Safety Evaluation of a Compound Lonicera rupicola Hook.f. et & Thomson Injection
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摘要
Safety of a compound Lonicera rupicola Hook. f. et & Thomson injection was evaluated by local irritation experiments including conjunctiva,skin and muscle irritant experiments,and the effect on weight gain was studied. The results showed that the compound L. rupicola Hook. f. et & Thomson injection had no irritation to rabbit eyes and weak irritation to rabbit ears,and had relatively strong irritation to the leg muscles of the mice. Its metabolism in mice had no abnormal toxicity.
Safety of a compound Lonicera rupicola Hook. f. et & Thomson injection was evaluated by local irritation experiments including conjunctiva,skin and muscle irritant experiments,and the effect on weight gain was studied. The results showed that the compound L. rupicola Hook. f. et & Thomson injection had no irritation to rabbit eyes and weak irritation to rabbit ears,and had relatively strong irritation to the leg muscles of the mice. Its metabolism in mice had no abnormal toxicity.
Safety of a compound Lonicera rupicola Hook. f. et & Thomson injection was evaluated by local irritation experiments including conjunctiva,skin and muscle irritant experiments,and the effect on weight gain was studied. The results showed that the compound L. rupicola Hook. f. et & Thomson injection had no irritation to rabbit eyes and weak irritation to rabbit ears,and had relatively strong irritation to the leg muscles of the mice. Its metabolism in mice had no abnormal toxicity.
引文
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[7]SHE SJ,ZHU Y.Advances in studies on chemical constituents of Lonicera[J].Strait Pharmaceutical Journal,2008,20(6):1-7.(in Chinese).
[8]SHAO ZH,WANG GX.Super delocalization of flavonoids[J].Journal of Molecular Science,1985,5(2):177.(in Chinese).
[9]DU WM,WANG YM.Surveillance of adverse reaction of traditional medicine[J].Drug Evaluation,2004,1(3):183.(in Chinese).
[10]LIN YQ,ZHANG LZ.Clinical analysis and prevention of adverse reactions caused by TCM injections[J].Journal of Practical Traditional Chinese Internal Medicine,2006,20(3):343.(in Chinese).
[11]LI YK,JIN RM,WANG QM.Pharmacological experimental methodology of TCM(2nd edition)[M].Shanghai:Shanghai Science and Technology Press,2006:1053-1054.(in Chinese).
[12]POGGE DJ,RICHTER EL,DREWNOSKI ME,et al.Mineral concentrations of plasma and liver after injection with a trace mineral complex differ among Angus and Simmental cattle[J].Journal of Animal Science,2012,90(8):2692-2698.
[2]Compilation Committee of the Flora of China,Chinese Academy of Sciences.The flora of China(volume 72)[M].Beijing:Science Press,1985:462.(in Chinese).
[3]GOU ZP,WAN DG.Survey of resources of medicinal plants of Lonicera L.in Sichuan Province[J].West China Journal of Pharmaceutical Sciences,2005,20(6):480-482.(in Chinese).
[4]YE HG,ZENG FY,YE YS,et al.Chinese medicinal plants(volume 4)[M].Beijing:Chemical Industry Press,2014.(in Chinese).
[5]DU JM,ZHANG YM,WANG Y.Advances in the studies on plants of Lonicera[J].Northern Horticulture,2005(4):11-13.(in Chinese).
[6]XING JB,LI P.Overview and prospect of research on chemical constituents of Lonicera plants[J].Jorunal of Chinese Medicinal Materials,1999,22(7):366-370.(in Chinese).
[7]SHE SJ,ZHU Y.Advances in studies on chemical constituents of Lonicera[J].Strait Pharmaceutical Journal,2008,20(6):1-7.(in Chinese).
[8]SHAO ZH,WANG GX.Super delocalization of flavonoids[J].Journal of Molecular Science,1985,5(2):177.(in Chinese).
[9]DU WM,WANG YM.Surveillance of adverse reaction of traditional medicine[J].Drug Evaluation,2004,1(3):183.(in Chinese).
[10]LIN YQ,ZHANG LZ.Clinical analysis and prevention of adverse reactions caused by TCM injections[J].Journal of Practical Traditional Chinese Internal Medicine,2006,20(3):343.(in Chinese).
[11]LI YK,JIN RM,WANG QM.Pharmacological experimental methodology of TCM(2nd edition)[M].Shanghai:Shanghai Science and Technology Press,2006:1053-1054.(in Chinese).
[12]POGGE DJ,RICHTER EL,DREWNOSKI ME,et al.Mineral concentrations of plasma and liver after injection with a trace mineral complex differ among Angus and Simmental cattle[J].Journal of Animal Science,2012,90(8):2692-2698.