硒与疾病的流行病学研究及展望
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摘要
硒是人体必需微量元素之一,硒环境本底值分布极不均匀,在世界范围内缺硒与富硒地区并存。过去10年中,大量流行病学研究探讨硒与死亡率、肿瘤、心血管疾病、2型糖尿病及生殖之间的关系。以近年来的人群研究为线索,综合阐述了硒与上述疾病之间关系的研究进展,从流行病学角度探讨了硒与疾病的关系。
Selenium(Se) is one of the essential trace elements in human body. The environmental background value of Se is extremely uneven,both Se deficient areas and Se rich areas exist. In the past 10 years,a large number of epidemiology studies investigated the association between Se and mortality,cancer,cardiovascular disease,type 2 diabetes mellitus,and reproduction.Based on the recent population studies,this paper comprehensively expounded the current research progress on Se and diseases above,and discussed the relationship between Se and disease from an epidemiological perspective.
Selenium(Se) is one of the essential trace elements in human body. The environmental background value of Se is extremely uneven,both Se deficient areas and Se rich areas exist. In the past 10 years,a large number of epidemiology studies investigated the association between Se and mortality,cancer,cardiovascular disease,type 2 diabetes mellitus,and reproduction.Based on the recent population studies,this paper comprehensively expounded the current research progress on Se and diseases above,and discussed the relationship between Se and disease from an epidemiological perspective.
引文
[1]Chen J.An original discovery:Selenium deficiency and Keshan disease(an endemic heart disease)[J].Asia.Pac.J.Clin.Nutr.,2012,21:320-326.
[2]Rayman M P.Selenium in cancer prevention:A review of the evidence and mechanism of action[J].Proc.Nutr.Soc.,2005,64:527-542.
[3]Fairweather-Tait S J,Bao Y,Broadley M R,et al..Selenium in human health and disease[J].Antioxid.Redox.Signal.,2011,14:1337-1383.
[4]US Department of Agriculture,Agricultural Research Service.Nutrient Intakes from Food:Mean amounts consumed per individual,one day,2005-2006[DB/OL].www.ars.usda.gov=ba=bhnrc=fsrg,2010.
[5]Ashton K,Hooper L,Harvey L J,et al..Methods of assessment of selenium status in humans:A systematic review[J].Am.J.Clin.Nutr.,2009,89:2025S-2039S.
[6]Waters D J,Chiang E C,Cooley D M,et al..Making sense of sex and supplements:Differences in the anticarcinogenic effects of selenium in men and women[J].Mutat.Res.,2004,551(1-2):91-107.
[7]Otten J J,Pitzi Hellwig J,Meyers L D.Dietary Reference Intakes:The Essential Guide to Nutrient Requirements[M].Washington DC:National Academies Press,2006.
[8]Hurst R,Armah C N,Dainty J R,et al..Establishing optimal selenium status:Results of a randomized,double-blind,placebo-controlled trial[J].Am.J.Clin.Nutr.,2010,91:923-931.
[9]Hill K E,Xia Y,Akesson B,et al..Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects[J].J.Nutr.,1996,126:138-145.
[10]Duffield A J,Thomson C D,Hill K E,et al..An estimation of selenium requirements for New Zealanders[J].Am.J.Clin.Nutr.,1999,70:896-903.
[11]Akbaraly N T,Arnaud J,Hininger-Favier I,et al..Selenium and mortality in the elderly:Results from the EVA study[J].Clin.Chem.,2005,51:2117-2123.
[12]Bleys J,Navas-Acien A,Guallar E.Serum selenium levels and all-cause,cancer,and cardiovascular mortality among US adults[J].Arch.Intern.Med.,2008,168:404-410.
[13]Sun J W,Shu X O,Li H L,et al..Dietary selenium intake and mortality in two population-based cohort studies of 133 957Chinese men and women[J].Public Health Nutr.,2016,19:2991-2998.
