YWHAE在大肠癌中的表达及临床意义
摘要
<正>酪氨酸3-单加氧酶/色氨酸5-单加氧酶活化蛋白(YWHAE),也称为14-3-3ε是14-3-3家庭的成员。这个家族的成员是约30kDa酸性多肽,具有高度调节多种细胞功能的保守序列,包括细胞周期调节、信号转导、粘附和恶性转化~([1])。14-3-3蛋白是真核生物体内存在的可溶性酸性蛋白,它通过与靶蛋
引文
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[6]Yan L,Gu H,Li J,et al.RKIP and 14-3-3εexert an opposite effect on human gastric cancer cells SGC7901by regulating the ERK/MAPKpathway differently[J].Dig Dis Sci,2013,58(2):389.
[7]Liu TA,JanYJ,KoBS,et al.14-3-3εoverexpression contributes to epithelial-mesenchymal transition of hepatocellular carcinoma[J].PLoS One,2013,8(3):e57968.
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[9]Leal MF,Ribeiro HF,Rey JA,et al.YWHAE silencing induces cell proliferation,invasion and migration through the up-regulation of CDC25Band MYC in gastric cancer cells:new insights about YWHAE role in the tumor development and metastasis process[J].Oncotarget,2016,7(51):85393.
[10]Yan L,Gu H,Li J,et al.RKIP and 14-3-3εExert an Opposite Effect on Human Gastric Cancer Cells SGC7901by Regulating the ERK/MAPK Pathway Differently[J].Digestive Diseases and Sciences,2013,58(2):389.
[11]Noor A,BogatanS,Watkins N,et al.Disruption of YWHAEgene at 17p13.3causes learning disabilities and brain abnormalities[J].Clinical Genetics,2018,93(2):365.
[2]Qian Chen X,Cheung Hoi Yu A.The association of 14-3-3γand actin plays a role in cell division and apoptosis in astrocytes[J].Biochemical and Biophysical Research Communications,2002,296(3):657.
[3]Martin H,Rostas J,Patel Y,et al.Subcellularlocalisation of 14-3-3isoforms in rat brain using specific antibodies[J].J Neurochem,1994,63(6):2259.
[4]杨建军,秦环龙.14-3-3蛋白与肿瘤发生发展的研究进展[J].世界华人消化杂志,2010,18(28):2997.
[5]Zhang X,Zeng B,Wen C,et al.YWHAE is a novel interaction partner of Helicobacter pylori CagA[J].FEMS Microbiol Lett,2018,365(2).doi:10.1093/femsle/fnx231.
[6]Yan L,Gu H,Li J,et al.RKIP and 14-3-3εexert an opposite effect on human gastric cancer cells SGC7901by regulating the ERK/MAPKpathway differently[J].Dig Dis Sci,2013,58(2):389.
[7]Liu TA,JanYJ,KoBS,et al.14-3-3εoverexpression contributes to epithelial-mesenchymal transition of hepatocellular carcinoma[J].PLoS One,2013,8(3):e57968.
[8]Liang S,Xu Y,Shen G,et al.Quantitative protein expression profiling of 14-3-3isoforms in human renal carcinoma shows 14-3-3epsilon is involved in limitedly increasing renal cell proliferation[J].Electrophoresis,2009,30(23):4152.
[9]Leal MF,Ribeiro HF,Rey JA,et al.YWHAE silencing induces cell proliferation,invasion and migration through the up-regulation of CDC25Band MYC in gastric cancer cells:new insights about YWHAE role in the tumor development and metastasis process[J].Oncotarget,2016,7(51):85393.
[10]Yan L,Gu H,Li J,et al.RKIP and 14-3-3εExert an Opposite Effect on Human Gastric Cancer Cells SGC7901by Regulating the ERK/MAPK Pathway Differently[J].Digestive Diseases and Sciences,2013,58(2):389.
[11]Noor A,BogatanS,Watkins N,et al.Disruption of YWHAEgene at 17p13.3causes learning disabilities and brain abnormalities[J].Clinical Genetics,2018,93(2):365.