Intercalated kaolinite as an emerging platform for cancer therapy

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英文篇名：Intercalated kaolinite as an emerging platform for cancer therapy 作者：Yi ; Zhang ; Peng ; Huang ; Mei ; Long ; Song ; Liu ; Huaming ; Yang ; Shuwen ; Yuan ; Shi ; Chang 英文作者：Yi Zhang;Peng Huang;Mei Long;Song Liu;Huaming Yang;Shuwen Yuan;Shi Chang;Department of Inorganic Materials, School of Minerals Processing and Bioengineering, Central South University;Hunan Key Laboratory of Mineral Materials and Application, Central South University;Xiangya Hospital, Central South University;Institute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University;Department of Radiology, The Second Xiangya Hospital, Central South University; 英文关键词：kaolinite;;pillared;;drug delivery system;;thyroid cancer 中文刊名：JBXG 英文刊名：中国科学:化学(英文版) 机构：Department of Inorganic Materials, School of Minerals Processing and Bioengineering, Central South University;Hunan Key Laboratory of Mineral Materials and Application, Central South University;Xiangya Hospital, Central South University;Institute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University;Department of Radiology, The Second Xiangya Hospital, Central South University; 出版日期：2018-12-07 10:56 出版单位：Science China(Chemistry) 年：2019 期：v.62 基金：supported by the National Natural Science Foundation of China(21878341,51804343,41572036,51225403);; the Strategic Priority Research Program of Central South University(ZLXD2017005);; the Natural Science Foundation of Hunan Province(2018JJ3670);; the Key R&D Program of Hunan Province(2017GK2251);; Hunan Provincial Science and Technology Project(2016RS2004,2015TP1006) 语种：英文; 页：JBXG201901008 页数：4 CN：01 ISSN：11-5839/O6 分类号：64-67

摘要

An innovative cancer therapy strategy regarding the interface engineering of kaolinite has been designed. The exposed silanol group facilitates more guest species with high dispersion on the supports. Mn_3O_4 magnetic nanoparticles are uniformly distributed on external surfaces of the Kaolin_(C12N)with the Al–O–Mn bond for the detection of the tumor microenvironment by T1-MRI; Doxorubicin(DOX) are loaded in the interlayer space with the electrostatic interaction for chemo-treating; and KI is coated on the outer layer of the nanocomposites based on the electrostatic interaction for thyroid cancer targeting. The synergetic effects and the treatment mechanism enhanced by the interface engineering, KI@DOX-Mn_3O_4-Kaolin_(C12N)can cause remarkably low cell viability(57%, 200 μg/mL), tumor shrinking(75%, 20 μg/kg), and accumulation into the tumor tissues. The novel kaolinite based drug delivery system is expected to incorporate imaging diagnosis, targeted therapy and drug delivery into one single system for postoperative residual thyroid cancer treatment and observation for metastasis of focal area.
        An innovative cancer therapy strategy regarding the interface engineering of kaolinite has been designed. The exposed silanol group facilitates more guest species with high dispersion on the supports. Mn_3O_4 magnetic nanoparticles are uniformly distributed on external surfaces of the Kaolin_(C12N)with the Al–O–Mn bond for the detection of the tumor microenvironment by T1-MRI; Doxorubicin(DOX) are loaded in the interlayer space with the electrostatic interaction for chemo-treating; and KI is coated on the outer layer of the nanocomposites based on the electrostatic interaction for thyroid cancer targeting. The synergetic effects and the treatment mechanism enhanced by the interface engineering, KI@DOX-Mn_3O_4-Kaolin_(C12N)can cause remarkably low cell viability(57%, 200 μg/mL), tumor shrinking(75%, 20 μg/kg), and accumulation into the tumor tissues. The novel kaolinite based drug delivery system is expected to incorporate imaging diagnosis, targeted therapy and drug delivery into one single system for postoperative residual thyroid cancer treatment and observation for metastasis of focal area.

引文

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