瞬时受体电位M2型离子通道在神经退行性病变和阿尔茨海默病病理学中的作用（英文）
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摘要
神经退行性病变是一种可导致神经细胞渐进性退变或死亡的不可治愈性疾病。该疾病可诱发功能性运动障碍以及精神问题,比如痴呆。在诸多种类的神经退行性病变中,阿尔茨海默病占据最大比例。瞬时受体电位M2型(TRPM2)离子通道是一个可通过钙离子的非选择性阳离子通道。研究表明,TRPM2离子通道有可能通过不同路径(包括炎症路径)参与阿尔茨海默病的病理过程。本综述主要通过对TRPM2与Aβ、氧化应激以及钙离子之间关系的讨论,总结概括了TRPM2在阿尔茨海默病病理学中的作用,也对近期TRPM2药理学领域的研究进展进行了探讨,并对如何进一步研究TRPM2在阿尔茨海默病中的作用进行了展望。
Neurodegenerative diseases refer to incurable conditions that result in progressive degeneration or death of nerve cells. This causes functional movement deficits and cognitive problems such as dementias. Among different types of neurodegenerative diseases, Alzheimer disease(AD)accounts for majority of the cases. The transient receptor potential melastatin member 2(TRPM2)channel is a Ca2+-permeable non-selective cation channel which has been studied and implicated in the pathological process of AD through different pathways including inflammation. This review summarizes the contribution of TRPM2 in AD pathology and recent advances in pharmacology of TRPM2, with a focus on relationships between β-amyloid, oxidative stress and Ca2 +. We also discuss the potential future research direction for neurodegenerative diseases.
Neurodegenerative diseases refer to incurable conditions that result in progressive degeneration or death of nerve cells. This causes functional movement deficits and cognitive problems such as dementias. Among different types of neurodegenerative diseases, Alzheimer disease(AD)accounts for majority of the cases. The transient receptor potential melastatin member 2(TRPM2)channel is a Ca2+-permeable non-selective cation channel which has been studied and implicated in the pathological process of AD through different pathways including inflammation. This review summarizes the contribution of TRPM2 in AD pathology and recent advances in pharmacology of TRPM2, with a focus on relationships between β-amyloid, oxidative stress and Ca2 +. We also discuss the potential future research direction for neurodegenerative diseases.
引文
[1]Simon F,Varela D,Cabello-Verrugio C.Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans[J].Cell Signal,2013,25(7):1614-1624.
[2]Irie S,Furukawa T.TRPM1[J].Handb Exp Pharmacol,2014,222:387-402.
[3]Hofmann T,Schaefer M,Schultz G,Gudermann T.Transient receptor potential channels as molecular substrates of receptor-mediated cation entry[J].J Mol Med(Berl),2000,78(1):14-25.
[4]Minke B.The history of the Drosophila TRP Channel:the birth of a new Channel superfamily[J].JNeurogenet,2010,24(4):216-233.
[5]Nilius B,Flockerzi V.Mammalian transient receptor potential(TRP)cation channels.Preface[J].Handb Exp Pharmacol,2014,223:v-vi.
[6]Montell C,Rubin GM.Molecular characterization of the Drosophila TRP locus:a putative integral membrane protein required for phototransduction[J].Neuron,1989,2(4):1313-1323.
[7]Huang CL.The transient receptor potential superfamily of ion channels[J].J Am Soc Nephrol,2004,15(7):1690-1699.
[8]Bouron A,Kiselyov K,Oberwinkler J.Permeation,regulation and control of expression of TRP channels by trace metal ions[J].Pflugers Arch,2015,467(6):1143-1164.
[9]Gees M,Colsoul B,Nilius B.The role of transient receptor potential cation channels in Ca2+signaling[J].Cold Spring Harb Perspect Biol,2010,2(10):a003962.
[10]Clapham DE,Runnels LW,Strübing C.The TRPion channel family[J].Nat Rev Neurosci,2001,2(6):387-396.
[11]Benemei S,De Cesaris F,Fusi C,Rossi E,Lupi C,Geppetti P.TRPA1 and other TRP channels in migraine[J].J Headache Pain,2013,14:71.
[12]Pan Z,Yang H,Reinach PS.Transient receptor potential(TRP)gene superfamily encoding cation channels[J].Hum Genomics,2011,5(2):108-116.
