:10.1097/00004872-200018050-00002]
26 Capasso G,Rizzo M,Garavaglia ML,Trepiccione F,Zacchia M,Mugione A,Ferrari P,Paulmichl M,Lang F,Loffing J,Carrel M,Damiano S,Wagner CA,Bianchi G,Meyer G.Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension.Am J Physiol Renal Physiol 2008;295:F556-F567[PMID:18480177 DOI:10.1152/ajprenal.00340.2007]
27 Horita S,Seki G,Yamada H,Suzuki M,Koike K,Fujita T.Insulin resistance,obesity,hypertension,and renal sodium transport.Int J Hypertens 2011;2011:391762[PMID:21629870DOI:10.4061/2011/391762]
28 Sechi LA,Griffin CA,Schambelan M.Effect of dietary sodium chloride on insulin receptor number and mRNA levels in rat kidney.Am J Physiol 1994;266:F31-F38[PMID:8304482 DOI:10.1152/ajprenal.1994.266.1.F31]
29 Catena C,Cavarape A,Novello M,Giacchetti G,Sechi LA.Insulin receptors and renal sodium handling in hypertensive fructose-fed rats.Kidney Int 2003;64:2163-2171[PMID:14633139 DOI:10.1046/j.1523-1755.2003.00313.x]
30 Blazer-Yost BL,Esterman MA,Vlahos CJ.Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity.Am J Physiol Cell Physiol 2003;284:C1645-C1653[PMID:12606308DOI:10.1152/ajpcell.00372.2002]
31 Féraille E,Carranza ML,Gonin S,Béguin P,Pedemonte C,Rousselot M,Caverzasio J,Geering K,Martin PY,Favre H.Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10.Mol Biol Cell1999;10:2847-2859[PMID:10473631 DOI:10.1091/mbc.10.9.2847]
32 Fuster DG,Bobulescu IA,Zhang J,Wade J,Moe OW.Characterization of the regulation of renal Na+/H+exchanger NHE3 by insulin.Am J Physiol Renal Physiol 2007;292:F577-F585[PMID:17018843 DOI:10.1152/ajprenal.00240.2006]
33 Salvetti A,Brogi G,Di Legge V,Bernini GP.The inter-relationship between insulin resistance and hypertension.Drugs 1993;46 Suppl 2:149-159[PMID:7512468 DOI:10.2165/00003495-199300462-00024]
34 Hall JE.Mechanisms of abnormal renal sodium handling in obesity hypertension.Am JHypertens 1997;10:49S-55S[PMID:9160781 DOI:10.1016/S0895-7061(97)00075-7]
35 Hall JE,do Carmo JM,da Silva AA,Wang Z,Hall ME.Obesity-induced hypertension:interaction of neurohumoral and renal mechanisms.Circ Res 2015;116:991-1006[PMID:25767285 DOI:10.1161/CIRCRESAHA.116.305697]
36 Soleimani M.Insulin resistance and hypertension:new insights.Kidney Int 2015;87:497-499[PMID:25723632 DOI:10.1038/ki.2014.392]
37 Nizar JM,Walczak EM,Dong W,Bankir L,Bhalla V.Inducible Renal Tubule-specific Insulin Receptor Knockout Mice Have Decreased NCC-mediated Sodium Reabsorption and Reduced Sensitivity to Mineralocorticoid-induced Hypertension in Obesity and Insulin Resistance(Abstract).FASEB J 2016;30:968
38 Hayashi K,Fujiwara K,Oka K,Nagahama T,Matsuda H,Saruta T.Effects of insulin on rat renal microvessels:studies in the isolated perfused hydronephrotic kidney.Kidney Int 1997;51:1507-1513[PMID:9150466 DOI:10.1038/ki.1997.207]
39 Schmetterer L,Müller M,Fasching P,Diepolder C,Gallenkamp A,Zanaschka G,Findl O,Strenn K,Mensik C,Tschernko E,Eichler HG,Wolzt M.Renal and ocular hemodynamic effects of insulin.Diabetes 1997;46:1868-1874[PMID:9356038 DOI:10.2337/diab.46.11.1868]
