婴儿骨化性肾肿瘤1例并文献复习
摘要
目的探讨婴儿骨化性肾肿瘤(ossifying renal tumor of infancy,ORTI)的临床特点、组织学特征、诊断及鉴别诊断。方法回顾性分析1例ORTI患儿的临床资料、病理学特征及免疫表型,并复习相关文献。结果患儿因肉眼血尿入院,CT示右肾实质内可见类圆形等低密度占位,其内可见少许片状高密度影。肾脏中部见棕红色结节状病灶,大小1cm×1 cm×0. 8 cm。肿瘤组织由骨样基质、骨母细胞样细胞及梭形细胞构成。免疫表型:梭形细胞表达WT-1、vimentin、CD99及SMA,不表达Pax-2、Pax-8;骨母细胞样细胞不表达WT-1,表达vimentin、CD99、SMA及SATB2。结论 ORTI属于非常罕见的良性肿瘤,临床主要表现为无痛性血尿,影像学检查可发现高密度占位或钙化灶,应根据其临床症状、影像学检查及组织学检查做出正确诊断,避免过度治疗。
引文
[1] Guan W,Yan Y,He W,et al. Ossifying renal tumor of infancy(ORIT):the clinicopathological and cytogenetic feature of two cases and literature review[J]. Pathol Res Pract,2016,212(11):1004-1009.
[2]焦丽丽,宋宏程,孙宁,等.婴儿骨化性肾肿瘤2例报告及文献分析[J].临床小儿外科杂志,2010,9(5):362-364.
[3]周峥珍,陈卫坚,姜楠,等.儿童非肾母细胞瘤肾脏肿瘤15例临床病理分析[J].临床与实验病理学杂志,2014,30(4):415-418.
[4] Chatten J,Cromie W J,Duckett J W. Ossifying tumor of infantile kidney:report of two cases[J]. Cancer,1980,45(3):609-612.
[5] Lee S H,Choi Y H,Kim W S,et al. Ossifying renal tumor of infancy:findings at ultrasound,CT and MRI[J]. Pediatr Radiol,2014,44(5):625-628.
[6] Vazquez J L,Barnewolt C E,Shamberger R C,et al. Ossifying renal tumor of infancy presenting as a palpable abdominal mass[J].Pediatr Radiol,1998,28(6):454-457.
[7] Seixas-Mikelus S A,Khan A,Williot P E,et al. Three-month-old boy with juvenile granulosa cell tumor of testis and ossifying renal tumor of infancy[J]. Urology,2009,74(2):311-313.
[8] Zhu K,Yang M,Zheng Y,et al. Coexisting differentiated neuroblastoma and ossifying renal tumor of infancy in a patient[J]. Fetal Pediatr Pathol,2015,34(1):14-17.
[9] Ito J,Shinohara N,Koyanagi T,et al. Ossifying renal tumor of infancy:the first Japanese case with long-term follow-up[J]. Pathol Int,1998,48(2):151-159.
[10] Sotelo-Avila C,Beckwith J B,Johnson J E. Ossifying renal tumor of infancy:a clinicopathologic study of nine cases[J]. Pediatr Pathol Lab Med,1995,15(5):745-762.
[11] Liu J,Guzman M A,Pawel B R,et al. Clonal trisomy 4 cells detected in the ossifying renal tumor of infancy:study of 3 cases[J].Mod Pathol,2013,26(2):275-281.
[12] Middlebrook P F,Jimenez C L,Schiflinger J F. Ossifying renal tumor of infancy:a case report[J]. J Urol,1992,147(5):1337-1339.
[2]焦丽丽,宋宏程,孙宁,等.婴儿骨化性肾肿瘤2例报告及文献分析[J].临床小儿外科杂志,2010,9(5):362-364.
[3]周峥珍,陈卫坚,姜楠,等.儿童非肾母细胞瘤肾脏肿瘤15例临床病理分析[J].临床与实验病理学杂志,2014,30(4):415-418.
[4] Chatten J,Cromie W J,Duckett J W. Ossifying tumor of infantile kidney:report of two cases[J]. Cancer,1980,45(3):609-612.
[5] Lee S H,Choi Y H,Kim W S,et al. Ossifying renal tumor of infancy:findings at ultrasound,CT and MRI[J]. Pediatr Radiol,2014,44(5):625-628.
[6] Vazquez J L,Barnewolt C E,Shamberger R C,et al. Ossifying renal tumor of infancy presenting as a palpable abdominal mass[J].Pediatr Radiol,1998,28(6):454-457.
[7] Seixas-Mikelus S A,Khan A,Williot P E,et al. Three-month-old boy with juvenile granulosa cell tumor of testis and ossifying renal tumor of infancy[J]. Urology,2009,74(2):311-313.
[8] Zhu K,Yang M,Zheng Y,et al. Coexisting differentiated neuroblastoma and ossifying renal tumor of infancy in a patient[J]. Fetal Pediatr Pathol,2015,34(1):14-17.
[9] Ito J,Shinohara N,Koyanagi T,et al. Ossifying renal tumor of infancy:the first Japanese case with long-term follow-up[J]. Pathol Int,1998,48(2):151-159.
[10] Sotelo-Avila C,Beckwith J B,Johnson J E. Ossifying renal tumor of infancy:a clinicopathologic study of nine cases[J]. Pediatr Pathol Lab Med,1995,15(5):745-762.
[11] Liu J,Guzman M A,Pawel B R,et al. Clonal trisomy 4 cells detected in the ossifying renal tumor of infancy:study of 3 cases[J].Mod Pathol,2013,26(2):275-281.
[12] Middlebrook P F,Jimenez C L,Schiflinger J F. Ossifying renal tumor of infancy:a case report[J]. J Urol,1992,147(5):1337-1339.