KIAA1199基因在消化系统肿瘤中的作用
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摘要
KIAA1199基因是HUGE数据库中的重要成员之一,通过表观遗传学等机制参与细胞内信号通路的转导,调控细胞生长、分化、凋亡、迁移等活动。近年研究发现,KIAA1199基因与肿瘤的发生、发展关系密切,在人类多种肿瘤尤其是消化系统肿瘤中的表达均异常升高,具有促进肿瘤细胞增殖、黏附、侵袭、迁移等作用。本文就KIAA1199基因在消化系统肿瘤中的作用作一综述。
KIAA1199 gene is an important member of the HUGE database,and is involved in the transduction of intracellular signaling pathway through epigenetic mechanism,regulating the cell growth,differentiation,apoptosis and migration. Recent studies showed that KIAA1199 gene is closely related to tumorigenesis and tumor development. The expression of KIAA1199 gene is highly upregulated in many types of tumor,especially in digestive system neoplasms,and having the effects of promoting proliferation,adhesion,invasion and migration of tumor cells. This article reviewed the role of KIAA1199 gene in digestive system neoplasms.
KIAA1199 gene is an important member of the HUGE database,and is involved in the transduction of intracellular signaling pathway through epigenetic mechanism,regulating the cell growth,differentiation,apoptosis and migration. Recent studies showed that KIAA1199 gene is closely related to tumorigenesis and tumor development. The expression of KIAA1199 gene is highly upregulated in many types of tumor,especially in digestive system neoplasms,and having the effects of promoting proliferation,adhesion,invasion and migration of tumor cells. This article reviewed the role of KIAA1199 gene in digestive system neoplasms.
引文
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15张婷,崔戈,章林平,等.结直肠腺癌KIAA1199基因表达与临床病理学相关性[J].中国公共卫生,2014,30(5):661-663.
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22 Matsuzaki S,Tanaka F,Mimori K,et al.Clinicopathologic significance of KIAA1199 overexpression in human gastric cancer[J].Ann Surg Oncol,2009,16(7):2042-2051.
23朱雅碧,张剑美,汪望月,等.KIAA1199基因在人胃癌组织中表达的意义[J].国际消化病杂志,2016,36(5):307-309.
24 Jia S,Qu T,Wang X,et al.KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer[J].PLo S One,2017,12(4):e0175058.
25 Suh HN,Jun S,Oh AY,et al.Identification of KIAA1199as a Biomarker for Pancreatic Intraepithelial Neoplasia[J].Sci Rep,2016,6:38273.
26 Kohi S,Sato N,Koga A,et al.KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer[J].Oncotarget,2017,8(10):17156-17163.
27 Shostak K,Zhang X,Hubert P,et al.NF-κB-induced KIAA1199 promotes survival through EGFR signaling[J].Nat Commun,2014,5:5232.
2 Kuscu C,Evensen N,Kim D,et al.Transcriptional and epigenetic regulation of KIAA1199 gene expression in human breast cancer[J].PLo S One,2012,7(9):e44661.
3 Paunu N,Lahermo P,Onkamo P,et al.A novel lowpenetrance locus for familial glioma at 15q23-q26.3[J].Cancer Res,2002,62(13):3798-3802.
4 Chanthammachat P,Promwikorn W,Pruegsanusak K,et al.Comparative proteomic analysis of oral squamous cell carcinoma and adjacent non-tumour tissue from Thailand[J].Arch Oral Biol,2013,58(11):1677-1685.
5 Evensen NA,Kuscu C,Nguyen HL,et al.Unraveling the role of KIAA1199,a novel endoplasmic reticulum protein,in cancer cell migration[J].J Natl Cancer Inst,2013,105(18):1402-1416.
6 Suyama M,Nagase T,Ohara O,et al.HUGE:a database for human large proteins identified by Kazusa c DNAsequencing project[J].Nucleic Acids Res,1999,27(1):338-339.
