microRNAs在高血压疾病中的作用机制
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摘要
高血压作为一种多因素的慢性疾病,其引起的一系列并发症是导致心血管疾病死亡的主要原因。微RNA(microRNA,miRNAs)作为内源性单链非编码RNA,在高血压的病理生理过程中发挥重要作用。miRNAs通过调控血管内皮细胞损伤、血管平滑肌细胞功能障碍、单核/巨噬细胞介导的免疫炎症反应、氧化应激、一氧化氮合成异常、肾素-血管紧张素-醛固酮系统的激活、交感神经激活、肾水钠潴留和胰岛素抵抗等过程,进而广泛参与高血压的发病过程。本文就miRNAs在高血压发生发展中的作用机制及其研究进展进行简要综述,为高血压早期诊断及治疗提供新思路。
Hypertension,as a multi-factor chronic disease,causes a series of complications that are the main causes of cardiovascular deaths. MicroRNAs( miRNAs),as endogenous single-strand non-coding RNAs,play an important role in the pathophysiological process of hypertension. miRNAs are involved in the pathogenesis of hypertension through regulating vascular endothelial cell injury,vascular smooth muscle cell dysfunction, monocyte/macrophage-mediated immune inflammatory response, oxidative stress,abnormal synthesis of nitric oxide,activation of renin-angiotensin-aldosterone system,sympathetic activation,sodium retention and insulin resistance. This review summarizes the role of miRNAs in the development of hypertension and provides new ideas for early diagnosis and therapy of hypertension.
Hypertension,as a multi-factor chronic disease,causes a series of complications that are the main causes of cardiovascular deaths. MicroRNAs( miRNAs),as endogenous single-strand non-coding RNAs,play an important role in the pathophysiological process of hypertension. miRNAs are involved in the pathogenesis of hypertension through regulating vascular endothelial cell injury,vascular smooth muscle cell dysfunction, monocyte/macrophage-mediated immune inflammatory response, oxidative stress,abnormal synthesis of nitric oxide,activation of renin-angiotensin-aldosterone system,sympathetic activation,sodium retention and insulin resistance. This review summarizes the role of miRNAs in the development of hypertension and provides new ideas for early diagnosis and therapy of hypertension.
引文
[1]Bartel DP.MicroRNAs:genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297
[2]Samanta S,Balasubramanian S,Rajasingh S,et al.MicroRNA:A new therapeutic strategy for cardiovascular diseases[J].Trends Cardiovasc Med,2016,26(5):407-419
[3]唐青,邢晓为,黄利华,et al.miRNA在高血压疾病中的应用及调控机制[J].中华高血压杂志(Tang Q,Xing XW,Huang LH,et al.Application and regulation mechanism of miRNA in hypertension[J].Chin J Hypertens),2013,21(2):121-126
[4]Brook RD,Appel LJ,Rubenfire M,et al.Beyond medications and diet:alternative approaches to lowering blood pressure:a scientific statement from the american heart association[J].Hypertension,2013,61(6):1360-1383
[5]Ivanovic B,Tadic M.Hypercholesterolemia and hypertension:two sides of the same coin[J].Am J Cardiovasc Drugs,2015,15(6):403-414
[6]Klimczak D,Jazdzewski K,Kuch M.Regulatory mechanisms in arterial hypertension:role of microRNA in pathophysiology and therapy[J].Blood Press,2017,26(1):2-8
[7]刘颖,刘颜,王立立,et al.血管内皮细胞功能障碍及修复与高血压关系探讨[J].中华老年心脑血管病杂志(Liu Y,Liu Y,Wang LL,et al.Relationship between vascular endothelial cell dysfunction and repair and hypertension[J].Chin J Geriatr Heart Brain Vessel Dis),2018,20(7):769-771
[8]Nemecz M,Alexandru N,Tanko G,et al.Role of MicroRNA in Endothelial Dysfunction and Hypertension[J].Curr Hypertens Rep,2016,18(12):87
[9]Wang S,Aurora AB,Johnson BA,et al.The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis[J].Dev Cell,2008,15(2):261-271
[10]Iaconetti C,Polimeni A,Sorrentino S,et al.Inhibition of miR-92a increases endothelial proliferation and migration in vitro as well as reduces neointimal proliferation in vivo after vascular injury[J].Basic Res Cardiol,2012,107(5):296
