IGF-1、IGF-2、IGFBP-3表达与子宫内膜癌患者临床病理特征参数的相关性分析
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摘要
目的探讨IGF-1、IGF-2、IGFBP-3表达与子宫内膜癌患者临床病理特征参数的相关性。方法选择120例子宫内膜癌患者的癌组织标本与癌旁组织标本,给予IGF-1、IGF-2、IGFBP-3的免疫组化分析,分析其与临床病理特征参数的相关性。结果癌组织中IGF-1、IGF-2、IGFBP-3表达阳性率与癌旁组织对比都有差异(P <0.05)。子宫内膜癌组织中IGF-1、IGF-2、IGFBP-3的表达阳性率与分化程度、临床分期、肌层浸润深度、淋巴结转移有相关性(P <0.05)。Spearman等级相关分析分析显示IGF-1与IGF-2呈正相关性(P <0.05),与IGFBP-3呈负相关性(P <0.05),IGF-2也与IGFBP-3呈负相关性(P <0.05)。结论 IGF-1、IGF-2、IGFBP-3与子宫内膜癌的临床病理特征参数密切相关,从而调节子宫内膜癌的形成。
Objective To investigate the correlation between the expression of IGF-1,IGF-2 and IGFBP-3 and the clinicopathological parameters of endometrial carcinoma. Methods A total of 120 cases of tumor tissuesand paracancerous tissues from endometrial cancer patients were selected. All tissues were stained with IGF-1,IGF-2,IGFBP-3 immunohistochemistry,and were to analysis of its correlation with clinical pathological characteristicsparameter. Results The positive rates of IGF-1,IGF-2 and IGFBP-3 expression in cancer tissues compared thosein paracancerous tissues were significant difference(P < 0.05). In the endometrial carcinoma,the positive expres-sion rates of IGF-1,IGF-2 and IGFBP-3 were related to the differentiation,clinical stage,the depth of myometrialinvasion and lymph node metastasis(P < 0.05). Spearman rank correlation analysis showed that IGF-1 were posi-tively correlated with IGF-2(P < 0.05),and were negatively correlated with IGFBP-3(P < 0.05). The IGF-2 werealso significantly negative correlation with IGFBP-3(P < 0.05). Conclusion The IGF-1,IGF-2 and IGFBP-3 areclosely related to the clinicopathological parameters of endometrial carcinoma.
Objective To investigate the correlation between the expression of IGF-1,IGF-2 and IGFBP-3 and the clinicopathological parameters of endometrial carcinoma. Methods A total of 120 cases of tumor tissuesand paracancerous tissues from endometrial cancer patients were selected. All tissues were stained with IGF-1,IGF-2,IGFBP-3 immunohistochemistry,and were to analysis of its correlation with clinical pathological characteristicsparameter. Results The positive rates of IGF-1,IGF-2 and IGFBP-3 expression in cancer tissues compared thosein paracancerous tissues were significant difference(P < 0.05). In the endometrial carcinoma,the positive expres-sion rates of IGF-1,IGF-2 and IGFBP-3 were related to the differentiation,clinical stage,the depth of myometrialinvasion and lymph node metastasis(P < 0.05). Spearman rank correlation analysis showed that IGF-1 were posi-tively correlated with IGF-2(P < 0.05),and were negatively correlated with IGFBP-3(P < 0.05). The IGF-2 werealso significantly negative correlation with IGFBP-3(P < 0.05). Conclusion The IGF-1,IGF-2 and IGFBP-3 areclosely related to the clinicopathological parameters of endometrial carcinoma.
引文
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[7]秦娟,李海英,寇莉.组织β-Catenin m RNA和IGF-1 m RNA检测在子宫内膜癌和子宫内膜息肉疾病鉴别诊断中的应用[J].临床和实验医学杂志,2017,16(5):468-471.
[8] KWASNIEWSKI W,GOZDZICKA-JOZEFIAK A,WOLUN-CHOLEWA M,et al. Microsatellite polymorphism in the P1 pro-moter region of the IGF 1 gene is associated with endometrialcancer[J].Mol Med Rep,2016,13(6):4950-4958.