[13]Hellmich UA,Gaudet R.Structural biology of TRPchannels[J].Handb Exp Pharmacol,2014,223:963-990.
[14]Li M,Yu Y,Yang J.Structural biology of TRPchannels[J].Adv Exp Med Biol,2011,704:1-23.
[15]Morelli MB,Amantini C,Liberati S,Santoni M,Nabissi M.TRP channels:new potential therapeutic approaches in CNS neuropathies[J].CNSNeurol Disord Drug Targets,2013,12(2):274-293.
[16]Zheng J.Molecular mechanism of TRP channels[J].Compr Physiol,2013,3(1):221-242.
[17]Uchida K,Dezaki K,Damdindorj B,Inada H,Shiuchi T,Mori Y,et al.Lack of TRPM2impaired insulin secretion and glucose metabolisms in mice[J].Diabetes,2011,60(1):119-126.
[18]Oberwinkler J,Philipp SE.TRPM3[J].Handb Exp Pharmacol,2007,179:253-267.
[19]Vriens J,Owsianik G,Hofmann T,Philipp SE,Stab J,Chen X,et al.TRPM3 is a nociceptor channel involved in the detection of noxious heat[J].Neuron,2011,70(3):482-494.
[20]Oberwinkler J,Philipp SE.TRPM3[J].Handb Exp Pharmacol,2014,222:427-459.
[21]Quallo T,Vastani N,Horridge E,Gentry C,Parra A,Moss S,et al.TRPM8 is a neuronal osmosensor that regulates eye blinking in mice[J].Nat Commun,2015,6:7150.
[22]Yee NS.Roles of TRPM8 ion channels in cancer:proliferation,survival,and invasion[J].Cancers(Basel),2015,7(4):2134-2146.
[23]Cheng H,Beck A,Launay P,Gross SA,Stokes AJ,Kinet JP,et al.TRPM4 controls insulin secretion in pancreatic beta cells[J].Cell Calcium,2007,41(1):51-61.
[24]Roper SD.TRPs in taste and chemesthesis[J].Handb Exp Pharmacol,2014,223:827-871.
[25]van der Wijst J,Bindels RJ,Hoenderop JG.Mg2+homeostasis:the balancing act of TRPM6[J].Curr Opin Nephrol Hypertens,2014,23(4):361-369.
[26]Sun HS,Jackson MF,Martin LJ,Jansen K,Teves L,Cui H,et al.Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia[J].Nat Neurosci,2009,12(10):1300-1307.
[27]Chen W,Xu B,Xiao A,Liu L,Fang X,Liu R,et al.TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury[J].Mol Brain,2015,8:11.
[28]Turlova E,Bae CY,Deurloo M,Chen W,Barszczyk A,Horgen FD,et al.TRPM7 regulates axonal outgrowth and maturation of primary hippocampal neurons[J].Mol Neurobiol,2016,53(1):595-610.
[29]Xie YF,Macdonald JF,Jackson MF.TRPM2,Calcium and neurodegenerative diseases[J].Int J Physiol Pathophysiol Pharmacol,2010,2(2):95-103.
[30]Maqbool M,Mobashir M,Hoda N.Pivotal role of glycogen synthase kinase-3:A therapeutic target for Alzheimer′s disease[J].Eur J Med Chem,2016,107:63-81.
[31]Sumoza-Toledo A,Penner R.TRPM2:a multifunctional ion channel for calcium signalling[J].JPhysiol,2011,589(Pt 7):1515-1525.
[32]Belrose JC,Xie YF,Gierszewski LJ,Macdonald JF,Jackson MF.Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons[J].Mol Brain,2012,5:11.
[33]Rempe DA,Takano T,Nedergaard M.TR(I)Pping towards treatment for ischemia[J].Nat Neurosci,2009,12(10):1215-1216.
[34]Tóth B,Iordanov I,Csanády L.Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating[J].Proc Natl Acad Sci USA,2014,111(47):16949-16954.
[35]Uemura T,Kudoh J,Noda S,Kanba S,Shimizu N.Characterization of human and mouse TRPM2genes:identification of a novel N-terminal truncated protein specifically expressed in human striatum[J].Biochem Biophys Res Commun,2005,328(4):1232-1243.
