三种检查方法在宫颈癌筛查中的应用效果对比及诊断效能研究
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摘要
目的探究TCT、DNA及涂片3种检查方法在宫颈癌筛查中的应用效果对比及诊断效能。方法将到本院进行宫颈癌检查的150例妇女作为本次研究对象,对其先后进行传统巴氏涂片细胞学检查、薄层液基细胞学检查(TCT)、细胞DNA定量分析技术检查,以病理学检查结果为准,比较3种检查方法的检出率、准确率、灵敏度、特异度。结果 DNA法筛查宫颈癌的检出率、准确率、灵敏度、特异性均比TCT法及涂片法高,除DNA与TCT的特异性外,其他数据比较差异有统计学意义(P<0.05)。结论相比于TCT法及涂片法,使用DNA法检测宫颈癌的诊断价值更高,值得临床大力推广。
Objective To explore the comparison and diagnostic efficacy of TCT, DNA and smear in cervical cancer screening. Methods 150 women who had been examined for cervical cancer in our hospital were examined by traditional Pap smear cytology, thin-layer liquid-based cytology, DNA quantitative analysis of(TCT), cells, and the results were compared with those of normal Pap smear cytology and thin-layer liquid-based cytology. The detection rate, accuracy, sensitivity and specificity of the three methods were compared. Results The detection rate, accuracy, sensitivity and specificity of DNA method for cervical cancer screening were higher than those of TCT method and smear method, in addition to the specificity of DNA and TCT, other data were statistically significant(P<0.05). Conclusion Compared with TCT and Smear method, the use of DNA method in the detection of cervical cancer is of higher value and is worthy of clinical popularization.
Objective To explore the comparison and diagnostic efficacy of TCT, DNA and smear in cervical cancer screening. Methods 150 women who had been examined for cervical cancer in our hospital were examined by traditional Pap smear cytology, thin-layer liquid-based cytology, DNA quantitative analysis of(TCT), cells, and the results were compared with those of normal Pap smear cytology and thin-layer liquid-based cytology. The detection rate, accuracy, sensitivity and specificity of the three methods were compared. Results The detection rate, accuracy, sensitivity and specificity of DNA method for cervical cancer screening were higher than those of TCT method and smear method, in addition to the specificity of DNA and TCT, other data were statistically significant(P<0.05). Conclusion Compared with TCT and Smear method, the use of DNA method in the detection of cervical cancer is of higher value and is worthy of clinical popularization.
引文
[1]顾颖.TCT检查对宫颈病变筛查的意义[J].临床医药文献电子杂志,2018,5(56):144.
[2]张云清,尹香利,韩慧慧,等.TCT与DNA倍体分析对早期宫颈癌联合筛查的临床研究[J].中国医刊,2018,53(5):550-553.
[3]李晓燕.液基薄层细胞学检查在宫颈病变病理诊断中的意义[J].临床医学研究与实践,2018,3(1):137-138.
[4]张喆,孔令婷,孙寒雪,等.细胞DNA定量分析在宫颈病变筛查中的应用价值[J].中国医科大学学报,2017,46(11):1013-1018.
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[2]张云清,尹香利,韩慧慧,等.TCT与DNA倍体分析对早期宫颈癌联合筛查的临床研究[J].中国医刊,2018,53(5):550-553.
[3]李晓燕.液基薄层细胞学检查在宫颈病变病理诊断中的意义[J].临床医学研究与实践,2018,3(1):137-138.
[4]张喆,孔令婷,孙寒雪,等.细胞DNA定量分析在宫颈病变筛查中的应用价值[J].中国医科大学学报,2017,46(11):1013-1018.
[5]贾惠,翟红岩,冯燕,等.DNA倍体定量分析在宫颈癌筛查中的临床应用研究[J].中国临床医生杂志,2017,45(9):94-96.
[6]侯卫健.TCT与巴氏细胞学在宫颈癌筛查中的临床比较观察[J].实用妇科内分泌杂志(电子版),2016,3(21):130,132.
[7]陈丽艳.DNA倍体定量分析联合TCT在宫颈癌筛查中的应用[J].中国医药指南,2016,14(9):169-170.
[8]杨静.600例体检育龄妇女TCT筛查宫颈癌病变的流行病学调查[J].当代医学,2015,21(29):159-160.
[9]孙立芳.TCT在妇女宫颈癌预防和普查中的应用价值[J].当代医学,2014,20(24):58-59.
[10]黄爱英.妇科检查中薄层细胞学与宫颈涂片检查的临床效果对比[J].当代医学,2014,20(14):100-101.
[11]郅辉.细胞DNA定量分析技术应用于宫颈癌筛查的临床研究[J].中国医药指南,2016,14(4):135.