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[10]陈勇,任全珍,蔡容霞,等.腹腔镜手术治疗早期子宫内膜癌的临床研究[J].癌症进展,2016,14(9):917-919,922.
[11] MCGRATH M,LEE I M,BURING J,et al. Common geneticvariation within IGFI,IGFII,IGFBP-1,and IGFBP-3 and en-dometrial cancer risk[J].Gynecol Oncol,2011,120(2):174-178.
[12]刘颖慧,黎金颜,吴又明,等.不同分型分期子宫内膜癌叶酸受体α的表达及诊断性能评估[J].实用医学杂志,2018,34(4):592-595.
[13] WEI R,DE VIVO I,HUANG S,et al. Meta-dimensional dataintegration identifies critical pathways for susceptibility,tumori-genesis and progression of endometrial cancer[J].Oncotarget,2016,7(34):55249-55263.
[14] NIMPTSCH K,PISCHON T. Obesity biomarkers,metabolismand risk of cancer:An epidemiological perspective[J]. RecentResults Cancer Res,2016,208(10):199-217.
[2] VELLONE V G,SPINA B,GRILLO F,et al. Mixed malignantmullerian tumor with neuroendocrine features in an irradiateduterus for cervical carcinoma. A unique association? A morpho-logical, immunohistochemisty and ultrastructural study[J].Pathologica,2017,109(4):392-397.
[3] GUO S,XIAO Y,LI D,et al. PGK1 and GRP78 overexpres-sion correlates with clinical significance and poor prognosis inChinese endometrial cancer patients[J].Oncotarget,2017,9(1):680-690.
[4]李春梅,代淑兰.腹腔镜辅助阴式手术对早期老年子宫内膜癌患者术后血清IGF-1、CA125水平及生存质量的影响[J].医学临床研究,2017,34(8):1504-1507.
[5] PEREIRA M C,MOHAMMED R,VAN OTTERLO W A L,etal. Evaluation of the effects of aminonaphthoquinone derivativesin combination with curcumin against er-positive breast cancerand related tumours[J].Anticancer Res,2017,37(12):6749-6759.
[6] MERRITT M A,STRICKLER H D,EINSTEIN M H,et al. In-sulin/IGF and sex hormone axes in human endometrium and as-sociations with endometrial cancer risk factors[J].CancerCauses Control,2016.27(6):737-348.
[7]秦娟,李海英,寇莉.组织β-Catenin m RNA和IGF-1 m RNA检测在子宫内膜癌和子宫内膜息肉疾病鉴别诊断中的应用[J].临床和实验医学杂志,2017,16(5):468-471.
[8] KWASNIEWSKI W,GOZDZICKA-JOZEFIAK A,WOLUN-CHOLEWA M,et al. Microsatellite polymorphism in the P1 pro-moter region of the IGF 1 gene is associated with endometrialcancer[J].Mol Med Rep,2016,13(6):4950-4958.
[9] GRIBBEN L,BAXTER R C,MARSH D J. Insulin-like growthfactor binding protein-3 inhibits migration of endometrial cancercells[J]. Cancer Lett,2012,317(1):41-48.
[10]陈勇,任全珍,蔡容霞,等.腹腔镜手术治疗早期子宫内膜癌的临床研究[J].癌症进展,2016,14(9):917-919,922.
[11] MCGRATH M,LEE I M,BURING J,et al. Common geneticvariation within IGFI,IGFII,IGFBP-1,and IGFBP-3 and en-dometrial cancer risk[J].Gynecol Oncol,2011,120(2):174-178.
[12]刘颖慧,黎金颜,吴又明,等.不同分型分期子宫内膜癌叶酸受体α的表达及诊断性能评估[J].实用医学杂志,2018,34(4):592-595.
[13] WEI R,DE VIVO I,HUANG S,et al. Meta-dimensional dataintegration identifies critical pathways for susceptibility,tumori-genesis and progression of endometrial cancer[J].Oncotarget,2016,7(34):55249-55263.
[14] NIMPTSCH K,PISCHON T. Obesity biomarkers,metabolismand risk of cancer:An epidemiological perspective[J]. RecentResults Cancer Res,2016,208(10):199-217.