Liposarcoma of the stomach: Report of two cases and review of the literature
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摘要
Liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a welldifferentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia. Several palpable masses were found with endoscopy. Endoscopic submucosal dissection was the treatment used, and the postoperative course was uneventful. The histopathological diagnosis was a well-differentiated liposarcoma. The two patients did not undergo any adjuvant therapy. They are both currently in good condition without recurrence. Therefore, we believe that the outcome of liposarcoma of the stomach is positive, and surgical resection may be the first choice for treatment at present.
Liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a welldifferentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia. Several palpable masses were found with endoscopy. Endoscopic submucosal dissection was the treatment used, and the postoperative course was uneventful. The histopathological diagnosis was a well-differentiated liposarcoma. The two patients did not undergo any adjuvant therapy. They are both currently in good condition without recurrence. Therefore, we believe that the outcome of liposarcoma of the stomach is positive, and surgical resection may be the first choice for treatment at present.
Liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a welldifferentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia. Several palpable masses were found with endoscopy. Endoscopic submucosal dissection was the treatment used, and the postoperative course was uneventful. The histopathological diagnosis was a well-differentiated liposarcoma. The two patients did not undergo any adjuvant therapy. They are both currently in good condition without recurrence. Therefore, we believe that the outcome of liposarcoma of the stomach is positive, and surgical resection may be the first choice for treatment at present.
引文
1 Bostano?lu A,Y?ld?z B,Kula?o?lu S,Av?ar F.Primary liposarcoma of the stomach.Turk J Gastroenterol 2013;24:167-169[PMID:23934465 DOI:10.4318/tjg.2013.0510]
2 Fletcher CDM,Bridge JA,Hogendoom PCW.World Health Organization classification of tumous.Pathology and genetics of tumours of soft tissue and bone.Lyon:IARC Press,2013:10-238
3 Elhjouji A,Jaiteh L,Mahfoud T,Belhamidi S,Bounaim A,Ait Ali A,Sair K,Zentar A.Giant Gastric Liposarcoma:A Fatal Exceptional Location.J Gastrointest Cancer 2016;47:482-485[PMID:26558372 DOI:10.1007/s12029-015-9779-z]
4 Matone J,Okazaki S,Maccapani GN,Amancio TT,Filippi RZ,Macedo AL.Giant gastric lipossarcoma:case report and review of the literature.Einstein(Sao Paulo)2016;14:557-560[PMID:28076606 DOI:10.1590/S1679-45082016RC3770]
5 Wu JM,Montgomery E.Classification and pathology.Surg Clin North Am 2008;88:483-520,v-vi[PMID:18514695 DOI:10.1016/j.suc.2008.03.007]
6 Tepetes K,Christodoulidis G,Spyridakis ME,Nakou M,Koukoulis G,Hatzitheofilou K.Liposarcoma of the stomach:a rare case report.World J Gastroenterol 2007;13:4154-4155[PMID:17696242 DOI:10.3748/wjg.v13.i30.4154]
