中医辨证配合活血通瘀方剂治疗排卵障碍性不孕症研究
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摘要
目的:探讨中医辨证配合活血通瘀在排卵障碍性不孕患者中的应用。方法:选择87例排卵障碍性不孕症患者,按照患者自愿选择原则,将患者分为西医对照组(44例)与中医辨证组(43例),对照组患者口服枸橼酸氯米芬片,辨证组患者采用中医辨证配合活血通瘀方剂治疗,两组患者在月经周期的第8天开始用药,直至行阴道B超检查显示卵泡成熟并成功排卵为止。观察两组患者的临床治疗效果,统计分析两组子宫内膜厚度、优势卵泡直径及成熟卵泡占比情况。结果:①治疗后辨证组患者的临床疗效比例为90.69%(39/43),对照组临床疗效为70.45%(31/44),两组比较差异有统计学意义(P<0.05);②子宫内膜厚度与优势卵泡直径方面,治疗前两组的差异无统计学意义(P>0.05),治疗后西医对照组患者子宫内膜厚度为(0.61±0.21)cm、优势卵泡直径为(1.62±0.13)cm,辨证组子宫内膜厚度为(0.93±0.24)cm、优势卵泡直径(1.96±0.17)cm,两组比较差异均有统计学意义(P均<0.05);③治疗前两组优势卵泡例数、成功排卵例数比较,无统计学差异性(P>0.05),治疗后辨证组患者优势卵泡例数、成功排卵例数与对照组比较均明显增多,比较差异显著(P<0.05)。结论:与西医治疗不孕症疗效比较,中医辨证结合活血通瘀方剂在治疗排卵障碍性不孕症方面具有更加明显的临床效果,同时增加了患者子宫内膜的厚度,为安全怀孕奠定了基础,因此更加适合运用于不孕症的治疗中。
Objective:To investigate the application of syndrome differentiation of traditional Chinese medicine complicated with Huoxue Tongyu method in the patients with anovulatory sterility.Methods:Eighty-seven patients with anovulatory sterility were selected for the study by voluntary principles,and all the patients were divided into western medicine control group(n=44)and syndrome differentiation of traditional Chinese Medicine group(n=43). Then the control group were treated with clomifene citrate tablets and the syndrome differentiation group were treated with syndrome differentiation of traditional Chinese Medicine complicated with Huoxue Tongyu Prescription. And the two groups were treated on 8 th day of menstrual cycle,until the follicle was mature and successfully ovulation. Then the clinical effects of two groups were observed,and the endometrial thickness,dominant follicle diameter and mature follicle ratio of two groups were analyzed. Results:①The clinical effect rate of syndrome differentiation group was 90.69%(39/43)and that of control group was 70.45%(31/44). The difference of two groups was significant(P<0.05). ②The endometrial thickness and dominant follicle diameter′ differences of two groups before treatment were not significant(P>0.05). The endometrial thickness of control group after the treatment was(0.61±0.21)cm,the dominant follicle diameter was(1.62±0.13)cm,the endometrial thickness of syndrome differentiation was(0.93±0.24)cm,the dominant follicle diameter was(1.96±0.17)cm and the differences of two groups were significant(P<0.05). ③The number of dominant follicles and number of successful ovulation of two groups before treatment were compared. The difference of two groups was not significant(P>0.05)and the number of dominant follicles and number of successful ovulation of syndrome differentiation group were more than those of control group. The differences of two groups were significant(P<0.05). Conclusion:The clinical effect of syndrome differentiation of traditional Chinese medicine complicated with Huoxue Tongyu Prescription in the patients with anovulatory sterility is more obvious than those of western medicine,and it can increase the endometrial thickness and lays function for the safe pregnancy,and so it is more suitable to the treatment of sterility.
