吸烟影响高密度脂蛋白代谢致动脉粥样硬化的新机制
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摘要
吸烟是动脉粥样硬化疾病的独立危险因素,吸烟时间越长,烟量越大,血管损伤越严重。吸烟可促进血浆中脂质尤其是胆固醇在动脉内膜下沉积,使胆固醇在巨噬细胞中的过量沉积而形成泡沫细胞,从而导致动脉粥样硬化病变的形成。吸烟对血浆脂质和脂蛋白具有负性调节作用,可降低高密度脂蛋白胆固醇(HDL-C)水平,改变脂蛋白转运的关键酶活性,减少逆胆固醇转运,改变HDL亚组分,从而损害HDL的抗动脉粥样硬化功能,促进动脉粥样硬化病变进展。
引文
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[19]Su Z,Zhang S,Zhang L,et al.A novel allele in the promoter of hepatic lipase is associated with increased with concentration of HDL-C and decreased promoter activity.J Lipid Res,2002,43:1595-1601.
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[22]Moffatt RJ,Chelland SA,Pecott DL,et al.Acute exposure to environmental tobacco smoke reduces HDL-C and HDL2-C.Prev Med,2004,38:637-641.
[23]Teo KK,Ounpuu S,Hawken S,et al.Tobacco use and risk of myocardial infarction in 52countries in the INTERHEART study:a case-control study.Lancet,2006,368:647-658.
[24]李晓斌,任艺虹,盖鲁粤.高敏C反应蛋白和肾动脉粥样硬化性狭窄的相关性研究.中国循环杂志,2006,21:365-367.
[25]刘永铭,彭晓,严祥.男性吸烟者细胞粘附分子和相关细胞因子水平的观察.中国循环杂志,2002,17:50-53.
[26]Botella-Carretero JI,Escobar-Morreale HF,Martin I,et al.Weight gain and cardiovascular risk factors during smoking cessation with bupropion or nicotine.Horm Metab Res,2004,36:178-182.
[27]Forey BA,Fry JS,Lee PN,et al.The effect of quitting smoking on HDLcholesterol-a review based on within-subject changes.Biomark Res,2013,1:26.
[28]Haustein KO,Krause J,Haustein H,et al.Changes in hemorheological and biochemical parameters following short-term and long-term smoking cessation induced by nicotine replacement therapy(NRT).Int J Clin Pharmacol Ther,2004,42:83-92.
[2]Rahman MM,Laher I.Structural and functional alteration of blood vessels caused by cigarette smoking:an overview of molecular mechanisms.Curr Vase Pharmacol,2007,5:276-292.
[3]Girdhar G,Xu S,Jesty J,Bluestein D.In vitro model of plateletendothelial activation due to cigarette smoke under cardiovascular circulation conditions.Ann Biomed Eng,2008,36:1142-1151.
[4]Drew BG,Rye KA,Duffy SJ,et al.The emerging role of HDL in glucose metabolism.Nat Rev Endocrinol,2012,8:237-245.
[5]WHO urges more countries to require large,graphic health warnings on tobacco packaging:The WHO report on the global tobacco epidemic,2011 examines anti-tobacco mass-media campaigns.Cent Eur J Public Health,2011,19:133-151.
[6]世界卫生组织烟草或健康合作中心,中国疾病预防控制中心控烟办公室,中国控制吸烟协会医院控烟专业委员会.临床戒烟指南.2007,6.
[7]Jha P,Ramasundarahettige C,Landsman V,et al.21st-Century Hazards of Smoking and Benefits of Cessation in the United States.N Engl J Med,2013,368:341-350.
[8]Chelland CS,Moffatt RJ,Stamford BA.Smoking and smoking cessationthe relationship between cardiovascular disease and lipoprotein metabolism:a review.Atherosclerosis,2008,201:225-235.
[9]高阅春,何继强,姜腾勇,等.冠心病患者冠状动脉病变严重程度与冠心病危险因素的相关分析.中国循环杂志,2012,27:178-181.