[36]Gelderblom M,Melzer N,Schattling B,G?b E,Hicking G,Arunachalam P,et al.Transient receptor potential melastatin subfamily member 2 cation channel regulates detrimental immune cel invasion in ischemic stroke[J].Stroke,2014,45(11):3395-3402.
[37]Tong Q,Zhang W,Conrad K,Mostoller K,Cheung JY,Peterson BZ,et al.Regulation of the transient receptor potential channel TRPM2 by the Ca2+sensor calmodulin[J].J Biol Chem,2006,281(14):9076-9085.
[38]Sano Y,Inamura K,Miyake A,Mochizuki S,Yokoi H,Matsushime H,et al.Immunocyte Ca2+influx system mediated by LTRPC2[J].Science,2001,293(5533):1327-1330.
[39]Mchugh D,Flemming R,Xu SZ,Perraud AL,Beech DJ.Critical intracellular Ca2+dependence of transient receptor potential melastatin 2(TRPM2)cation channel activation[J].J Biol Chem,2003,278(13):11002-11006.
[40]Kheradpezhouh E,Ma L,Morphett A,Barritt GJ,Rychkov GY.TRPM2 channels mediate acetaminophen-induced liver damage[J].Proc Natl Acad Sci USA,2014,111(8):3176-3181.
[41]Kolisek M,Beck A,Fleig A,Penner R.Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels[J].Mol Cell,2005,18(1):61-69.
[42]Yamamoto S,Shimizu S,Mori Y.Involvement of TRPM2 channel in amplification of reactive oxygen species-induced signaling and chronic inflammation[J].Nihon Yakurigaku Zasshi,2009,134(3):122-126.
[43]Yamamoto S,Wajima T,Hara Y,Nishida M,Mori Y.Transient receptor potential channels in Alzheimer′s disease[J].Biochim Biophys Acta,2007,1772(8):958-967.
[44]Ostapchenko VG,Chen M,Guzman MS,Xie YF,Lavine N,Fan J,et al.The transient receptor potential melastatin 2(TRPM2)channel contributes toβ-amyloid oligomer-related neurotoxicity and memory impairment[J].J Neurosci,2015,35(45):15157-15169.
[45]Wang J,Jackson MF,Xie YF.Glia and TRPM2channels in plasticity of central nervous system and Alzheimer′s diseases[J].Neural Plast,2016:1680905.
[46]Mattson MP,Cheng B,Davis D,Bryant K,Lieberburg I,Rydel RE.beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity[J].J Neurosci,1992,12(2):376-389.
[47]O′Brien RJ,Wong PC.Amyloid precursor protein processing and Alzheimer′s disease[J].Annu Rev Neurosci,2011,34(1):185-204.
[48]Nunan J,Small DH.Regulation of APP cleavage by alpha-,beta-and gamma-secretases[J].FEBSLett,2000,483(1):6-10.
[49]Irvine GB,El-Agnaf OM,Shankar GM,Walsh DM.Protein aggregation in the brain:the molecular basis for Alzheimer′s and Parkinson′s diseases[J].Mol Med,2008,14(7-8):451-464.
[50]Lemere CA,Masliah E.Can Alzheimer disease be prevented by amyloid-beta immunotherapy?[J].Nat Rev Neurol,2010,6(2):108-119.
[51]Mosconi L,Berti V,Glodzik L,Pupi A,De Santi S,de Leon MJ.Pre-clinical detection of Alzheimer′s disease using FDG-PET,with or without amyloid imaging[J].J Alzheimers Dis,2010,20(3):843-854.
[52]Uttara B,Singh AV,Zamboni P,Mahajan RT.Oxidative stress and neurodegenerative diseases:a review of upstream and downstream antioxidant therapeutic options[J].Curr Neuropharmacol,2009,7(1):65-74.
[53]Gebicki JM.Oxidative stress,free radicals and protein peroxides[J].Arch Biochem Biophys,2016,595:33-39.
[54]Buelow B,Song Y,Scharenberg AM.The poly-(ADP-ribose)polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes[J].J Biol Chem,2008,283(36):24571-24583.
[55]Starkus J,Beck A,Fleig A,Penner R.Regulation of TRPM2 by extra-and intracellular calcium[J].J Gen Physiol,2007,130(4):427-440.
