TCAB1在宫颈鳞状上皮内病变及宫颈鳞癌中的表达
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摘要
[目的]探讨TCAB1在宫颈鳞状上皮内病变及宫颈鳞癌的表达及意义。[方法]选取2016年1月至2018年8月海南医学院第二附属医院病理科宫颈鳞状细胞癌组织60例,低级别鳞状上皮内病变组织30例,高级别鳞状上皮内病变40例组织及正常宫颈组织30例,采用免疫组化法检测各组的TCAB1表达。[结果]低级别鳞状上皮内病变、高级别鳞状上皮内病变和宫颈鳞癌组TCAB1阳性比例逐渐升高,依次为40.0%(12/30)、75.0%(30/40)和81.7%(49/60),明显高于对照组的0.7%(2/30)(P<0.05)。[结论] TCAB1可能参与宫颈鳞状细胞癌的发生发展。
引文
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[4]Mahmoudi S,Henriksson S,Farnebo L,et al.WRAP53 promotes cancer cell survival and is a potential target for cancer therapy[J].Cell Death Dis,2011,2(1):e114.
[5]Sun CK,Luo XB,Gou YP,et al.TCAB1:a potential target for diagnosis and therapy of head and neck carcinomas[J].Mol Cancer,2014,13:180.