富血小板血浆治疗麻风溃疡三例
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摘要
目的:评价自体富血小板血浆(platelet-rich plasma,PRP)治疗麻风溃疡的疗效。方法:采用麻风3例患者的自体血10～20mL,经2次离心后,获取高浓度的富血小板血浆,在麻风溃疡周边及溃疡面内注射治疗,观察不同治疗次数情况下,麻风溃疡的愈合时间、愈合面积等情况。结果:3例患者中,2例患者的3处溃疡得到治愈,1例患者的溃疡面积缩小了95%。结论:PRP疗法治疗麻风溃疡简单、安全、有效。
Objective: To assess the efficacy of autologous platelet-rich plasma(PRP) in the treatment of leprosy soles ulcer. Methods: 10-20 mL autologous blood was obtained from three leprosy patients in each, and then, high-concentration platelet-rich plasma was obtained after centrifugation. The blood was injected into the tissues around foot ulcer and the ulcer surface. Results: Of 3 cases, ulcers were curred in 2 cases and significant improvement in one(95% reduction of the foot ulcer). Conclusion: PRP therapy is a simple, safe and effective methods for treating leprosy ulcers.
Objective: To assess the efficacy of autologous platelet-rich plasma(PRP) in the treatment of leprosy soles ulcer. Methods: 10-20 mL autologous blood was obtained from three leprosy patients in each, and then, high-concentration platelet-rich plasma was obtained after centrifugation. The blood was injected into the tissues around foot ulcer and the ulcer surface. Results: Of 3 cases, ulcers were curred in 2 cases and significant improvement in one(95% reduction of the foot ulcer). Conclusion: PRP therapy is a simple, safe and effective methods for treating leprosy ulcers.
引文
[1] 李文忠.现代麻风病学[M].上海:上海科学技术出版,2006:166-169.
[2] 钟均堂. 36 例麻风病足底溃疡的综合防治效果观察[J].皮肤性病诊疗学杂志,2011,18(3):183-203.
[3] 金永刚,谭又吉,王景权,等. 不同手术方法治疗麻风足底溃疡的疗效分析[J].中国修复重建外科杂志,2009,23(10):1183-1186.
[4] 孙明霞,尤卫平,王景权,等. 使用综合方法治疗麻风足底溃疡的效果观察[J].皮肤病与性病,2007,29(4):58-59.
[5] 梁建秀,黄培勇,陆云清,等. 复杂性麻风足底溃疡综合防治效果观察[J],广西医科大学学报,2002,19(4):512-513.
[6] Doucet C, Ernou I, Zhang Y, et al. Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications[J]. J Cell Physiol,2005,205:228-236.
[7] Marques LF, Stessuk T, Camargo IC, et al. Platelet-rich plasma (PRP): methodological aspects and clinical applications[J].Platelets,2015,26(2):101-113.
[8] Yuan T, Guo SC, Han P, et al. Applications of leukocyte-and Platelet-Rich plasma(L-PRP)in trauma surgery[J].Curr Pharm Biotechnol,2012,13(7):1173-1184.
[9] Anandan V, Jameela WA, Saraswathy P, et al. Platelet rich plasma:efficacy in treating trophic ulcers in leprosy[J]. J Clin Diagn Res,2016,10(10):WC06-WC09.
[10] 张长青,袁霆.富血小板血浆在临床应用中的争议与研究进展[J].中华关节外科杂志,2016,10(6):588-591.
[11] 伍爱金,游勇,佟根,等.麻风足底溃疡患者病原菌感染及耐药分析[J].北方药学,2016,13(6):175-176.
[12] 余爱如.鳞状细胞癌和麻风慢性下肢溃疡[J].中国麻风皮肤病杂志,2003,19(1):19-21.
[13] 侯玉鸿,王载明,陈家琨,等. 麻风足与小腿溃疡癌变5例报道[J].世界感染杂志,2009,9(3):174-175.
[14] 于德宝,李娟,杨爱香,等. 麻风足底溃疡继发鳞癌截肢术后转移1例[J].中国麻风皮肤病杂志,2012,28(11):808.
[15] 常毅,邓辰亮,屈悦,等.PRP对人皮肤成纤维细胞增殖、体外合成胶原与透明质酸的影响[J].组织工程与重建外科杂志,2012,8(2):61-64.
[16] Yang Y, Zhang W, Cheng B. Experimental research on the effects of different activators on the formation of platelet-rich gel and the release of bioactive substances in human platelet-rich plasma[J].Chin J Burns,2017,33(1):12-17.
[17] Castillo TN, Pouliot MA, Kim HJ. Comparison of growth factor and platelet concentration from commercial Platelet-Rich plasma separation systems[J]. Am J Sports Med,2011,39(2):266-271.
