LEEP刀宫颈锥切术与重组α-2b干扰素栓术前术后联合给药治疗宫颈上皮内瘤变的疗效评价
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摘要
目的探析宫颈上皮内瘤变(CIN)采用LEEP刀宫颈锥切术与术前术后联合应用重组α-2b干扰素栓治疗的临床效果。方法选择2015年1月—2018年1月该院接收的CIN患者260例,遵从双盲法分组标准均分为参照组、试验组,各130例,两组均采取LEEP刀宫颈锥切术治疗,参照组术后给予重组α-2b干扰素栓,试验组术前术后均应用重组α-2b干扰素栓。比较两组治疗效果、手术指标、免疫功能及复发率。结果试验组总疗效为96.15%,明显高于参照组的81.54%,复发率0.77%低于参照组33.85%,差异有统计学意义(χ~2=14.011 0,P=0.000 2;χ~2=49.688 9,P=0.000 0);参照组出血量(25.28±3.27)mL及愈合时间(5.72±1.83)d均大于试验组(4.49±1.71)mL与(4.11±1.52)d,差异有统计学意义(t=64.237 0,P=0.000 0;t=7.716 4,P=0.000 0);两组免疫功能指标诸如IgM(0.91±0.49)%vs (0.69±0.41)%对比差异有统计学意义(t=3.926 1,P=0.000 0)。结论 CIN采用LEEP刀宫颈锥切术结合重组α-2b干扰素栓术前术后使用效果显著,可调节免疫功能,降低复发率,值得采纳。
Objective To investigate the clinical effect of cervical intraepithelial neoplasia(CIN) with LEEP knife conization and preoperative and postoperative combined with recombinant α-2 b interferon suppository. Methods A total of 260 patients with CIN received from January 2015 to January 2018 were enrolled. The double-blind grouping criteria were divided into reference group and experimental group, 130 cases each. Both groups underwent LEEP scalpel conization. For the treatment, the reference group was given recombinant α-2 b interferon suppository, and the experimental group was treated with recombinant α-2 b interferon suppository before and after operation. The treatment effects, surgical indexes, immune function and recurrence rate were compared between the two groups. Results The total efficacy of the experimental group was 96.15%, which was significantly higher than 81.54% of the reference group.The recurrence rate was 0.77% lower than that of the reference group 33.85%, which the difference was statistically significant(χ~2=14.011 0, P=0.000 2; χ~2=49.688 9, P=0.000 0). The reference group bleeding volume(25.28±3.27)mL and healing time(5.72±1.83)d were greater than the test group(4.49±1.71)mL and(4.11±1.52)d, forming the difference was statistical significance(t=64.237 0, P=0.000 0; t=7.716 4, P=0.000 0); two groups of immune function indicators such as IgM(0.91±0.49)% vs(0.69±0.41)%, there was statistical significance(t=3.926 1, P=0.000 0). Conclusion CIN using LEEP knife cervical conization combined with recombinant α-2 b interferon suppository has a significant effect before and after surgery. It can regulate immune function and reduce recurrence rate. It is worthy of adoption.
Objective To investigate the clinical effect of cervical intraepithelial neoplasia(CIN) with LEEP knife conization and preoperative and postoperative combined with recombinant α-2 b interferon suppository. Methods A total of 260 patients with CIN received from January 2015 to January 2018 were enrolled. The double-blind grouping criteria were divided into reference group and experimental group, 130 cases each. Both groups underwent LEEP scalpel conization. For the treatment, the reference group was given recombinant α-2 b interferon suppository, and the experimental group was treated with recombinant α-2 b interferon suppository before and after operation. The treatment effects, surgical indexes, immune function and recurrence rate were compared between the two groups. Results The total efficacy of the experimental group was 96.15%, which was significantly higher than 81.54% of the reference group.The recurrence rate was 0.77% lower than that of the reference group 33.85%, which the difference was statistically significant(χ~2=14.011 0, P=0.000 2; χ~2=49.688 9, P=0.000 0). The reference group bleeding volume(25.28±3.27)mL and healing time(5.72±1.83)d were greater than the test group(4.49±1.71)mL and(4.11±1.52)d, forming the difference was statistical significance(t=64.237 0, P=0.000 0; t=7.716 4, P=0.000 0); two groups of immune function indicators such as IgM(0.91±0.49)% vs(0.69±0.41)%, there was statistical significance(t=3.926 1, P=0.000 0). Conclusion CIN using LEEP knife cervical conization combined with recombinant α-2 b interferon suppository has a significant effect before and after surgery. It can regulate immune function and reduce recurrence rate. It is worthy of adoption.
引文
[1]谷丽静.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J].中国计划生育学杂志,2015,23(9):600-602,606.
[2]王梓媛,张永芳.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J].大家健康,2017,11(11上旬版):208-209.
[3]赵洪霞,翟艺筱.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J].中国保健营养,2017,27(18):88.
[4]崔英敏.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J].中西医结合心血管病电子杂志,2016,4(33):189.
[5]孔令敏.LEEP刀宫颈锥切术结合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变的临床效果[J].系统医学,2018,3(1):99-101.
[6]李晓燕.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J].医药前沿,2017,7(24):95-96.
[7]田艳冰.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变的临床效果[J].母婴世界2016,17(19):38.
[8]桑敏,李晓梅.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J]心理医生,2018,24(22):50-51.
[9]Thomsen,Louise T,Frederiksen Kirsten,Munk Christian et al Long-term risk of cervical intraepithelial neoplasia grade3 or worse according to high-risk human papillomavirus genotype and semi-quantitative viral load among 33,288women with normal cervical cytology[J].International Journal of Cancer=:Journal International du Cancer,2015,137(1):193-203.
[10]Zhao Q,He Y,Wang X-L,et al.Differentially expressed proteins amo ng normal cervix,cervical intraepithelial neoplasia and cervical squamous cell carcinoma[J].Clinical&translational oncology:official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico,2015,17(8)620-631.
[2]王梓媛,张永芳.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J].大家健康,2017,11(11上旬版):208-209.
[3]赵洪霞,翟艺筱.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J].中国保健营养,2017,27(18):88.
[4]崔英敏.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J].中西医结合心血管病电子杂志,2016,4(33):189.
[5]孔令敏.LEEP刀宫颈锥切术结合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变的临床效果[J].系统医学,2018,3(1):99-101.
[6]李晓燕.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J].医药前沿,2017,7(24):95-96.
[7]田艳冰.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变的临床效果[J].母婴世界2016,17(19):38.
[8]桑敏,李晓梅.LEEP刀宫颈锥切术联合术前术后应用重组α-2b干扰素栓治疗宫颈上皮内瘤变临床疗效分析[J]心理医生,2018,24(22):50-51.
[9]Thomsen,Louise T,Frederiksen Kirsten,Munk Christian et al Long-term risk of cervical intraepithelial neoplasia grade3 or worse according to high-risk human papillomavirus genotype and semi-quantitative viral load among 33,288women with normal cervical cytology[J].International Journal of Cancer=:Journal International du Cancer,2015,137(1):193-203.
[10]Zhao Q,He Y,Wang X-L,et al.Differentially expressed proteins amo ng normal cervix,cervical intraepithelial neoplasia and cervical squamous cell carcinoma[J].Clinical&translational oncology:official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico,2015,17(8)620-631.