Dubin-Johnson综合征1例报道并文献复习
摘要
<正>Dubin-Johnson综合征(DJS)又称慢性特发性黄疸,由Dubin和Johnson于1954年首先报道~([1]),是一种少见的以慢性持续性或间歇性黄疸为临床特点的常染色体隐性遗传病~([2])。单纯DJS临床表现症状轻微,预后良好。DJS发病率低,临床少见,相关文献报道较少,现笔者将临床所见1例DJS病例进行报道并对相关文献进行复习,以指导临床。1病例资料
引文
[1]Dubin I,Johnson F.Chronic idiopathic jaundice with unidentified pigment in liver cells:a new clinicopathologic entity with a report of 12 cases[J].Medicine(Balimoret),1954,33(3):155-197.
[2]康新迪,孙颖,温晓玉,等.Dubin-Johnson综合征1例报告[J].临床肝胆病杂志,2016,32(6):1175-1176.
[3]Paulusma CC,Kool M,Bosma PJ,et al.A mutation in the human canalicular multispecific organic anion transporter gene cause the Dubin-Johnson syndrome[J].Hepatology,1997,25(6):1539-1542.
[4]Gao M,Loe DW,Grant CE,et al.Reconstitution of ATP-dependent leukotriene C4 transport by co-expression of both half-molecules of human multidrug resistance protein in insect cells[J].J Biol Chem,1996,271:27782-27787.
[5]Oude Elferink RPJ,Meijer DKF,Kuipers F,et al.Hepatobiliary secretion of organic compounds:molecular mechanisms of membrane transport[J].Biochim Biophys Acta,1995,1241:215-268.
[6]Uchiumi T,Tanamachi H,Kuchiwaki K,et al.Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome[J].Hepatol Res,2013,43(5):569-575.
[7]郭长吉,林三仁,李益农,等.腹腔镜和肝活检对Dubin-Johnson综合征诊断的价值[J].北京医科大学学报,2000,32(2):128-130.
[8]Strassburg CP.Hyperbilirubinemia syndromes(Gilbert-Meulengracht,Crigler-Najjar,Dubin-Johnson,and Rotor syndrome)[J].Best Pract Res Clin Gastroenterol,2010,24(5):555-571.
[9]向理科,罗子国,李圆圆,等.Dubin-Johnson综合征的病理学特征[J].中华肝脏病杂志,2000,8(1):45-47.
[10]王娟.熊去氧胆酸配合金胆片治疗慢性胆囊炎疗效观察[J].中华实用中西医杂志,2011,24(5):4.
[11]Zhou L,Liu C,Bai J,et al.Dubin-Johnson syndrome with cholecystolithiasis and choledocholithiasis[J].Int J Surg Case Rep,2013,4(7):587-588.
[2]康新迪,孙颖,温晓玉,等.Dubin-Johnson综合征1例报告[J].临床肝胆病杂志,2016,32(6):1175-1176.
[3]Paulusma CC,Kool M,Bosma PJ,et al.A mutation in the human canalicular multispecific organic anion transporter gene cause the Dubin-Johnson syndrome[J].Hepatology,1997,25(6):1539-1542.
[4]Gao M,Loe DW,Grant CE,et al.Reconstitution of ATP-dependent leukotriene C4 transport by co-expression of both half-molecules of human multidrug resistance protein in insect cells[J].J Biol Chem,1996,271:27782-27787.
[5]Oude Elferink RPJ,Meijer DKF,Kuipers F,et al.Hepatobiliary secretion of organic compounds:molecular mechanisms of membrane transport[J].Biochim Biophys Acta,1995,1241:215-268.
[6]Uchiumi T,Tanamachi H,Kuchiwaki K,et al.Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome[J].Hepatol Res,2013,43(5):569-575.
[7]郭长吉,林三仁,李益农,等.腹腔镜和肝活检对Dubin-Johnson综合征诊断的价值[J].北京医科大学学报,2000,32(2):128-130.
[8]Strassburg CP.Hyperbilirubinemia syndromes(Gilbert-Meulengracht,Crigler-Najjar,Dubin-Johnson,and Rotor syndrome)[J].Best Pract Res Clin Gastroenterol,2010,24(5):555-571.
[9]向理科,罗子国,李圆圆,等.Dubin-Johnson综合征的病理学特征[J].中华肝脏病杂志,2000,8(1):45-47.
[10]王娟.熊去氧胆酸配合金胆片治疗慢性胆囊炎疗效观察[J].中华实用中西医杂志,2011,24(5):4.
[11]Zhou L,Liu C,Bai J,et al.Dubin-Johnson syndrome with cholecystolithiasis and choledocholithiasis[J].Int J Surg Case Rep,2013,4(7):587-588.