[18] Magalon J, Bausset O, Serratrice NA, et al. Characterization and comparison of 5 Platelet-Rich plasma preparations in a Single-Donor Model[J]. Arthroscopy,2014,30(5):629-638.
[19] 王君婷,回蔷,郭冰玉,等.富血小板血浆在慢性创面修复中的应用[J].中国美容整形外科杂志,2017,28(1):63-64.
[20] Oryan A, Alidadi S, Moshiri A. Platelet-rich plasma for bone healing and regeneration[J]. Expert Opin Biol Ther,2016,16(2):213-232.
[21] 刘宸,章宏伟.富血小板血浆促进慢性创面愈合研究进展[J].中华烧伤杂志,2014,30(5):433-436.
[22] 赵月强,朱占勇,李爱林,等.富血小板血浆治疗慢性难愈性创面的临床研究[J].临床外科杂志,2016,24(3):175-177.
[2] 钟均堂. 36 例麻风病足底溃疡的综合防治效果观察[J].皮肤性病诊疗学杂志,2011,18(3):183-203.
[3] 金永刚,谭又吉,王景权,等. 不同手术方法治疗麻风足底溃疡的疗效分析[J].中国修复重建外科杂志,2009,23(10):1183-1186.
[4] 孙明霞,尤卫平,王景权,等. 使用综合方法治疗麻风足底溃疡的效果观察[J].皮肤病与性病,2007,29(4):58-59.
[5] 梁建秀,黄培勇,陆云清,等. 复杂性麻风足底溃疡综合防治效果观察[J],广西医科大学学报,2002,19(4):512-513.
[6] Doucet C, Ernou I, Zhang Y, et al. Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications[J]. J Cell Physiol,2005,205:228-236.
[7] Marques LF, Stessuk T, Camargo IC, et al. Platelet-rich plasma (PRP): methodological aspects and clinical applications[J].Platelets,2015,26(2):101-113.
[8] Yuan T, Guo SC, Han P, et al. Applications of leukocyte-and Platelet-Rich plasma(L-PRP)in trauma surgery[J].Curr Pharm Biotechnol,2012,13(7):1173-1184.
[9] Anandan V, Jameela WA, Saraswathy P, et al. Platelet rich plasma:efficacy in treating trophic ulcers in leprosy[J]. J Clin Diagn Res,2016,10(10):WC06-WC09.
[10] 张长青,袁霆.富血小板血浆在临床应用中的争议与研究进展[J].中华关节外科杂志,2016,10(6):588-591.
[11] 伍爱金,游勇,佟根,等.麻风足底溃疡患者病原菌感染及耐药分析[J].北方药学,2016,13(6):175-176.
[12] 余爱如.鳞状细胞癌和麻风慢性下肢溃疡[J].中国麻风皮肤病杂志,2003,19(1):19-21.
[13] 侯玉鸿,王载明,陈家琨,等. 麻风足与小腿溃疡癌变5例报道[J].世界感染杂志,2009,9(3):174-175.
[14] 于德宝,李娟,杨爱香,等. 麻风足底溃疡继发鳞癌截肢术后转移1例[J].中国麻风皮肤病杂志,2012,28(11):808.
[15] 常毅,邓辰亮,屈悦,等.PRP对人皮肤成纤维细胞增殖、体外合成胶原与透明质酸的影响[J].组织工程与重建外科杂志,2012,8(2):61-64.
[16] Yang Y, Zhang W, Cheng B. Experimental research on the effects of different activators on the formation of platelet-rich gel and the release of bioactive substances in human platelet-rich plasma[J].Chin J Burns,2017,33(1):12-17.
[17] Castillo TN, Pouliot MA, Kim HJ. Comparison of growth factor and platelet concentration from commercial Platelet-Rich plasma separation systems[J]. Am J Sports Med,2011,39(2):266-271.
[18] Magalon J, Bausset O, Serratrice NA, et al. Characterization and comparison of 5 Platelet-Rich plasma preparations in a Single-Donor Model[J]. Arthroscopy,2014,30(5):629-638.
[19] 王君婷,回蔷,郭冰玉,等.富血小板血浆在慢性创面修复中的应用[J].中国美容整形外科杂志,2017,28(1):63-64.
[20] Oryan A, Alidadi S, Moshiri A. Platelet-rich plasma for bone healing and regeneration[J]. Expert Opin Biol Ther,2016,16(2):213-232.
[21] 刘宸,章宏伟.富血小板血浆促进慢性创面愈合研究进展[J].中华烧伤杂志,2014,30(5):433-436.
[22] 赵月强,朱占勇,李爱林,等.富血小板血浆治疗慢性难愈性创面的临床研究[J].临床外科杂志,2016,24(3):175-177.