中西医结合分期治疗儿童肺炎支原体感染咳嗽的临床观察
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摘要
目的:探索中西医结合分期治疗儿童肺炎支原体感染咳嗽的治疗方法和临床效果。方法:112例由支原体感染引起咳嗽的儿童肺炎患儿,按照随机数字表法随机分为对照组和试验组,每组各56例。对照组给予西医常规治疗方法,试验组给予中西医结合分期治疗。干预治疗2周后,分别对两组患者的临床疗效、炎症指标水平、临床症状以及体征改善情况、以及不良反应发生情况进行比较。结果:①两组患儿病情均有明显改善,对照组的临床总有效率为85.71%,试验组患儿的临床总有效率为96.43%,试验组患儿的临床疗效明显比对照组高(χ~2=5.973,0.032);②试验组患儿咳嗽、发热以及肺部体征等缓解情况,以及住院时间都明显的优于对照组(t=8.638,7.210,5.917,-6.648;P<0.05);③两组患儿干预治疗后的各炎症指标水平均较干预治疗前显著降低(t=14.073,15.834,11.623,13.169,15.331,13.071;P<0.05),且试验组患儿的IL-8、IL-6以及TNF-α炎症指标水平均显著优于对照组患儿,差异有统计学意义(t=9.300,7.807,6.959;P<0.05);④试验组患儿的不良反应发生率显著低于对照组患儿,差异有统计学意义(χ~2=4.998,4.350,6.935;P=0.025,0.037,0.008)。结论:就肺炎支原体感染儿童而言,采用中西医结合方法具有显著的临床疗效,不仅能有效的改善患儿的临床症状以及体征,而且能够有效降低患儿的炎症指标水平,并减少不良反应的发生。
Objective:To explore the clinical observation on treating cough in children with mycoplasma pneumoniae infection by integrated traditional Chinese and Western medicine. Methods:A total of 112 children with pneumonia caused by mycoplasma infection were randomly divided into the control group and the experimental group according to the random number table method, with 56 cases in each group. The control group was given conventional western medicine treatment, and the experimental group was treated by integrated traditional Chinese and Western medicine. After 2 weeks intervention, the clinical efficacy, the level of inflammation index, the clinical symptoms and the improvement of the signs and the incidence of adverse reactions were compared in the two groups. Results:①The two groups' children were obviously improved. The total effective rate of the control group was 85.71% and the clinical total effective rate of the experimental group was 96.43%, and the clinical efficacy of the experimental group was higher than that of the control group(χ~2=5.973,0.032). ②The cough, fever, pulmonary signs and hospital stays in the experimental group were significantly better than those of the control group(t=8.638, 7.210,5.917,-6.648; P<0.05). ③The levels of the inflammatory markers in the two groups were significantly lower than those before the intervention(t=14.073,15.834,11.623,13.169,15.331,13.071; P<0.05), and the levels of IL-8, IL-6 and TNF-α in the experimental group were significantly better than those in the control group(t=9.300,7.807,6.959; P<0.05). ④The incidence of adverse reactions in the experimental group was significantly lower than that in the control group(χ~2=4.998,4.350,6.935;P=0.025,0.037,0.008). Conclusion: In the case of mycoplasma pneumoniae infection in children, the combination of traditional Chinese and Western medicine has significant clinical effect. It can not only effectively improve the clinical symptoms and signs of children, but also effectively reduce the level of inflammation, and reduce the incidence of adverse reactions.
Objective:To explore the clinical observation on treating cough in children with mycoplasma pneumoniae infection by integrated traditional Chinese and Western medicine. Methods:A total of 112 children with pneumonia caused by mycoplasma infection were randomly divided into the control group and the experimental group according to the random number table method, with 56 cases in each group. The control group was given conventional western medicine treatment, and the experimental group was treated by integrated traditional Chinese and Western medicine. After 2 weeks intervention, the clinical efficacy, the level of inflammation index, the clinical symptoms and the improvement of the signs and the incidence of adverse reactions were compared in the two groups. Results:①The two groups' children were obviously improved. The total effective rate of the control group was 85.71% and the clinical total effective rate of the experimental group was 96.43%, and the clinical efficacy of the experimental group was higher than that of the control group(χ~2=5.973,0.032). ②The cough, fever, pulmonary signs and hospital stays in the experimental group were significantly better than those of the control group(t=8.638, 7.210,5.917,-6.648; P<0.05). ③The levels of the inflammatory markers in the two groups were significantly lower than those before the intervention(t=14.073,15.834,11.623,13.169,15.331,13.071; P<0.05), and the levels of IL-8, IL-6 and TNF-α in the experimental group were significantly better than those in the control group(t=9.300,7.807,6.959; P<0.05). ④The incidence of adverse reactions in the experimental group was significantly lower than that in the control group(χ~2=4.998,4.350,6.935;P=0.025,0.037,0.008). Conclusion: In the case of mycoplasma pneumoniae infection in children, the combination of traditional Chinese and Western medicine has significant clinical effect. It can not only effectively improve the clinical symptoms and signs of children, but also effectively reduce the level of inflammation, and reduce the incidence of adverse reactions.
引文
[1] 张颖,尚伟,宋喜明,等.儿童肺炎支原体肺炎与肺炎支原体合并链球菌感染肺炎的胸部CT鉴别诊断研究[J].中华医院感染学杂志,2017,27(6):1391-1393,1397.