[11]Daniel JM,Penzkofer D,Teske R,et al.Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury[J].Cardiovasc Res,2014,103(4):564-572
[12]Fiedler J,Jazbutyte V,Kirchmaier BC,et al.MicroRNA-24regulates vascularity after myocardial infarction[J].Circulation,2011,124(6):720-730
[13]刘思管.MiR-34a在高血压诱导血管损伤中的表达及其作用机制研究[D].山东大学(Liu SG.Molecular mechanisms in vascular injury induced by hypertension:expression and role of miR-34a[D].Shandong University),2016
[14]Yi F,Hao Y,Chong X,et al.Overexpression of microRNA-506-3p aggravates the injury of vascular endothelial cells in patients with hypertension by downregulating Beclin1 expression[J].Exp Ther Med,2018,15(3):2844-2850
[15]Zhang L,Huang D,Wang Q,et al.MiR-132 inhibits expression of SIRT1 and induces pro-inflammatory processes of vascular endothelial inflammation through blockade of the SREBP-1c metabolic pathway[J].Cardiovasc Drugs Ther,2014,28(4):303-311
[16]Harris TA,Yamakuchi M,Ferlito M,et al.MicroRNA-126regulates endothelial expression of vascular cell adhesion molecule1[J].Proc Natl Acad Sci U S A,2008,105(5):1516-1521
[17]纪禄风,石向慧,陈蓓蓓,et al.MicroRNA与原发性高血压病发病机制的研究进展[J].临床心血管病杂志(Ji LF,Shi XH,Chen BB,et al.Advances in research on the pathogenesis of microRNA and essential hypertension[J].J Clin Cardiol),2016,32(7):654-658
[18]Cheng Y,Liu X,Yang J,et al.MicroRNA-145,a novel smooth muscle cell phenotypic marker and modulator,controls vascular neointimal lesion formation[J].Circ Res,2009,105(2):158-166
[19]Sun SG,Zheng B,Han M,et al.miR-146a and Kruppel-like factor 4 form a feedback loop to participate in vascular smooth muscle cell proliferation[J].EMBO Rep,2011,12(1):56-62
[20]Boettger T,Beetz N,Kostin S,et al.Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster[J].J Clin Invest,2009,119(9):2634-2647
[21]Elia L,Quintavalle M,Zhang J,et al.The knockout of miR-143and-145 alters smooth muscle cell maintenance and vascular homeostasis in mice:correlates with human disease[J].Cell Death Differ,2009,16(12):1590-1598
[22]Xin M,Small EM,Sutherland LB,et al.MicroRNAs miR-143and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury[J].Genes Dev,2009,23(18):2166-2178
[23]Gu Q,Zhao G,Wang Y,et al.Silencing miR-16 expression promotes angiotensin II stimulated vascular smooth muscle cell growth[J].Cell Dev Biol,2017,6(1).pii:181
[24]Kim MH,Ham O,Lee SY,et al.MicroRNA-365 inhibits the proliferation of vascular smooth muscle cells by targeting cyclin D1[J].J Cell Biochem,2014,115(10):1752-1761
[25]Merlet E,Atassi F,Motiani RK,et al.miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat[J].Cardiovasc Res,2013,98(3):458-468
[26]Yang F,Li H,Du Y,et al.Downregulation of microRNA-34b is responsible for the elevation of blood pressure in spontaneously hypertensive rats[J].Mol Med Rep,2017,15(3):1031-1036
[27]Leeper NJ,Raiesdana A,Kojima Y,et al.MicroRNA-26a is a novel regulator of vascular smooth muscle cell function[J].JCell Physiol,2011,226(4):1035-1043
[28]陈浥尘,陈广洁,陈红.M1/M2型巨噬细胞与心血管疾病关系的研究进展[J].现代免疫学(Chen YC,Chen GH,Chen H.Research progress on the relationship between M1/M2macrophages and cardiovascular diseases[J].Chin Curr Immunol),2015,35(6):507-510
[29]Huang F,Zhao JL,Wang L,et al.miR-148a-3p mediates notch signaling to promote the differentiation and M1 activation of macrophages[J].Front Immunol,2017,8:1327
[30]Banerjee S,Cui H,Xie N,et al.miR-125a-5p regulates differential activation of macrophages and inflammation[J].JBiol Chem,2013,288(49):35428-35436
