Research on Characteristic Manifestations of Xiaochaihu Decoction Based on Association Rules Mining
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摘要
Objective: The aim of this study is to explore the characteristic manifestations and contraindications of Xiaochaihu decoction(XD [It also stands for all the seven herbs in XD]) syndrome and to clarify the principle of using XD. Methods: By searching on the Encyclopedia of Traditional Chinese Medicine, 254 cases whose symptoms were relieved by XD and 48 cases who misused XD in ancient time were selected. Moreover, they are divided into two groups. Microsoft Excel 2016 was used as a storage tool. These two groups of cases were all treated with XD because of their similar manifestations, but therapeutic efficacies are reverse. The manifestations mislead doctors should be selected out to clarify the indications of using XD. Thus, the professional data mining software RapidMiner was used as a platform to do the frequent statistic and to create association rules between manifestations and herbs of both groups, respectively. After comparing the results of two groups, we can make a conclusion. Results: The characteristics of XD syndrome are alternative chills and fever, hypochondriac pain, and inflammatory swelling and pain(ear or breast). When any of these manifestations occur, XD can be used. Wiry pulse paired with alternative chills and fever, headache, thirst, or hypochondriac pain is also regarded as the indications of using XD. XD should not treat for fever paired with other manifestations, such as headache, delirium, or aversion to cold. In addition, the manifestations with high concurrence frequency do not mean the high correlation. Moreover, only according to the frequency, statistics cannot make correct conclusions. Conclusions:(1) XD is more fit for the excess syndrome such as excess fire in the liver or gallbladder meridians.(2) The medical records in which the XD is misused are also worth analyzing.(3) Association rules cannot be substituted with frequency statistics.
Objective: The aim of this study is to explore the characteristic manifestations and contraindications of Xiaochaihu decoction(XD [It also stands for all the seven herbs in XD]) syndrome and to clarify the principle of using XD. Methods: By searching on the Encyclopedia of Traditional Chinese Medicine, 254 cases whose symptoms were relieved by XD and 48 cases who misused XD in ancient time were selected. Moreover, they are divided into two groups. Microsoft Excel 2016 was used as a storage tool. These two groups of cases were all treated with XD because of their similar manifestations, but therapeutic efficacies are reverse. The manifestations mislead doctors should be selected out to clarify the indications of using XD. Thus, the professional data mining software RapidMiner was used as a platform to do the frequent statistic and to create association rules between manifestations and herbs of both groups, respectively. After comparing the results of two groups, we can make a conclusion. Results: The characteristics of XD syndrome are alternative chills and fever, hypochondriac pain, and inflammatory swelling and pain(ear or breast). When any of these manifestations occur, XD can be used. Wiry pulse paired with alternative chills and fever, headache, thirst, or hypochondriac pain is also regarded as the indications of using XD. XD should not treat for fever paired with other manifestations, such as headache, delirium, or aversion to cold. In addition, the manifestations with high concurrence frequency do not mean the high correlation. Moreover, only according to the frequency, statistics cannot make correct conclusions. Conclusions:(1) XD is more fit for the excess syndrome such as excess fire in the liver or gallbladder meridians.(2) The medical records in which the XD is misused are also worth analyzing.(3) Association rules cannot be substituted with frequency statistics.
Objective: The aim of this study is to explore the characteristic manifestations and contraindications of Xiaochaihu decoction(XD [It also stands for all the seven herbs in XD]) syndrome and to clarify the principle of using XD. Methods: By searching on the Encyclopedia of Traditional Chinese Medicine, 254 cases whose symptoms were relieved by XD and 48 cases who misused XD in ancient time were selected. Moreover, they are divided into two groups. Microsoft Excel 2016 was used as a storage tool. These two groups of cases were all treated with XD because of their similar manifestations, but therapeutic efficacies are reverse. The manifestations mislead doctors should be selected out to clarify the indications of using XD. Thus, the professional data mining software RapidMiner was used as a platform to do the frequent statistic and to create association rules between manifestations and herbs of both groups, respectively. After comparing the results of two groups, we can make a conclusion. Results: The characteristics of XD syndrome are alternative chills and fever, hypochondriac pain, and inflammatory swelling and pain(ear or breast). When any of these manifestations occur, XD can be used. Wiry pulse paired with alternative chills and fever, headache, thirst, or hypochondriac pain is also regarded as the indications of using XD. XD should not treat for fever paired with other manifestations, such as headache, delirium, or aversion to cold. In addition, the manifestations with high concurrence frequency do not mean the high correlation. Moreover, only according to the frequency, statistics cannot make correct conclusions. Conclusions:(1) XD is more fit for the excess syndrome such as excess fire in the liver or gallbladder meridians.(2) The medical records in which the XD is misused are also worth analyzing.(3) Association rules cannot be substituted with frequency statistics.
引文
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7.Zhang XG,Jia B,Chen G,Li CG.Analysis of characteristics of modern TCM doctors applying xiaochaihu decoction.Chin J Inf TCM2010;193:93-4.
8.Tao FZ.Study on Xiaochaihu Catogrized Formulas.Nanjing:Nanjing University of Chinese Medicine;2009.p.25.
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10.Matthew N.Data Mining for the Masses.Athens:Global Text Project;2012.
11.Cremaschi P,Carriero R,Astrologo S,Coli C,Lisa A,Parolo S,et al.An Association rule mining approach to discover lncrnas expression patterns in cancer datasets.Biomed Res Int 2015;12:15.
