Antibiotic resistance of Neisseria species in Iran: A systematic review and meta-analysis
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摘要
Objective: To estimate the prevalence of antibiotic resistance of Neisseria species in Iran. Methods: A systematic and electronic search using relevant keywords in major national and international databases was performed until 6th July, 2018 in order to find studies reporting the prevalence of antibiotic resistance of Neisseria species in Iran. Results: A total of nine studies were found to be eligible based on predefined inclusion and exclusion criteria. Our analysis indicated that the prevalence of Neisseria gonorrhoeae resistance to different antibiotics was as follows: 66.9% to penicillin, 59.1% to ciprofloxacin, 11.1% to ceftriaxone, 21.6% to spectinomycin, 13.8% to cefixime, 82.4% to co-trimoxazole, 52.7% to tetracycline, 29.9% to gentamicin, 87.5% to ampicillin, 11.1% to azithromycin, 2.2% to chloramphenicol, 50.1% to cefepime and 50.0% to vancomycin. Antimicrobial resistance rates of Neisseria meningitidis was as follows: 30.0% to penicillin, 33.3% to amoxicillin, 33.3% to cephalexin, 55.6% to ampicillin and 0.0% to ciprofloxacin, ceftriaxone, cefotaxime, amikacin, co-trimoxazole, gentamicin, kanamycin, chloramphenicol and ceftizoxime. Conclusion: Neisseria gonorrhoeae and Neisseria meningitidis isolates of Iran show resistance to different types of antibiotics. Therefore, care should be exercised for the use of penicillin, ciprofloxacin, co-trimoxazole, tetracycline, gentamicin, ampicillin, cefepime and vancomycin for gonococcal infections, and also with respect to the use of penicillin, amoxicillin, ampicillin and cephalexin for meningococcal infections in Iran.
Objective: To estimate the prevalence of antibiotic resistance of Neisseria species in Iran. Methods: A systematic and electronic search using relevant keywords in major national and international databases was performed until 6th July, 2018 in order to find studies reporting the prevalence of antibiotic resistance of Neisseria species in Iran. Results: A total of nine studies were found to be eligible based on predefined inclusion and exclusion criteria. Our analysis indicated that the prevalence of Neisseria gonorrhoeae resistance to different antibiotics was as follows: 66.9% to penicillin, 59.1% to ciprofloxacin, 11.1% to ceftriaxone, 21.6% to spectinomycin, 13.8% to cefixime, 82.4% to co-trimoxazole, 52.7% to tetracycline, 29.9% to gentamicin, 87.5% to ampicillin, 11.1% to azithromycin, 2.2% to chloramphenicol, 50.1% to cefepime and 50.0% to vancomycin. Antimicrobial resistance rates of Neisseria meningitidis was as follows: 30.0% to penicillin, 33.3% to amoxicillin, 33.3% to cephalexin, 55.6% to ampicillin and 0.0% to ciprofloxacin, ceftriaxone, cefotaxime, amikacin, co-trimoxazole, gentamicin, kanamycin, chloramphenicol and ceftizoxime. Conclusion: Neisseria gonorrhoeae and Neisseria meningitidis isolates of Iran show resistance to different types of antibiotics. Therefore, care should be exercised for the use of penicillin, ciprofloxacin, co-trimoxazole, tetracycline, gentamicin, ampicillin, cefepime and vancomycin for gonococcal infections, and also with respect to the use of penicillin, amoxicillin, ampicillin and cephalexin for meningococcal infections in Iran.
Objective: To estimate the prevalence of antibiotic resistance of Neisseria species in Iran. Methods: A systematic and electronic search using relevant keywords in major national and international databases was performed until 6th July, 2018 in order to find studies reporting the prevalence of antibiotic resistance of Neisseria species in Iran. Results: A total of nine studies were found to be eligible based on predefined inclusion and exclusion criteria. Our analysis indicated that the prevalence of Neisseria gonorrhoeae resistance to different antibiotics was as follows: 66.9% to penicillin, 59.1% to ciprofloxacin, 11.1% to ceftriaxone, 21.6% to spectinomycin, 13.8% to cefixime, 82.4% to co-trimoxazole, 52.7% to tetracycline, 29.9% to gentamicin, 87.5% to ampicillin, 11.1% to azithromycin, 2.2% to chloramphenicol, 50.1% to cefepime and 50.0% to vancomycin. Antimicrobial resistance rates of Neisseria meningitidis was as follows: 30.0% to penicillin, 33.3% to amoxicillin, 33.3% to cephalexin, 55.6% to ampicillin and 0.0% to ciprofloxacin, ceftriaxone, cefotaxime, amikacin, co-trimoxazole, gentamicin, kanamycin, chloramphenicol and ceftizoxime. Conclusion: Neisseria gonorrhoeae and Neisseria meningitidis isolates of Iran show resistance to different types of antibiotics. Therefore, care should be exercised for the use of penicillin, ciprofloxacin, co-trimoxazole, tetracycline, gentamicin, ampicillin, cefepime and vancomycin for gonococcal infections, and also with respect to the use of penicillin, amoxicillin, ampicillin and cephalexin for meningococcal infections in Iran.