[31]Bras JP,Silva AM,Calin GA,et al.miR-195 inhibits macrophages pro-inflammatory profile and impacts the crosstalk with smooth muscle cells[J].PLoS One,2017,12(11):e0188530
[32]刘莉,叶鹏,FI P,et al.初诊高血压患者微小RNA与尿白蛋白排泄的关系[J].中华高血压杂志(Liu L,Ye P,FI P,et al.Relationship between microRNA and urinary albumin excretion in newly diagnosed hypertensive patients[J].Chin JHypertens),2016,24(4):372
[33]Yang Z,Kaye DM.Mechanistic insights into the link between a polymorphism of the 3’UTR of the SLC7A1 gene and hypertension[J].Hum Mutat,2009,30(3):328-333
[34]Sun HX,Zeng DY,Li RT,et al.Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase[J].Hypertension,2012,60(6):1407-1414
[35]Zhang W,Yan L,Li Y,et al.Roles of miRNA-24 in regulating endothelial nitric oxide synthase expression and vascular endothelial cell proliferation[J].Mol Cell Biochem,2015,405(1-2):281-289
[36]Bi R,Bao C,Jiang L,et al.MicroRNA-27b plays a role in pulmonary arterial hypertension by modulating peroxisome proliferator-activated receptor gamma dependent Hsp90-eNOSsignaling and nitric oxide production[J].Biochem Biophys Res Commun,2015,460(2):469-475
[37]Luo P,Zhang WF,Qian ZX,et al.MiR-590-5p-meidated LOX-1 upregulation promotes Angiotensin II-induced endothelial cell apoptosis[J].Biochem Biophys Res Commun,2016,471(4):402-408
[38]Wang HJ,Huang YL,Shih YY,et al.MicroRNA-146a decreases high glucose/thrombin-induced endothelial inflammation by inhibiting NAPDH oxidase 4 expression[J].Mediators Inflamm,2014,2014:379537
[39]Sun HJ,Zhao MX,Liu TY,et al.Salusin-beta induces foam cell formation and monocyte adhesion in human vascular smooth muscle cells via miR155/NOX2/NFkappaB pathway[J].Sci Rep,2016,6:23596
[40]Li P,Fan JB,Gao Y,et al.miR-135b-5p inhibits LPS-induced TNFalpha production via silencing AMPK phosphatase Ppm1e[J].Oncotarget,2016,7(47):77978-77986
[41]Wang HB,Yang J.The role of renin-angiotensin aldosterone system related micro-ribonucleic acids in hypertension[J].Saudi Med J,2015,36(10):1151-1155
[42]Eskildsen TV,Jeppesen PL,Schneider M,et al.Angiotensin IIregulates microRNA-132/-212 in hypertensive rats and humans[J].Int J Mol Sci,2013,14(6):11190-11207
[43]Zhu N,Zhang D,Chen S,et al.Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration[J].Atherosclerosis,2011,215(2):286-293
[44]Cheng W,Liu T,Jiang F,et al.microRNA-155 regulates angiotensin II type 1 receptor expression in umbilical vein endothelial cells from severely pre-eclamptic pregnant women[J].Int J Mol Med,2011,27(3):393-399
[45]Kemp JR,Unal H,Desnoyer R,et al.Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system[J].J Mol Cell Cardiol,2014,75:25-39
[46]Jackson KL,Marques FZ,Watson AM,et al.A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice[J].Hypertension,2013,62(4):775-781
[47]李杰,覃智芳,颜彦,et al.SHR大鼠肾脏去交感神经与主动脉miRNA相关性分析[J].东南大学学报(Li J,Tan ZF,Yan Y,et al.Correlation analysis between renal desympathetic nerve and aortic miRNA in SHR rats[J].J Southeast Univ(Med Sci Ed),2018,37(1):6-11
[48]Zheng X,Li X,Lyu Y,et al.Renal Sympathetic Denervation in Rats Ameliorates Cardiac Dysfunction and Fibrosis PostMyocardial Infarction Involving MicroRNAs[J].Med Sci Monit,2016,22:2751-2760
[49]Dorr O,Liebetrau C,Mollmann H,et al.Effect of renal sympathetic denervation on specific micrornas as an indicator of reverse remodeling processes in hypertensive heart disease[J].JClin Hypertens(Greenwich),2016,18(6):497-502