40 Ter Maaten JC,Bakker SJ,SernéEH,Moshage HJ,Donker AJ,Gans RO.Insulin-mediated increases in renal plasma flow are impaired in insulin-resistant normal subjects.Eur J Clin Invest2000;30:1090-1098[PMID:11122324 DOI:10.1046/j.1365-2362.2000.00749.x]
41 Scherrer U,Sartori C.Insulin as a vascular and sympathoexcitatory hormone:implications for blood pressure regulation,insulin sensitivity,and cardiovascular morbidity.Circulation 1997;96:4104-4113[PMID:9403636 DOI:10.1161/01.CIR.96.11.4104]
42 Erdely A,Freshour G,Maddox DA,Olson JL,Samsell L,Baylis C.Renal disease in rats with type 2 diabetes is associated with decreased renal nitric oxide production.Diabetologia 2004;47:1672-1676[PMID:15490111 DOI:10.1007/s00125-004-1509-1]
43 Elkayam U,Cohen G,Gogia H,Mehra A,Johnson JV,Chandraratna PA.Renal vasodilatory effect of endothelial stimulation in patients with chronic congestive heart failure.J Am Coll Cardiol 1996;28:176-182[PMID:8752811 DOI:10.1016/0735-1097(96)00092-7]
44 Ortiz PA,Hong NJ,Garvin JL.NO decreases thick ascending limb chloride absorption by reducing Na(+)-K(+)-2Cl(-)cotransporter activity.Am J Physiol Renal Physiol 2001;281:F819-F825[PMID:11592939 DOI:10.1152/ajprenal.2001.281.5.F819]
45 Stoos BA,Garcia NH,Garvin JL.Nitric oxide inhibits sodium reabsorption in the isolated perfused cortical collecting duct.J Am Soc Nephrol 1995;6:89-94[PMID:7579075 DOI:10.1111/j.1464-410X.1995.tb07860.x]
46 Li L,Garikepati RM,Tsukerman S,Tiwari S,Ecelbarger CM.Salt sensitivity of nitric oxide generation and blood pressure in mice with targeted knockout of the insulin receptor from the renal tubule.Am J Physiol Regul Integr Comp Physiol 2012;303:R505-R512[PMID:22814664 DOI:10.1152/ajpregu.00033.2012]
47 Cowley AW Jr,Mattson DL,Lu S,Roman RJ.The renal medulla and hypertension.Hypertension1995;25:663-673[PMID:7721413 DOI:10.1161/01.HYP.25.4.663]
48 Cowley AW Jr,Mori T,Mattson D,Zou AP.Role of renal NO production in the regulation of medullary blood flow.Am J Physiol Regul Integr Comp Physiol 2003;284:R1355-R1369[PMID:12736168 DOI:10.1152/ajpregu.00701.2002]
49 Wu F,Park F,Cowley AW Jr,Mattson DL.Quantification of nitric oxide synthase activity in microdissected segments of the rat kidney.Am J Physiol 1999;276:F874-F881[PMID:10362776DOI:10.1152/ajprenal.1999.276.6.F874]
50 Pandey G,Makhija E,George N,Chakravarti B,Godbole MM,Ecelbarger CM,Tiwari S.Insulin regulates nitric oxide production in the kidney collecting duct cells.J Biol Chem 2015;290:5582-5591[PMID:25533472 DOI:10.1074/jbc.M114.592741]
51 Underwood PC,Adler GK.The renin angiotensin aldosterone system and insulin resistance in humans.Curr Hypertens Rep 2013;15:59-70[PMID:23242734 DOI:10.1007/s11906-012-0323-2]
52 Csibi A,Communi D,Müller N,Bottari SP.Angiotensin II inhibits insulin-stimulated GLUT4translocation and Akt activation through tyrosine nitration-dependent mechanisms.PLoS One2010;5:e10070[PMID:20383279 DOI:10.1371/journal.pone.0010070]
