摘要
气管的一些良性或恶性病变从理论上说是可以通过简单的手术切除,并将断端进行端端吻合来治疗的。然而这仅限于病损长度不超过成人气管长度的50%、小孩气管长度的30%。对大多患者而言,可以进行气管移植替代。然而气管移植有诸多问题有待解决,例如免疫排斥、再血管化、感染、肉芽组织增生等方面的问题。本文主要针对如何用不同的降低免疫排斥反应的方法来阐述免疫排斥反应在同种异体气管移植物领域的研究进展及应用现状。
A variety of benign and malignant disorders affecting the trachea can theoretically be treated by simple resection and subsequent end-to-end anastomosis of remained trachea. Unfortunately, it is feasible only when the affected tracheal length does not exceed 50% of the entire length in adults and about 30% in children. Tracheal transplantation may be a treatment option for those patients, but still has many problems to be solved, such as immunological rejection, revascularization, infection and granulation tissue hyperplasia. This review focuses on how to use different methods to inhibit immunological rejection of tracheal transplantation, and current research progress of immunological rejection in tracheal allograft.
引文
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