急性痛风性关节炎患者血清IL-1βIL-6 IL-8与疼痛的相关性
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摘要
目的:探讨急性痛风性关节炎患者血清IL-1β、IL-6、IL-8与疼痛的相关性。方法:回顾性研究分析石家庄市中医院骨科自2017年3月至2018年6月收治的痛风性关节炎患者60例,作为观察组,同期选取30名健康人员,作为对照组。将两组人员的血清IL-1β、IL-6、IL-8水平进行检测并比较,同时分析观察组中不同疼痛程度患者的白介素水平,并以Pearson相关分析处理血清IL-1β、IL-6、IL-8与患者疼痛的关系。结果:观察组的血清IL-1β、IL-6、IL-8水平均显著地高于对照组,经Pearson相关分析显示,观察组患者的疼痛与IL-1β、IL-6、IL-8的水平呈正相关,差异均具有统计学意义(P<0.05)。结论:急性痛风性关节炎患者血清IL-1β、IL-6、IL-8与其疼痛呈正相关的关系,在急性痛风性关节炎中具有较高的临床检测价值。
Objective: To study the relationship between the expression of serum IL-1β,IL-6 and IL-8 and pain in patients with acute gouty arthritis(AGA). Methods: 60 patients with AGA in Shijiazhuang Hospital of Traditional Chinese Medicine from March 2017 to June 2018 were selected as observation group,30 healthy persons at the same time were selected as control group,then serum IL-1β,IL-6 and IL-8 of two groups were detected and compared,and the detection levels of observation group with different pain index were compared,then the relationship between serum IL-1β,IL-6 and IL-8 and the pain degree of patients were analyzed by Pearson correlation analysis. Results: The serum IL-1β,IL-6 and IL-8 of observation group were all significantly higher than those of control group,and there was a positive correlation between the degree of pain and the level of serum IL-1β,IL-6,IL-8 in observation group by Pearson correlation analysis,the difference was statistically significant(P <0.05). Conclusions: Serum IL-1β,IL-6 and IL-8 was positively correlated with pain in patients with acute gouty arthritis,and had high clinical value in acute gouty arthritis.
Objective: To study the relationship between the expression of serum IL-1β,IL-6 and IL-8 and pain in patients with acute gouty arthritis(AGA). Methods: 60 patients with AGA in Shijiazhuang Hospital of Traditional Chinese Medicine from March 2017 to June 2018 were selected as observation group,30 healthy persons at the same time were selected as control group,then serum IL-1β,IL-6 and IL-8 of two groups were detected and compared,and the detection levels of observation group with different pain index were compared,then the relationship between serum IL-1β,IL-6 and IL-8 and the pain degree of patients were analyzed by Pearson correlation analysis. Results: The serum IL-1β,IL-6 and IL-8 of observation group were all significantly higher than those of control group,and there was a positive correlation between the degree of pain and the level of serum IL-1β,IL-6,IL-8 in observation group by Pearson correlation analysis,the difference was statistically significant(P <0.05). Conclusions: Serum IL-1β,IL-6 and IL-8 was positively correlated with pain in patients with acute gouty arthritis,and had high clinical value in acute gouty arthritis.
引文
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[2] Neogi T,Jansen T L,Dalbeth N,et al.2015 Gout classification criteria:an american college of rheumatology/european league against rheumatism collaborative initiative[J]. Ann Rheum Dis,2015,74(10):1789~1798.
[3] Harland NJ,Dawkin MJ,Martin D.Relative utility of a visual analogue scale vs. a six-point Likert scale in the measurement of global subject outcome in patients with low back pain receiving physiotherapy[J].Physiothempy,2015,101(1):50~54.
[4] Joosten LA,Cris an TO,Azam T,et al.Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1 beta and by the induction of endogenous IL-1Ra[J].Ann Rheum Dis,2016,75:1219~1227.
[5] Cavalcanti N G,Marques C D,Lins E LT U,et al.Cytokine profile in gout:inflammation driven by IL-6 and IL-18[J].Immunol Invest,2016,45(5):383~395.
[6] Hirsch JD,Gnanasakthy A,Lale R,et al.Efficacy of Canakinumab vs. triamcinolone acetonide according to multiple gouty arthritis-related health outcomes measures[J].Int Clin Pract,2014,68:1503~1507.