血管生成素样蛋白betatrophin水平与高血压患者血压变异性和血压昼夜节律的关系
摘要
目的观察血清血管生成素样蛋白betatrophin水平与高血压患者血压变异性(BPV)和血压昼夜节律的关系。方法入选2016年10月—2018年10月原发性高血压患者162例为观察组,同期年龄和性别相匹配的体检健康者150人为对照组;检测两组人群血清betatrophin水平,受试者均行24 h动态血压监测,比较两组间BPV和昼夜节律的差异。结果观察组血清betatrophin水平高于对照组[(563.24±51.26)比(285.37±27.18)ng/L,P<0.05];观察组24 h平均收缩压(24hSBP)、日间平均收缩压(dSBP)、夜间平均收缩压(nSBP)、6:00-9:00平均收缩压(mSBP)高于对照组,而24 h平均舒张压(24hDBP)、日间平均舒张压(dDBP)、夜间平均舒张压(nDBP)、6:00-9:00平均舒张压(mDBP)低于对照组(均P<0.05);观察组24 h收缩压标准差(24hSBPSD)、24 h舒张压标准差(24hDBPSD)、夜间舒张压标准差(nDBPSD)、6:00-9:00收缩压标准差(mSBPSD)与对照组相比差异有统计学意义(均P<0.05);观察组昼夜节律异常率高于对照组(34.0%比15.3%,χ~2=14.40,P<0.01)。Pearson相关分析显示,高血压患者血清betatrophin水平与24hSBPSD、mSBPSD呈正相关(r=0.563,0.572;均P<0.05),而与24hDBPSD、nDBPSD呈负相关(r=-0.528,-0.503;均P<0.05)。多元线性回归分析显示,高血压患者血清betatrophin水平是24hSBPSD、mSBPSD、24hDBPSD、nDBPSD和夜间血压下降率的影响因素(均P<0.05)。结论血清betatrophin水平与高血压患者BPV和血压昼夜节律异常相关。
引文
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[3] 邓洁,邓浩,谭丽艳.Betatrophin在糖尿病中的研究进展[J].微量元素与健康研究,2018,35(4):69-70.
[4] 谢心苗,高婷,杨梅丽,等.糖耐量正常人群而非2型糖尿病患者血清Betatrophin水平与Irisin相关[J].上海医学,2014,37(11):931-934.
[5] 程小兵,潘文博,钟万生,等.超敏C反应蛋白和同型半胱氨酸与原发性高血压患者血压变异性的关系研究[J].临床心血管病杂志,2016,17(3):277-279.
[6] Wang Q,Cui Y,Yogendranath P,et al.Blood pressure and heart rate variability are linked with hyperphosphatemia in chronic kidney disease patients[J].Chronobiol Int,2018,17(3):1-6.
[7] 孙宁宁,董凤英,吴自强,等.老年H型高血压患者364例动态血压变异性及动脉硬化特点[J].广东医学,2017,38(7):1020-1023.
[8] 寇惠娟,汪鑫,高登峰,等.高血压患者血压昼夜节律、B型脑钠肽与左心室肥厚的关系[J].中国医学科学院学报,2016,38(5):514-521.
[9] Kario K,Bhatt DL,Brar S,et al.Differences in dynamic diurnal blood pressure variability between Japanese and American treatment-resistant hypertensive populations[J].Cir J,2017,81(9):1337-1345.
[10] 齐曼古丽·伊米尔艾散,许建忠,唐晓峰,等.原发性高血压患者24h尿钠与血浆肾素活性、醛固酮水平及血压节律的关系[J].中华高血压杂志,2017,25(8):762-766.
[11] 黄晓民,徐琳,邱健,等.高血压患者左室整体长轴收缩期峰值应变与动态血压的关系[J].山东医药,2016,56(33):1-4.
[12] Grimaldi D,Carter JR,Van CE,et al.Adverse impact of sleep restriction and circadian misalignment on autonomic function in healthy young adults[J].Hypertension,2016,68(1):243-250.
[13] 郭志军,郑绍平,张静怡.高血压患者血清尿酸水平与血压变异性的关系[J].中华高血压杂志,2017,16(11):1077-1080.
[14] 翟志红,王忠,李小雷,等.血清Betatrophin水平与冠状动脉粥样硬化性心脏病的关系[J].山东医药,2016,56(5):53-54.
[15] Jacobs BA,Deenen MJ,Pluim D,et al.Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers[J].Bri J Clin Pharmacol,2016,82(3):706-716.
[16] Ren G,Kim JY,Smas CM.Identification of RIFL,a novel adipocyte enriched insulin target gene with a role in lipid metabolism[J].Am J Physiol Endocrinol Metab,2012,303:E334-351.
[17] Zhang R.Lipasin,a novel nutritionally regulated liver enriched factor that regulates serum triglyceride levels[J].Biochem Biophys Res Commun,2012,424:786-792.
[18] Quagliarini F,Wang Y,Kozlitina J,et al.Atypical angiopoietin like protein that regulates ANGPTL3[J].Proc Natl Acad SciUSA,2012,109(48):19751-19756.
[19] Yi P,Park JS,Melton DA.Betatrophin:a hormone that controls pancreatic beta cell proliferation[J].Cell,2013,153(4):747-758.
[20] Ono M,Shimizugawa T,Shimamura M,et al.Protein region important for regulation of lipid metabolism in angiopoietin like 3(ANGPTL3):ANGPTL3 is cleaved and activated in vivo[J].J Biol Chem,2003,278(43):41804-41809.
[21] Mattijssen F,Kersten S.Rugulation of triglyceride metabolism by angiopoietinlike proteins[J].Biochim Biophys Acta,2012,1821(5):782-789.