健康体检人群中甲状腺功能异常与非酒精性脂肪肝的相关性研究
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摘要
目的了解甲状腺功能异常和脂肪肝的相关性。方法整群选取2018年1—9月在该院进行健康体检并行上腹部彩超和甲状腺功能检测的11 563例进行调查。其内容包括采集患者甲状腺功能和上腹彩超中非酒精性脂肪肝的患病数据等。结果 11 563例中共发现甲状腺功能异常患者1 454例,占总体检人数的12.57%。脂肪肝患者3 628例,占总体检人数的31.38%。既有脂肪肝又有甲状腺功能异常的患者411例,占总体检人数的3.55%。甲状腺功能异常的患病率:对照组<脂肪肝组,差异有统计学意义(χ~2=7.467,P<0.01)。结论脂肪肝患者患甲状腺功能异常的可能性较正常人群明显增高。
Objective To understand the relationship between thyroid dysfunction and fatty liver. Methods A total of 11 563 patients who underwent a physical examination in our hospital from January to September 2018 were group selected, in parallel with upper abdominal color Doppler ultrasound and thyroid function tests were investigated. The contents include collecting the thyroid function of the patient and the disease data of non-alcoholic fatty liver in the upper abdominal color Doppler ultrasound. Statistical analysis was performed using SPSS 24.0 software. Results Of the 11 563 cases, 1 454 cases of thyroid dysfunction were found, accounting for 12.57% of the total number of patients. There were 3 628 patients with fatty liver, accounting for 31.38% of the total number of patients. There were 411 patients with both fatty liver and thyroid dysfunction, accounting for 3.55% of the total number of patients. The prevalence of thyroid disfunction:contrast group
Objective To understand the relationship between thyroid dysfunction and fatty liver. Methods A total of 11 563 patients who underwent a physical examination in our hospital from January to September 2018 were group selected, in parallel with upper abdominal color Doppler ultrasound and thyroid function tests were investigated. The contents include collecting the thyroid function of the patient and the disease data of non-alcoholic fatty liver in the upper abdominal color Doppler ultrasound. Statistical analysis was performed using SPSS 24.0 software. Results Of the 11 563 cases, 1 454 cases of thyroid dysfunction were found, accounting for 12.57% of the total number of patients. There were 3 628 patients with fatty liver, accounting for 31.38% of the total number of patients. There were 411 patients with both fatty liver and thyroid dysfunction, accounting for 3.55% of the total number of patients. The prevalence of thyroid disfunction:contrast group
引文
[1]He Weiwei,An Xiaofei,Li Ling,et al.Relationship between hypothyroidism and Non-Alcoholic Fatty Liver Disease:ASystematic Review and Meta-analysis[J].Front Endocrinol(Lausanne),2017(8):335.
[2]梁珊珊,王霞,秦恳,等.亚临床甲状腺功能减低与非酒精性脂肪肝的相关性分析[J].四川大学学报:医学版,2018,49(3):504-506.
[3]刘国丽.甲状腺激素及促甲状腺激素与非酒精性脂肪肝的相关性研究[D].济南:山东大学,2015:1-98.
[4]樊静洁,刘世新.深圳市某医院2015年职工健康体检结果[J].浙江预防医学,2016,28(5):505-507.
[5]秦恳,李乔,佘春燕,等.成都地区健康体检人群女性亚临床甲减与代谢综合征各组分的相关性研究[J].四川医学,2015(7):965-967.
[6]Adolph,T.E.Adipokines and Non-Alcoholic Fatty Liver Disease:Multiple Interactions[J].Int J Mol Sci,2017,18(8):1649
[7]Adams,A.C.Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner[J].J Biol Chem,2010,285(19):14078-14082.
[8]Reinehr T.Fibroblast growth factor 21(FGF-21)and its relation to obesity,metabolic syndrome,and nonalcoholic fatty liver in children:a longitudinal analysis[J].J Clin Endocrinol Metab,2012,97(6):2143-2150.
[9]Shin,D.J,T.F.Osborne.Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2(SREBP-2)[J].J Biol Chem,2003,278(36):34114-34118.
[10]朱传安,朱家彬,梁志强,等.低三碘甲腺原氨酸综合征和亚临床甲状腺功能减退及血清同型半胱氨酸水平与老年人代谢综合征的相关性研究[J].中华老年医学杂志,2018,37(9):988-991.
[11]Bellentani,S.The epidemiology of non-alcoholic fatty liver disease.Liver Int.2017,37(1):81-84.
[12]常彬霞.《2016年欧洲肝病学会、欧洲糖尿病学会和欧洲肥胖学会临床实践指南:非酒精性脂肪性肝病》摘译[J].临床肝胆病杂志,2016,32(8):1450-1454.
[13]牛海艳,李海,丁玉平.非酒精性脂肪性肝病的治疗进展[J].临床肝胆病杂志,2018,34(2):433-437.
[2]梁珊珊,王霞,秦恳,等.亚临床甲状腺功能减低与非酒精性脂肪肝的相关性分析[J].四川大学学报:医学版,2018,49(3):504-506.
[3]刘国丽.甲状腺激素及促甲状腺激素与非酒精性脂肪肝的相关性研究[D].济南:山东大学,2015:1-98.
[4]樊静洁,刘世新.深圳市某医院2015年职工健康体检结果[J].浙江预防医学,2016,28(5):505-507.
[5]秦恳,李乔,佘春燕,等.成都地区健康体检人群女性亚临床甲减与代谢综合征各组分的相关性研究[J].四川医学,2015(7):965-967.
[6]Adolph,T.E.Adipokines and Non-Alcoholic Fatty Liver Disease:Multiple Interactions[J].Int J Mol Sci,2017,18(8):1649
[7]Adams,A.C.Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner[J].J Biol Chem,2010,285(19):14078-14082.
[8]Reinehr T.Fibroblast growth factor 21(FGF-21)and its relation to obesity,metabolic syndrome,and nonalcoholic fatty liver in children:a longitudinal analysis[J].J Clin Endocrinol Metab,2012,97(6):2143-2150.
[9]Shin,D.J,T.F.Osborne.Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2(SREBP-2)[J].J Biol Chem,2003,278(36):34114-34118.
[10]朱传安,朱家彬,梁志强,等.低三碘甲腺原氨酸综合征和亚临床甲状腺功能减退及血清同型半胱氨酸水平与老年人代谢综合征的相关性研究[J].中华老年医学杂志,2018,37(9):988-991.
[11]Bellentani,S.The epidemiology of non-alcoholic fatty liver disease.Liver Int.2017,37(1):81-84.
[12]常彬霞.《2016年欧洲肝病学会、欧洲糖尿病学会和欧洲肥胖学会临床实践指南:非酒精性脂肪性肝病》摘译[J].临床肝胆病杂志,2016,32(8):1450-1454.
[13]牛海艳,李海,丁玉平.非酒精性脂肪性肝病的治疗进展[J].临床肝胆病杂志,2018,34(2):433-437.