[10]Teo KK,Ounpuu S,Hawken S,et al.Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study:a case-control study.Lancet,2006,368:647-658.
[11]《中国成人血脂异常防治指南》制订联合委员会.中国成人血脂异常防治指南.北京:人民卫生出版社,2007:8.
[12]Craig WY,Palomaki GE,Haddow JE.Cigarette smoking and serum lipid and lipoprotein concentrations:an analysis of published data.BMJ,1989,298:784-788.
[13]McCall MR,van den Berg JJM,Kuypers FA,et al.Modification of LCAT activity and HDL structure:new links between cigarette smoke and coronary heart disease.Arteriosc Thromb,1994,14:248-253.
[14]Kong C,Nimano L,Elatroy T,et al.Smoking is associated with increased hepatic lipase activity,insulin resistance,dyslipidemia and early atherosclerosis in type 2 diabetes.Atherosclerosis,2001,156:373-378.
[15]Ueyama K,Yokode M,Arai H,et al.Cholesterol efflux effect of high density lipoprotein is impaired by whole cigarette smoke extracts throu gh lipid peroxidation.Free Radic Biol Med.1998,24:182-190.
[16]Imamura H,Teshima K,Miyamoto N,Shirota T.Cigarette smoking,high-density lipoprotein cholesterol subfractions,and lecithin:cholesterol acyltransferase in young women.Metabolism,2002,51:1313-1316.
[17]Dullart RPF,Hoogenberg K,Dikkeschu BD,et al.High plasma lipid transfer protein activities and unfavorable lipoprotein changes in cigarette smoking men.Aterioscler Thromb,1995,14:1581-1585.
[18]Freeman DJ,Caslake MJ,Griffin BA,et al.The effect of smoking on post-heparin lipoprotein and hepatic lipase,cholesteryl ester transfer protein and lecithin:cholesterol acyl transferase activities in human plasma.Eur J Clin Invest,1998,28:584-591.
[19]Su Z,Zhang S,Zhang L,et al.A novel allele in the promoter of hepatic lipase is associated with increased with concentration of HDL-C and decreased promoter activity.J Lipid Res,2002,43:1595-1601.
[20]Zaratin AC,Quintao EC,Sposito AC,et al.Smoking prevents the intravascular remodeling of high-density lipoprotein particles;implications for reverse cholesterol transport.Metabolism,2004,53:858-862.
[21]Ruel IL,Co uture P,Cohn JS,et al.Evidence that hepatic deficiency in humans is not associated with proatherogenic changes in HDL composition and metabolism.J Lipid Res,2004,45:1528-1537.
[22]Moffatt RJ,Chelland SA,Pecott DL,et al.Acute exposure to environmental tobacco smoke reduces HDL-C and HDL2-C.Prev Med,2004,38:637-641.
[23]Teo KK,Ounpuu S,Hawken S,et al.Tobacco use and risk of myocardial infarction in 52countries in the INTERHEART study:a case-control study.Lancet,2006,368:647-658.
[24]李晓斌,任艺虹,盖鲁粤.高敏C反应蛋白和肾动脉粥样硬化性狭窄的相关性研究.中国循环杂志,2006,21:365-367.
[25]刘永铭,彭晓,严祥.男性吸烟者细胞粘附分子和相关细胞因子水平的观察.中国循环杂志,2002,17:50-53.
[26]Botella-Carretero JI,Escobar-Morreale HF,Martin I,et al.Weight gain and cardiovascular risk factors during smoking cessation with bupropion or nicotine.Horm Metab Res,2004,36:178-182.
[27]Forey BA,Fry JS,Lee PN,et al.The effect of quitting smoking on HDLcholesterol-a review based on within-subject changes.Biomark Res,2013,1:26.
[28]Haustein KO,Krause J,Haustein H,et al.Changes in hemorheological and biochemical parameters following short-term and long-term smoking cessation induced by nicotine replacement therapy(NRT).Int J Clin Pharmacol Ther,2004,42:83-92.