7 Michiels A,Hubens G,Ruppert M,Balliu L,Vaneerdeweg W.Giant liposarcoma of the stomach involving the mediastinum.Acta Chir Belg 2007;107:468-471[PMID:17966553 DOI:10.1080/00015458.2007.11680102]
8 Einarsdóttir H,Skoog L,S?derlund V,Bauer HC.Accuracy of cytology for diagnosis of lipomatous tumors:comparison with magnetic resonance and computed tomography findings in 175cases.Acta Radiol 2004;45:840-846[PMID:15690614 DOI:10.1080/02841850410008180]
9 Laky D,Stoica T.Gastric liposarcoma.A case report.Pathol Res Pract 1986;181:112-117[PMID:3703739 DOI:10.1016/S0344-0338(86)80202-3]
10 Arndt CA,Crist WM.Common musculoskeletal tumors of childhood and adolescence.N Engl J Med 1999;341:342-352[PMID:10423470 DOI:10.1056/NEJM199907293410507]
11 Hamdane MM,Brahim EB,Salah MB,Haouas N,Bouhafa A,Chedly-Debbiche A.Giant gastric lipoma mimicking welldifferentiated liposarcoma.Gastroenterol Hepatol Bed Bench2012;5:60-63[PMID:24834200]
12 Seki K,Hasegawa T,Konegawa R,Hizawa K,Sano T.Primary liposarcoma of the stomach:a case report and a review of the literature.Jpn J Clin Oncol 1998;28:284-288[PMID:9657017]
13 Hisata Y,Tasaki Y,Kozaki S,Yamada T.A case of dedifferentiated liposarcoma of the heart and stomach.Int J Surg Case Rep 2017;41:36-38[PMID:29031176 DOI:10.1016/j.ijscr.2017.10.001]
14 Jiang HF,Ying XJ.Synchronous liposarcoma of pancreas and stomach:a case report and literature review.Int Surg J 2017,4:780-783[DOI:10.18203/2349-2902.isj20170231]
15 Noushin AM,Safaei M.Primary Liposarcoma of the Stomach:A Rare Mesenchymal Tumor.Medical J Islamic Republic of lran2005,19:275-278
16 López-Negrete L,Luyando L,Sala J,López C,Menéndez de Llano R,Gomez JL.Liposarcoma of the stomach.Abdom Imaging 1997;22:373-375[PMID:9157853 DOI:10.1007/s002619900213]
17 Mutter D,Marescaux J.Gastrectomies pour lesions benignes.Techniques chirurgicales-Appareil digestif 2001,16:40-320[DOI:10.1016/S1282-9129(01)72065-X]
18 Bramwell VH.Adjuvant chemotherapy for adult soft tissue sarcoma:Is there a standard of care?J Clin Oncol 2001;19:1235-1237[PMID:11230463 DOI:10.1200/JCO.2001.19.5.1235]
19 Kim MJ,Gu MJ,Choi JH,Kim SW,Kim KO.Gastric liposarcoma presenting as a huge pedunculated polyp.Endoscopy 2014;46Suppl 1 UCTN:E441-E442[PMID:25314184 DOI:10.1055/s-0034-1377501]
20 Hohf RP,Engel KL,Capos NJ.Liposarcoma of the stomach.Ann Surg 1955;142:1029-1033[PMID:13269065]
21 Hawkins PE,Terrell GK.Liposarcoma of the stomach:a case report.JAMA 1965;191:758-759[PMID:14245524 DOI:10.1001/jama.1965.03080090072023]
22 Orita K,Kokumai Y,Kawada K,Takagi S,Kawahara T.Liposarcoma of stomach:report of a case.Acta Med Okayama1968;22:167-173[PMID:4239074]
23 Hisanobu S,Toshiki S,Yasuhide O,Tetsuya I,Kouichi M,Ryugo O,Kenji S,Taiji A.Primary Gastric Liposarcoma,Report of a Case and Review of the Literature.Gastroenterol Endosc 2002;44:1168-1174[DOI:10.11280/gee1973b.44.1168]
24 Seki H,Kataba Y,Okamura R,Namatame K,M Hagiwara M.Metastatic Liposarcoma of the Stomach Report of a Case.Gastroenterological Endoscopy 1983;4:628-635[DOI:10.11280/gee1973b.25.628]
25 Ferrozzi F,Bova D,Garlaschi G.Gastric liposarcoma:CTappearance.Abdom Imaging 1993;18:232-233[PMID:8508081DOI:10.1007/BF00198110]
