摘要
目的:分析慢性乙肝合并细菌感染患者血清降钙素原(PCT)、C反应蛋白(CRP)及白介素-6(IL-6)水平变化与细菌感染的关系。方法:收集2016年2月至2018年4月广西钦州市第二人民医院收治的88例慢性乙肝患者为研究对象,其中35例患者发生细菌感染,作为感染组;未发生感染的53例作为未感染组。获取所有患者血清标本,检测PCT、CRP与IL-6水平,评价其诊断细菌感染的特异性、敏感性。结果:与未感染组相比,感染组患者血清PCT、CRP、IL-6水平显著高,差异有统计学意义(P<0.05)。血清PCT、CRP、IL-6的受试者工作特征(ROC)曲线下面积依次为0.87、0.82、0.76,其诊断合并细菌感染的特异性、敏感性均>70%,其中PCT的特异性、敏感性均>85%,与CRP、IL-6相比诊断效能更高。Pearson相关分析显示,慢性乙肝患者血清PCT与CRP、IL-6呈正相关关系,CRP与IL-6呈正相关关系(均P<0.05)。结论:慢性乙肝合并细菌感染患者血清PCT、CRP与IL-6水平明显升高,PCT对细菌感染的诊断效能较高,PCT、CRP与IL-6均可作为预测细菌感染的血清标志物。
Objective:To analyze the relationship between the changes of serum procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)in patients with chronic hepatitis B and bacterial infection.Methods:A total of 88 patients with chronic hepatitis B admitted to our hospital from February 2016 to April 2018 were selected,including 35 cases with bacterial infection(infection group)and 53 cases without infection(non-infection group).Serum levels of PCT,CRP and IL-6 were measured,and their specificity and sensitivity in the diagnosis of bacterial infection were evaluated.Results:Compared with non-infection group,the levels of serum PCT,CRP and IL-6 were significantly higher in infection group(P<0.05).The area under the receiver operating characteristic(ROC)curve of PCT,CRP and IL-6 was 0.87,0.82 and0.76,respectively.The specificity and sensitivity of PCT,CRP and IL-6 in the diagnosis of bacterial infection were over 70%,and the specificity and sensitivity of PCT were over 85%,and the diagnostic efficacy of PCT was higher than that of CRP and IL-6.Pearson correlation analysis showed that serum PCT was positively correlated with CRP and IL-6 in patients with chronic hepatitis B,and CRP was positively correlated with IL-6(P<0.05).Conclusion:The serum levels of PCT,CRP and IL-6 were significantly increased in patients with chronic hepatitis B complicated with bacterial infection,and PCT had higher diagnostic efficacy for bacterial infection.PCT,CRP and IL-6 could be used as the predictive indicators for bacterial infection.
引文
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