E2F1在肿瘤中的研究进展
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摘要
E2F1是E2F转录因子家族的重要一员,参与人体生命活动中重要的细胞周期和细胞凋亡环节,E2F1促进S期的细胞增多,同时通过p53依赖和非依赖途径诱导细胞凋亡。近来研究显示,E2F1在多种肿瘤如肺癌、前列腺癌、乳腺癌等组织细胞中呈高表达,表现为促癌基因的作用,其表达水平与肿瘤的发生、发展及预后密切相关。本文结合国内外最新研究报道,对E2F1在肿瘤中的研究进展作一综述。
E2 F1 is an important member of the E2 F transcription factor family,involved in important cell cycle and apoptosis in human life activities.E2 F1 promotes S-phase cell proliferation and induces apoptosis through p53-dependent and non-dependent pathways.Recent studies have shown that E2 F1 is highly expressed in various tumor cells such as lung cancer,prostate cancer,breast cancer and so on,which is a function of oncogenes,and its expression level is closely related to tumor occurrence,development and prognosis.This article summarizes the research progress of E2 F1 in tumors in combination with the latest research reports at home and abroad.
E2 F1 is an important member of the E2 F transcription factor family,involved in important cell cycle and apoptosis in human life activities.E2 F1 promotes S-phase cell proliferation and induces apoptosis through p53-dependent and non-dependent pathways.Recent studies have shown that E2 F1 is highly expressed in various tumor cells such as lung cancer,prostate cancer,breast cancer and so on,which is a function of oncogenes,and its expression level is closely related to tumor occurrence,development and prognosis.This article summarizes the research progress of E2 F1 in tumors in combination with the latest research reports at home and abroad.
引文
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[22] Qi P,Lin WR,Zhang M,et al.E2F1 induces LSINCT5 transcriptional activity and promotes gastric cancer progression by affecting the epithelial-mesenchymal transition[J].Cancer Manag Res,2018,10:2563-2571.
[23] Zhang X,Ni Z,Duan Z,et al.Overexpression of E2F mRNAs associated with gastric cancer progression identified by the transcription factor and miRNA co-regulatory network analysis[J].PLoS One,2015,10(2):e0116979.
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[25] Chen LM,Kang YN,Cheng HP,et al.Expression and significance of HOXB9 and E2F1 in colon cancer[J].Chongqing Medical Journal,2016,45(15):2104-2106.[陈丽梅,康颖娜,程红平,等.HOXB9和E2F1在结肠癌中的表达及其意义[J].重庆医学,2016,45(15):2104-2106.]
[26] Fang Z,Gong C,Yu S,et al.NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling[J].Cancer Lett,2018,415:58-72.
[27] Fenner F,Goody D,Protzel C,et al.E2F1 signalling is predictive of chemoresistance and lymphogenic metastasis in penile cancer:A pilot functional study reveals new prognostic biomarkers[J].Eur Urol Focus,2017,4(4):599-607.
[28] Farra R,Farra R,Grassi G,et al.The role of the transcription factor E2F1 in hepatocellular carcinoma[J].Curr Drug Deliv,2017,14(2):272-281.
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[2] Ogawa H,Ishiguro K,Gaubatz S,et al.A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells[J].Science,2002,296(5570):1132-1136.
[3] Helin K,Lees JA,Vidal M,et al.A cDNA encoding a pRb-binding protein with properties of the transcription factor E2F[J].Cell,1992,70(2):337-350.
[4] Xu MJ,Huang Y,Xie GR,et al.Research progress of E2F1 and tumor metabolic reprogramming[J].Journal of Practical Medicine,2014,30(23):3858-3860.[徐梦婕,黄耀,谢国然,等.E2F1与肿瘤代谢重编程的研究进展[J].实用医学杂志,2014,30(23):3858-3860.]
[5] Bell LA,Ryan KM.Life and death decisions by E2F-1[J].Cell Death and Differentiation,2003,11(2):137-142.
[6] Wang N,Wu Y,Zeng N,et al.E2F1 hinders skin wound healing by repressing vascular endothelial growth factor (VEGF) expression,neovascularization,and macrophage recruitment[J].PLoS One,2016,11(8):e0160411.
[7] Wang T,Cheng X,Qiao W,et al.Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer[J].BMC Cancer,2017,17(1):719.
[8] Liang YX,Lu JM,Mo RJ,et al.E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer[J].Int J Oncol,2016,48(4):1650-1658.