26 Yamamoto K,Teramae N,Uehira H,Wakabayashi N,Fukuda S,Kodama T,Kashina K,Tsuchihashi Y.Primary liposarcoma of the stomach resected endoscopically.Endoscopy 1995;27:711[PMID:8903993 DOI:10.1055/s-2007-1005798]
27 Philipps B,L?rken M,Manegold E,Kasperk R,Schumpelick V.[Primary liposarcoma of the stomach wall--a rare mesenchymal tumor].Chirurg 2000;71:334-336[PMID:10789053]
28 López de la Riva M,Urquijo Tomatti H.[Gastric liposarcoma.Presentation of a case].Rev Esp Enferm Apar Dig 1984;66:335-338[PMID:6515090]
29 Shokouh-Amiri MH,Hansen CP,Moesgaard F.Liposarcoma of the stomach.A case report.Acta Chir Scand 1986;152:389-391[PMID:3739551]
30 Costa e Silva N,Melo CM,Naves EB,Dias MA.[Gastric liposarcoma:report of a case].Rev Hosp Clin Fac Med Sao Paulo1992;47:89-91[PMID:1340019]
31 Tomofuji K,Watanabe J,Ishida N,Kajiwara S.Gastric liposarcoma resected by laparoscopic total gastrectomy to achieve a wide surgical margin.BMJ Case Rep 2017;2017[PMID:29212871 DOI:10.1136/bcr-2017-221703]
32 Girardot-Miglierina A,Clerc D,Suter M.Gastric liposarcoma in a patient with severe obesity.Ann R Coll Surg Engl 2018;100:e88-e90[PMID:29484946 DOI:10.1308/rcsann.2018.0018]
2 Fletcher CDM,Bridge JA,Hogendoom PCW.World Health Organization classification of tumous.Pathology and genetics of tumours of soft tissue and bone.Lyon:IARC Press,2013:10-238
3 Elhjouji A,Jaiteh L,Mahfoud T,Belhamidi S,Bounaim A,Ait Ali A,Sair K,Zentar A.Giant Gastric Liposarcoma:A Fatal Exceptional Location.J Gastrointest Cancer 2016;47:482-485[PMID:26558372 DOI:10.1007/s12029-015-9779-z]
4 Matone J,Okazaki S,Maccapani GN,Amancio TT,Filippi RZ,Macedo AL.Giant gastric lipossarcoma:case report and review of the literature.Einstein(Sao Paulo)2016;14:557-560[PMID:28076606 DOI:10.1590/S1679-45082016RC3770]
5 Wu JM,Montgomery E.Classification and pathology.Surg Clin North Am 2008;88:483-520,v-vi[PMID:18514695 DOI:10.1016/j.suc.2008.03.007]
6 Tepetes K,Christodoulidis G,Spyridakis ME,Nakou M,Koukoulis G,Hatzitheofilou K.Liposarcoma of the stomach:a rare case report.World J Gastroenterol 2007;13:4154-4155[PMID:17696242 DOI:10.3748/wjg.v13.i30.4154]
7 Michiels A,Hubens G,Ruppert M,Balliu L,Vaneerdeweg W.Giant liposarcoma of the stomach involving the mediastinum.Acta Chir Belg 2007;107:468-471[PMID:17966553 DOI:10.1080/00015458.2007.11680102]
8 Einarsdóttir H,Skoog L,S?derlund V,Bauer HC.Accuracy of cytology for diagnosis of lipomatous tumors:comparison with magnetic resonance and computed tomography findings in 175cases.Acta Radiol 2004;45:840-846[PMID:15690614 DOI:10.1080/02841850410008180]
9 Laky D,Stoica T.Gastric liposarcoma.A case report.Pathol Res Pract 1986;181:112-117[PMID:3703739 DOI:10.1016/S0344-0338(86)80202-3]
10 Arndt CA,Crist WM.Common musculoskeletal tumors of childhood and adolescence.N Engl J Med 1999;341:342-352[PMID:10423470 DOI:10.1056/NEJM199907293410507]
11 Hamdane MM,Brahim EB,Salah MB,Haouas N,Bouhafa A,Chedly-Debbiche A.Giant gastric lipoma mimicking welldifferentiated liposarcoma.Gastroenterol Hepatol Bed Bench2012;5:60-63[PMID:24834200]
12 Seki K,Hasegawa T,Konegawa R,Hizawa K,Sano T.Primary liposarcoma of the stomach:a case report and a review of the literature.Jpn J Clin Oncol 1998;28:284-288[PMID:9657017]