引文
[1]Carroll KC,Butel JS,Morse SA.Jawetz Melnick&Adelbergs medical microbiology.27th ed.Pennsylvania:McGraw Hill Professional;2016,p.281-291.
[2]Murray PR,Rosenthal KS,Pfaller MA.Medical microbiology.8th ed.UK:Elsevier Health Sciences;2015,p.234-242.
[3]Tonjum T.Genus I.Neisseria.Bergey’s manual of systematic bacteriology.2th ed.New York:Springer-Verlag;2005,p.777-798.
[4]Unemo M,del Rio C,Shafer WM.Antimicrobial resistance expressed by Neisseria gonorrhoeae:a major global public health problem in the 21st century.Microbiol Spectr 2016;4(3):1-31.
[5]Newman L,Rowley J,Vander Hoorn S,Wijesooriya NS,Unemo M,Low N,et al.Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting.Plo S One 2015;10(12):e0143304.
[6]Dillon J-AR,Parti RP,Thakur SD.Antibiotic resistance in Neisseria gonorrhoeae:will infections be untreatable in the future?Immunodeficiency2016;2:5.
[7]Lewis DA.Global resistance of Neisseria gonorrhoeae:when theory becomes reality.Curr Opin Infect Dis 2014;1:27(1):62-67.
[8]Buder S,Dudareva S,Jansen K,Loenenbach A,Nikisins S,Sailer A,et al.Antimicrobial resistance of Neisseria gonorrhoeae in Germany:low levels of cephalosporin resistance,but high azithromycin resistance.BMC Infect Dis 2018;18(1):44.
[9]World Health Organization.WHO publishes list of bacteria for which new antibiotics are urgently needed.Geneva:WHO;2017.
[10]Zapun A,Morlot C,Taha MK.Resistance to毬-lactams in Neisseria ssp due to chromosomally encoded penicillin-binding proteins.Antibiotics2016;5(4):35.
[11]Houri H,Pormohammad A,Riahi SM,Nasiri MJ,Fallah F,Dabiri H,et al.Acute bacterial meningitis in Iran:Systematic review and metaanalysis.Plo S One 2017;12(2):e0169617.
[12]Teleb N,Pilishvili T,Van Beneden C,Ghoneim A,Amjad K,Mostafa A,et al.Bacterial meningitis surveillance in the Eastern Mediterranean region,2005-2010:Successes and challenges of a regional network.JPediatr 2013;163(1 Suppl):S25-S31.
[13]Nadel S.Treatment of meningococcal disease.J Adolesc Health 2016;59:S21-S28.
[14]Harcourt BH,Anderson RD,Wu HM,Cohn AC,MacNeil JR,Taylor TH,et al.Population-based surveillance of Neisseria meningitidis antimicrobial resistance in the United States.Open Forum Infect Dis 2015;2(3):1-6.
[15]Liberati A,Altman DG,Tetzlaff J,Mulrow C,G?tzsche PC,Ioannidis JP,et al.The PRISMA statement for reporting systematic reviews and metaanalyses of studies that evaluate health care interventions:explanation and elaboration.PLo S Med 2009;6(7):e1000100.
[16]Zirak-Zadeh T,Delavarian H,Beahavar M,Yaminifar R.A study on the penicilline-resistant strains of N.gonorrhoeae isolated from females.Iran J Public Health 1973;2(2):199-205.
[17]Rahimi MK,Zakerbostanabadi S,Mirfakhraei M,Adimi Naghan P,Bossak M,Masoomi M,et al.Evaluation of antibiotic resistance of gonococcal infections in women referred to Azad University hospitals.Medical Sciences 2011;21(1):50-54.[In Persian]
[18]Azizmohammadi S,Azizmohammadi S.Antimicrobial susceptibility pattern of Neisseria gonorrhoeae isolated from fertile and infertile women.Trop J Pharm Res 2016;15(12):2653-2657.