[14]Schwingshackl L,Boeing H,Stelmach-Mardas M,et al..Dietary supplements and risk of cause-specific death,cardiovascular disease,and cancer:A systematic review and meta-analysis of primary prevention trials[J].Adv.Nutr.,2017,8(1):27-39.
[15]Zhuo H,Smith A H,Steinmaus C.Selenium and lung cancer:A quantitative analysis of heterogeneity in the current epidemiological literature[J].Cancer Epidemiol.Biomarkers Prev.,2004,13:771-778.
[16]Vinceti M,Dennert G,Crespi C M,et al..Selenium for preventing cancer[J].Cochrane Database Syst.Rev.,2014,3(3):005195.
[17]Amaral A F,Cantor K P,Silverman D T,et al..Selenium and bladder cancer risk:A meta-analysis[J].Cancer Epidemiol.Biomarkers Prev.,2010,19:2407-2415.
[18]Kellen E,Zeegers M,Buntinx F.Selenium is inversely associated with bladder cancer risk:A report from the Belgian casecontrol study on bladder cancer[J].Int.J.Urol.,2006,13:1180-1184.
[19]Wallace K,Kelsey K T,Schned A,et al..Selenium and risk of bladder cancer:A population-based case-control study[J].Cancer Prev.Res.,2009,2:70-73.
[20]Hurst R,Hooper L,Norat T,et al..Selenium and prostate cancer:Systematic review and meta-analysis[J].Am.J.Clin.Nutr.,2012,96:111-122.
[21]Waters D J,Shen S,Glickman L T,et al..Prostate cancer risk and DNA damage:Translational significance of selenium supplementation in a canine model[J].Carcinogenesis,2005,26:1256-1262.
[22]Chiang E C,Shen S,Kengeri S S,et al..Defining the optimal selenium dose for prostate cancer risk reduction:Insights from the U-shaped relationship between selenium status,DNA damage,and apoptosis[J].Dose Response,2009,8:285-300.
[23]Kristal A R,Darke A K,Morris J S,et al..Baseline selenium status and effects of selenium and vitamin E supplementation on prostate cancer risk[J].J.Natl.Cancer Inst.,2014,106:456.
[24]Chan J M,Oh W K,Xie W,et al..Plasma selenium,manganese superoxide dismutase,and intermediate-or high-risk prostate cancer[J].J.Clin.Oncol.,2009,27:3577-3583.
[25]Thompson P A,Ashbeck E L,Roe D J,et al..Selenium supplementation for prevention of colorectal adenomas and risk of associated type 2 diabetes[J].J.Natl.Cancer Inst.,2016,doi:10.1093/jnci/djw152.
[26]Bleys J,Navas-Acien A,Laclaustra M,et al..Serum selenium and peripheral arterial disease:Results from the national health and nutrition examination survey,2003-2004[J].Am.J.Epidemiol.,2009,169:996-1003.
[27]Flores-Mateo G,Navas-Acien A,Pastor-Barriuso R,et al..Selenium and coronary heart disease:A meta-analysis[J].Am.J.Clin.Nutr.,2006,84:762-773.
[28]Stranges S,Marshall J R,Trevisan M,et al..Effects of selenium supplementation on cardiovascular disease incidence and mortality:Secondary analyses in a randomized clinical trial[J].Am.J.Epidemiol.,2006,163:694-699.
[29]Rayman M P,Stranges S,Griffin B A,et al..Effect of supplementation with high-selenium yeast on plasma lipids:A randomized trial[J].Ann.Int.Med.,2011,154:656-665.
[30]Akbaraly T N,Arnaud J,Rayman M P,et al..Plasma selenium and risk of dysglycemia in an elderly French population:Results from the prospective Epidemiology of Vascular Ageing Study[J].Nutr.Metab.,2010,7:21.
[31]Laclaustra M,Navas-Acien A,Stranges S,et al..Serum selenium concentrations and diabetes in U.S.adults:National Health and Nutrition Examination Survey(NHANES)2003-2004[J].Environ.Health Perspect,2009,117:1409-1413.
