脑氧代谢相关参数在中枢神经系统疾病中的应用进展
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摘要
颅内静脉血氧饱和度、氧摄取分数、脑氧代谢率是一组反映脑组织氧的利用及代谢情况的指标,可间接评估脑功能及脑组织发育程度。多种医学成像技术可测量静脉血氧饱和度,包括如血氧水平依赖成像(BOLD)、自旋标记下T_2弛豫成像(TRUST)、磁敏感加权成像(SWI)、定量磁敏感图(QSM)等。综述血氧饱和度及其相关代谢参数的测量在脑梗死、创伤性脑损伤、多发性硬化、肝性脑病、肾性脑病及镰状细胞贫血疾病中的应用及研究。
Cerebral venous oxygen saturation, oxygen extraction fraction, and cerebral metabolic rate of oxygen are a group of indicators that can reflect utilization and metabolism of intracranial oxygen. They can be used to indirectly assess brain function and degree of brain tissue development. Many radiological techniques can be used to measure venous oxygen saturation, including blood oxygenation level dependent(BOLD), T_2-relaxation-under-spin-tagging(TRUST), susceptibility weighted imaging(SWI), and quantitative susceptibility mapping(QSM), etc. In the current paper, we reviewed the applications and study progresses of blood oxygen saturation and its related metabolic parameters in cerebral infarction, traumatic brain injury, multiple sclerosis, hepatic encephalopathy, renal encephalopathy, and sickle cell anemia.
Cerebral venous oxygen saturation, oxygen extraction fraction, and cerebral metabolic rate of oxygen are a group of indicators that can reflect utilization and metabolism of intracranial oxygen. They can be used to indirectly assess brain function and degree of brain tissue development. Many radiological techniques can be used to measure venous oxygen saturation, including blood oxygenation level dependent(BOLD), T_2-relaxation-under-spin-tagging(TRUST), susceptibility weighted imaging(SWI), and quantitative susceptibility mapping(QSM), etc. In the current paper, we reviewed the applications and study progresses of blood oxygen saturation and its related metabolic parameters in cerebral infarction, traumatic brain injury, multiple sclerosis, hepatic encephalopathy, renal encephalopathy, and sickle cell anemia.
引文
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[17]Luo Y,Gong Z,Zhou Y,et al.Increased susceptibility of asymmetrically prominent cortical veins correlates with misery perfusion in patients with occlusion of the middle cerebral artery[J].Eur Radiol,2017,27:1-10.
[18]杨晴媛,常斌鸽,柴超,等.定量磁敏感加权成像在急性缺血性脑卒中的应用进展[J].国际医学放射学杂志,2016,39:489-494.
[19]Chen CY,Chen CI,Tsai FY,et al.Prominent vessel sign on susceptibility-weighted imaging in acute stroke:prediction of infarct growth and clinical outcome[J].PLoS One,2015,10:e131118.
[20]Chang FY,Xiao JX,Xie S,et al.Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion[J].Sci Rep,2016,6:30332.
[21]Iraji A,Chen H,Wiseman N,et al.Connectome-scale assessment of structural and functional connectivity in mild traumatic brain injury at the acute stage[J].Neuroimage Clin,2016,12:100-115.
[22]Kagari A,Tohru S,Chietsugu K,et al.Relationship between intelligence quotient(IQ)and cerebral metabolic rate of oxygen in patients with neurobehavioural disability after traumatic brain injury[J].Brain Inj,2018,32:1367-1372.
[23]Chai C,Guo R,Zuo C,et al.Decreased susceptibility of major veins in mild traumatic brain injury is correlated with post-concussive symptoms:a quantitative susceptibility mapping study[J].Neuroimage Clin,2017,15:625-632.
[24]吴铁军,田辉,张连群.重症颅脑损伤患者脑氧利用率的变化及其意义[J].中华神经外科疾病研究杂志,2004,3:268-269.
[25]Hardik D,Natalie W,Jun L,et al.Cerebral hemodynamic changes of mild traumatic brain injury at the acute stage[J].PLoS One,2015,10:e118061.
[26]Weiwei C,Gauthier SA,Ajay G,et al.Quantitative susceptibility mapping of multiple sclerosis lesions at various ages[J].Radiology,2014,271:183-192.
[27]唐乐梅,刘铁利,冯洁,等.采用磁敏感加权成像测量多发性硬化患者脑深部静脉血氧含量[J].中华放射学杂志,2015,8:561-565.
[28]Vilstrup H,Amodio P,Bajaj J,et al.Hepatic encephalopathy in chronic liver disease:2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver[J].Hepatology,2014,61:642-659.