7 Nagase T,Ishikawa K,Kikuno R,et al.Prediction of the coding sequences of unidentified human genes.ⅩⅤ.The complete sequences of 100 new c DNA clones from brain which code for large proteins in vitro[J].DNA Res,1999,6(5):337-345.
8 Li L,Yan LH,Manoj S,et al.Central Role of CEMIP in Tumorigenesis and Its Potential as Therapeutic Target[J].J Cancer,2017,8(12):2238-2246.
9 Sabates-Bellver J,Van der Flier LG,de Palo M,et al.Transcriptome profile of human colorectal adenomas[J].Mol Cancer Res,2007,5(12):1263-1275.
10 Kikuno R,Nagase T,Nakayama M,et al.HUGE:a database for human KIAA proteins,a 2004 update integrating HUGEppi and ROUGE[J].Nucleic Acids Res,2004,32(Database issue):D502-D504.
11 Yamamoto H,Tobisawa Y,Inubushi T,et al.Amammalian homolog of the zebrafish transmembrane protein2(TMEM2)is the long-sought-after cell-surface hyaluronidase[J].J Biol Chem,2017,292(18):7304-7313.
12 Tiwari A,Schneider M,Fiorino A,et al.Early insights into the function of KIAA1199,a markedly overexpressed protein in human colorectal tumors[J].PLo S One,2013,8(7):e69473.
13 Xu J,Liu Y,Wang X,et al.Association between KIAA1199 overexpression and tumor invasion,TNM stage,and poor prognosis in colorectal cancer[J].Int J Clin Exp Pathol,2015,8(3):2909-2918.
14 Birkenkamp-Demtroder K,Maghnouj A,Mansilla F,et al.Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells[J].Br JCancer,2011,105(4):552-561.
15张婷,崔戈,章林平,等.结直肠腺癌KIAA1199基因表达与临床病理学相关性[J].中国公共卫生,2014,30(5):661-663.
16 Terashima M,Fujita Y,Togashi Y,et al.KIAA1199interacts with glycogen phosphorylase kinaseβ-subunit(PHKB)to promote glycogen breakdown and cancer cell survival[J].Oncotarget,2014,5(16):7040-7050.
17 Jami MS,Hou J,Liu M,et al.Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth,motility and invasiveness[J].BMCCancer,2014,14:194.
18 Evensen NA,Li Y,Kuscu C,et al.Hypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein(CEMIP)[J].Oncotarget,2015,6(24):20723-20739.
19 Zhang D,Zhao L,Shen Q,et al.Down-regulation of KIAA1199/CEMIP by miR-216a suppresses tumor invasion and metastasis in colorectal cancer[J].Int J Cancer,2017,140(10):2298-2309.
20 Yachida S,Mudali S,Martin SA,et al.Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation[J].Am J Surg Pathol,2009,33(12):1823-1832.
21 Chivu Economescu M,Necula LG,Dragu D,et al.Identification of potential biomarkers for early and advanced gastric adenocarcinoma detection[J].Hepatogastroenterology,2010,57(104):1453-1464.
22 Matsuzaki S,Tanaka F,Mimori K,et al.Clinicopathologic significance of KIAA1199 overexpression in human gastric cancer[J].Ann Surg Oncol,2009,16(7):2042-2051.
23朱雅碧,张剑美,汪望月,等.KIAA1199基因在人胃癌组织中表达的意义[J].国际消化病杂志,2016,36(5):307-309.
24 Jia S,Qu T,Wang X,et al.KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer[J].PLo S One,2017,12(4):e0175058.
25 Suh HN,Jun S,Oh AY,et al.Identification of KIAA1199as a Biomarker for Pancreatic Intraepithelial Neoplasia[J].Sci Rep,2016,6:38273.
26 Kohi S,Sato N,Koga A,et al.KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer[J].Oncotarget,2017,8(10):17156-17163.
27 Shostak K,Zhang X,Hubert P,et al.NF-κB-induced KIAA1199 promotes survival through EGFR signaling[J].Nat Commun,2014,5:5232.