[56]Csanády L,T?rocsik B.Four Ca2+ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate[J].JGen Physiol,2009,133(2):189-203.
[57]Lange I,Penner R,Fleig A,Beck A.Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils[J].Cell Calcium,2008,44(6):604-615.
[58]Zhang Y,Qin W,Zhang L,Wu X,Du N,Hu Y,et al.Micro RNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis[J].Sci Rep,2015,5:9401.
[59]Timothy SK,Teng S,Stolie r AJ,Bolton JS,Fuhrman GM.Postmastectomy radiation in patients with four or more positive nodes[J].Am Surg,2002,68(6):539-544.
[60]Mattson MP,Duan W.″Apoptotic″biochemical cascades in synaptic compartments:roles in adaptive plasticity and neurodegenerative disorders[J].J Neurosci Res,1999,58(1):152-166.
[61]Kraft R,Grimm C,Grosse K,Hoffmann A,Sauerbruch S,Kettenmann H,et al.Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia[J].Am J Physiol Cell Physiol,2004,286(1):C129-C137.
[62]Hara Y,Wakamori M,Ishii M,Maeno E,Nishida M,Yoshida T,et al.LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death[J].Mol Cell,2002,9(1):163-173.
[63]Takahashi N,Kozai D,Kobayashi R,Ebert M,Mori Y.Roles of TRPM2 in oxidative stress[J].Cell Calcium,2011,50(3,SI):279-287.
[64]Knowles H,Li Y,Perraud AL.The TRPM2 ion channel,an oxidative stress and metabolic sensor regulating innate immunity and inflammation[J].Immunol Res,2013,55(1-3):241-248.
[65]Miyake T,Shirakawa H,Kusano A,Sakimoto S,Konno M,Nakagawa T,et al.TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia[J].Biochem Biophys Res Commun,2014,444(2):212-217.
[66]Zhong Z,Zhai Y,Liang S,Mori Y,Han R,Sutterwala FS,et al.TRPM2 links oxidative stress to NLRP3 inflammasome activation[J].Nat Commun,2013,4:1611.
[67]Haraguchi K,Kawamoto A,Isami K,Maeda S,Kusano A,Asakura K,et al.TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice[J].J Neurosci,2012,32(11):3931-3941.
[68]Isami K,Haraguchi K,So K,Asakura K,Shirakawa H,Mori Y,et al.Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model[J].PLo S One,2013,8(7):e66410.
[69]So K,Haraguchi K,Asakura K,Isami K,Sakimoto S,Shirakawa H,et al.Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models[J].J Pharmacol Sci,2015,127(3):237-243.
[70]Fonfria E,Marshall IC,Boyfield I,Skaper SD,Hughes JP,Owen DE,et al.Amyloid betapeptide(1-42)and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures[J].J Neurochem,2005,95(3):715-723.
[71]Hill K,Mcnulty S,Randall AD.Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole[J].Naunyn Schmiedebergs Arch Pharmacol,2004,370(4):227-237.
[72]Ullrich ND,Voets T,Prenen J,Vennekens R,Talavera K,Droogmans G,et al.Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice[J].Cell Calcium,2005,37(3):267-278.
[73]Kraft R,Harteneck C.The mammalian melastatinrelated transient receptor potential cation channels:an overview[J].Pflugers Arch,2005,451(1):204-211.
[74]Inoue R,Okada T,Onoue H,Hara Y,Shimizu S,Naitoh S,et al.The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha1-adrenoceptoractivated Ca2+-permeable cation channel[J].Circ Res,2001,88(3):325-332.
[75]Eisfeld J,Luckhoff A.TRPM2[M]//Rosenthal W,ed.Transient Receptor Potential(TRP)Channels.Springer Berlin Heidelberg,2007:237-252.
[76]Maruyama T,Kanaji T,Nakade S,Kanno T,Mikoshiba K.2APB,2-aminoethoxydiphenyl borate,a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+release[J].J Biochem,1997,122(3):498-505.
[77]Togashi K,Inada H,Tominaga M.Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate(2-APB)[J].Br J Pharmacol,2008,153(6):1324-1330.