[29]Zheng G,Lu H,Yu W,et al.Severity-specific alterations in CBF,OEF and CMRO2in cirrhotic patients with hepatic encephalopathy[J].Eur Radiol,2017,27:4699-4709.
[30]Findlay MD,Dawson J,Dickie DA,et al.Investigating the relationship between cerebral blood flow and cognitive function in hemodialysis patients[J].J Am Soc Nephrol,2018,30:147-158.
[31]Chai C,Liu S,Fan L,et al.Reduced deep regional cerebral venous oxygen saturation in hemodialysis patients using quantitative susceptibility mapping[J].Metab Brain Dis,2018,33:313-323.
[32]Zheng G,Wen J,Lu H,et al.Elevated global cerebral blood flow,oxygen extraction fraction and unchanged metabolic rate of oxygen in young adults with end-stage renal disease:an MRI study[J].Eur Radiol,2016,26:1732-1741.
[33]Jordan LC,Debaun MR.Cerebral hemodynamic assessment and neuroimaging across the lifespan in sickle cell disease[J].J Cereb Blood Flow Metab,2017,38:1438-1448.
[34]Nottage KA,Ware RE,Aygun B,et al.Hydroxycarbamide treatment and brain MRI/MRA findings in children with sickle cell anaemia[J].Br J Haematol,2016,175:331-338.
[35]Bernaudin F,Verlhac S,Arnaud C,et al.Chronic acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia[J].Blood,2015,125:1653-1661.
[36]Jordan LC,Gindville MC,Scott AO,et al.Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia[J].Brain,2016,139(Pt 3):738-750.
[37]Fields ME,Guilliams KP,Ragan DK,et al.Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease[J].Neurology,2018,90:e1134-e1142.
[38]Bush AM,Coates TD,Wood JC.Diminished cerebral oxygen extraction and metabolic rate in sickle cell disease using T2 relaxation under spin tagging MRI[J].Magn Reson Med,2018,80:294-303.
[2]Buch S,Ye Y,Haacke EM.Quantifying the changes in oxygen extraction fraction and cerebral activity caused by caffeine and acetazolamide[J].J Cereb Blood Flow Metab,2017,37:825-836.
[3]Fan AP,Benner T,Bolar DS,et al.Phase-based regional oxygen metabolism(PROM)using MRI[J].Magn Reson Med,2012,67:669-678.
[4]李雪松.早期缺血性脑梗死脑氧代谢及血流灌注的MRI研究[D].大连医科大学,2014.
[5]Fahmeed H,Peter H,Sanganahalli BG,et al.Role of ongoing,intrinsic activity of neuronal populations for quantitative neuroimaging of functional magnetic resonance imaging-based networks[J].Brain Connect,2011,1:185-193.
[6]Gauthier CJ,Hoge RD.A generalized procedure for calibrated MRIincorporating hyperoxia and hypercapnia[J].Hum Brain Mapp,2013,34:1053-1069.
[7]Lajoie I,Nugent S,Debacker C,et al.Application of calibrated fMRIin Alzheimer’s disease[J].Neuroimage Clin,2017,15:348-358.
[8]Lu H,Ge Y.Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI[J].Magn Reson Med,2010,60:357-363.
[9]杨星,陶晓峰.定量磁敏感图研究进展及临床应用现状[J].国际医学放射学杂志,2017,40:556-560.
[10]Barhoum S,Rodgers ZB,Langham M,et al.Comparison of MRImethods for measuring whole-brain venous oxygen saturation[J].Magn Reson Med,2015,73:2122-2128.
[11]Krishnamurthy LC,Liu P,Ge Y,et al.Vessel-specific quantification of blood oxygenation with T2-relaxation-under-phase-contrast MRI[J].Magn Reson Med,2014,71:978-989.
[12]Uwano I,Kudo K,Sato R,et al.Noninvasive assessment of oxygen extraction fraction in chronic ischemia using quantitative susceptibility mapping at 7 Tesla[J].Stroke,2017,48:2136-2141.
[13]Baik N,Urlesberger B,Schwaberger B,et al.Reference ranges for cerebral tissue oxygen saturation index in term neonates during immediate neonatal transition after birth[J].Neonatology,2015,108:283-286.
[14]Pichler G,Urlesberger B,Baik N,et al.Cerebral oxygen saturation to guide oxygen delivery in preterm neonates for the immediate transition after birth:A2-center randomized controlled pilot feasibility trial[J].J Pediatr,2016,170:73-78.
[15]Liu Z,Li Y.Cortical cerebral blood flow,oxygen extraction fraction,and metabolic rate in patients with middle cerebral artery stenosis or acute stroke[J].AJNR,2016,37:607-614.