[32]Stranges S,Marshall J R,Natarajan R,et al..Effects of longterm selenium supplementation on the incidence of type 2 diabetes:A randomized trial[J].Ann.Intern.Med.,2007,147:217-223.
[33]Lippman S M,Klein E A,Goodman P J,et al..Effect of selenium and vitamin E on risk of prostate cancer and other cancers:The Selenium and Vitamin E Cancer Prevention Trial(SELECT)[J].J.Am.Med.Assoc.,2009,301:39-51.
[34]Thompson P A,Ashbeck E L,Roe D J,et al..Selenium supplementation for prevention of colorectal adenomas and risk of associated type 2 diabetes[J].J.Natl.Cancer Inst.,2016,doi:10.1093/jnci/djw152.
[35]Steinbrenner H,Speckmann B,Pinto A,et al..High selenium intake and increased diabetes risk:Experimental evidence for interplay between selenium and carbohydrate metabolism[J].J.Clin.Biochem.Nutr.,2011,48:40-45.
[36]Mc Clung J P,Roneker C A,Mu W,et al..Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase[J].Proc.Natl.Acad.Sci.USA,2004,101:8852-8857.
[37]Labunskyy V M,Lee B C,Handy D E,et al..Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice[J].Antioxid.Redox.Signal.,2011,14:2327-2336.
[38]Imai H,Suzuki K,Ishizaka K,et al..Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males[J].Biol.Reprod.,2001,64:674-683.
[39]Hawkes W C,Turek P J.Effects of dietary selenium on sperm motility in healthy men[J].J.Androl.,2001,22:764-772.
[40]Steegers E A,von Dadelszen P,Duvekot J J,et al..Preeclampsia[J].Lancet,2010,376:631-644.
[41]Hutcheon J A,Lisonkova S,Joseph K S.Epidemiology of preeclampsia and the other hypertensive disorders of pregnancy[J].Best Pract.Res.Clin.Obstet.Gynaecol.,2011,25:391-403.
[42]Rayman M P,Bode P,Redman C W.Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom[J].Am.J.Obstet.Gynecol.,2003,189:1343-1349.
[43]Rayman M P,Bath S C,Westaway J,et al..Selenium status in UK pregnant women and its relationship with hypertensive conditions of pregnancy[J].British J.Nutr.,2015,113:249-258.
[44]Moses E K,Johnson M P,Tommerdal L,et al..Genetic association of preeclampsia to the inflammatory response gene SEPS1[J].Am.J.Obstet.Gynecol.,2008,198:331-335.
[45]Rayman M P,Wijnen H,Vader H,et al..Maternal selenium status during early gestation and risk for preterm birth[J].Can.Med.Assoc.J.,2011,183:549-555.
[46]Rayman M P.Selenium and human health[J].Lancet,2012,379:1256-1268.
[2]Rayman M P.Selenium in cancer prevention:A review of the evidence and mechanism of action[J].Proc.Nutr.Soc.,2005,64:527-542.
[3]Fairweather-Tait S J,Bao Y,Broadley M R,et al..Selenium in human health and disease[J].Antioxid.Redox.Signal.,2011,14:1337-1383.
[4]US Department of Agriculture,Agricultural Research Service.Nutrient Intakes from Food:Mean amounts consumed per individual,one day,2005-2006[DB/OL].www.ars.usda.gov=ba=bhnrc=fsrg,2010.
[5]Ashton K,Hooper L,Harvey L J,et al..Methods of assessment of selenium status in humans:A systematic review[J].Am.J.Clin.Nutr.,2009,89:2025S-2039S.
[6]Waters D J,Chiang E C,Cooley D M,et al..Making sense of sex and supplements:Differences in the anticarcinogenic effects of selenium in men and women[J].Mutat.Res.,2004,551(1-2):91-107.
[7]Otten J J,Pitzi Hellwig J,Meyers L D.Dietary Reference Intakes:The Essential Guide to Nutrient Requirements[M].Washington DC:National Academies Press,2006.
