Value-added anticancer reactivity of sub-5 nm Ag-drug nanoparticles derived from organosilver (Ⅰ) MOF
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摘要
A totally structure-determined organosilver(I) metal-oganic framework(MOF) of [{Ag_(18)(CF_3COO)_(18)(H_2O)_2}{Ag_4(erlotinib)_4}]_n·7nCH_3OH·3nH_2O(1) was first synthesized by the self-assembly of erlotinib drug ligand and silver salts in the study. 1 formed a NbO-like 3D network, which was built from Ag(I)-erlotinib induced chains and 18-core silver(I) nanoclusters. When 1 was dispersed in methanol solution, it formed derivative nanoparticles(1-NPs) with the average size of 3.81 nm. Silver(Ⅰ) ion is an efficient reactive oxygen species(ROS) evocator, whereas the erlotinib ligand possesses the targeting activity towards tumor cells. Therefore, IC_(50) values of 1-NPs for A549 and MRC-5 cells were respectively 0.97 and 7.28 μM, which were lower than IC_(50) value of erlotinib. It should be noted that the 7.5-fold higher inhibition effect on A549 cells allows 1-NPs to be a potential targeting anticancer drug for curing lung cancer. The study opens a new avenue to design anticancer drugs based on organosilver(I)MOF derivatives that can realize the value-added reactivity by combining clinical drugs with ROS-inductive silver(Ⅰ) ion.
A totally structure-determined organosilver(I) metal-oganic framework(MOF) of [{Ag_(18)(CF_3COO)_(18)(H_2O)_2}{Ag_4(erlotinib)_4}]_n·7nCH_3OH·3nH_2O(1) was first synthesized by the self-assembly of erlotinib drug ligand and silver salts in the study. 1 formed a NbO-like 3D network, which was built from Ag(I)-erlotinib induced chains and 18-core silver(I) nanoclusters. When 1 was dispersed in methanol solution, it formed derivative nanoparticles(1-NPs) with the average size of 3.81 nm. Silver(Ⅰ) ion is an efficient reactive oxygen species(ROS) evocator, whereas the erlotinib ligand possesses the targeting activity towards tumor cells. Therefore, IC_(50) values of 1-NPs for A549 and MRC-5 cells were respectively 0.97 and 7.28 μM, which were lower than IC_(50) value of erlotinib. It should be noted that the 7.5-fold higher inhibition effect on A549 cells allows 1-NPs to be a potential targeting anticancer drug for curing lung cancer. The study opens a new avenue to design anticancer drugs based on organosilver(I)MOF derivatives that can realize the value-added reactivity by combining clinical drugs with ROS-inductive silver(Ⅰ) ion.
A totally structure-determined organosilver(I) metal-oganic framework(MOF) of [{Ag_(18)(CF_3COO)_(18)(H_2O)_2}{Ag_4(erlotinib)_4}]_n·7nCH_3OH·3nH_2O(1) was first synthesized by the self-assembly of erlotinib drug ligand and silver salts in the study. 1 formed a NbO-like 3D network, which was built from Ag(I)-erlotinib induced chains and 18-core silver(I) nanoclusters. When 1 was dispersed in methanol solution, it formed derivative nanoparticles(1-NPs) with the average size of 3.81 nm. Silver(Ⅰ) ion is an efficient reactive oxygen species(ROS) evocator, whereas the erlotinib ligand possesses the targeting activity towards tumor cells. Therefore, IC_(50) values of 1-NPs for A549 and MRC-5 cells were respectively 0.97 and 7.28 μM, which were lower than IC_(50) value of erlotinib. It should be noted that the 7.5-fold higher inhibition effect on A549 cells allows 1-NPs to be a potential targeting anticancer drug for curing lung cancer. The study opens a new avenue to design anticancer drugs based on organosilver(I)MOF derivatives that can realize the value-added reactivity by combining clinical drugs with ROS-inductive silver(Ⅰ) ion.