[2] 黄静,魏萍.中西医结合治疗耐药性儿童支原体肺炎的疗效观察及对血清IL-6、IL-8、IL-10的影响[J].中国妇幼保健,2017,32(14):3220-3222.
[3] 孟瑞荣.小儿肺热咳喘口服液联合阿奇霉素治疗肺炎支原体性肺炎的疗效观察[J].世界中医药,2016,11(8):1517-1519,1523.
[4] Adeoye PO, Johnson WR, Desalu OO, et al. Etiology, clinical characteristics, and management of pleural effusion in Ilorin, Nigeria[J]. Niger Med J, 2017,58(2):76-80.
[5] 梅淑芬,金海丽,王孙尧,等.儿童难治性肺炎支原体肺炎临床特点分析[J].中国中西医结合急救杂志,2017,24(2):129-132.
[6] 高群英,袁纯,丁国标,等.阿奇霉素序贯疗法治疗学龄前儿童肺炎支原体感染的疗效、安全性及对炎性因子水平的影响[J].现代中西医结合杂志,2015,(32):3549-3551,3555.
[7] Gie RP, Goussard P. CMV pneumonia in HIV-infected and HIV-uninfected infants: a neglected disease?[J]. Int J Tuberc Lung Dis, 2017,21(12):1209-1210.
[8] 汤东澄.中西医结合治疗对支原体肺炎儿童血浆凝血酶调节蛋白和D-二聚体的影响[J].中国中医急症,2015,24(1):152-154.
[9] Relationship between growth and illness, enteropathogens and dietary intakes in the first 2 years of life: findings from the MAL-ED birth cohort study[J]. BMJ Glob Health, 2017,2(4):e000370.
[10] 张峥嵘,邢刚,赵园珠,等.善散汤加减治疗小儿肺炎支原体感染疗效观察[J].陕西中医,2017,38(10):1356-1357.
[11] 王彦平,高貂艳,郝巧茸,等.加味五虎汤加减灌肠辅治痰热闭肺型小儿肺炎60例[J].陕西中医,2017,38(10):1360-1361.
[12] Gray AZ, Morpeth M, Duke T, et al. Improved oxygen systems in district hospitals in Lao PDR: a prospective field trial of the impact on outcomes for childhood pneumonia and equipment sustainability[J]. BMJ Paediatr Open, 2017,1(1):e000083.
[13] 王林群,段云雁,刘汉玉,等.中医定向透药疗法治疗儿童支气管肺炎临床观察[J].中国中医急症,2017,26(2):334-336.
[14] 任靖,汪受传,张秋月,等.儿童病毒性肺炎风寒郁肺证代谢组学研究[J].南京中医药大学学报,2017,33(2):193-197.
[2] 黄静,魏萍.中西医结合治疗耐药性儿童支原体肺炎的疗效观察及对血清IL-6、IL-8、IL-10的影响[J].中国妇幼保健,2017,32(14):3220-3222.
[3] 孟瑞荣.小儿肺热咳喘口服液联合阿奇霉素治疗肺炎支原体性肺炎的疗效观察[J].世界中医药,2016,11(8):1517-1519,1523.
[4] Adeoye PO, Johnson WR, Desalu OO, et al. Etiology, clinical characteristics, and management of pleural effusion in Ilorin, Nigeria[J]. Niger Med J, 2017,58(2):76-80.
[5] 梅淑芬,金海丽,王孙尧,等.儿童难治性肺炎支原体肺炎临床特点分析[J].中国中西医结合急救杂志,2017,24(2):129-132.
[6] 高群英,袁纯,丁国标,等.阿奇霉素序贯疗法治疗学龄前儿童肺炎支原体感染的疗效、安全性及对炎性因子水平的影响[J].现代中西医结合杂志,2015,(32):3549-3551,3555.
[7] Gie RP, Goussard P. CMV pneumonia in HIV-infected and HIV-uninfected infants: a neglected disease?[J]. Int J Tuberc Lung Dis, 2017,21(12):1209-1210.
[8] 汤东澄.中西医结合治疗对支原体肺炎儿童血浆凝血酶调节蛋白和D-二聚体的影响[J].中国中医急症,2015,24(1):152-154.
[9] Relationship between growth and illness, enteropathogens and dietary intakes in the first 2 years of life: findings from the MAL-ED birth cohort study[J]. BMJ Glob Health, 2017,2(4):e000370.
[10] 张峥嵘,邢刚,赵园珠,等.善散汤加减治疗小儿肺炎支原体感染疗效观察[J].陕西中医,2017,38(10):1356-1357.
[11] 王彦平,高貂艳,郝巧茸,等.加味五虎汤加减灌肠辅治痰热闭肺型小儿肺炎60例[J].陕西中医,2017,38(10):1360-1361.
[12] Gray AZ, Morpeth M, Duke T, et al. Improved oxygen systems in district hospitals in Lao PDR: a prospective field trial of the impact on outcomes for childhood pneumonia and equipment sustainability[J]. BMJ Paediatr Open, 2017,1(1):e000083.
[13] 王林群,段云雁,刘汉玉,等.中医定向透药疗法治疗儿童支气管肺炎临床观察[J].中国中医急症,2017,26(2):334-336.
[14] 任靖,汪受传,张秋月,等.儿童病毒性肺炎风寒郁肺证代谢组学研究[J].南京中医药大学学报,2017,33(2):193-197.