[78]Halaszovich CR,Zitt C,Jungling E,Luckhoff A.Inhibition of TRP3 channels by lanthanides.Block from the cytosolic side of the plasma membrane[J].J Biol Chem,2000,275(48):37423-37428.
[79]Tousova K,Vyklicky L,Susankova K,Benedikt J,Vlachova V.Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites[J].Mol Cell Neurosci,2005,30(2):207-217.
[80]Zeng B,Chen GL,Xu SZ.Divalent copper is a potent extracellular blocker for TRPM2 channel[J].Biochem Biophys Res Commun,2012,424(2):279-284.
[81]Shimizu S,Yonezawa R,Hagiwara T,Yoshida T,Takahashi N,Hamano S,et al.Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+entry[J].Eur J Pharmacol,2014,742:22-30.
[82]Naziroglu M,Lückhoff A.A calcium influx pathway regulated separately by oxidative stress and ADP-ribose in TRPM2 channels:single channel events[J].Neurochem Res,2008,33(7):1256-1262.
[83]Rosenbaum T.Activators of TRPM2:getting it right[J].J Gen Physiol,2015,145(6):485-487.
[84]Tóth B,Iordanov I,Csanády L.Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate[J].J Gen Physiol,2015,145(5):419-430.
[2]Irie S,Furukawa T.TRPM1[J].Handb Exp Pharmacol,2014,222:387-402.
[3]Hofmann T,Schaefer M,Schultz G,Gudermann T.Transient receptor potential channels as molecular substrates of receptor-mediated cation entry[J].J Mol Med(Berl),2000,78(1):14-25.
[4]Minke B.The history of the Drosophila TRP Channel:the birth of a new Channel superfamily[J].JNeurogenet,2010,24(4):216-233.
[5]Nilius B,Flockerzi V.Mammalian transient receptor potential(TRP)cation channels.Preface[J].Handb Exp Pharmacol,2014,223:v-vi.
[6]Montell C,Rubin GM.Molecular characterization of the Drosophila TRP locus:a putative integral membrane protein required for phototransduction[J].Neuron,1989,2(4):1313-1323.
[7]Huang CL.The transient receptor potential superfamily of ion channels[J].J Am Soc Nephrol,2004,15(7):1690-1699.
[8]Bouron A,Kiselyov K,Oberwinkler J.Permeation,regulation and control of expression of TRP channels by trace metal ions[J].Pflugers Arch,2015,467(6):1143-1164.
[9]Gees M,Colsoul B,Nilius B.The role of transient receptor potential cation channels in Ca2+signaling[J].Cold Spring Harb Perspect Biol,2010,2(10):a003962.
[10]Clapham DE,Runnels LW,Strübing C.The TRPion channel family[J].Nat Rev Neurosci,2001,2(6):387-396.
[11]Benemei S,De Cesaris F,Fusi C,Rossi E,Lupi C,Geppetti P.TRPA1 and other TRP channels in migraine[J].J Headache Pain,2013,14:71.
[12]Pan Z,Yang H,Reinach PS.Transient receptor potential(TRP)gene superfamily encoding cation channels[J].Hum Genomics,2011,5(2):108-116.
[13]Hellmich UA,Gaudet R.Structural biology of TRPchannels[J].Handb Exp Pharmacol,2014,223:963-990.
[14]Li M,Yu Y,Yang J.Structural biology of TRPchannels[J].Adv Exp Med Biol,2011,704:1-23.
[15]Morelli MB,Amantini C,Liberati S,Santoni M,Nabissi M.TRP channels:new potential therapeutic approaches in CNS neuropathies[J].CNSNeurol Disord Drug Targets,2013,12(2):274-293.
[16]Zheng J.Molecular mechanism of TRP channels[J].Compr Physiol,2013,3(1):221-242.
[17]Uchida K,Dezaki K,Damdindorj B,Inada H,Shiuchi T,Mori Y,et al.Lack of TRPM2impaired insulin secretion and glucose metabolisms in mice[J].Diabetes,2011,60(1):119-126.
[18]Oberwinkler J,Philipp SE.TRPM3[J].Handb Exp Pharmacol,2007,179:253-267.
[19]Vriens J,Owsianik G,Hofmann T,Philipp SE,Stab J,Chen X,et al.TRPM3 is a nociceptor channel involved in the detection of noxious heat[J].Neuron,2011,70(3):482-494.