[50]Sober S,Laan M,Annilo T.MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene(NR3C2)expression[J].Biochem Biophys Res Commun,2010,391(1):727-732
[51]Zhu Q,Hu J,Wang L,et al.Inhibition of microRNA-429 in the renal medulla increased salt sensitivity of blood pressure in Sprague Dawley rats[J].J Hypertens,2017,35(9):1872-1880
[52]Guo TS,Zhang J,Mu JJ,et al.High-salt intake suppressed microRNA-133a expression in Dahl SS rat myocardium[J].Int JMol Sci,2014,15(6):10794-10805
[53]Hu X,Chi L,Zhang W,et al.Down-regulation of the miR-543alleviates insulin resistance through targeting the SIRT1[J].Biochem Biophys Res Commun,2015,468(4):781-787
[54]杨晓忱.补肾降压方对miR-145调控自发性高血压大鼠胰岛素抵抗信号通路的影响[D].北京中医药大学(Yang XC.Effect of Bushen Jiangya Recipe on miR-145 regulation of insulin resistance signaling pathway in spontaneously hypertensive rats[D].Beijing University of Chinese Medicine),2013
[55]Wang J,Gao Y,Duan L,et al.Metformin ameliorates skeletal muscle insulin resistance by inhibiting miR-21 expression in a high-fat dietary rat model[J].Oncotarget,2017,8(58):98029-98039
[2]Samanta S,Balasubramanian S,Rajasingh S,et al.MicroRNA:A new therapeutic strategy for cardiovascular diseases[J].Trends Cardiovasc Med,2016,26(5):407-419
[3]唐青,邢晓为,黄利华,et al.miRNA在高血压疾病中的应用及调控机制[J].中华高血压杂志(Tang Q,Xing XW,Huang LH,et al.Application and regulation mechanism of miRNA in hypertension[J].Chin J Hypertens),2013,21(2):121-126
[4]Brook RD,Appel LJ,Rubenfire M,et al.Beyond medications and diet:alternative approaches to lowering blood pressure:a scientific statement from the american heart association[J].Hypertension,2013,61(6):1360-1383
[5]Ivanovic B,Tadic M.Hypercholesterolemia and hypertension:two sides of the same coin[J].Am J Cardiovasc Drugs,2015,15(6):403-414
[6]Klimczak D,Jazdzewski K,Kuch M.Regulatory mechanisms in arterial hypertension:role of microRNA in pathophysiology and therapy[J].Blood Press,2017,26(1):2-8
[7]刘颖,刘颜,王立立,et al.血管内皮细胞功能障碍及修复与高血压关系探讨[J].中华老年心脑血管病杂志(Liu Y,Liu Y,Wang LL,et al.Relationship between vascular endothelial cell dysfunction and repair and hypertension[J].Chin J Geriatr Heart Brain Vessel Dis),2018,20(7):769-771
[8]Nemecz M,Alexandru N,Tanko G,et al.Role of MicroRNA in Endothelial Dysfunction and Hypertension[J].Curr Hypertens Rep,2016,18(12):87
[9]Wang S,Aurora AB,Johnson BA,et al.The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis[J].Dev Cell,2008,15(2):261-271
[10]Iaconetti C,Polimeni A,Sorrentino S,et al.Inhibition of miR-92a increases endothelial proliferation and migration in vitro as well as reduces neointimal proliferation in vivo after vascular injury[J].Basic Res Cardiol,2012,107(5):296
[11]Daniel JM,Penzkofer D,Teske R,et al.Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury[J].Cardiovasc Res,2014,103(4):564-572
[12]Fiedler J,Jazbutyte V,Kirchmaier BC,et al.MicroRNA-24regulates vascularity after myocardial infarction[J].Circulation,2011,124(6):720-730
[13]刘思管.MiR-34a在高血压诱导血管损伤中的表达及其作用机制研究[D].山东大学(Liu SG.Molecular mechanisms in vascular injury induced by hypertension:expression and role of miR-34a[D].Shandong University),2016
[14]Yi F,Hao Y,Chong X,et al.Overexpression of microRNA-506-3p aggravates the injury of vascular endothelial cells in patients with hypertension by downregulating Beclin1 expression[J].Exp Ther Med,2018,15(3):2844-2850
[15]Zhang L,Huang D,Wang Q,et al.MiR-132 inhibits expression of SIRT1 and induces pro-inflammatory processes of vascular endothelial inflammation through blockade of the SREBP-1c metabolic pathway[J].Cardiovasc Drugs Ther,2014,28(4):303-311
