乌头类中药临床不良反应及影响因素分析
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摘要
目的探讨乌头类中药临床不良反应及影响因素。方法研究对象为方便选取乌头类中药引起不良反应患者,例数100例,患者收取时间在2012年6月—2015年12月,回顾性分析患者临床资料。结果通过分析100例患者不良反应分布情况后,不良反应主要包括超剂量使用患者27例、所占比为27.00%;服用方法不当患者22例(22.00%);配伍不当患者18例(18.00%);煎煮不当患者15例(15.00%);炮制不当患者8例(8.00%);个体差异有10例(10.00%),其中不良反应最严重的为超剂量使用,与其他不良反应所占比差异有统计学意义(P<0.05);通过分析100例患者的临床表现后,其中唇舌发麻、面色苍白有30例;心慌肢冷、麻木上移患者27例;烦躁不安、腹痛腹泻患者10例;血压下降、吞咽困难患者23例;面色唇紫、不省人事患者10例,其中临床表现所占比最多的为唇舌发麻、面色苍白,其次为心慌肢冷、麻木上移(P<0.05)。结论通过分析乌头类中药不良反应影响因素后,再采取有效的措施,能预防乌头类中药不良反应情况发生,保障患者用药安全。
Objective To investigate the clinical adverse reactions and influencing factors of Aconitum herbs. Methods A total of 100 convenient selected patients with adverse reactions caused by aconitum herbs were studied. The patients were collected from June 2012 to December 2015. The clinical data of the patients were analyzed retrospectively. Results After analyzing the distribution of adverse reactions in 100 patients, the adverse reactions mainly included 27 cases(27.00%) of overdose patients, 22 cases(22.00%) of improper use methods, 18 cases(18.00%) of improper compatibility, 15 cases(15.00%) of improper decoction, There were 8 cases(8.00%) of improper processing, 10 cases(10.00%) of the individual differences. The most serious adverse reaction was overdose use, which was statistically significantly different from other adverse reactions(P<0.05). After analyzing the clinical manifestations of 100 patients, there were 30 cases of pale lips and tongues, 30 cases of pale complexion, and 27 cases of panic limbs, cold and numbness. There were 27 patients with numbness, 10 patients with restlessness, abdominal pain and diarrhea, 23 patients with blood pressure drop and dysphagia, 10 patients with purple lips and unconsciousness, among which the most common clinical manifestations were pallor and numbness of lips and tongue, followed by palpitation, cold limbs and numbness(P<0.05). Conclusion After analyzing the influencing factors of adverse reactions of Aconitum traditional Chinese medicine, effective measures can be taken to prevent the occurrence of adverse reactions of Aconitum traditional Chinese medicine and ensure the safety of medication for patients.
Objective To investigate the clinical adverse reactions and influencing factors of Aconitum herbs. Methods A total of 100 convenient selected patients with adverse reactions caused by aconitum herbs were studied. The patients were collected from June 2012 to December 2015. The clinical data of the patients were analyzed retrospectively. Results After analyzing the distribution of adverse reactions in 100 patients, the adverse reactions mainly included 27 cases(27.00%) of overdose patients, 22 cases(22.00%) of improper use methods, 18 cases(18.00%) of improper compatibility, 15 cases(15.00%) of improper decoction, There were 8 cases(8.00%) of improper processing, 10 cases(10.00%) of the individual differences. The most serious adverse reaction was overdose use, which was statistically significantly different from other adverse reactions(P<0.05). After analyzing the clinical manifestations of 100 patients, there were 30 cases of pale lips and tongues, 30 cases of pale complexion, and 27 cases of panic limbs, cold and numbness. There were 27 patients with numbness, 10 patients with restlessness, abdominal pain and diarrhea, 23 patients with blood pressure drop and dysphagia, 10 patients with purple lips and unconsciousness, among which the most common clinical manifestations were pallor and numbness of lips and tongue, followed by palpitation, cold limbs and numbness(P<0.05). Conclusion After analyzing the influencing factors of adverse reactions of Aconitum traditional Chinese medicine, effective measures can be taken to prevent the occurrence of adverse reactions of Aconitum traditional Chinese medicine and ensure the safety of medication for patients.
引文
[1]张云丽,吴永佩,刘丽婷.乌头类中药炮制配伍减毒增效的研究进展[J].中国医药指南, 2017, 15(32):10-11.
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[9]肖志超.探究乌头类中药临床中毒反应及治疗效果分析[J].按摩与康复医学, 2017, 8(1):65-66.
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[11]李玉凤.乌头类中药临床中毒反应及治疗的分析[J].中医临床研究, 2016, 8(30):147-148.
[12]杨翠荣.乌头类中药37例临床中毒反应及治疗分析[J].实用中西医结合临床, 2017,17(3):161-162.
[2]张晓朦,李凡,张冰,等.数据挖掘乌头类中成药不良反应特点与合理用药警戒[J].中国中药杂志, 2018(2):216-221.
[3]刘帅,李妍,李卫飞,等.乌头类中药毒性及现代毒理学研究进展[J].中草药, 2016, 47(22):4095-4102.
[4]黄玉明,林润锋.乌头类中药临床中毒反应及治疗的分析[J].北方药学,2015(6):161-162.
[5]施玉琴.中药乌头发生不良反应的原因和对策探讨[J].中国医药指南,2018,16(9):171.
[6]吉宜宏.浅析中药乌头不良反应原因及控制对策[J].中国处方药,2016,14(12):45-46.
[7]杨翠荣.乌头类中药37例临床中毒反应及治疗分析[J].实用中西医结合临床, 2017, 17(3):161-162.
[8]张蕴,周郁鸿,刘淑艳.乌头类中药的临床安全用药思考[J].浙江临床医学, 2017, 19(1):191-192.
[9]肖志超.探究乌头类中药临床中毒反应及治疗效果分析[J].按摩与康复医学, 2017, 8(1):65-66.
[10]卢恒清.乌头类中药临床不良反应研究[J].转化医学电子杂志,2015,2(7):65,67.
[11]李玉凤.乌头类中药临床中毒反应及治疗的分析[J].中医临床研究, 2016, 8(30):147-148.
[12]杨翠荣.乌头类中药37例临床中毒反应及治疗分析[J].实用中西医结合临床, 2017,17(3):161-162.