53 Yavuz D,Ko?M,Toprak A,Akpinar I,Velio?lu A,Deyneli O,Haklar G,Akalin S.Effects of ACEinhibition and AT1-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients.J Renin Angiotensin Aldosterone Syst 2003;4:197-203[PMID:14608527 DOI:10.3317/jraas.2003.032]
54 Andreozzi F,Laratta E,Sciacqua A,Perticone F,Sesti G.Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells.Circ Res2004;94:1211-1218[PMID:15044323 DOI:10.1161/01.RES.0000126501.34994.96]
55 Stumvoll M,Meyer C,Mitrakou A,Nadkarni V,Gerich JE.Renal glucose production and utilization:new aspects in humans.Diabetologia 1997;40:749-757[PMID:9243094 DOI:10.1007/s001250050745]
56 Stumvoll M,Meyer C,Mitrakou A,Gerich JE.Important role of the kidney in human carbohydrate metabolism.Med Hypotheses 1999;52:363-366[PMID:10416940 DOI:10.1054/mehy.1997.0655]
57 Cano N.Bench-to-bedside review:glucose production from the kidney.Crit Care 2002;6:317-321[PMID:12225606 DOI:10.1186/cc1517]
58 Meyer C,Stumvoll M,Nadkarni V,Dostou J,Mitrakou A,Gerich J.Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus.J Clin Invest 1998;102:619-624[PMID:9691098DOI:10.1172/JCI2415]
59 Stumvoll M,Meyer C,Kreider M,Perriello G,Gerich J.Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans.Metabolism 1998;47:1227-1232[PMID:9781626 DOI:10.1016/S0026-0495(98)90328-6]
60 Cersosimo E,Judd RL,Miles JM.Insulin regulation of renal glucose metabolism in conscious dogs.J Clin Invest 1994;93:2584-2589[PMID:8200996 DOI:10.1172/JCI117270]
61 Bergman H,Drury DR.The relationship of kidney function to the glucose utilization of the extra abdominal tissues.Am J Physiol(legacy content)1938;124:279-284[DOI:10.1152/ajplegacy.1938.124.2.279]
62 Wilding JP.The role of the kidneys in glucose homeostasis in type 2 diabetes:clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors.Metabolism 2014;63:1228-1237[PMID:25104103 DOI:10.1016/j.metabol.2014.06.018]
63 Krebs HA,Bennett DA,DE Gasquet P,Gasquet P,Gascoyne T,Yoshida T.Renal gluconeogenesis.The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices.Biochem J 1963;86:22-27[PMID:14035641 DOI:10.1042/bj0860022]
64 Peres LA,Bredt LC,Cipriani RF.Acute renal injury after partial hepatectomy.World J Hepatol2016;8:891-901[PMID:27478539 DOI:10.4254/wjh.v8.i21.891]
65 Coward RJ,Welsh GI,Yang J,Tasman C,Lennon R,Koziell A,Satchell S,Holman GD,Kerjaschki D,TavaréJM,Mathieson PW,Saleem MA.The human glomerular podocyte is a novel target for insulin action.Diabetes 2005;54:3095-3102[PMID:16249431 DOI:10.2337/diabetes.54.11.3095]
66 Cersosimo E,Garlick P,Ferretti J.Insulin regulation of renal glucose metabolism in humans.Am J Physiol 1999;276:E78-E84[PMID:9886953 DOI:10.1016/S0303-7207(98)00201-9]
67 Meyer C,Dostou J,Nadkarni V,Gerich J.Effects of physiological hyperinsulinemia on systemic,renal,and hepatic substrate metabolism.Am J Physiol 1998;275:F915-F921[PMID:9843908 DOI:10.1152/ajprenal.1998.275.6.f915]
68 McGivan JD,Pastor-Anglada M.Regulatory and molecular aspects of mammalian amino acid transport.Biochem J 1994;299:321-334[PMID:8172590 DOI:10.1042/bj2990321]
