FGF7亚家族在卵巢中的分布及卵泡发育过程中的作用
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摘要
成纤维细胞生长因子(fibroblastgrowthfactor,FGF)家族是生长因子中的一个大家族,包括23个家族成员,具有相似的编码基因序列和空间结构,基于序列同源性和演变特征,将18种哺乳动物的FGFs分为6个亚家族,其中,FGF7亚家族(包括FGF3、FGF7、FGF10和FGF22)通过旁分泌途径发挥生理学作用。在女性生殖领域,国内外大多专注于研究FGFs对卵巢的影响。目前,已有报道显示FGF7和FGF10分布于卵母细胞和/或颗粒细胞,具有促进颗粒细胞增殖、抑制黄体酮和类固醇生成及分泌等功能,介导卵泡的募集和发育作用。对于其它两个成员FGF3和FGF22,其编码mRNA虽然在大鼠卵母细胞中表达,但是其对卵泡生长的生理作用尚不明确。
引文
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[25]Ivan P,Jovanovic,Radosavljevic,et al.Clinical significance of Cyclin D1,FGF3 and p21 protein expression in laryngeal squamous cell carcinoma[J].Journal of B.U.ON.:official journal of the Balkan Union of Oncology,1900,19(4):944-52.
[26]Wu,B.-T,Wen,S.-H,Hwang S.-P,et al.Control of Wnt5b secretion by Wntless modulates chondrogenic cell proliferation through fine-tuning fgf3 expression[J].Journal of Cell Science,2015,128(12):2328-2339.
[2]Vernon RK&Spicer LJ.Effects of basic fibroblast growth factor and heparin on follicle-stimulating hormone-induced steroidogenesis by bovine granulosa cells[J].Journal of Animal Science,1994,72:2696-2702.
[3]Parrott JA&Skinner MK.Developmental and Hormonal Regulation of Keratinocyte Growth Factor Expression and Action in the Ovarian Follicle[J].Endocrinology,1998,139:228-235.
[4]Buratini,Pinto MGL,Castilho AC,et al.Expression and function of fibroblast growth factor 10 and its receptor,fibroblast growth factor receptor 2B,in bovine follicles[J].Biology of Reproduction,2007,77:743-750.
[5]A.C.S,Castilho,Price,et al.Evidence that fibroblast growth factor 10 plays a role in follicle selection in cattle[J].Reproduction,Fertility and Development,2015,29(2):234-243.
[6]Hui Q,Jin Z,Li X,et al.FGF Family:From Drug Development to Clinical Application[J].International Journal of Molecular Sciences,2018,19(7):1875.
[7]Zhang X,Ibrahimi OA,Olsen SK,et al.Receptor specificity of the fibroblast growth factor family.The complete mammalian FGF family[J].Journal of Biological Chemistry,2006,281:15694-15700.
[8]Belov Artur A,Mohammadi Moosa.Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology[J].Cold Spring Harbor perspectives in biology,2013,56.
[9]Orr-Urtreger A,Bedford MT,Burakova T,et al.Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2(FGFR2)[J].Developmental Biology,1993,158:475-486.
[10]Berisha B,Sinowatz F&Schams D.Expression and localization of fibroblast growth factor(FGF)family members during the final growth of bovine ovarian follicles[J].Molecular Reproduction and Development,2004,67:162-171.
[11]Bajram Berisha,Harald Welter,Takashi Shimizu,et al.Expression of fibroblast growth factor 1(FGF1)and FGF7 in mature follicles during the periovulatory period after GnRH in the cow[J].Journal of Reproduction and Development,2006,52(2):307-13.
[12]Songsasen N,Pukazhenthi B&Wildt D.Follicular Morphology,Oocyte Diameter and Localisation of Fibroblast Growth Factors in the Domestic Dog Ovary[J].Reproduction in Domestic Animals,2009,44:65-70.
[13]Mishra,S.R,Thakur N,et al.Expression and localization of fibroblast growth factor(FGF)family in buffalo ovarian follicle during different stages of development and modulatory role of FGF2 on steroidogenesis and survival of cultured buffalo granulosa cells[J].Research in Veterinary Science,2016,108:98-111.
[14]Castilho AC,da Silva RB,Price CA,et al.Expression of fibroblast growth factor 10 and cognate receptors in the developing bovine ovary[J].Theriogenology,2014,81:1268-1274.
[15]McGee EA,Chun SY,Lai S,et al.Keratinocyte growth factor promotes the survival,growth,and differentiation of preantral ovarian follicles[J].Fertility and Sterility,1999,71:732-738.
[16]Faustino LR,Rossetto R,Lima IMT,et al.Expression of Keratinocyte Growth Factor in Goat Ovaries and Its Effects on Preantral Follicles Within Cultured Ovarian Cortex[J].Reproductive Sciences,2011,18:1222-1229.
[17]Chaves RN,Lima-Verde IB,Celestino JJH,et al.Fibroblast growth factor-10 maintains the survival and promotes the growth of cultured goat preantral follicles[J].Domestic Animal Endocrinology,2010,39:249-258.
[18]Zhang K,Hansen PJ,Ealy AD.Fibroblast growth factor 10enhances bovine oocyte maturation and developmental competence in vitro[J].Reproduction,2010,140:815-826.
[19]Yeo-Jin Son,Seung-Eun Lee,Hyuk Hyu,et al.Fibroblast growth factor 10 markedly improves in vitro maturation of porcine cumulus-oocyte complexes[J].Molecular Reproduction and Development,2017,84(1):67-75.
[20]Caixeta ES,Sutton-McDowall ML,Gilchrist RB,et al.Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion,glucose uptake,and expression of genes in the ovulatory cascade during in vitro maturation of bovine cumulusoocyte complexes[J].Reproduction,2013,146:27-35.
[21]Pomini Pinto RF,Fontes PK,Loureiro B,et al.Effects of FGF10 on bovine oocyte meiosis progression,apoptosis,embryo development and relative abundance of developmentally important genes in vitro[J].Reproduction in Domestic Animals,2015,50:84-90.
[22]Sun Y.-W,Chen K.-M,Imamura Kawasawa,et al.Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene[J].PLOS ONE,2017,12(10):e0186873.
[23]Dos Santos,í.G.D,Jorge,et al.FGF2,FGF3 and FGF4expression pattern during molars odontogenesis in Didelphis albiventris[J].Acta Histochemica,2017,119(2):129-141.
[24]Olaya-Sánchez D,Sánchez-Guardado,L.ó,et al.Fgf3 and Fgf16 expression patterns define spatial and temporal domains in the developing chick inner ear[J].Brain Structure and Function,2016,222(1):131-149.
[25]Ivan P,Jovanovic,Radosavljevic,et al.Clinical significance of Cyclin D1,FGF3 and p21 protein expression in laryngeal squamous cell carcinoma[J].Journal of B.U.ON.:official journal of the Balkan Union of Oncology,1900,19(4):944-52.
[26]Wu,B.-T,Wen,S.-H,Hwang S.-P,et al.Control of Wnt5b secretion by Wntless modulates chondrogenic cell proliferation through fine-tuning fgf3 expression[J].Journal of Cell Science,2015,128(12):2328-2339.