Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology
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  • 英文篇名:Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology
  • 作者:CHENG ; Xiao-Rui ; QI ; Chun-Hui ; WANG ; Tong-Xing ; ZHOU ; Wen-Xia ; ZHANG ; Yong-Xiang
  • 英文作者:CHENG Xiao-Rui;QI Chun-Hui;WANG Tong-Xing;ZHOU Wen-Xia;ZHANG Yong-Xiang;Academy of Military Medical Science, Institute of Pharmacology and Toxicology;State Key Laboratory of Toxicology and Medical Countermeasures;
  • 英文关键词:Liu-Wei-Di-Huang;;Traditional Chinese medicine;;Pharmacology;;Phytochemistry;;Pharmacokinetics;;Toxicology
  • 中文刊名:ZGTR
  • 英文刊名:中国天然药物(英文版)
  • 机构:Academy of Military Medical Science, Institute of Pharmacology and Toxicology;State Key Laboratory of Toxicology and Medical Countermeasures;
  • 出版日期:2019-02-20
  • 出版单位:Chinese Journal of Natural Medicines
  • 年:2019
  • 期:v.17
  • 基金:supported by the National Natural Science Foundation of China(No.81473191);; the national key research and development program(No.2016YFC1306300)
  • 语种:英文;
  • 页:ZGTR201902002
  • 页数:19
  • CN:02
  • ISSN:32-1845/R
  • 分类号:31-49
摘要
Liu-Wei-Di-Huang(LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW,including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature review indicates that the LW prescription possesses a unique combination of pharmacological characteristics that can be safely used for treating very different diseases. Quality control and pharmacokinetic parameters of LW are mostly based on its major bioactive phytochemical constituents. We postulate that modulating or rebalancing the neuroendocrine immunomodulation network in the body is the underlying mechanism of the multiple pharmacological activities displayed by LW.
        Liu-Wei-Di-Huang(LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW,including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature review indicates that the LW prescription possesses a unique combination of pharmacological characteristics that can be safely used for treating very different diseases. Quality control and pharmacokinetic parameters of LW are mostly based on its major bioactive phytochemical constituents. We postulate that modulating or rebalancing the neuroendocrine immunomodulation network in the body is the underlying mechanism of the multiple pharmacological activities displayed by LW.
引文
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