共刺激分子(ICOS)及其特异性配体(ICOSL)在骨性关节炎滑膜组织中的表达及其临床意义研究
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摘要
目的研究共刺激分子(ICOS)及其特异性配体(ICOSL)在膝关节骨性关节炎(OA)滑膜组织中的表达及其临床意义。方法分别采集14例OA轻度及18例OA重度患者滑膜病变部位和远离病变部位,经HE染色法观察其病理改变,免疫组织化学法检测滑膜组织中ICOS、ICOSL的表达情况。结果 OA轻度患病组和重度患病组滑膜组织病变部位出现明显的炎性改变。ICOS、ICOSL在OA患者病变滑膜组织中高表达,且重度患病组表达最高。结论 ICOS、ICOSL共刺激分子在OA患者病变滑膜组织中高表达,对炎症反应的免疫紊乱和免疫损伤发挥重要作用。
Objective To research on the expression of ICOS,ICOSL stimulus molecule in the synovial tissue of osteroarthritis(OA)patientsand its clinical significance.Methods Synovial tissue lesions and distant sites of 14 cases of mild illness groups and 18 cases of severe illness group were collected to take HE staining.Immunohistochemistry were used to detect the expression of ICOS,ICOSL.Results OA synovial tissue of patients had pathological changes.ICOS,ICOSL were highly expressed in OA patients,and severe illness group had the highest expression level with the change of the disease varies.Conclusion The level of ICOS,ICOSL significantly increased in OA synovial tissue of patients might be due tochronic inflammation immune disorders and immune injury.
Objective To research on the expression of ICOS,ICOSL stimulus molecule in the synovial tissue of osteroarthritis(OA)patientsand its clinical significance.Methods Synovial tissue lesions and distant sites of 14 cases of mild illness groups and 18 cases of severe illness group were collected to take HE staining.Immunohistochemistry were used to detect the expression of ICOS,ICOSL.Results OA synovial tissue of patients had pathological changes.ICOS,ICOSL were highly expressed in OA patients,and severe illness group had the highest expression level with the change of the disease varies.Conclusion The level of ICOS,ICOSL significantly increased in OA synovial tissue of patients might be due tochronic inflammation immune disorders and immune injury.
引文
[1]宋维亚,厉小梅,李向培.T细胞在骨性关节炎发病机制中的作用[J].安徽医药,2010,14(4):476-478.
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[5]Smith SC,Folefac VA,Revell PA,et al.An immunocytochemical study of the distribution of proline-4-hydroxylase in normal,osteoarthritic and rheumatoid arthritic synovium at both the light and electron microscopic level[J].Br J Rheumatol,1998,37(3):287-291.
[6]王婷,蒋觉安,胡筱涵,等.ICOS/ICOSL在类风湿关节炎患者外周血淋巴细胞的表达及临床意义[J].中国免疫学杂志,2015,31(3):369-374.
[7]王青松,厉小梅.阻断ICOS/ICOSL途径用于治疗自身免疫性疾病的研究进展[J].细胞与分子免疫学杂志,2015,7(31):985-988.
[8]李盛村,王婷,王国祥.ICOS/ICOSL的免疫调节作用与相关疾病的研究进展[J].基础医学与临床,2014,34(10):1434-1437.
[2]李盛村,王婷,王国祥.ICOS/ICOSL的免疫调节作用与相关疾病的研究进展[J].基础医学与临床,2014,34(10):1434-1437.
[3]王秀义,王文强,王文军,等.膝关节骨性关节炎(KOA)诊疗规范[C]//中华中医药学会针刀医学分会二〇〇八年度学术会议.2008.
[4]张卫东,戴刚,杨柳,等.近10年滑膜相关疾病研究的文献计量学分析[J].重庆医学,2006,35(4):316-321.
[5]Smith SC,Folefac VA,Revell PA,et al.An immunocytochemical study of the distribution of proline-4-hydroxylase in normal,osteoarthritic and rheumatoid arthritic synovium at both the light and electron microscopic level[J].Br J Rheumatol,1998,37(3):287-291.
[6]王婷,蒋觉安,胡筱涵,等.ICOS/ICOSL在类风湿关节炎患者外周血淋巴细胞的表达及临床意义[J].中国免疫学杂志,2015,31(3):369-374.
[7]王青松,厉小梅.阻断ICOS/ICOSL途径用于治疗自身免疫性疾病的研究进展[J].细胞与分子免疫学杂志,2015,7(31):985-988.
[8]李盛村,王婷,王国祥.ICOS/ICOSL的免疫调节作用与相关疾病的研究进展[J].基础医学与临床,2014,34(10):1434-1437.