Objective:To investigate the application of syndrome differentiation of traditional Chinese medicine complicated with Huoxue Tongyu method in the patients with anovulatory sterility.Methods:Eighty-seven patients with anovulatory sterility were selected for the study by voluntary principles,and all the patients were divided into western medicine control group(n=44)and syndrome differentiation of traditional Chinese Medicine group(n=43). Then the control group were treated with clomifene citrate tablets and the syndrome differentiation group were treated with syndrome differentiation of traditional Chinese Medicine complicated with Huoxue Tongyu Prescription. And the two groups were treated on 8 th day of menstrual cycle,until the follicle was mature and successfully ovulation. Then the clinical effects of two groups were observed,and the endometrial thickness,dominant follicle diameter and mature follicle ratio of two groups were analyzed. Results:①The clinical effect rate of syndrome differentiation group was 90.69%(39/43)and that of control group was 70.45%(31/44). The difference of two groups was significant(P<0.05). ②The endometrial thickness and dominant follicle diameter′ differences of two groups before treatment were not significant(P>0.05). The endometrial thickness of control group after the treatment was(0.61±0.21)cm,the dominant follicle diameter was(1.62±0.13)cm,the endometrial thickness of syndrome differentiation was(0.93±0.24)cm,the dominant follicle diameter was(1.96±0.17)cm and the differences of two groups were significant(P<0.05). ③The number of dominant follicles and number of successful ovulation of two groups before treatment were compared. The difference of two groups was not significant(P>0.05)and the number of dominant follicles and number of successful ovulation of syndrome differentiation group were more than those of control group. The differences of two groups were significant(P<0.05). Conclusion:The clinical effect of syndrome differentiation of traditional Chinese medicine complicated with Huoxue Tongyu Prescription in the patients with anovulatory sterility is more obvious than those of western medicine,and it can increase the endometrial thickness and lays function for the safe pregnancy,and so it is more suitable to the treatment of sterility.
引文
[1] 李长慧,崔光豪,王艳萍.中药治疗排卵障碍性不孕症78例临床疗效分析[J].中国实用医药,2016,11(28):218-219.
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[3] 李芙蓉.中药促排卵汤治疗排卵障碍性不孕的临床效果研究[J].中医临床研究,2016,8(24):83-84.
[4] 王芳芳,张小娥.调经促孕丸对克罗米芬周期子宫内膜容受性及妊娠率的影响[J].中医临床研究,2016,8(20):56-58.
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[6] 庞保珍,赵焕云.不孕不育中医治疗学[M].北京:人民军医出版社,2008:110-112.
[7] 徐福花,郑月萍.益气活血通络法治疗排卵障碍性不孕症68例的临床观察[J].中医临床研究,2017,9(7):66-68.
[8] 吴丽丽,王志音.促排卵验方联合枸橼酸氯米芬片辨治肾虚血瘀型排卵障碍性不孕症患者的临床研究[J].湖北中医药大学学报,2017,19(2):19-22.
[9] 廖越,吴熙,王小红,等.中医周期疗法治疗排卵障碍性不孕的相关研究[J].实用中西医结合临床,2017,17(11):32-34.
[10] 常会娈.加味助孕汤联合补肾化瘀方对排卵障碍性不孕患者子宫内膜厚度变化及妊娠率的影响[J].北方药学,2018,15(2):98-99.
[11] 张鸿雁,焦艳英.中医中药辨证周期给药治疗排卵障碍性不孕症的临床研究[J].光明中医,2016,31(8):1100-1103.
[12] 陈兆鑫.中药内服配合保留灌肠治疗排卵障碍性不孕临床观察[J].山西中医,2017,33(4):12-15.
[13] 张娟.中医补肾法与克罗米芬治疗排卵障碍性不孕疗效的系统评价[J].医学理论与实践,2018,31(2):243-244.
[14] 甄英贤.中医辨证治疗排卵障碍性不孕疗效初步观察及评估[J].中西医结合心血管病杂志(电子版),2016,4(21):121-122.
[15] 范小雪,王烨,魏绍斌.排卵障碍性不孕症中医治疗思路探析[J].四川中医,2017,35(11):35-37.
[16] 谷长秀,李滨.中药治疗排卵障碍性不孕临床观察[J].中国继续医学教育,2016,8(2):183-184.
[17] 叶秋芳.温肾活血中药结合克罗米芬促排卵治疗排卵障碍性不孕症的临床疗效分析及安全性评价[J].中医临床研究,2016,8(36):34-36.
[18] 袁宇红.中医辨证周期给药治疗排卵障碍性不孕症的临床研究[J].中医临床研究,2016,8(16):74-75.
[19] 张迎春.中医补肾结合克罗米芬在排卵障碍性不孕症患者治疗中的临床效果[J].现代诊断与治疗,2017,28(13):2375-2376.
[20] 崔丽.补肾活血方案治疗排卵障碍性不孕不育的多中心随机双盲对照临床研究[J].实用妇科内分泌杂志(电子版),2016,3(4):27.
