子宫内膜容受性低中医证型特点初探
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摘要
目的:总结子宫内膜容受性低的中医证型分布特点,以期为临床辨证论治提供依据。方法:通过对子宫内膜容受性低下患者的病证特点进行观察,并对其进行中医辨证分型,将资料整理,应用SPSS 17.0软件,采用聚类分析的方法进行统计处理。结果:子宫内膜容受性低主要证候频次为:月经量少(100.00%),腰膝酸软(85.58%),耳鸣(75.96%),头晕(60.58%),小便清长或夜尿频多(58.65%),舌质淡黯,苔薄(57.69%),性欲减退(56.73%),经色黯淡(54.81%),畏寒肢冷(51.92%),脉沉细(48.08%),舌质黯红,有瘀点(47.12%),经色紫黯,有块(34.62%),月经提前(32.69%),经行腹痛(31.73%)。证属肾气虚为主,兼有血瘀的症状。结论:子宫内膜容受性低的主要病机为肾气不足,胞脉不畅,治以补肾气,通胞脉。
Objective: To summarize the distribution of TCM syndrome types in patients with low endometrial receptivity. This study aimed to provide new evidence for differentiation and treatment. Methods: The signs and symptoms of patients with low endometrial receptivity were observed to differentiate TCM syndrome types. The cluster analysis in SPSS 17.0 software was used to analyze the data. Results: The symptoms and signs in patients with low endometrial receptivity are, in frequency order, small amount of menses(100.00%), relative weakness in the loins and knees(85.58%), tinnitus(75.96%), dizziness(60.58%), copious and clear urine or large amount of nocturnal urine(58.65%), obscure tongue with whitish coating(57.69%), sexual hypoesthesia(56.73%), menses in obscure colour(54.81%), chilly sensation and the cold limbs(51.92%), deep and faint pulse(48.08%), dark tongue body with petechial(47.12%), menses in dark purple colour with blood lumps(34.62%), advanced menstruation(32.69%), abdominal pain during menstruation(31.73%). The main TCM syndrome type of patients with low endometrial receptivity is the syndrome of deficiency of the kidney qi with blood stasis symptoms and signs. Conclusion: The main pathogenesis of low endometrial receptivity was caused by the deficiency of the kidney qi combining with blood stasis in uterine collaterals, so that the principle of treatment should invigorate the kidney qi and activate the blood flow in uterine collaterals.
Objective: To summarize the distribution of TCM syndrome types in patients with low endometrial receptivity. This study aimed to provide new evidence for differentiation and treatment. Methods: The signs and symptoms of patients with low endometrial receptivity were observed to differentiate TCM syndrome types. The cluster analysis in SPSS 17.0 software was used to analyze the data. Results: The symptoms and signs in patients with low endometrial receptivity are, in frequency order, small amount of menses(100.00%), relative weakness in the loins and knees(85.58%), tinnitus(75.96%), dizziness(60.58%), copious and clear urine or large amount of nocturnal urine(58.65%), obscure tongue with whitish coating(57.69%), sexual hypoesthesia(56.73%), menses in obscure colour(54.81%), chilly sensation and the cold limbs(51.92%), deep and faint pulse(48.08%), dark tongue body with petechial(47.12%), menses in dark purple colour with blood lumps(34.62%), advanced menstruation(32.69%), abdominal pain during menstruation(31.73%). The main TCM syndrome type of patients with low endometrial receptivity is the syndrome of deficiency of the kidney qi with blood stasis symptoms and signs. Conclusion: The main pathogenesis of low endometrial receptivity was caused by the deficiency of the kidney qi combining with blood stasis in uterine collaterals, so that the principle of treatment should invigorate the kidney qi and activate the blood flow in uterine collaterals.