引文
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2 Jin S,Wang S,Song Y,Zhou M,Zhong J,Zhang J,Xia A,Pei Y,Chen M,Li P,Zhu M.J Am Chem Soc,2014,136:15559-15565
3 Fuhr O,Dehnen S,Fenske D.Chem Soc Rev,2013,42:1871-1906
4 Jin R.Nanoscale,2015,7:1549-1565
5 Wang QM,Lin YM,Liu KG.Acc Chem Res,2015,48:1570-1579
6 Joshi CP,Bootharaju MS,Bakr OM.J Phys Chem Lett,2015,6:3023-3035
7 Anson CE,Eichh?fer A,Issac I,Fenske D,Fuhr O,Sevillano P,Persau C,Stalke D,Zhang J.Angew Chem Int Ed,2008,47:1326-1331
8 Joshi CP,Bootharaju MS,Alhilaly MJ,Bakr OM.J Am Chem Soc,2015,137:11578-11581
9 Li S,Du XS,Li B,Wang JY,Li GP,Gao GG,Zang SQ.J Am Chem Soc,2018,140:594-597
10 Gruber F,Schulz-Dobrick M,Jansen M.Chem Eur J,2010,16:1464-1469
11 Li XY,Su HF,Yu K,Tan YZ,Wang XP,Zhao YQ,Sun D,Zheng LS.Nanoscale,2015,7:8284-8288
12 Gao CY,Zhao L,Wang MX.J Am Chem Soc,2012,134:824-827
13 Hau SCK,Cheng PS,Mak TCW.J Am Chem Soc,2012,134:2922-2925
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35 Chakraborty I,Udayabhaskararao T,Pradeep T.Chem Commun,2012,48:6788-6790
36 Bian SD,Jia JH,Wang QM.J Am Chem Soc,2009,131:3422-3423
37 Song CY,Chai DF,Zhang RR,Liu H,Qiu YF,Guo HD,Gao GG.Dalton Trans,2015,44:3997-4002
38 Bestgen S,Fuhr O,Breitung B,Kiran Chakravadhanula VS,Guthausen G,Hennrich F,Yu W,Kappes MM,Roesky PW,Fenske D.Chem Sci,2017,8:2235-2240
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44 Wang D,Lippard SJ.Nat Rev Drug Discov,2005,4:307-320
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46 Chen Q,Yang Y,Lin X,Ma W,Chen G,Li W,Wang X,Yu Z.Chem Commun,2018,54:5369-5372
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51 Yu Z,Schmaltz RM,Bozeman TC,Paul R,Rishel MJ,Tsosie KS,Hecht SM.J Am Chem Soc,2013,135:2883-2886
52 Wang H,Lu Z,Wang L,Guo T,Wu J,Wan J,Zhou L,Li H,Li Z,Jiang D,Song P,Xie H,Zhou L,Xu X,Zheng S.Cancer Res,2017,77:6963-6974
53 Kawata K,Osawa M,Okabe S.Environ Sci Technol,2009,43:6046-6051
54 Miura N,Shinohara Y.Biochem Biophys Res Commun,2009,390:733-737
55 Foldbjerg R,Dang DA,Autrup H.Arch Toxicol,2011,85:743-750
56 Liu J,Zhao Y,Guo Q,Wang Z,Wang H,Yang Y,Huang Y.Biomaterials,2012,33:6155-6161
57 Ong C,Lim JZ,Ng CT,Li JJ,Yung LY,Bay BH.Curr Med Chem,2013,20:772-781
58 Shen DF,Wu SS,Wang RR,Zhang Q,Ren ZJ,Liu H,Guo HD,Gao GG.Small,2016,12:6153-6159
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62 Sheldrick GM.SADABS 2.05.G?ttingen:University of G?ttingen,2002
63 Sheldrick GM.Acta Crystlogr A Found Crystlogr,1990,46:467-473
64 Sheldrick GM.SHELXS-97,Program for Solution of Crystal Structures.G?ttingen:University of G?ttingen,1997
65 Sheldrick GM.Acta Crystlogr A Found Crystlogr,2008,64:112-122
66 Costa DB,Nguyen KSH,Cho BC,Sequist LV,Jackman DM,Riely GJ,Yeap BY,Halmos B,Kim JH,J?nne PA,Huberman MS,Pao W,Tenen DG,Kobayashi S.Clin Cancer Res,2008,14:7060-7067
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68 Pennell NA,Neal JW,Chaft JE,Azzoli CG,Janne PA,Govindan R,Evans TL,Costa DB,Rosovsky RPG,Wakelee HA,Heist RS,Shaw AT,Temel JS,Shapiro MA,Muzikansky A,Lanuti M,Lynch TJ,Kris MG,Sequist LV.J Clin Oncol,2014,32:7514-7514