尿素联合博来霉素局部注射治疗咽喉部海绵状血管瘤12例
摘要
<正>咽喉部海绵状血管瘤临床上较少见,发病机制尚不清楚~([1]),目前临床上尚无统一的治疗方式。患者常无明显临床表现,一般在体检中发现,部分瘤体侵及范围较大,临床表现可有声嘶、呼吸困难、痰中带血等症状。由于咽喉部位置特殊,瘤体一旦破裂可引发大出血、感染、窒息等危险,因此本病需积极治疗。本研究采用支撑喉镜下自制喉注射器尿素联合博来霉素局部注射术治疗咽喉部海绵状血管瘤,近期疗效显著、安全性好、创伤小、术后并发症少,现将临床资料总结分析如下。1 资
引文
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[1] 邱志利, 蒋晓平. 支撑喉镜下手术切除联合平阳霉素注射治疗咽喉部较大血管瘤23例[J]. 山东大学耳鼻喉眼学报, 2014, 28(6): 53-56. QIU Zhili, JIANG Xiaoping. Operation plus pingyangmycin injection to treat laryngopharyngeal hemangioma in 23 patients[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2014, 28(6): 53-56.
[5] Rush BF Jr. Treatment of a giant cutaneous hemangioma by intra-arterial injection of nitrogen mustard: case report[J]. Ann Surg, 1966, 164(5): 921-923.
[6] 渠海英, 周罗, 王茜. 博来霉素治疗颌面部海绵状血管瘤临床分析及护理体会[J]. 全科口腔医学电子杂志, 2017, 4(10): 61-62.
[7] 梁荷英, 李京宏, 付伟娟, 等. 超声引导下经皮穿刺平阳霉素注射治疗巨大肝血管瘤[J/CD]. 中华医学超声杂志(电子版), 2010, 7(11): 1902-1910. LIANG Heying, LI Jinghong, FU Weijuan, et al. Ultrasound-guided Pingyangmycin injection for huge hepatic hemangioma[J/CD]. Chinese Journal of Medical Ultrasound(Electronic Version), 2010, 7(11): 1902-1910.
[8] 曹绿红, 张竞飞, 孙广滨, 等. 平阳霉素注射治疗喉部血管瘤致声带固定一例[J]. 听力学及言语疾病杂志, 2013, 21(5): 558-559.
[9] 董长宪. 血管瘤与脉管畸形的尿素注射治疗[J]. 皮肤科学通报, 2018(5): 588-592.DONG Changxian. The application of urea injection in the treatment of vascular tumors and vascular malformation[J]. China Medical Abstracts(Dermatology), 2018(5): 588-592.
[10] Wang ZL, Li J, Xu X, et al. Urea immunoliposome inhibits human vascular endothelial cell proliferation for hemangioma treatment[J]. World J Surg Oncol, 2013, 11: 300. doi:10.1186/1477-7819-11-300.
[11] 梁新亮,董长宪,马玉春,等.局部尿素注射治疗体表海绵状血管瘤[J].中国医院药学杂志,2011,31(16):1396-1397.
[3] 中华医学会整形外科分会血管瘤和脉管畸形学组.血管瘤和脉管畸形诊断和治疗指南(2016版)[J]. 组织工程与重建外科, 2016, 12(2): 63-93,97.
[4] Buckmiller LM, Richter GT, Suen JY. Diagnosis and management of hemangiomas and vascular malformations of the head and neck[J]. Oral Dis, 2010, 16(5): 405-418.
[1] 邱志利, 蒋晓平. 支撑喉镜下手术切除联合平阳霉素注射治疗咽喉部较大血管瘤23例[J]. 山东大学耳鼻喉眼学报, 2014, 28(6): 53-56. QIU Zhili, JIANG Xiaoping. Operation plus pingyangmycin injection to treat laryngopharyngeal hemangioma in 23 patients[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2014, 28(6): 53-56.
[5] Rush BF Jr. Treatment of a giant cutaneous hemangioma by intra-arterial injection of nitrogen mustard: case report[J]. Ann Surg, 1966, 164(5): 921-923.
[6] 渠海英, 周罗, 王茜. 博来霉素治疗颌面部海绵状血管瘤临床分析及护理体会[J]. 全科口腔医学电子杂志, 2017, 4(10): 61-62.
[7] 梁荷英, 李京宏, 付伟娟, 等. 超声引导下经皮穿刺平阳霉素注射治疗巨大肝血管瘤[J/CD]. 中华医学超声杂志(电子版), 2010, 7(11): 1902-1910. LIANG Heying, LI Jinghong, FU Weijuan, et al. Ultrasound-guided Pingyangmycin injection for huge hepatic hemangioma[J/CD]. Chinese Journal of Medical Ultrasound(Electronic Version), 2010, 7(11): 1902-1910.
[8] 曹绿红, 张竞飞, 孙广滨, 等. 平阳霉素注射治疗喉部血管瘤致声带固定一例[J]. 听力学及言语疾病杂志, 2013, 21(5): 558-559.
[9] 董长宪. 血管瘤与脉管畸形的尿素注射治疗[J]. 皮肤科学通报, 2018(5): 588-592.DONG Changxian. The application of urea injection in the treatment of vascular tumors and vascular malformation[J]. China Medical Abstracts(Dermatology), 2018(5): 588-592.
[10] Wang ZL, Li J, Xu X, et al. Urea immunoliposome inhibits human vascular endothelial cell proliferation for hemangioma treatment[J]. World J Surg Oncol, 2013, 11: 300. doi:10.1186/1477-7819-11-300.
[11] 梁新亮,董长宪,马玉春,等.局部尿素注射治疗体表海绵状血管瘤[J].中国医院药学杂志,2011,31(16):1396-1397.