引文
[1]黄向红,谭小军,贺艳坤,等.生长激素改善冻融胚胎移植周期结局的研究.中国实用妇科与产科杂志,2011,27(7):530-533
[2]Salle B,Bied-Damon V,Benchaib M,et al.Preliminary report of an ultrasonography and colour Doppleruterine score to predictuterine receptivity in an invitro fertilization programme.Hum Reprod,1998,13(6):1669-1673
[3]李秀然,方如丹.中药改善促排卵周期子宫内膜容受性的临床研究.现代诊断与治疗,2009,20(3):147-149
[4]周彬,王缤,孙付和,等.坤宝颗粒改善子宫内膜容受性的研究.现代中西医结合杂志,2006,15(21):2886-2887
[5]丁彩飞,郑若姮,张永华,等.助孕汤对育龄期妇女子宫内膜容受性的影响.中医杂志,2009,50(4):317-320
[6]CFDA.中药新药临床研究指导原则.北京:中国医药科技出版社,2002:231-235
[7]国家中医药管理局颁布.中华人民共和国国家标准·中医临床诊疗术语证候部分.GB/T16751.2.1997:317-317
[8]张玉珍.中医妇科学.北京:中国中医药出版社,2002:87
[9]吴云霞,黄光英.补肾益气活血汤对小鼠血清雌-孕激素浓度及其受体表达的影响.现代生物医学进展,2006,6(2):19-21
[10]王素霞,赵红丽,孙玉英.安胎合剂对Gn RHa超排卵小鼠子宫内膜容受性的影响.中华中医药学刊,2009,27(2):344-346
[11]刘艳娟,黄光英,杨明炜,等.健胎液对模型小鼠着床期子宫内膜容受性的影响.安徽中医学院学报,2006,25(5):28-32
[12]周惠芳,李爱萍,谈勇.补肾助孕方对大鼠胚胎着床期子宫内膜ER、PR及整合素α5、β3蛋白表达的影响.中国中西医结合杂志,2009,29(7):628-631
[13]夏誉薇,张树成,蔡连香,等.女贞孕育汤对不孕症子宫内膜组织形态、雌孕激素受体和血管生成因子表达的影响.中国中医药信息杂志,2004,11(1):26-28
[14]冉雪梦,张华,祁秀娟,等.补肾活血方影响子宫内膜容受性的实验研究.中国优生与遗传杂志,2007,15(4):56-58
[15]江媚,刘雁峰,黄羚,等.基于小鼠胚泡着床障碍模型探讨二补助育汤对子宫内膜SCF m RNA表达的影响.中华中医药杂志,2014,29(5):1583-1586
[2]Salle B,Bied-Damon V,Benchaib M,et al.Preliminary report of an ultrasonography and colour Doppleruterine score to predictuterine receptivity in an invitro fertilization programme.Hum Reprod,1998,13(6):1669-1673
[3]李秀然,方如丹.中药改善促排卵周期子宫内膜容受性的临床研究.现代诊断与治疗,2009,20(3):147-149
[4]周彬,王缤,孙付和,等.坤宝颗粒改善子宫内膜容受性的研究.现代中西医结合杂志,2006,15(21):2886-2887
[5]丁彩飞,郑若姮,张永华,等.助孕汤对育龄期妇女子宫内膜容受性的影响.中医杂志,2009,50(4):317-320
[6]CFDA.中药新药临床研究指导原则.北京:中国医药科技出版社,2002:231-235
[7]国家中医药管理局颁布.中华人民共和国国家标准·中医临床诊疗术语证候部分.GB/T16751.2.1997:317-317
[8]张玉珍.中医妇科学.北京:中国中医药出版社,2002:87
[9]吴云霞,黄光英.补肾益气活血汤对小鼠血清雌-孕激素浓度及其受体表达的影响.现代生物医学进展,2006,6(2):19-21
[10]王素霞,赵红丽,孙玉英.安胎合剂对Gn RHa超排卵小鼠子宫内膜容受性的影响.中华中医药学刊,2009,27(2):344-346
[11]刘艳娟,黄光英,杨明炜,等.健胎液对模型小鼠着床期子宫内膜容受性的影响.安徽中医学院学报,2006,25(5):28-32
[12]周惠芳,李爱萍,谈勇.补肾助孕方对大鼠胚胎着床期子宫内膜ER、PR及整合素α5、β3蛋白表达的影响.中国中西医结合杂志,2009,29(7):628-631
[13]夏誉薇,张树成,蔡连香,等.女贞孕育汤对不孕症子宫内膜组织形态、雌孕激素受体和血管生成因子表达的影响.中国中医药信息杂志,2004,11(1):26-28
[14]冉雪梦,张华,祁秀娟,等.补肾活血方影响子宫内膜容受性的实验研究.中国优生与遗传杂志,2007,15(4):56-58
[15]江媚,刘雁峰,黄羚,等.基于小鼠胚泡着床障碍模型探讨二补助育汤对子宫内膜SCF m RNA表达的影响.中华中医药杂志,2014,29(5):1583-1586