[16]Xia S,Utriainen D,Tang J,et al.Decreased oxygen saturation in asymmetrically prominent cortical veins in patients with cerebral ischemic stroke[J].Magn Reson Imaging,2014,32:1272-1276.
[17]Luo Y,Gong Z,Zhou Y,et al.Increased susceptibility of asymmetrically prominent cortical veins correlates with misery perfusion in patients with occlusion of the middle cerebral artery[J].Eur Radiol,2017,27:1-10.
[18]杨晴媛,常斌鸽,柴超,等.定量磁敏感加权成像在急性缺血性脑卒中的应用进展[J].国际医学放射学杂志,2016,39:489-494.
[19]Chen CY,Chen CI,Tsai FY,et al.Prominent vessel sign on susceptibility-weighted imaging in acute stroke:prediction of infarct growth and clinical outcome[J].PLoS One,2015,10:e131118.
[20]Chang FY,Xiao JX,Xie S,et al.Determination of oxygen extraction fraction using magnetic resonance imaging in canine models with internal carotid artery occlusion[J].Sci Rep,2016,6:30332.
[21]Iraji A,Chen H,Wiseman N,et al.Connectome-scale assessment of structural and functional connectivity in mild traumatic brain injury at the acute stage[J].Neuroimage Clin,2016,12:100-115.
[22]Kagari A,Tohru S,Chietsugu K,et al.Relationship between intelligence quotient(IQ)and cerebral metabolic rate of oxygen in patients with neurobehavioural disability after traumatic brain injury[J].Brain Inj,2018,32:1367-1372.
[23]Chai C,Guo R,Zuo C,et al.Decreased susceptibility of major veins in mild traumatic brain injury is correlated with post-concussive symptoms:a quantitative susceptibility mapping study[J].Neuroimage Clin,2017,15:625-632.
[24]吴铁军,田辉,张连群.重症颅脑损伤患者脑氧利用率的变化及其意义[J].中华神经外科疾病研究杂志,2004,3:268-269.
[25]Hardik D,Natalie W,Jun L,et al.Cerebral hemodynamic changes of mild traumatic brain injury at the acute stage[J].PLoS One,2015,10:e118061.
[26]Weiwei C,Gauthier SA,Ajay G,et al.Quantitative susceptibility mapping of multiple sclerosis lesions at various ages[J].Radiology,2014,271:183-192.
[27]唐乐梅,刘铁利,冯洁,等.采用磁敏感加权成像测量多发性硬化患者脑深部静脉血氧含量[J].中华放射学杂志,2015,8:561-565.
[28]Vilstrup H,Amodio P,Bajaj J,et al.Hepatic encephalopathy in chronic liver disease:2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver[J].Hepatology,2014,61:642-659.
[29]Zheng G,Lu H,Yu W,et al.Severity-specific alterations in CBF,OEF and CMRO2in cirrhotic patients with hepatic encephalopathy[J].Eur Radiol,2017,27:4699-4709.
[30]Findlay MD,Dawson J,Dickie DA,et al.Investigating the relationship between cerebral blood flow and cognitive function in hemodialysis patients[J].J Am Soc Nephrol,2018,30:147-158.
[31]Chai C,Liu S,Fan L,et al.Reduced deep regional cerebral venous oxygen saturation in hemodialysis patients using quantitative susceptibility mapping[J].Metab Brain Dis,2018,33:313-323.
[32]Zheng G,Wen J,Lu H,et al.Elevated global cerebral blood flow,oxygen extraction fraction and unchanged metabolic rate of oxygen in young adults with end-stage renal disease:an MRI study[J].Eur Radiol,2016,26:1732-1741.
[33]Jordan LC,Debaun MR.Cerebral hemodynamic assessment and neuroimaging across the lifespan in sickle cell disease[J].J Cereb Blood Flow Metab,2017,38:1438-1448.
[34]Nottage KA,Ware RE,Aygun B,et al.Hydroxycarbamide treatment and brain MRI/MRA findings in children with sickle cell anaemia[J].Br J Haematol,2016,175:331-338.
[35]Bernaudin F,Verlhac S,Arnaud C,et al.Chronic acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia[J].Blood,2015,125:1653-1661.
[36]Jordan LC,Gindville MC,Scott AO,et al.Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia[J].Brain,2016,139(Pt 3):738-750.
[37]Fields ME,Guilliams KP,Ragan DK,et al.Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease[J].Neurology,2018,90:e1134-e1142.
[38]Bush AM,Coates TD,Wood JC.Diminished cerebral oxygen extraction and metabolic rate in sickle cell disease using T2 relaxation under spin tagging MRI[J].Magn Reson Med,2018,80:294-303.