[16]Harris TA,Yamakuchi M,Ferlito M,et al.MicroRNA-126regulates endothelial expression of vascular cell adhesion molecule1[J].Proc Natl Acad Sci U S A,2008,105(5):1516-1521
[17]纪禄风,石向慧,陈蓓蓓,et al.MicroRNA与原发性高血压病发病机制的研究进展[J].临床心血管病杂志(Ji LF,Shi XH,Chen BB,et al.Advances in research on the pathogenesis of microRNA and essential hypertension[J].J Clin Cardiol),2016,32(7):654-658
[18]Cheng Y,Liu X,Yang J,et al.MicroRNA-145,a novel smooth muscle cell phenotypic marker and modulator,controls vascular neointimal lesion formation[J].Circ Res,2009,105(2):158-166
[19]Sun SG,Zheng B,Han M,et al.miR-146a and Kruppel-like factor 4 form a feedback loop to participate in vascular smooth muscle cell proliferation[J].EMBO Rep,2011,12(1):56-62
[20]Boettger T,Beetz N,Kostin S,et al.Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster[J].J Clin Invest,2009,119(9):2634-2647
[21]Elia L,Quintavalle M,Zhang J,et al.The knockout of miR-143and-145 alters smooth muscle cell maintenance and vascular homeostasis in mice:correlates with human disease[J].Cell Death Differ,2009,16(12):1590-1598
[22]Xin M,Small EM,Sutherland LB,et al.MicroRNAs miR-143and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury[J].Genes Dev,2009,23(18):2166-2178
[23]Gu Q,Zhao G,Wang Y,et al.Silencing miR-16 expression promotes angiotensin II stimulated vascular smooth muscle cell growth[J].Cell Dev Biol,2017,6(1).pii:181
[24]Kim MH,Ham O,Lee SY,et al.MicroRNA-365 inhibits the proliferation of vascular smooth muscle cells by targeting cyclin D1[J].J Cell Biochem,2014,115(10):1752-1761
[25]Merlet E,Atassi F,Motiani RK,et al.miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat[J].Cardiovasc Res,2013,98(3):458-468
[26]Yang F,Li H,Du Y,et al.Downregulation of microRNA-34b is responsible for the elevation of blood pressure in spontaneously hypertensive rats[J].Mol Med Rep,2017,15(3):1031-1036
[27]Leeper NJ,Raiesdana A,Kojima Y,et al.MicroRNA-26a is a novel regulator of vascular smooth muscle cell function[J].JCell Physiol,2011,226(4):1035-1043
[28]陈浥尘,陈广洁,陈红.M1/M2型巨噬细胞与心血管疾病关系的研究进展[J].现代免疫学(Chen YC,Chen GH,Chen H.Research progress on the relationship between M1/M2macrophages and cardiovascular diseases[J].Chin Curr Immunol),2015,35(6):507-510
[29]Huang F,Zhao JL,Wang L,et al.miR-148a-3p mediates notch signaling to promote the differentiation and M1 activation of macrophages[J].Front Immunol,2017,8:1327
[30]Banerjee S,Cui H,Xie N,et al.miR-125a-5p regulates differential activation of macrophages and inflammation[J].JBiol Chem,2013,288(49):35428-35436
[31]Bras JP,Silva AM,Calin GA,et al.miR-195 inhibits macrophages pro-inflammatory profile and impacts the crosstalk with smooth muscle cells[J].PLoS One,2017,12(11):e0188530
[32]刘莉,叶鹏,FI P,et al.初诊高血压患者微小RNA与尿白蛋白排泄的关系[J].中华高血压杂志(Liu L,Ye P,FI P,et al.Relationship between microRNA and urinary albumin excretion in newly diagnosed hypertensive patients[J].Chin JHypertens),2016,24(4):372
[33]Yang Z,Kaye DM.Mechanistic insights into the link between a polymorphism of the 3’UTR of the SLC7A1 gene and hypertension[J].Hum Mutat,2009,30(3):328-333
[34]Sun HX,Zeng DY,Li RT,et al.Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase[J].Hypertension,2012,60(6):1407-1414
[35]Zhang W,Yan L,Li Y,et al.Roles of miRNA-24 in regulating endothelial nitric oxide synthase expression and vascular endothelial cell proliferation[J].Mol Cell Biochem,2015,405(1-2):281-289