[21] 李晶,唐艳玲.排卵障碍性不孕症中西医结合治疗临床观察[J].医药论坛杂志,2016,37(11):70-71.
[22] 李彬,罗海霞.中西医结合治疗排卵障碍性不孕症疗效观察及其安全性评价[J].世界中医药,2017,12(10):2347-2349.
[23] 刘振丹.中西医结合治疗排卵障碍性不孕临床效果分析[J].亚太传统医药,2017,13(19):105-106.
[24] 周文静.中西医结合治疗排卵障碍性不孕临床研究[J].实用中医药杂志,2017,33(6):663-664.
[2] 谷光明.补肾活血颗粒联合克罗米芬治疗排卵障碍性不孕症的临床分析[J].中国卫生标准管理,2016,7(3):131-132.
[3] 李芙蓉.中药促排卵汤治疗排卵障碍性不孕的临床效果研究[J].中医临床研究,2016,8(24):83-84.
[4] 王芳芳,张小娥.调经促孕丸对克罗米芬周期子宫内膜容受性及妊娠率的影响[J].中医临床研究,2016,8(20):56-58.
[5] 罗世芳.排卵障碍性不孕症诊断及治疗[M].北京:中国医药科技出版社,2012:15-16.
[6] 庞保珍,赵焕云.不孕不育中医治疗学[M].北京:人民军医出版社,2008:110-112.
[7] 徐福花,郑月萍.益气活血通络法治疗排卵障碍性不孕症68例的临床观察[J].中医临床研究,2017,9(7):66-68.
[8] 吴丽丽,王志音.促排卵验方联合枸橼酸氯米芬片辨治肾虚血瘀型排卵障碍性不孕症患者的临床研究[J].湖北中医药大学学报,2017,19(2):19-22.
[9] 廖越,吴熙,王小红,等.中医周期疗法治疗排卵障碍性不孕的相关研究[J].实用中西医结合临床,2017,17(11):32-34.
[10] 常会娈.加味助孕汤联合补肾化瘀方对排卵障碍性不孕患者子宫内膜厚度变化及妊娠率的影响[J].北方药学,2018,15(2):98-99.
[11] 张鸿雁,焦艳英.中医中药辨证周期给药治疗排卵障碍性不孕症的临床研究[J].光明中医,2016,31(8):1100-1103.
[12] 陈兆鑫.中药内服配合保留灌肠治疗排卵障碍性不孕临床观察[J].山西中医,2017,33(4):12-15.
[13] 张娟.中医补肾法与克罗米芬治疗排卵障碍性不孕疗效的系统评价[J].医学理论与实践,2018,31(2):243-244.
[14] 甄英贤.中医辨证治疗排卵障碍性不孕疗效初步观察及评估[J].中西医结合心血管病杂志(电子版),2016,4(21):121-122.
[15] 范小雪,王烨,魏绍斌.排卵障碍性不孕症中医治疗思路探析[J].四川中医,2017,35(11):35-37.
[16] 谷长秀,李滨.中药治疗排卵障碍性不孕临床观察[J].中国继续医学教育,2016,8(2):183-184.
[17] 叶秋芳.温肾活血中药结合克罗米芬促排卵治疗排卵障碍性不孕症的临床疗效分析及安全性评价[J].中医临床研究,2016,8(36):34-36.
[18] 袁宇红.中医辨证周期给药治疗排卵障碍性不孕症的临床研究[J].中医临床研究,2016,8(16):74-75.
[19] 张迎春.中医补肾结合克罗米芬在排卵障碍性不孕症患者治疗中的临床效果[J].现代诊断与治疗,2017,28(13):2375-2376.
[20] 崔丽.补肾活血方案治疗排卵障碍性不孕不育的多中心随机双盲对照临床研究[J].实用妇科内分泌杂志(电子版),2016,3(4):27.
[21] 李晶,唐艳玲.排卵障碍性不孕症中西医结合治疗临床观察[J].医药论坛杂志,2016,37(11):70-71.
[22] 李彬,罗海霞.中西医结合治疗排卵障碍性不孕症疗效观察及其安全性评价[J].世界中医药,2017,12(10):2347-2349.
[23] 刘振丹.中西医结合治疗排卵障碍性不孕临床效果分析[J].亚太传统医药,2017,13(19):105-106.
[24] 周文静.中西医结合治疗排卵障碍性不孕临床研究[J].实用中医药杂志,2017,33(6):663-664.