摘要
目的了解鱼油对维持性血液透析(hemodialysis, HD)患者炎症和骨矿物质水平的影响。方法选取HD患者74例,随机分为对照组和观察组,每组37例。对照组患者接受规律HD治疗,观察组患者在对照组的基础上服用鱼油1 000 mg,3次/d,连续服用6个月。在治疗前和治疗6个月后检测两组患者的血红蛋白(Hb)、白细胞(WBC)、铁蛋白、尿酸、高敏C反应蛋白(hs-CRP)、钙、磷、甲状旁腺素(PTH)、碱性磷酸酶(ALP)和骨保护素(OPG)水平。结果两组患者治疗前Hb、WBC、铁蛋白、尿酸、hs-CRP、钙、磷、PTH、ALP和OPG水平差异无统计学意义(P>0.05)。治疗后对照组患者的铁蛋白水平显著高于治疗前(P<0.01);观察组患者的铁蛋白和钙水平亦高于治疗前,而hs-CRP水平则低于治疗前(P<0.01);且治疗后观察组患者的hs-CRP水平显著低于对照组,钙水平则高于对照组(P<0.05或0.01)。两组患者治疗后Hb、WBC、尿酸、磷、PTH、ALP、OPG水平以及不良反应发生情况差异无统计学意义(P>0.05)。结论鱼油可降低HD患者体内炎症因子水平,提高血钙浓度,值得临床应用。
Objective To explore the effect of fish oil on inflammatory and bone mineral level of maintenance hemodialysis(HD) patients. Methods A total of 74 HD patients were randomly divided into the Control Group and the Experimental Group, 37 cases in each group. Patients in the Control Group received regular HD treatment while those in the Experimental Group were orally administered with 1000 mg fish oil three times per day continuously for six months on the basis of regular HD treatment. The hemoglobin(Hb), white blood cells(WBC), serum ferritin, uric acid, high-sensitivity Creactive protein(hs-CRP), calcium, phosphorus, parathyroid hormone(PTH), alkaline phosphatase(ALP) and osteoprotegerin(OPG) level of both groups was detected before the treatment and 6 months after treatment. Results There was no significant difference in Hb, WBC, serum ferritin, uric acid, hs-CRP, calcium, phosphorus, PTH, ALP and OPG level between the two groups before treatment(P>0.05). After the treatment, the serum ferritin level of the Control Group was significantly higher than that before treatment(P<0.01). In the Experimental Group, the serum ferritin and calcium level was significantly higher than that before the treatment, but the hs-CRP level was significantly lower than that before treatment(P<0.01). Moreover, the Experimental Group had the hs-CRP level significantly lower and the calcium level significantly higher than the Control Group after the treatment(P<0.05 or 0.01). There was no significant difference in Hb, WBC, uric acid, phosphorus, PTH, ALP and OPG level as well as the incidence of adverse reactions between the two groups after the treatment(P>0.05). Conclusion Fish oil can decrease the inflammatory level and increase the calcium level in HD patients, which is worth clinical promotion.
引文
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