[36]Bi R,Bao C,Jiang L,et al.MicroRNA-27b plays a role in pulmonary arterial hypertension by modulating peroxisome proliferator-activated receptor gamma dependent Hsp90-eNOSsignaling and nitric oxide production[J].Biochem Biophys Res Commun,2015,460(2):469-475
[37]Luo P,Zhang WF,Qian ZX,et al.MiR-590-5p-meidated LOX-1 upregulation promotes Angiotensin II-induced endothelial cell apoptosis[J].Biochem Biophys Res Commun,2016,471(4):402-408
[38]Wang HJ,Huang YL,Shih YY,et al.MicroRNA-146a decreases high glucose/thrombin-induced endothelial inflammation by inhibiting NAPDH oxidase 4 expression[J].Mediators Inflamm,2014,2014:379537
[39]Sun HJ,Zhao MX,Liu TY,et al.Salusin-beta induces foam cell formation and monocyte adhesion in human vascular smooth muscle cells via miR155/NOX2/NFkappaB pathway[J].Sci Rep,2016,6:23596
[40]Li P,Fan JB,Gao Y,et al.miR-135b-5p inhibits LPS-induced TNFalpha production via silencing AMPK phosphatase Ppm1e[J].Oncotarget,2016,7(47):77978-77986
[41]Wang HB,Yang J.The role of renin-angiotensin aldosterone system related micro-ribonucleic acids in hypertension[J].Saudi Med J,2015,36(10):1151-1155
[42]Eskildsen TV,Jeppesen PL,Schneider M,et al.Angiotensin IIregulates microRNA-132/-212 in hypertensive rats and humans[J].Int J Mol Sci,2013,14(6):11190-11207
[43]Zhu N,Zhang D,Chen S,et al.Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration[J].Atherosclerosis,2011,215(2):286-293
[44]Cheng W,Liu T,Jiang F,et al.microRNA-155 regulates angiotensin II type 1 receptor expression in umbilical vein endothelial cells from severely pre-eclamptic pregnant women[J].Int J Mol Med,2011,27(3):393-399
[45]Kemp JR,Unal H,Desnoyer R,et al.Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system[J].J Mol Cell Cardiol,2014,75:25-39
[46]Jackson KL,Marques FZ,Watson AM,et al.A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice[J].Hypertension,2013,62(4):775-781
[47]李杰,覃智芳,颜彦,et al.SHR大鼠肾脏去交感神经与主动脉miRNA相关性分析[J].东南大学学报(Li J,Tan ZF,Yan Y,et al.Correlation analysis between renal desympathetic nerve and aortic miRNA in SHR rats[J].J Southeast Univ(Med Sci Ed),2018,37(1):6-11
[48]Zheng X,Li X,Lyu Y,et al.Renal Sympathetic Denervation in Rats Ameliorates Cardiac Dysfunction and Fibrosis PostMyocardial Infarction Involving MicroRNAs[J].Med Sci Monit,2016,22:2751-2760
[49]Dorr O,Liebetrau C,Mollmann H,et al.Effect of renal sympathetic denervation on specific micrornas as an indicator of reverse remodeling processes in hypertensive heart disease[J].JClin Hypertens(Greenwich),2016,18(6):497-502
[50]Sober S,Laan M,Annilo T.MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene(NR3C2)expression[J].Biochem Biophys Res Commun,2010,391(1):727-732
[51]Zhu Q,Hu J,Wang L,et al.Inhibition of microRNA-429 in the renal medulla increased salt sensitivity of blood pressure in Sprague Dawley rats[J].J Hypertens,2017,35(9):1872-1880
[52]Guo TS,Zhang J,Mu JJ,et al.High-salt intake suppressed microRNA-133a expression in Dahl SS rat myocardium[J].Int JMol Sci,2014,15(6):10794-10805
[53]Hu X,Chi L,Zhang W,et al.Down-regulation of the miR-543alleviates insulin resistance through targeting the SIRT1[J].Biochem Biophys Res Commun,2015,468(4):781-787
[54]杨晓忱.补肾降压方对miR-145调控自发性高血压大鼠胰岛素抵抗信号通路的影响[D].北京中医药大学(Yang XC.Effect of Bushen Jiangya Recipe on miR-145 regulation of insulin resistance signaling pathway in spontaneously hypertensive rats[D].Beijing University of Chinese Medicine),2013
[55]Wang J,Gao Y,Duan L,et al.Metformin ameliorates skeletal muscle insulin resistance by inhibiting miR-21 expression in a high-fat dietary rat model[J].Oncotarget,2017,8(58):98029-98039