外泌体在肿瘤转移过程中作用机制的研究进展
摘要
外泌体是直径30～150 nm的细胞外囊泡,含有核酸、蛋白质等其他生物大分子能促进细胞间的信息传递。外泌体可促进肿瘤转移。外泌体可通过增加肿瘤细胞的侵袭性、促进血管生成、参与形成免疫抑制的微环境等途径作用于肿瘤微环境,促进肿瘤的转移;外泌体在血液中可协助肿瘤细胞逃脱免疫细胞的攻击,促进肿瘤的转移;外泌体可通过参与转移前微环境建立和决定转移器官倾向性,促进肿瘤的转移。
引文
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[2]Lobb RJ,Lima LG,M ller A. Exosomes:Key mediators of metastasis and pre-metastatic niche formation[J]. Semin Cell Dev Biol,2017,67:3-10.
[3]van der Pol E,B ing AN,Gool EL,et al. Recent developments in the nomenclature,presence,isolation,detection and clinical impact of extracellular vesicles[J]. J Thromb Haemost,2016,14(1):48-56.
[4]Trams EG,Lauter CJ,Salem N,et al. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles[J]. Biochim Biophys Acta,1981,645(1):63-70.
[5]Mathieu M,Martin-Jaular L,Lavieu G,et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication[J]. Nat Cell Biol,2019,21(1):9-17.
[6]Purushothaman A. Exosomes from Cell Culture-Conditioned Medium:Isolation by Ultracentrifugation and Characterization[J].Methods Mol Biol,2019,1952:233-244.
[7]Steinbichler TB,Dudás J,Riechelmann H,et al. The role of exosomes in cancer metastasis[J]. Semin Cancer Biol,2017,44:170-181.
[8]Zomer A,Maynard C,Verweij FJ,et al. In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior[J]. Cell,2015,161(5):1046-1057.
[9]Zhou W,Fong MY,Min Y,et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis[J].Cancer Cell,2014,25(4):501-515.
[10] Pastushenko I,Blanpain C. EMT Transition States during Tumor Progression and Metastasis[J]. Trends Cell Biol,2019,29(3):212-226.
[11]Chen Y,Zeng C,Zhan Y,et al. Aberrant low expression of p85αin stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b[J]. Oncogene,2017,36(33):4692-4705.
[12] Xue M,Chen W,Xiang A,et al. Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1[J]. Mol Cancer,2017,16(1):143.
[13]Bao L,You B,Shi S,et al. Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10[J]. Oncogene,2018,37(21):2873-2889.
[14]Zeng Z,Li Y,Pan Y,et al. Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permea bility and angiogenesis[J]. Nat Commun,2018,9(1):5395.
[15] Chowdhury R,Webber JP,Gurney M,et al. Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive my ofibroblasts[J]. Oncotarget,2015,6(2):715-731.
[16]Whiteside TL. Exosomes and tumor-mediated immune suppression[J]. J Clin Invest,2016,126(4):1216-1223.
[17] Labani-Motlagh A,Israelsson P,Ottander U,et al. Differential expression of ligands for NKG2D and DNAM-1 receptors by epithelial ovarian cancer-derived exosomes and its influence on NK cell cytotoxicity[J]. Tumour Biol,2016,37(4):5455-5466.
[18]Cai Z,Yang F,Yu L,et al. Activated T cell exosomes promote tumor invasion via Fas signaling pathway[J]. J Immunol,2012,188(12):5954-5961.
[19] Nieswandt B,Hafner M,Echtenacher B,et al. Lysis of tumor cells by natural killer cells in mice is impeded by platelets[J].Cancer Res,1999,59(6):1295-300.
[20]Pang JH,Coupland LA,Freeman C,et al. Activation of tumour cell ECM degradation by thrombin-activated platelet membranes:potentially a P-selectin and GPIIb/IIIa-dependent process[J].Clin Exp Metastasis,2015,32(5):495-505.
[21]Gay LJ,Felding-Habermann B. Contribution of platelets to tumour metastasis[J]. Nat Rev Cancer,2011,11(2):123-134.
[22]Moreau J,Pelletier F,Biichle S,et al. Increased levels of circulating platelet-derived microparticles are associated with metastatic cutaneous melanoma[J]. Exp Dermatol,2017,26(10):961-963.
[23]Di Meo A,Bartlett J,Cheng Y,et al. Liquid biopsy:a step forward towards precision medicine in urologic malignancies[J]. Mol Cancer,2017,16(1):80.
[24] Melo SA,Luecke LB,Kahlert C,et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer[J]. Nature,2015,523(7559):177-182.
[25]Qu L,Ding J,Chen C,et al. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA[J]. Cancer Cell,2016,29(5):653-668.
[26] Paget S. The distribution of secondary growths in cancer of the breast. 1889[J]. Cancer Metastasis Rev,1989,8(2):98-101.
[27]Peinado H,Zhang H,Matei IR,et al. Pre-metastatic niches:organ-specific homes for metastases[J]. Nat Rev Cancer,2017,17(5):302-317.
[28]Peinado H,Ale kovi M,Lavotshkin S,et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET[J]. Nat Med,2012,18(6):883-891.
[29]Fong MY,Zhou W,Liu L,et al. Breast-cancer-secreted miR-122reprograms glucose metabolism in premetastatic niche to promote metastasis[J]. Nat Cell Biol,2015,17(2):183-194.
[30]Costa-Silva B,Aiello NM,Ocean AJ,et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver[J]. Nat Cell Biol,2015,17(6):816-826.
[31] Suetsugu A,Honma K,Saji S,et al. Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models[J]. Adv Drug Deliv Rev,2013,65(3):383-390.
[32]Hoshino A,Costa-Silva B,Shen TL,et al. Tumour exosome integrins determine organotropic metastasis[J]. Nature,2015,527(7578):329-335.
[33]Zhang L,Zhang S,Yao J,et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth[J].Nature,2015,527(7576):100-104.