[8]Hurst R,Armah C N,Dainty J R,et al..Establishing optimal selenium status:Results of a randomized,double-blind,placebo-controlled trial[J].Am.J.Clin.Nutr.,2010,91:923-931.
[9]Hill K E,Xia Y,Akesson B,et al..Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects[J].J.Nutr.,1996,126:138-145.
[10]Duffield A J,Thomson C D,Hill K E,et al..An estimation of selenium requirements for New Zealanders[J].Am.J.Clin.Nutr.,1999,70:896-903.
[11]Akbaraly N T,Arnaud J,Hininger-Favier I,et al..Selenium and mortality in the elderly:Results from the EVA study[J].Clin.Chem.,2005,51:2117-2123.
[12]Bleys J,Navas-Acien A,Guallar E.Serum selenium levels and all-cause,cancer,and cardiovascular mortality among US adults[J].Arch.Intern.Med.,2008,168:404-410.
[13]Sun J W,Shu X O,Li H L,et al..Dietary selenium intake and mortality in two population-based cohort studies of 133 957Chinese men and women[J].Public Health Nutr.,2016,19:2991-2998.
[14]Schwingshackl L,Boeing H,Stelmach-Mardas M,et al..Dietary supplements and risk of cause-specific death,cardiovascular disease,and cancer:A systematic review and meta-analysis of primary prevention trials[J].Adv.Nutr.,2017,8(1):27-39.
[15]Zhuo H,Smith A H,Steinmaus C.Selenium and lung cancer:A quantitative analysis of heterogeneity in the current epidemiological literature[J].Cancer Epidemiol.Biomarkers Prev.,2004,13:771-778.
[16]Vinceti M,Dennert G,Crespi C M,et al..Selenium for preventing cancer[J].Cochrane Database Syst.Rev.,2014,3(3):005195.
[17]Amaral A F,Cantor K P,Silverman D T,et al..Selenium and bladder cancer risk:A meta-analysis[J].Cancer Epidemiol.Biomarkers Prev.,2010,19:2407-2415.
[18]Kellen E,Zeegers M,Buntinx F.Selenium is inversely associated with bladder cancer risk:A report from the Belgian casecontrol study on bladder cancer[J].Int.J.Urol.,2006,13:1180-1184.
[19]Wallace K,Kelsey K T,Schned A,et al..Selenium and risk of bladder cancer:A population-based case-control study[J].Cancer Prev.Res.,2009,2:70-73.
[20]Hurst R,Hooper L,Norat T,et al..Selenium and prostate cancer:Systematic review and meta-analysis[J].Am.J.Clin.Nutr.,2012,96:111-122.
[21]Waters D J,Shen S,Glickman L T,et al..Prostate cancer risk and DNA damage:Translational significance of selenium supplementation in a canine model[J].Carcinogenesis,2005,26:1256-1262.
[22]Chiang E C,Shen S,Kengeri S S,et al..Defining the optimal selenium dose for prostate cancer risk reduction:Insights from the U-shaped relationship between selenium status,DNA damage,and apoptosis[J].Dose Response,2009,8:285-300.
[23]Kristal A R,Darke A K,Morris J S,et al..Baseline selenium status and effects of selenium and vitamin E supplementation on prostate cancer risk[J].J.Natl.Cancer Inst.,2014,106:456.
[24]Chan J M,Oh W K,Xie W,et al..Plasma selenium,manganese superoxide dismutase,and intermediate-or high-risk prostate cancer[J].J.Clin.Oncol.,2009,27:3577-3583.
[25]Thompson P A,Ashbeck E L,Roe D J,et al..Selenium supplementation for prevention of colorectal adenomas and risk of associated type 2 diabetes[J].J.Natl.Cancer Inst.,2016,doi:10.1093/jnci/djw152.
[26]Bleys J,Navas-Acien A,Laclaustra M,et al..Serum selenium and peripheral arterial disease:Results from the national health and nutrition examination survey,2003-2004[J].Am.J.Epidemiol.,2009,169:996-1003.
