糖尿病酮症酸中毒合并急性胰腺炎临床指标变化特点分析
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摘要
目的观察糖尿病酮症酸中毒(DKA)合并急性胰腺炎(AP)患者的生化指标变化特点,探讨其临床意义。方法回顾性分析本院2014年01月～2018年06月DKA患者资料,将其分为DKA合并AP组(观察组)和DKA未合并AP组(对照组),观察组共纳入患者26例,随机选取DKA未合并AP患者40例作为对照组,比较两组之间血糖、血PH值、甘油三酯(TG)及血尿淀粉酶等指标的变化特点。结果观察组甘油三酯、血尿粉酶水平明显高于对照组,观察组血PH值明显低于对照组,差异均有统计学意义(P <0.05);两组血糖水平比较差异无统计学意义(P> 0.05)。结论 DKA合并AP者淀粉酶水平更高,血PH值更低。
Objective To observe the changes of clinical indicators of diabetic ketoaci-dosis complicated with acute pancreatitis,and explore its clinical signi?cance. Methods Retrospective analysis the diabetic ketoacidosis patient data from January 2014 to June 2018 in our hospital.They were divided into DKA combined with AP group(observation group) and DKA without AP group(control group).A total of 26 patients were enrolled in the observation group, and 40 patients with DKA without AP were randomLy selected as the control group. The changes of blood glucose, PH, triglyceride(TG) and hematurimase were compared between the two groups. Results The analysis showed that the triglyceride and hematuria levels were signi?cantly higher in the observation group than that in the control group(P < 0.05).The pH in the observation group was signi?cantly lower than that in the control group, and the difference was statistically signi?cant(P < 0.05). There was no signi?cant difference in blood glucose levels between the two groups(P > 0.05). Conclusion DKA combined with AP has higher amylase levels and lower blood pH.
Objective To observe the changes of clinical indicators of diabetic ketoaci-dosis complicated with acute pancreatitis,and explore its clinical signi?cance. Methods Retrospective analysis the diabetic ketoacidosis patient data from January 2014 to June 2018 in our hospital.They were divided into DKA combined with AP group(observation group) and DKA without AP group(control group).A total of 26 patients were enrolled in the observation group, and 40 patients with DKA without AP were randomLy selected as the control group. The changes of blood glucose, PH, triglyceride(TG) and hematurimase were compared between the two groups. Results The analysis showed that the triglyceride and hematuria levels were signi?cantly higher in the observation group than that in the control group(P < 0.05).The pH in the observation group was signi?cantly lower than that in the control group, and the difference was statistically signi?cant(P < 0.05). There was no signi?cant difference in blood glucose levels between the two groups(P > 0.05). Conclusion DKA combined with AP has higher amylase levels and lower blood pH.
引文
[1]中华医学会消化病学分会胰腺疾病学组.中国急性胰腺炎诊治指南(2013年,上海)[J].中华消化杂志,2013,29(4):428-433.
[2]Nair S,Yadav D,Pitchumoni C S.Association of Diabetic Ketoacidosis and Acute Pancreatitis:Observations in 100Consecutive Episodes of DKA[J].American Journal of Gastroenterology,2000,95(10):2795-2800.
[3]Vinicor F,Lehrner L M,Karn R C,et al.Hyperamylasemia in diabetic ketoacidosis:sources and significance[J].Annals of Internal Medicine,1979,91(2):200-204.
[4]Wolfsdorf J I,Glaser N,Agus M,et al.Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State:A Consensus Statement from the International Society for Pediatric and Adolescent Diabetes[J]Pediatric diabetes,2018.
[5]中华医学会糖尿病学分会.中国高血糖危象诊断与治疗指南[J].中国糖尿病杂志,2013,5(8):449-461.
[6]王丽娜,刘东屏,李茵茵,等.以腹痛为首发症状的糖尿病酮症酸中毒临床分析[J].中华实用诊断与治疗杂志,201630(1):78-79.
[7]姚群英,林建园,钟远慎,等.糖尿病酮症酸中毒合并急性胰腺炎15例临床分析[J].海南医学,2017,28(4):641-642.
[8]柯培锋,周海涛,万泽民,等.血β-羟丁酸诊断2型糖尿病酮症酸中毒阈值的建立[J].南方医科大学学报,201434(10):1507-1510.
[9]杜荣云.腹部手术后功能性胃排空障碍30例临床分析[J].中华实用诊断与治疗杂志,2012,26(4):391-392.
[2]Nair S,Yadav D,Pitchumoni C S.Association of Diabetic Ketoacidosis and Acute Pancreatitis:Observations in 100Consecutive Episodes of DKA[J].American Journal of Gastroenterology,2000,95(10):2795-2800.
[3]Vinicor F,Lehrner L M,Karn R C,et al.Hyperamylasemia in diabetic ketoacidosis:sources and significance[J].Annals of Internal Medicine,1979,91(2):200-204.
[4]Wolfsdorf J I,Glaser N,Agus M,et al.Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State:A Consensus Statement from the International Society for Pediatric and Adolescent Diabetes[J]Pediatric diabetes,2018.
[5]中华医学会糖尿病学分会.中国高血糖危象诊断与治疗指南[J].中国糖尿病杂志,2013,5(8):449-461.
[6]王丽娜,刘东屏,李茵茵,等.以腹痛为首发症状的糖尿病酮症酸中毒临床分析[J].中华实用诊断与治疗杂志,201630(1):78-79.
[7]姚群英,林建园,钟远慎,等.糖尿病酮症酸中毒合并急性胰腺炎15例临床分析[J].海南医学,2017,28(4):641-642.
[8]柯培锋,周海涛,万泽民,等.血β-羟丁酸诊断2型糖尿病酮症酸中毒阈值的建立[J].南方医科大学学报,201434(10):1507-1510.
[9]杜荣云.腹部手术后功能性胃排空障碍30例临床分析[J].中华实用诊断与治疗杂志,2012,26(4):391-392.