滋阴定眩汤联合银杏叶片治疗梅尼埃病
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摘要
目的:观察滋阴定眩汤联合银杏叶片治疗梅尼埃病的临床疗效。方法:根据随机数字表法将116例梅尼埃病患者分成两组,对照组58例采用银杏叶片治疗,研究组58例采用滋阴定眩汤联合银杏叶片治疗。比较两组治疗前后血液流变学指标(全血黏度、全血黏度高切、全血黏度低切)、中医证候积分及生存质量评分,并对两组临床疗效进行评价。结果:两组梅尼埃病患者治疗后的血液流变学指标(全血黏度、全血黏度高切、全血黏度低切)以及中医证候积分相较于治疗前下降明显,且研究组较对照组改善幅度更大,差异具有统计学意义(P <0. 05);治疗后,研究组情绪角色、躯体健康、心理健康、精力、总体健康、社会功能、身体疼痛、躯体角色评分均高于对照组,差异具有统计学意义(P <0. 05);研究组临床有效率为93. 10%(54/58),高于对照组72. 41%(42/58),差异具有统计学意义(P <0. 05)。结论:滋阴定眩汤联合银杏叶片治疗梅尼埃病疗效确切,患者的临床症状和血液流变学得到了显著改善,有助于患者身体早期转归,提高生存质量。
Objective: To observe the clinical efficacy of Ziyin Dingxuan Decoction combined with ginkgo leaves in the treatment of Meniere's disease. Methods: According to the random number table method,116 patients with Meniere's disease were divided into two groups. 58 patients in the control group were treated with ginkgo leaves,and 58 patients in the study group were treated with Ziyin Dingxuan Decoction combined with ginkgo leaves. The hemorheological indexes( whole blood viscosity,high shear viscosity,low shear viscosity),TCM syndrome score and quality of life score before and after treatment were compared between the two groups,and the clinical efficacy of the two groups was evaluated. Results: The hemorheological indexes( whole blood viscosity,whole blood viscosity high shear,whole blood viscosity low shear) and TCM syndrome scores of two groups of Meniere's disease patients after treatment were significantly lower than those before treatment,and the improvement was greater than that of the control group. The difference was statistically significant( P < 0. 05). After treatment,the scores of emotional role,physical health,mental health,energy,general health,social function,physical pain and physical role in the study group were higher than those in the control group. The difference was statistically significant( P < 0. 05). The clinical effective rate of the study group was 93. 10%( 54/58),which was higher than 72. 41%( 42/58) of the control group. The difference was statistically significant( P < 0. 05).Conclusion: Ziyin Dingxuan Decoction combined with ginkgo leaves is effective for Meniere's disease patients. The clinical symptoms and hemorheology of patients have been significantly improved,which is helpful to the early recovery of patients and improve their quality of life.
Objective: To observe the clinical efficacy of Ziyin Dingxuan Decoction combined with ginkgo leaves in the treatment of Meniere's disease. Methods: According to the random number table method,116 patients with Meniere's disease were divided into two groups. 58 patients in the control group were treated with ginkgo leaves,and 58 patients in the study group were treated with Ziyin Dingxuan Decoction combined with ginkgo leaves. The hemorheological indexes( whole blood viscosity,high shear viscosity,low shear viscosity),TCM syndrome score and quality of life score before and after treatment were compared between the two groups,and the clinical efficacy of the two groups was evaluated. Results: The hemorheological indexes( whole blood viscosity,whole blood viscosity high shear,whole blood viscosity low shear) and TCM syndrome scores of two groups of Meniere's disease patients after treatment were significantly lower than those before treatment,and the improvement was greater than that of the control group. The difference was statistically significant( P < 0. 05). After treatment,the scores of emotional role,physical health,mental health,energy,general health,social function,physical pain and physical role in the study group were higher than those in the control group. The difference was statistically significant( P < 0. 05). The clinical effective rate of the study group was 93. 10%( 54/58),which was higher than 72. 41%( 42/58) of the control group. The difference was statistically significant( P < 0. 05).Conclusion: Ziyin Dingxuan Decoction combined with ginkgo leaves is effective for Meniere's disease patients. The clinical symptoms and hemorheology of patients have been significantly improved,which is helpful to the early recovery of patients and improve their quality of life.
引文
[1]高云,王大勇,王洪阳,等.家族性梅尼埃病的临床表型及相关基因研究(附3例家系报道)[J].中华耳鼻咽喉头颈外科杂志,2015,50(11):915-924.
[2]肖汉琼,张国明,吴倩如,等.小剂量庆大霉素鼓室内注射治疗难治性梅尼埃病对听力影响的研究[J].中国耳鼻咽喉头颈外科杂志,2015,50(5):233-235.
[3]龙宇,江洪,陈丽鸿,等.庆大霉素与糖皮质激素治疗梅尼埃病效果的Meta分析[J].重庆医学,2015,44(20):2805-2808.
[4]王聘益.加味苓桂术甘汤治疗梅尼埃病47例[J].河南中医,2013,33(2):182.