[20]Oberwinkler J,Philipp SE.TRPM3[J].Handb Exp Pharmacol,2014,222:427-459.
[21]Quallo T,Vastani N,Horridge E,Gentry C,Parra A,Moss S,et al.TRPM8 is a neuronal osmosensor that regulates eye blinking in mice[J].Nat Commun,2015,6:7150.
[22]Yee NS.Roles of TRPM8 ion channels in cancer:proliferation,survival,and invasion[J].Cancers(Basel),2015,7(4):2134-2146.
[23]Cheng H,Beck A,Launay P,Gross SA,Stokes AJ,Kinet JP,et al.TRPM4 controls insulin secretion in pancreatic beta cells[J].Cell Calcium,2007,41(1):51-61.
[24]Roper SD.TRPs in taste and chemesthesis[J].Handb Exp Pharmacol,2014,223:827-871.
[25]van der Wijst J,Bindels RJ,Hoenderop JG.Mg2+homeostasis:the balancing act of TRPM6[J].Curr Opin Nephrol Hypertens,2014,23(4):361-369.
[26]Sun HS,Jackson MF,Martin LJ,Jansen K,Teves L,Cui H,et al.Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia[J].Nat Neurosci,2009,12(10):1300-1307.
[27]Chen W,Xu B,Xiao A,Liu L,Fang X,Liu R,et al.TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury[J].Mol Brain,2015,8:11.
[28]Turlova E,Bae CY,Deurloo M,Chen W,Barszczyk A,Horgen FD,et al.TRPM7 regulates axonal outgrowth and maturation of primary hippocampal neurons[J].Mol Neurobiol,2016,53(1):595-610.
[29]Xie YF,Macdonald JF,Jackson MF.TRPM2,Calcium and neurodegenerative diseases[J].Int J Physiol Pathophysiol Pharmacol,2010,2(2):95-103.
[30]Maqbool M,Mobashir M,Hoda N.Pivotal role of glycogen synthase kinase-3:A therapeutic target for Alzheimer′s disease[J].Eur J Med Chem,2016,107:63-81.
[31]Sumoza-Toledo A,Penner R.TRPM2:a multifunctional ion channel for calcium signalling[J].JPhysiol,2011,589(Pt 7):1515-1525.
[32]Belrose JC,Xie YF,Gierszewski LJ,Macdonald JF,Jackson MF.Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons[J].Mol Brain,2012,5:11.
[33]Rempe DA,Takano T,Nedergaard M.TR(I)Pping towards treatment for ischemia[J].Nat Neurosci,2009,12(10):1215-1216.
[34]Tóth B,Iordanov I,Csanády L.Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating[J].Proc Natl Acad Sci USA,2014,111(47):16949-16954.
[35]Uemura T,Kudoh J,Noda S,Kanba S,Shimizu N.Characterization of human and mouse TRPM2genes:identification of a novel N-terminal truncated protein specifically expressed in human striatum[J].Biochem Biophys Res Commun,2005,328(4):1232-1243.
[36]Gelderblom M,Melzer N,Schattling B,G?b E,Hicking G,Arunachalam P,et al.Transient receptor potential melastatin subfamily member 2 cation channel regulates detrimental immune cel invasion in ischemic stroke[J].Stroke,2014,45(11):3395-3402.
[37]Tong Q,Zhang W,Conrad K,Mostoller K,Cheung JY,Peterson BZ,et al.Regulation of the transient receptor potential channel TRPM2 by the Ca2+sensor calmodulin[J].J Biol Chem,2006,281(14):9076-9085.
[38]Sano Y,Inamura K,Miyake A,Mochizuki S,Yokoi H,Matsushime H,et al.Immunocyte Ca2+influx system mediated by LTRPC2[J].Science,2001,293(5533):1327-1330.
[39]Mchugh D,Flemming R,Xu SZ,Perraud AL,Beech DJ.Critical intracellular Ca2+dependence of transient receptor potential melastatin 2(TRPM2)cation channel activation[J].J Biol Chem,2003,278(13):11002-11006.