13 Hisata Y,Tasaki Y,Kozaki S,Yamada T.A case of dedifferentiated liposarcoma of the heart and stomach.Int J Surg Case Rep 2017;41:36-38[PMID:29031176 DOI:10.1016/j.ijscr.2017.10.001]
14 Jiang HF,Ying XJ.Synchronous liposarcoma of pancreas and stomach:a case report and literature review.Int Surg J 2017,4:780-783[DOI:10.18203/2349-2902.isj20170231]
15 Noushin AM,Safaei M.Primary Liposarcoma of the Stomach:A Rare Mesenchymal Tumor.Medical J Islamic Republic of lran2005,19:275-278
16 López-Negrete L,Luyando L,Sala J,López C,Menéndez de Llano R,Gomez JL.Liposarcoma of the stomach.Abdom Imaging 1997;22:373-375[PMID:9157853 DOI:10.1007/s002619900213]
17 Mutter D,Marescaux J.Gastrectomies pour lesions benignes.Techniques chirurgicales-Appareil digestif 2001,16:40-320[DOI:10.1016/S1282-9129(01)72065-X]
18 Bramwell VH.Adjuvant chemotherapy for adult soft tissue sarcoma:Is there a standard of care?J Clin Oncol 2001;19:1235-1237[PMID:11230463 DOI:10.1200/JCO.2001.19.5.1235]
19 Kim MJ,Gu MJ,Choi JH,Kim SW,Kim KO.Gastric liposarcoma presenting as a huge pedunculated polyp.Endoscopy 2014;46Suppl 1 UCTN:E441-E442[PMID:25314184 DOI:10.1055/s-0034-1377501]
20 Hohf RP,Engel KL,Capos NJ.Liposarcoma of the stomach.Ann Surg 1955;142:1029-1033[PMID:13269065]
21 Hawkins PE,Terrell GK.Liposarcoma of the stomach:a case report.JAMA 1965;191:758-759[PMID:14245524 DOI:10.1001/jama.1965.03080090072023]
22 Orita K,Kokumai Y,Kawada K,Takagi S,Kawahara T.Liposarcoma of stomach:report of a case.Acta Med Okayama1968;22:167-173[PMID:4239074]
23 Hisanobu S,Toshiki S,Yasuhide O,Tetsuya I,Kouichi M,Ryugo O,Kenji S,Taiji A.Primary Gastric Liposarcoma,Report of a Case and Review of the Literature.Gastroenterol Endosc 2002;44:1168-1174[DOI:10.11280/gee1973b.44.1168]
24 Seki H,Kataba Y,Okamura R,Namatame K,M Hagiwara M.Metastatic Liposarcoma of the Stomach Report of a Case.Gastroenterological Endoscopy 1983;4:628-635[DOI:10.11280/gee1973b.25.628]
25 Ferrozzi F,Bova D,Garlaschi G.Gastric liposarcoma:CTappearance.Abdom Imaging 1993;18:232-233[PMID:8508081DOI:10.1007/BF00198110]
26 Yamamoto K,Teramae N,Uehira H,Wakabayashi N,Fukuda S,Kodama T,Kashina K,Tsuchihashi Y.Primary liposarcoma of the stomach resected endoscopically.Endoscopy 1995;27:711[PMID:8903993 DOI:10.1055/s-2007-1005798]
27 Philipps B,L?rken M,Manegold E,Kasperk R,Schumpelick V.[Primary liposarcoma of the stomach wall--a rare mesenchymal tumor].Chirurg 2000;71:334-336[PMID:10789053]
28 López de la Riva M,Urquijo Tomatti H.[Gastric liposarcoma.Presentation of a case].Rev Esp Enferm Apar Dig 1984;66:335-338[PMID:6515090]
29 Shokouh-Amiri MH,Hansen CP,Moesgaard F.Liposarcoma of the stomach.A case report.Acta Chir Scand 1986;152:389-391[PMID:3739551]
30 Costa e Silva N,Melo CM,Naves EB,Dias MA.[Gastric liposarcoma:report of a case].Rev Hosp Clin Fac Med Sao Paulo1992;47:89-91[PMID:1340019]
31 Tomofuji K,Watanabe J,Ishida N,Kajiwara S.Gastric liposarcoma resected by laparoscopic total gastrectomy to achieve a wide surgical margin.BMJ Case Rep 2017;2017[PMID:29212871 DOI:10.1136/bcr-2017-221703]
32 Girardot-Miglierina A,Clerc D,Suter M.Gastric liposarcoma in a patient with severe obesity.Ann R Coll Surg Engl 2018;100:e88-e90[PMID:29484946 DOI:10.1308/rcsann.2018.0018]