[9] Li Yunhai,Huang Jing,Yang Dejuan,et al.Expression patterns of E2F transcription factors and their potential prognostic roles in breast cancer[J].Oncology Letters,2018,15(6):9216-9230.
[10] Xu TP,Wang YF,Xiong WL,et al.E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis[J].Cell Death and Disease,2017,8(6):e2837.
[11] Yin Yanwei,Jin Hongjian,Zhao Wenjing,et al.The histone acetyltransferase GCN5 expression is elevated and regulated by c-Myc and E2F1 Transcription factors in human colon cancer[J].Gene Expression,2015,16(4):187-196.
[12] Fu D,Zhang Y,Cui H,et al.Long noncoding RNA CCAT2 is activated by E2F1 and exerts oncogenic properties by interacting with PTTG1 in pituitary adenomas[J].Am J Cancer Res,2018,8(2):245-255.
[13] Rocca MS,Di Nisio A,Marchiori A,et al.Copy number variations of E2F1:A new genetic risk factor for testicular cancer[J].Endocr Relat Cancer,2017,24(3):119-125.
[14] Lee SR,Roh YG,Kim SK,et al.Activation of EZH2 and SUZ12 regulated by E2F1 predicts the disease rrogression and aggressive characteristics of bladder cancer[J].Clin Cancer Res,2015,21(23):5391-5403.
[15] Li Z,Guo Y,Jiang H,et al.Differential regulation of MMPs by E2F1,Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype[J].Cancer,2014,14(1):276.
[16] Sun CC,Zhou Q,Hu W,et al.Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma[J].Aging (Albany NY),2018,10(5):973-987.
[17] Bi XC,Pu XY,Liu JM,et al.Effects of transcription factor E2F1 expression on invasion ability of prostate cancer cells[J].Chinese Journal of Medicine,2017,97(36):2856-2859.[毕学成,蒲小勇,刘久敏,等.转录因子E2F1表达对前列腺癌细胞侵袭能力的影响[J].中华医学杂志,2017,97(36):2856-2859.]
[18] Pertega-Gomes,Vizcaino JR,Miranda-Goncalves V,et al.Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer[J].BMC Cancer,2011,11:312.
[19] Ren Z,Kang W,Wang L,et al.E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-kappaB modulation[J].Mol Cancer,2014,13:84.
[20] Hallett RM,Hassell JA.E2F1 and KIAA0191 expression predicts breast cancer patient survival[J].BMC Research Notes,2011,4(1):95.
[21] Wang HK,Zheng HX,Liang JF,et al.Expression and clinical significance of ECT2 and E2F1 proteins in breast cancer[J].Journal of Shanxi Medical University,2017,8(26):852-855.[王宏坤,郑绘霞,梁建芳,等 ECT2和E2F1蛋白在乳腺癌中的表达及临床意义[J].山西医科大学学报,2017,8(26):852-855.]
[22] Qi P,Lin WR,Zhang M,et al.E2F1 induces LSINCT5 transcriptional activity and promotes gastric cancer progression by affecting the epithelial-mesenchymal transition[J].Cancer Manag Res,2018,10:2563-2571.
[23] Zhang X,Ni Z,Duan Z,et al.Overexpression of E2F mRNAs associated with gastric cancer progression identified by the transcription factor and miRNA co-regulatory network analysis[J].PLoS One,2015,10(2):e0116979.
[24] Guo X,Guo L,Ji J,et al.miRNA-331-3p directly targets E2F1 and induces growth arrest in human gastric cancer[J].Biochem Biophys Res Commun,2010,398(1):1-6.
[25] Chen LM,Kang YN,Cheng HP,et al.Expression and significance of HOXB9 and E2F1 in colon cancer[J].Chongqing Medical Journal,2016,45(15):2104-2106.[陈丽梅,康颖娜,程红平,等.HOXB9和E2F1在结肠癌中的表达及其意义[J].重庆医学,2016,45(15):2104-2106.]
[26] Fang Z,Gong C,Yu S,et al.NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling[J].Cancer Lett,2018,415:58-72.
[27] Fenner F,Goody D,Protzel C,et al.E2F1 signalling is predictive of chemoresistance and lymphogenic metastasis in penile cancer:A pilot functional study reveals new prognostic biomarkers[J].Eur Urol Focus,2017,4(4):599-607.
[28] Farra R,Farra R,Grassi G,et al.The role of the transcription factor E2F1 in hepatocellular carcinoma[J].Curr Drug Deliv,2017,14(2):272-281.
[29] Kent LN,Bae S,Tsai SY,et al.Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma[J].J Clin Invest,2017,127(3):830-842.