69 Eid A,Bodin S,Ferrier B,Delage H,Boghossian M,Martin M,Baverel G,Conjard A.Intrinsic gluconeogenesis is enhanced in renal proximal tubules of Zucker diabetic fatty rats.J Am Soc Nephrol 2006;17:398-405[PMID:16396963 DOI:10.1681/ASN.2005070742]
70 Tejada T,Catanuto P,Ijaz A,Santos JV,Xia X,Sanchez P,Sanabria N,Lenz O,Elliot SJ,Fornoni A.Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death.Kidney Int 2008;73:1385-1393[PMID:18385666 DOI:10.1038/ki.2008.109]
71 Barthel A,Schmoll D.Novel concepts in insulin regulation of hepatic gluconeogenesis.Am JPhysiol Endocrinol Metab 2003;285:E685-E692[PMID:12959935 DOI:10.1152/ajpendo.00253.2003]
72 Valenti L,Rametta R,Dongiovanni P,Maggioni M,Fracanzani AL,Zappa M,Lattuada E,Roviaro G,Fargion S.Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis.Diabetes 2008;57:1355-1362[PMID:18316359 DOI:10.2337/db07-0714]
73 Michael MD,Kulkarni RN,Postic C,Previs SF,Shulman GI,Magnuson MA,Kahn CR.Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.Mol Cell 2000;6:87-97[PMID:10949030 DOI:10.1016/S1097-2765(05)00015-8]
74 DeFronzo RA,Davidson JA,Del Prato S.The role of the kidneys in glucose homeostasis:a new path towards normalizing glycaemia.Diabetes Obes Metab 2012;14:5-14[PMID:21955459 DOI:10.1111/j.1463-1326.2011.01511.x]
75 Winzell MS,Ahrén B.The high-fat diet-fed mouse:a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes.Diabetes 2004;53 Suppl 3:S215-S219[PMID:15561913 DOI:10.2337/diabetes.53.suppl_3.S215]
76 Radziuk J,Pye S.Hepatic glucose uptake,gluconeogenesis and the regulation of glycogen synthesis.Diabetes Metab Res Rev 2001;17:250-272[PMID:11544610 DOI:10.1002/dmrr.217]
77 Pandey G,Shankar K,Makhija E,Gaikwad A,Ecelbarger C,Mandhani A,Srivastava A,Tiwari S.Reduced Insulin Receptor Expression Enhances Proximal Tubule Gluconeogenesis.J Cell Biochem 2017;118:276-285[PMID:27322100 DOI:10.1002/jcb.25632]
78 Horita S,Nakamura M,Suzuki M,Satoh N,Suzuki A,Seki G.Selective Insulin Resistance in the Kidney.Biomed Res Int 2016;2016:5825170[PMID:27247938 DOI:10.1155/2016/5825170]
79 Biddinger SB,Hernandez-Ono A,Rask-Madsen C,Haas JT,Alemán JO,Suzuki R,Scapa EF,Agarwal C,Carey MC,Stephanopoulos G,Cohen DE,King GL,Ginsberg HN,Kahn CR.Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.Cell Metab 2008;7:125-134[PMID:18249172 DOI:10.1016/j.cmet.2007.11.013]
80 Brown MS,Goldstein JL.Selective versus total insulin resistance:a pathogenic paradox.Cell Metab 2008;7:95-96[PMID:18249166 DOI:10.1016/j.cmet.2007.12.009]
81 Laplante M,Sabatini DM.mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.Proc Natl Acad Sci USA 2010;107:3281-3282[PMID:20167806 DOI:10.1073/pnas.1000323107]
82 Sasaki M,Sasako T,Kubota N,Sakurai Y,Takamoto I,Kubota T,Inagi R,Seki G,Goto M,Ueki K,Nangaku M,Jomori T,Kadowaki T.Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney.Diabetes 2017;66:2339-2350[PMID:28630133DOI:10.2337/db16-1602]
83 Ya?ez AJ,Ludwig HC,Bertinat R,Spichiger C,Gatica R,Berlien G,Leon O,Brito M,Concha II,Slebe JC.Different involvement for aldolase isoenzymes in kidney glucose metabolism:aldolase B but not aldolase A colocalizes and forms a complex with FBPase.J Cell Physiol 2005;202:743-753[PMID:15389646 DOI:10.1002/jcp.20183]