[19]Tabasi Z,khorshidi A,Alinaghipour M,sadat Z,Akbari H.Study of gonococcal frequency in cervicitis and drug resistance in patients that admitted in genitourinary clinics of kashan in first half of 1380.J Kashan Uni Med Sci 2002;6:70-79.[In Persian]
[20]Afrasiabi S,Moniri R,Samimi M,Mousavi SG.The frequency of Neisseria gonorrhoeae endocervical infection among female carrier and changing trends of antimicrobial susceptibility patterns in Kashan,Iran.Iran J Microbiol 2014;6(3):194-197.
[21]Bokaeian M,Qureshi MI,Dabiri S,Fard AHM.An investigation on antibiotic resistance of Neisseria gonorrhoeae isolated from gonorrheal patients in Zahedan,Iran from 2007 to 2010.Afr J Microbiol Res 2011;5(17):2455-2459.
[22]Taghvaeii MR,Esmaeili H,Ejtehadi MM.Rate of drug sensitivity to Neissevra gonorrhoae and laboratory resistance to fluoroquinolones and third generation cephalosporins in gonococcal urethritis of men.Zahedan J Res Med Sci 2005;7:9-15.[In Persian]
[23]Abdinia B,Rezaee MA,Oskouie SA.Etiology and antimicrobial resistance patterns of acute bacterial meningitis in children:a 10-year referral hospital-based study in northwest iran.Iran Red Crescent Med J2014;16(7):e17616.
[24]Mashouf RY,Hashemi SH,Bijarchi M.Bacterial agents of meningitis in children and detection of their antibiotic resistance patterns in Hamadan,Western Iran.Pak J Biol Sci 2006;9(7):1293-1298.
[25]World Health Organization.Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae.Geneva:WHO;2012.
[26]Mechergui A,Achour W,Hassen AB.Antibiotic resistance among commensal Neisseria species.Rev Med Microbiol 2014;25(4):93-99.
[27]Lee H,Unemo M,Kim HJ,Seo Y,Lee K,Chong Y.Emergence of decreased susceptibility and resistance to extended-spectrum cephalosporins in Neisseria gonorrhoeae in Korea.J Antimicrob Chemother2015;70:2536-2542.
[28]World Health Organization.Emergence of multi-drug resistant Neisseria gonorrhoeae:Threat of global rise in untreatable sexually transmitted infections.Geneva:WHO;2011.
[29]Khademi F,Faghri J,Moghim S,Esfahani BN,Fazeli H,Poursina F,et al.The study of mutation in 23S rRNA resistance gene of Helicobacter pylori to clarithromycin in patients with gastrointestinal disorders in Isfahan-Iran.Adv Biomed Res 2014;3:98.
[2]Murray PR,Rosenthal KS,Pfaller MA.Medical microbiology.8th ed.UK:Elsevier Health Sciences;2015,p.234-242.
[3]Tonjum T.Genus I.Neisseria.Bergey’s manual of systematic bacteriology.2th ed.New York:Springer-Verlag;2005,p.777-798.
[4]Unemo M,del Rio C,Shafer WM.Antimicrobial resistance expressed by Neisseria gonorrhoeae:a major global public health problem in the 21st century.Microbiol Spectr 2016;4(3):1-31.
[5]Newman L,Rowley J,Vander Hoorn S,Wijesooriya NS,Unemo M,Low N,et al.Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting.Plo S One 2015;10(12):e0143304.
[6]Dillon J-AR,Parti RP,Thakur SD.Antibiotic resistance in Neisseria gonorrhoeae:will infections be untreatable in the future?Immunodeficiency2016;2:5.
[7]Lewis DA.Global resistance of Neisseria gonorrhoeae:when theory becomes reality.Curr Opin Infect Dis 2014;1:27(1):62-67.
[8]Buder S,Dudareva S,Jansen K,Loenenbach A,Nikisins S,Sailer A,et al.Antimicrobial resistance of Neisseria gonorrhoeae in Germany:low levels of cephalosporin resistance,but high azithromycin resistance.BMC Infect Dis 2018;18(1):44.
[9]World Health Organization.WHO publishes list of bacteria for which new antibiotics are urgently needed.Geneva:WHO;2017.
[10]Zapun A,Morlot C,Taha MK.Resistance to毬-lactams in Neisseria ssp due to chromosomally encoded penicillin-binding proteins.Antibiotics2016;5(4):35.
[11]Houri H,Pormohammad A,Riahi SM,Nasiri MJ,Fallah F,Dabiri H,et al.Acute bacterial meningitis in Iran:Systematic review and metaanalysis.Plo S One 2017;12(2):e0169617.