[40]Kheradpezhouh E,Ma L,Morphett A,Barritt GJ,Rychkov GY.TRPM2 channels mediate acetaminophen-induced liver damage[J].Proc Natl Acad Sci USA,2014,111(8):3176-3181.
[41]Kolisek M,Beck A,Fleig A,Penner R.Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels[J].Mol Cell,2005,18(1):61-69.
[42]Yamamoto S,Shimizu S,Mori Y.Involvement of TRPM2 channel in amplification of reactive oxygen species-induced signaling and chronic inflammation[J].Nihon Yakurigaku Zasshi,2009,134(3):122-126.
[43]Yamamoto S,Wajima T,Hara Y,Nishida M,Mori Y.Transient receptor potential channels in Alzheimer′s disease[J].Biochim Biophys Acta,2007,1772(8):958-967.
[44]Ostapchenko VG,Chen M,Guzman MS,Xie YF,Lavine N,Fan J,et al.The transient receptor potential melastatin 2(TRPM2)channel contributes toβ-amyloid oligomer-related neurotoxicity and memory impairment[J].J Neurosci,2015,35(45):15157-15169.
[45]Wang J,Jackson MF,Xie YF.Glia and TRPM2channels in plasticity of central nervous system and Alzheimer′s diseases[J].Neural Plast,2016:1680905.
[46]Mattson MP,Cheng B,Davis D,Bryant K,Lieberburg I,Rydel RE.beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity[J].J Neurosci,1992,12(2):376-389.
[47]O′Brien RJ,Wong PC.Amyloid precursor protein processing and Alzheimer′s disease[J].Annu Rev Neurosci,2011,34(1):185-204.
[48]Nunan J,Small DH.Regulation of APP cleavage by alpha-,beta-and gamma-secretases[J].FEBSLett,2000,483(1):6-10.
[49]Irvine GB,El-Agnaf OM,Shankar GM,Walsh DM.Protein aggregation in the brain:the molecular basis for Alzheimer′s and Parkinson′s diseases[J].Mol Med,2008,14(7-8):451-464.
[50]Lemere CA,Masliah E.Can Alzheimer disease be prevented by amyloid-beta immunotherapy?[J].Nat Rev Neurol,2010,6(2):108-119.
[51]Mosconi L,Berti V,Glodzik L,Pupi A,De Santi S,de Leon MJ.Pre-clinical detection of Alzheimer′s disease using FDG-PET,with or without amyloid imaging[J].J Alzheimers Dis,2010,20(3):843-854.
[52]Uttara B,Singh AV,Zamboni P,Mahajan RT.Oxidative stress and neurodegenerative diseases:a review of upstream and downstream antioxidant therapeutic options[J].Curr Neuropharmacol,2009,7(1):65-74.
[53]Gebicki JM.Oxidative stress,free radicals and protein peroxides[J].Arch Biochem Biophys,2016,595:33-39.
[54]Buelow B,Song Y,Scharenberg AM.The poly-(ADP-ribose)polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes[J].J Biol Chem,2008,283(36):24571-24583.
[55]Starkus J,Beck A,Fleig A,Penner R.Regulation of TRPM2 by extra-and intracellular calcium[J].J Gen Physiol,2007,130(4):427-440.
[56]Csanády L,T?rocsik B.Four Ca2+ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate[J].JGen Physiol,2009,133(2):189-203.
[57]Lange I,Penner R,Fleig A,Beck A.Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils[J].Cell Calcium,2008,44(6):604-615.
[58]Zhang Y,Qin W,Zhang L,Wu X,Du N,Hu Y,et al.Micro RNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis[J].Sci Rep,2015,5:9401.
[59]Timothy SK,Teng S,Stolie r AJ,Bolton JS,Fuhrman GM.Postmastectomy radiation in patients with four or more positive nodes[J].Am Surg,2002,68(6):539-544.
[60]Mattson MP,Duan W.″Apoptotic″biochemical cascades in synaptic compartments:roles in adaptive plasticity and neurodegenerative disorders[J].J Neurosci Res,1999,58(1):152-166.
[61]Kraft R,Grimm C,Grosse K,Hoffmann A,Sauerbruch S,Kettenmann H,et al.Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia[J].Am J Physiol Cell Physiol,2004,286(1):C129-C137.
