LyP-1 peptide-functionalized gold nanoprisms for SERRS imaging and tumor growth suppressing by PTT induced-hyperthermia

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英文篇名：LyP-1 peptide-functionalized gold nanoprisms for SERRS imaging and tumor growth suppressing by PTT induced-hyperthermia 作者：Xi ; Huang ; Yanlong ; Yin ; Min ; Wu ; Wang ; Zan ; Qian ; Yang 英文作者：Xi Huang;Yanlong Yin;Min Wu;Wang Zan;Qian Yang;The School of Pharmacy, College Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College;Ophthalmic Laboratory and Department of Ophthalmology,State Key Laboratory and Collaborative Innovation Center of Biotherapy, West China Hospital,Sichuan University; 英文关键词：Gold nanoprisms;;SERRS imaging;;LyP-1 peptide;;Tumor targeting;;Photothermal therapy 中文刊名：FXKB 英文刊名：中国化学快报(英文版) 机构：The School of Pharmacy, College Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College;Ophthalmic Laboratory and Department of Ophthalmology,State Key Laboratory and Collaborative Innovation Center of Biotherapy, West China Hospital,Sichuan University; 出版日期：2019-06-15 出版单位：Chinese Chemical Letters 年：2019 期：v.30 基金：financially supported by the Application Fundamental Research Foundation of Sichuan Province Science and Technology Department, China (No. 2016JY0157);; the State Sponsored Scholarship for Visiting Scholar from China Scholarship Council, the Outstanding Science and Technology Projects for Returned Overseas Chinese Scholars, Sichuan Province, China, theNational Natural Science Foundation of China (No. 31600811);; the National Training Program of Innovation and Entrepreneurship for Undergraduates(No. 201813705025) 语种：英文; 页：FXKB201906044 页数：6 CN：06 ISSN：11-2710/O6 分类号：219-224

摘要

Gold-based nano materials with plasmonic properties exhibit various potentials for biomedical applications.In this work,gold nanoprisms(GNPs)was synthesized and then modified with LyP-1,a tumo r-homing peptide,to imp rove the affinity of the GNPs to tumor cells,thus,to imp rove the efficacy of tumor-targe ted photothermal therapy.The introduction of NIR dye IR780 not only enabled the GNPsbased nanosystem with the surface-enhanced resonant Raman scattering(SERRS)property,but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation.The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo,which resulted in enhanced tumor-targe ting photothermal therapeutic efficacy after laser irradiation.Hence,the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment.
        Gold-based nano materials with plasmonic properties exhibit various potentials for biomedical applications.In this work,gold nanoprisms(GNPs)was synthesized and then modified with LyP-1,a tumo r-homing peptide,to imp rove the affinity of the GNPs to tumor cells,thus,to imp rove the efficacy of tumor-targe ted photothermal therapy.The introduction of NIR dye IR780 not only enabled the GNPsbased nanosystem with the surface-enhanced resonant Raman scattering(SERRS)property,but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation.The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo,which resulted in enhanced tumor-targe ting photothermal therapeutic efficacy after laser irradiation.Hence,the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment.

引文

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