[12]Teleb N,Pilishvili T,Van Beneden C,Ghoneim A,Amjad K,Mostafa A,et al.Bacterial meningitis surveillance in the Eastern Mediterranean region,2005-2010:Successes and challenges of a regional network.JPediatr 2013;163(1 Suppl):S25-S31.
[13]Nadel S.Treatment of meningococcal disease.J Adolesc Health 2016;59:S21-S28.
[14]Harcourt BH,Anderson RD,Wu HM,Cohn AC,MacNeil JR,Taylor TH,et al.Population-based surveillance of Neisseria meningitidis antimicrobial resistance in the United States.Open Forum Infect Dis 2015;2(3):1-6.
[15]Liberati A,Altman DG,Tetzlaff J,Mulrow C,G?tzsche PC,Ioannidis JP,et al.The PRISMA statement for reporting systematic reviews and metaanalyses of studies that evaluate health care interventions:explanation and elaboration.PLo S Med 2009;6(7):e1000100.
[16]Zirak-Zadeh T,Delavarian H,Beahavar M,Yaminifar R.A study on the penicilline-resistant strains of N.gonorrhoeae isolated from females.Iran J Public Health 1973;2(2):199-205.
[17]Rahimi MK,Zakerbostanabadi S,Mirfakhraei M,Adimi Naghan P,Bossak M,Masoomi M,et al.Evaluation of antibiotic resistance of gonococcal infections in women referred to Azad University hospitals.Medical Sciences 2011;21(1):50-54.[In Persian]
[18]Azizmohammadi S,Azizmohammadi S.Antimicrobial susceptibility pattern of Neisseria gonorrhoeae isolated from fertile and infertile women.Trop J Pharm Res 2016;15(12):2653-2657.
[19]Tabasi Z,khorshidi A,Alinaghipour M,sadat Z,Akbari H.Study of gonococcal frequency in cervicitis and drug resistance in patients that admitted in genitourinary clinics of kashan in first half of 1380.J Kashan Uni Med Sci 2002;6:70-79.[In Persian]
[20]Afrasiabi S,Moniri R,Samimi M,Mousavi SG.The frequency of Neisseria gonorrhoeae endocervical infection among female carrier and changing trends of antimicrobial susceptibility patterns in Kashan,Iran.Iran J Microbiol 2014;6(3):194-197.
[21]Bokaeian M,Qureshi MI,Dabiri S,Fard AHM.An investigation on antibiotic resistance of Neisseria gonorrhoeae isolated from gonorrheal patients in Zahedan,Iran from 2007 to 2010.Afr J Microbiol Res 2011;5(17):2455-2459.
[22]Taghvaeii MR,Esmaeili H,Ejtehadi MM.Rate of drug sensitivity to Neissevra gonorrhoae and laboratory resistance to fluoroquinolones and third generation cephalosporins in gonococcal urethritis of men.Zahedan J Res Med Sci 2005;7:9-15.[In Persian]
[23]Abdinia B,Rezaee MA,Oskouie SA.Etiology and antimicrobial resistance patterns of acute bacterial meningitis in children:a 10-year referral hospital-based study in northwest iran.Iran Red Crescent Med J2014;16(7):e17616.
[24]Mashouf RY,Hashemi SH,Bijarchi M.Bacterial agents of meningitis in children and detection of their antibiotic resistance patterns in Hamadan,Western Iran.Pak J Biol Sci 2006;9(7):1293-1298.
[25]World Health Organization.Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae.Geneva:WHO;2012.
[26]Mechergui A,Achour W,Hassen AB.Antibiotic resistance among commensal Neisseria species.Rev Med Microbiol 2014;25(4):93-99.
[27]Lee H,Unemo M,Kim HJ,Seo Y,Lee K,Chong Y.Emergence of decreased susceptibility and resistance to extended-spectrum cephalosporins in Neisseria gonorrhoeae in Korea.J Antimicrob Chemother2015;70:2536-2542.
[28]World Health Organization.Emergence of multi-drug resistant Neisseria gonorrhoeae:Threat of global rise in untreatable sexually transmitted infections.Geneva:WHO;2011.
[29]Khademi F,Faghri J,Moghim S,Esfahani BN,Fazeli H,Poursina F,et al.The study of mutation in 23S rRNA resistance gene of Helicobacter pylori to clarithromycin in patients with gastrointestinal disorders in Isfahan-Iran.Adv Biomed Res 2014;3:98.