摘要
目的评价A型肉毒毒素(BTX-A)防治增生性瘢痕的疗效。方法计算机检索pubmed文献数据库、中国知网中文数据库、万方数据库。收集所有使用A型肉毒毒素注射治疗增生性瘢痕的相关文献,进行Meta分析,以进行系统评价。结果共纳入8个随机对照试验518例患者。目前Meta分析结果显示:1 BTX-A组与对照组的温哥华瘢痕量表评分无统计学差异(Z=0.57,P>0.05)。2 BTX-A组患者满意率高于对照组(Z=4.59,P<0.01)。3BTX-A组视觉模拟量表得分高于对照组(Z=9.40,P<0.01)。4BTX-A组的瘢痕宽度小于对照组(Z=4.91,P<0.01)。结论 A型肉毒毒素注射治疗增生性瘢痕有一定的疗效,无明显的副作用,但其治疗效果的确切性和稳定性仍需更多高质量的研究验证。
Objective To systematically evaluate the curative effect of botulinum toxin type A curing the hypertrophic scar.Methods Used computer to search Pub Med literature database, China hownet database in Chinese and wanfang database,to collect all the relevant clinical reports of using BTX-A improve the hypertrophic scar,then using the Meta analysis to evaluate the system. Results Participants included eight randomized controlled trial of 518 patients.(1)the vancouver scar scale score have no significant difference between BTX-A group and the control group(Z=0.57,P >0.05).(2) patients satisfaction rate of BTX-A group is higher than the control group( Z=4.59,P <0.01).(3) the visual analogue scale score of BTX- A group is higher than the control group(Z=9.40,P <0.01).(4) the scar width of BTX-A group is less than the control group(Z=4.91,P <0.01).Conclusion The injection treatment of BTX-A for hyperplastic scar has certain curative effect,without obvious side effects, but the authenticity and stability of therapeutic effect has to be verified by more high quality research.
引文
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