84 Mitrakou A.Kidney:its impact on glucose homeostasis and hormonal regulation.Diabetes Res Clin Pract 2011;93 Suppl 1:S66-S72[PMID:21864754 DOI:10.1016/S0168-8227(11)70016-X]
85 Wang Q,Guo T,Portas J,McPherron AC.A soluble activin receptor type IIB does not improve blood glucose in streptozotocin-treated mice.Int J Biol Sci 2015;11:199-208[PMID:25561902DOI:10.7150/ijbs.10430]
86 Tesch GH.Review:Serum and urine biomarkers of kidney disease:A pathophysiological perspective.Nephrology(Carlton)2010;15:609-616[PMID:20883281 DOI:10.1111/j.1440-1797.2010.01361.x]
87 Mogensen CE,Christensen CK.Predicting diabetic nephropathy in insulin-dependent patients.N Engl J Med 1984;311:89-93[PMID:6738599 DOI:10.1056/NEJM198407123110204]
88 Russo LM,Sandoval RM,Campos SB,Molitoris BA,Comper WD,Brown D.Impaired tubular uptake explains albuminuria in early diabetic nephropathy.J Am Soc Nephrol 2009;20:489-494[PMID:19118149 DOI:10.1681/ASN.2008050503]
89 Tojo A,Onozato ML,Ha H,Kurihara H,Sakai T,Goto A,Fujita T,Endou H.Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats.Histochem Cell Biol 2001;116:269-276[PMID:11685557 DOI:10.1007/s004180100317]
90 Dickson LE,Wagner MC,Sandoval RM,Molitoris BA.The proximal tubule and albuminuria:really!J Am Soc Nephrol 2014;25:443-453[PMID:24408874 DOI:10.1681/ASN.2013090950]
91 Christensen EI,Birn H.Megalin and cubilin:synergistic endocytic receptors in renal proximal tubule.Am J Physiol Renal Physiol 2001;280:F562-F573[PMID:11249847 DOI:10.1152/ajprenal.2001.280.4.F562]
92 Pilz S,Rutters F,Nijpels G,Stehouwer CD,H?jlund K,Nolan JJ,Balkau B,Dekker JM;RISCInvestigators.Insulin sensitivity and albuminuria:the RISC study.Diabetes Care 2014;37:1597-1603[PMID:24623021 DOI:10.2337/dc13-2573]
93 Coffey S,Costacou T,Orchard T,Erkan E.Akt Links Insulin Signaling to Albumin Endocytosis in Proximal Tubule Epithelial Cells.PLoS One 2015;10:e0140417[PMID:26465605 DOI:10.1371/journal.pone.0140417]
94 Zeng B,Chen GL,Garcia-Vaz E,Bhandari S,Daskoulidou N,Berglund LM,Jiang H,Hallett T,Zhou LP,Huang L,Xu ZH,Nair V,Nelson RG,Ju W,Kretzler M,Atkin SL,Gomez MF,Xu SZ.ORAI channels are critical for receptor-mediated endocytosis of albumin.Nat Commun 2017;8:1920[PMID:29203863 DOI:10.1038/s41467-017-02094-y]
95 Mottl AK,Divers J,Dabelea D,Maahs DM,Dolan L,Pettitt D,Marcovina S,Imperatore G,Pihoker C,Mauer M,Mayer-Davis EJ;SEARCH for Diabetes in Youth Study.The dose-response effect of insulin sensitivity on albuminuria in children according to diabetes type.Pediatr Nephrol2016;31:933-940[PMID:26754041 DOI:10.1007/s00467-015-3276-2]
96 Bryniarski MA,Yee BM,Jaffri I,Chaves LD,Yu JA,Guan X,Ghavam N,Yacoub R,Morris ME.Increased Megalin Expression in Early Type 2 Diabetes:Role of Insulin Signaling Pathways.Am JPhysiol Renal Physiol 2018[PMID:29949391 DOI:10.1152/ajprenal.00210.2018]
97 Salem ES,Grobe N,Elased KM.Insulin treatment attenuates renal ADAM17 and ACE2shedding in diabetic Akita mice.Am J Physiol Renal Physiol 2014;306:F629-F639[PMID:24452639DOI:10.1152/ajprenal.00516.2013]