[27]Flores-Mateo G,Navas-Acien A,Pastor-Barriuso R,et al..Selenium and coronary heart disease:A meta-analysis[J].Am.J.Clin.Nutr.,2006,84:762-773.
[28]Stranges S,Marshall J R,Trevisan M,et al..Effects of selenium supplementation on cardiovascular disease incidence and mortality:Secondary analyses in a randomized clinical trial[J].Am.J.Epidemiol.,2006,163:694-699.
[29]Rayman M P,Stranges S,Griffin B A,et al..Effect of supplementation with high-selenium yeast on plasma lipids:A randomized trial[J].Ann.Int.Med.,2011,154:656-665.
[30]Akbaraly T N,Arnaud J,Rayman M P,et al..Plasma selenium and risk of dysglycemia in an elderly French population:Results from the prospective Epidemiology of Vascular Ageing Study[J].Nutr.Metab.,2010,7:21.
[31]Laclaustra M,Navas-Acien A,Stranges S,et al..Serum selenium concentrations and diabetes in U.S.adults:National Health and Nutrition Examination Survey(NHANES)2003-2004[J].Environ.Health Perspect,2009,117:1409-1413.
[32]Stranges S,Marshall J R,Natarajan R,et al..Effects of longterm selenium supplementation on the incidence of type 2 diabetes:A randomized trial[J].Ann.Intern.Med.,2007,147:217-223.
[33]Lippman S M,Klein E A,Goodman P J,et al..Effect of selenium and vitamin E on risk of prostate cancer and other cancers:The Selenium and Vitamin E Cancer Prevention Trial(SELECT)[J].J.Am.Med.Assoc.,2009,301:39-51.
[34]Thompson P A,Ashbeck E L,Roe D J,et al..Selenium supplementation for prevention of colorectal adenomas and risk of associated type 2 diabetes[J].J.Natl.Cancer Inst.,2016,doi:10.1093/jnci/djw152.
[35]Steinbrenner H,Speckmann B,Pinto A,et al..High selenium intake and increased diabetes risk:Experimental evidence for interplay between selenium and carbohydrate metabolism[J].J.Clin.Biochem.Nutr.,2011,48:40-45.
[36]Mc Clung J P,Roneker C A,Mu W,et al..Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase[J].Proc.Natl.Acad.Sci.USA,2004,101:8852-8857.
[37]Labunskyy V M,Lee B C,Handy D E,et al..Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice[J].Antioxid.Redox.Signal.,2011,14:2327-2336.
[38]Imai H,Suzuki K,Ishizaka K,et al..Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males[J].Biol.Reprod.,2001,64:674-683.
[39]Hawkes W C,Turek P J.Effects of dietary selenium on sperm motility in healthy men[J].J.Androl.,2001,22:764-772.
[40]Steegers E A,von Dadelszen P,Duvekot J J,et al..Preeclampsia[J].Lancet,2010,376:631-644.
[41]Hutcheon J A,Lisonkova S,Joseph K S.Epidemiology of preeclampsia and the other hypertensive disorders of pregnancy[J].Best Pract.Res.Clin.Obstet.Gynaecol.,2011,25:391-403.
[42]Rayman M P,Bode P,Redman C W.Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom[J].Am.J.Obstet.Gynecol.,2003,189:1343-1349.
[43]Rayman M P,Bath S C,Westaway J,et al..Selenium status in UK pregnant women and its relationship with hypertensive conditions of pregnancy[J].British J.Nutr.,2015,113:249-258.
[44]Moses E K,Johnson M P,Tommerdal L,et al..Genetic association of preeclampsia to the inflammatory response gene SEPS1[J].Am.J.Obstet.Gynecol.,2008,198:331-335.
[45]Rayman M P,Wijnen H,Vader H,et al..Maternal selenium status during early gestation and risk for preterm birth[J].Can.Med.Assoc.J.,2011,183:549-555.
[46]Rayman M P.Selenium and human health[J].Lancet,2012,379:1256-1268.