2010—2015年北京医院外科病房万古霉素的使用情况分析
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摘要
目的回顾分析北京医院外科住院病房2010—2015年万古霉素的用药情况,为临床合理使用万古霉素提供参考。方法筛选北京医院2010年1月—2015年12月使用万古霉素的外科住院患者的全部病例,提取详细病例信息,并对各科室使用情况、药敏送检情况、临床有效率及用药合理性进行统计分析。结果共筛选出病例454例,其中用药不合理89例(占19.6%),治疗有效的432例,有效率95.2%;万古霉素的总用药量4 263.3 g,总用药天数为3 307 d,限定日剂量(DDD)为2 g/d,药物利用指数(DUI)=0.64。结论北京医院外科病房万古霉素使用基本合理,但仍有部分病例存在使用不规范情况。
Objective To analyze the usage of vancomycin in the surgical ward of Beijing Hospital during 2010 — 2015,so as to provide references for the rational use of vancomycin.Methods All hospitalized cases used vancomycin in Beijing Hospital from January 2010 to December 2015 were screened,and the detailed information was extracted.The usage of vancomycin in different departments,drug sensitive test,clinical efficiency percentage,and rationality of usage were then analyzed.Results A total of 454 cases were screened,of which 89 cases(19.6%) were unreasonable and 432 cases(95.2%) showed effective results;The total dosage of 4 263.3 g of vancomycin was used in 3 307 d,the DDD was 2 g/d,therefore,the DUI was 0.64.Conclusion The use of vancomycin in the surgical ward of Beijing Hospital is generally rational,however,some irrational cases are also found.
Objective To analyze the usage of vancomycin in the surgical ward of Beijing Hospital during 2010 — 2015,so as to provide references for the rational use of vancomycin.Methods All hospitalized cases used vancomycin in Beijing Hospital from January 2010 to December 2015 were screened,and the detailed information was extracted.The usage of vancomycin in different departments,drug sensitive test,clinical efficiency percentage,and rationality of usage were then analyzed.Results A total of 454 cases were screened,of which 89 cases(19.6%) were unreasonable and 432 cases(95.2%) showed effective results;The total dosage of 4 263.3 g of vancomycin was used in 3 307 d,the DDD was 2 g/d,therefore,the DUI was 0.64.Conclusion The use of vancomycin in the surgical ward of Beijing Hospital is generally rational,however,some irrational cases are also found.
引文
[1]陈新谦,金有豫,汤光.新编药物学[M].第17版.北京:人民卫生出版社,2011:86.
[2]卫生部办公厅关于抗菌药物临床应用管理有关问题的通知[EB/OL].(2009-03-25)[2016-02-20].http://www.moh.gov.cn/mohbgt/s9508/200903/39723.shtml
[3]郑顺富.从药物利用指数上评价某医院合理用药情况[J].中国基层医药,2013,20(24):3792-3793.
[4]抗菌药物临床应用指导原则(2015年版)[EB/OL].(2015-08-27)[2016-03-20].http://10.115.241.6/files/6105000004EE0E70/www.nhfpc.gov.cn/ewebeditor/uplo adfile/2015/08/20150826165222335.pdf
[5]万古霉素临床应用中国专家共识(2011)[J].中国新药与临床杂志,2011,30(8):561-573.
[6]于中华,赵志刚,张秉尧,等.某院颅脑手术抗菌药物使用调查分析[J].中国医院用药评价与分析,2010,10(8):696-698.
[7]王进,肖永红,李耘.2004-2005年度全国革兰阳性菌耐药监测(Mohnarin)[J].中华传染病杂志,2008,26(5):268-274.
[8]李耘,吕媛,薛峰,等.卫生部全国细菌耐药监测网(Mohnarin)2011-2012年革兰阳性菌耐药监测报告[J].中国临床药理学杂志,2014,30(3):251-259.
[9]郑波,吕媛.Mohnarin 2009年度报告:革兰阳性菌耐药监测[J].中国临床药理学杂志,2011,27(5):335-339.
[10]肖永红,沈萍,魏泽庆,等.Mohnarin 2011年度全国细菌耐药监测[J].中华医院感染学杂志,2012,22(22):4946-4952.
[11]Kiramatsu K,Hanaki H,Ino T,et al.Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility[J].J Antimicrob Chemother,1997,40(1):135-136.
[12]朱曼,王东晓,郭代红,等.老年住院患者万古霉素用药情况分析[J].药物不良反应杂志,2014,16(4):193-197.
[2]卫生部办公厅关于抗菌药物临床应用管理有关问题的通知[EB/OL].(2009-03-25)[2016-02-20].http://www.moh.gov.cn/mohbgt/s9508/200903/39723.shtml
[3]郑顺富.从药物利用指数上评价某医院合理用药情况[J].中国基层医药,2013,20(24):3792-3793.
[4]抗菌药物临床应用指导原则(2015年版)[EB/OL].(2015-08-27)[2016-03-20].http://10.115.241.6/files/6105000004EE0E70/www.nhfpc.gov.cn/ewebeditor/uplo adfile/2015/08/20150826165222335.pdf
[5]万古霉素临床应用中国专家共识(2011)[J].中国新药与临床杂志,2011,30(8):561-573.
[6]于中华,赵志刚,张秉尧,等.某院颅脑手术抗菌药物使用调查分析[J].中国医院用药评价与分析,2010,10(8):696-698.
[7]王进,肖永红,李耘.2004-2005年度全国革兰阳性菌耐药监测(Mohnarin)[J].中华传染病杂志,2008,26(5):268-274.
[8]李耘,吕媛,薛峰,等.卫生部全国细菌耐药监测网(Mohnarin)2011-2012年革兰阳性菌耐药监测报告[J].中国临床药理学杂志,2014,30(3):251-259.
[9]郑波,吕媛.Mohnarin 2009年度报告:革兰阳性菌耐药监测[J].中国临床药理学杂志,2011,27(5):335-339.
[10]肖永红,沈萍,魏泽庆,等.Mohnarin 2011年度全国细菌耐药监测[J].中华医院感染学杂志,2012,22(22):4946-4952.
[11]Kiramatsu K,Hanaki H,Ino T,et al.Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility[J].J Antimicrob Chemother,1997,40(1):135-136.
[12]朱曼,王东晓,郭代红,等.老年住院患者万古霉素用药情况分析[J].药物不良反应杂志,2014,16(4):193-197.