[5]吴凡.补阳还五汤加减治疗气虚血瘀证梅尼埃病[J].浙江中医药大学学报,2015,39(1):51-52,56.
[6]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉科学分会.梅尼埃病的诊断依据和疗效评估(2006年,贵阳)[J].中华耳鼻咽喉头颈外科杂志,2007,42(3):163.
[7]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994.
[8]贺思,赵晓峰,文妍,等.不同针刺手法治疗后循环缺血性眩晕患者120例随机双盲对照试验[J].中医杂志,2015,56(6):478-482.
[9]乔莉,张逸博,陆成会,等.微波联合药物对梅尼埃病患者纯音测听能力恢复的影响[J].长春中医药大学学报,2015,31(3):625-627.
[10]高云,单希征.梅尼埃病的病因及发病机制研究进展[J].听力学及言语疾病杂志,2014,22(4):426-431.
[11]张月琴,孙爱玲,魏晓娜,等.高压氧综合治疗梅尼埃病60例中长期疗效观察[J].中华航海医学与高气压医学杂志,2013,20(4):249-251,257.
[12]潘海聪,汪静波,项云飞,等.梅尼埃病继发良性阵发性位置性眩晕临床特点分析[J].中国医药,2015,10(6):882-884.
[13]褚春梅,高岗.自拟中药汤剂对痰浊型眩晕患者生活功能及躯体功能的影响[J].长春中医药大学学报,2015,31(2):351-353.
[14]杨淑芬.中西医结合治疗内耳眩晕病的疗效观察[J].山东大学学报(医学版),2014,52(1):106.
[15]许凤莲.桃红四物汤加味治疗颈性眩晕临床研究[J].中医学报,2013,28(11):1730-1731.
[16]王强,沈岚,梁爽,等.川芎对天麻指标成分在偏头痛大鼠体内药动学的影响[J].中成药,2015,37(1):62-69.
[17]马立华.盐酸多奈哌齐片联合银杏叶片治疗老年血管性认知障碍分析[J].中国实用神经疾病杂志,2015,18(4):102-103.
[18]项琼,宋恩峰,梅莎莎.银杏叶片联合多烯磷脂酰胆碱胶囊对非酒精性脂肪性肝病血流变及血脂的影响[J].中国中西医结合消化杂志,2014,22(9):532-534.
[2]肖汉琼,张国明,吴倩如,等.小剂量庆大霉素鼓室内注射治疗难治性梅尼埃病对听力影响的研究[J].中国耳鼻咽喉头颈外科杂志,2015,50(5):233-235.
[3]龙宇,江洪,陈丽鸿,等.庆大霉素与糖皮质激素治疗梅尼埃病效果的Meta分析[J].重庆医学,2015,44(20):2805-2808.
[4]王聘益.加味苓桂术甘汤治疗梅尼埃病47例[J].河南中医,2013,33(2):182.
[5]吴凡.补阳还五汤加减治疗气虚血瘀证梅尼埃病[J].浙江中医药大学学报,2015,39(1):51-52,56.
[6]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉科学分会.梅尼埃病的诊断依据和疗效评估(2006年,贵阳)[J].中华耳鼻咽喉头颈外科杂志,2007,42(3):163.
[7]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994.
[8]贺思,赵晓峰,文妍,等.不同针刺手法治疗后循环缺血性眩晕患者120例随机双盲对照试验[J].中医杂志,2015,56(6):478-482.
[9]乔莉,张逸博,陆成会,等.微波联合药物对梅尼埃病患者纯音测听能力恢复的影响[J].长春中医药大学学报,2015,31(3):625-627.
[10]高云,单希征.梅尼埃病的病因及发病机制研究进展[J].听力学及言语疾病杂志,2014,22(4):426-431.
[11]张月琴,孙爱玲,魏晓娜,等.高压氧综合治疗梅尼埃病60例中长期疗效观察[J].中华航海医学与高气压医学杂志,2013,20(4):249-251,257.
[12]潘海聪,汪静波,项云飞,等.梅尼埃病继发良性阵发性位置性眩晕临床特点分析[J].中国医药,2015,10(6):882-884.
[13]褚春梅,高岗.自拟中药汤剂对痰浊型眩晕患者生活功能及躯体功能的影响[J].长春中医药大学学报,2015,31(2):351-353.
[14]杨淑芬.中西医结合治疗内耳眩晕病的疗效观察[J].山东大学学报(医学版),2014,52(1):106.
[15]许凤莲.桃红四物汤加味治疗颈性眩晕临床研究[J].中医学报,2013,28(11):1730-1731.
[16]王强,沈岚,梁爽,等.川芎对天麻指标成分在偏头痛大鼠体内药动学的影响[J].中成药,2015,37(1):62-69.
[17]马立华.盐酸多奈哌齐片联合银杏叶片治疗老年血管性认知障碍分析[J].中国实用神经疾病杂志,2015,18(4):102-103.
[18]项琼,宋恩峰,梅莎莎.银杏叶片联合多烯磷脂酰胆碱胶囊对非酒精性脂肪性肝病血流变及血脂的影响[J].中国中西医结合消化杂志,2014,22(9):532-534.