[62]Hara Y,Wakamori M,Ishii M,Maeno E,Nishida M,Yoshida T,et al.LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death[J].Mol Cell,2002,9(1):163-173.
[63]Takahashi N,Kozai D,Kobayashi R,Ebert M,Mori Y.Roles of TRPM2 in oxidative stress[J].Cell Calcium,2011,50(3,SI):279-287.
[64]Knowles H,Li Y,Perraud AL.The TRPM2 ion channel,an oxidative stress and metabolic sensor regulating innate immunity and inflammation[J].Immunol Res,2013,55(1-3):241-248.
[65]Miyake T,Shirakawa H,Kusano A,Sakimoto S,Konno M,Nakagawa T,et al.TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia[J].Biochem Biophys Res Commun,2014,444(2):212-217.
[66]Zhong Z,Zhai Y,Liang S,Mori Y,Han R,Sutterwala FS,et al.TRPM2 links oxidative stress to NLRP3 inflammasome activation[J].Nat Commun,2013,4:1611.
[67]Haraguchi K,Kawamoto A,Isami K,Maeda S,Kusano A,Asakura K,et al.TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice[J].J Neurosci,2012,32(11):3931-3941.
[68]Isami K,Haraguchi K,So K,Asakura K,Shirakawa H,Mori Y,et al.Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model[J].PLo S One,2013,8(7):e66410.
[69]So K,Haraguchi K,Asakura K,Isami K,Sakimoto S,Shirakawa H,et al.Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models[J].J Pharmacol Sci,2015,127(3):237-243.
[70]Fonfria E,Marshall IC,Boyfield I,Skaper SD,Hughes JP,Owen DE,et al.Amyloid betapeptide(1-42)and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures[J].J Neurochem,2005,95(3):715-723.
[71]Hill K,Mcnulty S,Randall AD.Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole[J].Naunyn Schmiedebergs Arch Pharmacol,2004,370(4):227-237.
[72]Ullrich ND,Voets T,Prenen J,Vennekens R,Talavera K,Droogmans G,et al.Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice[J].Cell Calcium,2005,37(3):267-278.
[73]Kraft R,Harteneck C.The mammalian melastatinrelated transient receptor potential cation channels:an overview[J].Pflugers Arch,2005,451(1):204-211.
[74]Inoue R,Okada T,Onoue H,Hara Y,Shimizu S,Naitoh S,et al.The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha1-adrenoceptoractivated Ca2+-permeable cation channel[J].Circ Res,2001,88(3):325-332.
[75]Eisfeld J,Luckhoff A.TRPM2[M]//Rosenthal W,ed.Transient Receptor Potential(TRP)Channels.Springer Berlin Heidelberg,2007:237-252.
[76]Maruyama T,Kanaji T,Nakade S,Kanno T,Mikoshiba K.2APB,2-aminoethoxydiphenyl borate,a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+release[J].J Biochem,1997,122(3):498-505.
[77]Togashi K,Inada H,Tominaga M.Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate(2-APB)[J].Br J Pharmacol,2008,153(6):1324-1330.
[78]Halaszovich CR,Zitt C,Jungling E,Luckhoff A.Inhibition of TRP3 channels by lanthanides.Block from the cytosolic side of the plasma membrane[J].J Biol Chem,2000,275(48):37423-37428.
[79]Tousova K,Vyklicky L,Susankova K,Benedikt J,Vlachova V.Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites[J].Mol Cell Neurosci,2005,30(2):207-217.
[80]Zeng B,Chen GL,Xu SZ.Divalent copper is a potent extracellular blocker for TRPM2 channel[J].Biochem Biophys Res Commun,2012,424(2):279-284.
[81]Shimizu S,Yonezawa R,Hagiwara T,Yoshida T,Takahashi N,Hamano S,et al.Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+entry[J].Eur J Pharmacol,2014,742:22-30.
[82]Naziroglu M,Lückhoff A.A calcium influx pathway regulated separately by oxidative stress and ADP-ribose in TRPM2 channels:single channel events[J].Neurochem Res,2008,33(7):1256-1262.
[83]Rosenbaum T.Activators of TRPM2:getting it right[J].J Gen Physiol,2015,145(6):485-487.
[84]Tóth B,Iordanov I,Csanády L.Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate[J].J Gen Physiol,2015,145(5):419-430.