12.Hu W,Li X,Wang T,Zheng S.Association mining of mutated cancer genes in different clinical stages across 11 cancer types.Oncotarget2016;7:68270-7.
13.Chen HY,Lin YH,Hu S,Yang SH,Chen JL,Chen YC.Identifying Chinese herbal medicine network for eczema:Implications from a nationwide prescription database.Evid Based Complement Altern Med 2015;1:19.
14.Chen YC,Lin YH,Hu S,Chen HY.Characteristics of traditional Chinese medicine users and prescription analysis for pediatric atopic dermatitis:A population-based study.BMC Complement Altern Med 2016;16:173.
15.Hofmann M,Klinkenberg R.RapidMiner:DATA Mining use Cases and Business Analytics Applications.Boca Raton:CRC Press;2013.
16.Han J,Kamber M,Pei J.Data Mining Concepts and Techniques.3rd ed.San Francisco:Morgan Kaufmann Publisher;2012.
17.Kitagawa I.Licorice root.A natural sweetener and an important ingredient in Chinese medicine.Pure Appl Chemr 2002;74:1189-98.
18.Tang ZH,Li T,Tong YG,Chen XJ,Chen XP,Wang YT,et al.A systematic review of the anticancer properties of compounds isolated from licorice(Gancao).Planta Med 2015;81:1670-87.
19.Hu ML,Rayner CK,Wu KL,Chuah SK,Tai WC,Chou YP,et al.Effect of ginger on gastric motility and symptoms of functional dyspepsia.World J Gastroenterol 2011;17:105-10.
20.Jia YL,Zhao JM,Zhang LH,Sun BS,Bao MJ,Fen-Fen LI,et al.Analgesic and anti-inflammatory effects of ginger oil.Chin Herbal Med2011;3:150-5.
21.Hasan N,Sorkhy MA,Albattah F.Ziziphus jujube of the Middle East,food and medicine.Unique J Ayurvedic Herbal Med 2014;2:7-11.
2.You ZJ.A String of Beads from Treatise on Cold-Induced Diseases.Beijing:Academy Press;2009.
3.Wang H.Various Dialectical Comments on the Treatise on Cold-Induced Diseases.Shanghai:Shanghai Medical Publishing House;1958.
4.Cheng WJ.Treatise on Cold-Induced Diseases with Notes.Beijing:The Medicine Science and Technology Press of China;2011.
5.Ke Qin.Renewal of Treatise on Cold-Induced Diseases.Taiyuan:Shanxi Science and Technology Press;2010.
6.Wu GE.Explore of Application of Xiaochaihu Decoction in Past Dynasty.Beijing:Beijing University of Chinese Medicine;2005.p.20.
7.Zhang XG,Jia B,Chen G,Li CG.Analysis of characteristics of modern TCM doctors applying xiaochaihu decoction.Chin J Inf TCM2010;193:93-4.
8.Tao FZ.Study on Xiaochaihu Catogrized Formulas.Nanjing:Nanjing University of Chinese Medicine;2009.p.25.
9.Wang GB.Study on Correspondence of Xiaochaihu Decoction and its Syndrome.Nanjing:Nanjing University of Chinese Medicine;2010.p.2049.
10.Matthew N.Data Mining for the Masses.Athens:Global Text Project;2012.
11.Cremaschi P,Carriero R,Astrologo S,Coli C,Lisa A,Parolo S,et al.An Association rule mining approach to discover lncrnas expression patterns in cancer datasets.Biomed Res Int 2015;12:15.
12.Hu W,Li X,Wang T,Zheng S.Association mining of mutated cancer genes in different clinical stages across 11 cancer types.Oncotarget2016;7:68270-7.
13.Chen HY,Lin YH,Hu S,Yang SH,Chen JL,Chen YC.Identifying Chinese herbal medicine network for eczema:Implications from a nationwide prescription database.Evid Based Complement Altern Med 2015;1:19.
14.Chen YC,Lin YH,Hu S,Chen HY.Characteristics of traditional Chinese medicine users and prescription analysis for pediatric atopic dermatitis:A population-based study.BMC Complement Altern Med 2016;16:173.
15.Hofmann M,Klinkenberg R.RapidMiner:DATA Mining use Cases and Business Analytics Applications.Boca Raton:CRC Press;2013.
16.Han J,Kamber M,Pei J.Data Mining Concepts and Techniques.3rd ed.San Francisco:Morgan Kaufmann Publisher;2012.
17.Kitagawa I.Licorice root.A natural sweetener and an important ingredient in Chinese medicine.Pure Appl Chemr 2002;74:1189-98.
18.Tang ZH,Li T,Tong YG,Chen XJ,Chen XP,Wang YT,et al.A systematic review of the anticancer properties of compounds isolated from licorice(Gancao).Planta Med 2015;81:1670-87.
19.Hu ML,Rayner CK,Wu KL,Chuah SK,Tai WC,Chou YP,et al.Effect of ginger on gastric motility and symptoms of functional dyspepsia.World J Gastroenterol 2011;17:105-10.
20.Jia YL,Zhao JM,Zhang LH,Sun BS,Bao MJ,Fen-Fen LI,et al.Analgesic and anti-inflammatory effects of ginger oil.Chin Herbal Med2011;3:150-5.
21.Hasan N,Sorkhy MA,Albattah F.Ziziphus jujube of the Middle East,food and medicine.Unique J Ayurvedic Herbal Med 2014;2:7-11.