幽门螺杆菌相关miRNA与胃癌关系的研究进展
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摘要
微小核糖核酸(microRNA,miRNA)是一种由内源基因编码长度约为22个核苷酸的非编码RNA,其能抑制靶基因蛋白质表达,有多种生物学功能。越来越多的研究表明,miRNA在多种肿瘤中异常表达,参与肿瘤发生、发展过程。幽门螺杆菌(Helicobacter pylori,Hp)作为胃癌的主要致病因素,可通过调节miRNA的表达,在胃癌中起促进或抑制作用。现就Hp相关miRNA在胃癌中的作用作一概述。
MicroRNA(miRNA) are non-coding RNA of approximately 22 nucleotides encoded by endogenous gene that inhibit expression of target protein and have multiple biological functions.Increasing studies have shown that miRNAs are abnormally expressed in a variety of tumors and participate in the genesis and development.As the main pathogenic factor in gastric cancer,Helicobacter pylori(Hp) can promote or inhibit gastric cancer by regulating the expression of miRNA.This review summarized the recent progress on the research of Helicobacter pylori associated miRNA in gastric cancer.
MicroRNA(miRNA) are non-coding RNA of approximately 22 nucleotides encoded by endogenous gene that inhibit expression of target protein and have multiple biological functions.Increasing studies have shown that miRNAs are abnormally expressed in a variety of tumors and participate in the genesis and development.As the main pathogenic factor in gastric cancer,Helicobacter pylori(Hp) can promote or inhibit gastric cancer by regulating the expression of miRNA.This review summarized the recent progress on the research of Helicobacter pylori associated miRNA in gastric cancer.
引文
[1]常敏,张久聪,周琴,等.胃癌流行病学研究进展[J].胃肠病学和肝病学杂志,2017,26(9):966-969.
[2]SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics,2018[J].CA Cancer J Clin,2018,68(1):7-30.
[3]樊菡,罗和生.DNA甲基化与胃癌诊治研究进展[J].医学综述,2016,22(3):519-522.
[4]NIWA T,TSUKAMOTO T,TOYODA T,et al.Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells[J].Cancer Res,2010,70(4):1430-1440.
[5]LEE Y,CHIANG T,CHOU C,et al.Association between Helicobacter pylori eradication and gastric cancer incidence:A systematic review and meta-analysis[J].Gastroenterology,2016,150(5):1113-1124.
[6]HUA H B,YAN T T,SUN Q M.mi RNA polymorphisms and risk of gastric cancer in Asian population[J].World J Gastroenterol,2014,20(19):5700-5707.
[7]HAO N B,HE Y F,LI X Q,et al.The role of mi RNA and lnc RNA in gastric cancer[J].Oncotarget,2017,8(46):81572-81582.
[8]兰敏,陈艳,王熙才.mi R-370在肿瘤中的作用及其机制[J].中国肿瘤生物治疗杂志,2016,23(2):291-296.
[9]张自立,王金亮,孟祥朝.mi RNA-183家族在恶性肿瘤中作用的研究[J].天津医药,2017,45(12):1337-1340.
[10]SONG J,BAI Z,ZHANG Z.micro RNAs are implicated in the initiation and progression of gastric cancer[J].Chin Med J(Engl),2014,127(3):554-559.
[11]张欣悦,邱栾,李建雄.micro RNA在胃癌中的作用及临床意义[J].解放军医学院学报,2016,37(12):1301-1303,1307.
[12]CHANG H,NAYOUNG K,HYUN P J,et al.Different Micro R-NA expression levels in gastric cancer depending on Helicobacter pylori infection[J].Gut&Liver,2015,9(2):188-196.
[13]ZHANG Z,LI Z,GAO C,et al.mi R-21 plays a pivotal role in gastric cancer pathogenesis and progression[J].Lab Invest,2008,88(12):1358-1366.
[14]IKURA A,SAITO Y,SUZUKI H,et al.W1751 Micro RNA-21plays a critical role in Helicobacter pylori-associated gastric cancer by suppressing Btg2[J].Gastroenterology,2010,138(5):732.
[15]SEKAR D,KRISHNAN R,THIRUGNANASAMBANTHAM K,et al.Significance of micro RNA 21 in gastric cancer[J].Clin Res Hepatol Gastroenterol,2016,40(5):538-545.
[16]LI L,ZHOU L,LI Y,et al.Micro RNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog[J].J Buon,2014,19(1):228-236.
[17]LI C,SONG L,ZHANG Z,et al.Micro RNA-21 promotes TGF-beta1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression[J].Oncotarget,2016,7(41):66989-67003.
[18]ZHANG B G,LI J F,YU B Q,et al.Micro RNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN[J].Oncol Rep,2012,27(4):1019-1026.
[19]LI L,WANG X,LI W,et al.mi R-21 modulates prostaglandin signaling and promotes gastric tumorigenesis by targeting 15-PG-DH[J].Biochem Biophys Res Commun,2018,495(1):928-934.
[20]WANG G,CAO X,LAI S,et al.Altered p53 regulation of mi R-148b and p55PIK contributes to tumor progression in colorectal cancer.[J].Oncogene,2015,34(7):912-921.
[21]LIU G L,LIU X,LX B,et al.mi R-148b functions as a tumor suppressor in non-small cell lung cancer by targeting carcinoembryonic antigen(CEA)[J].Int J Clin Exp Med,2014,7(8):1990-1999.
[22]ZHAO G,ZHANG J G,LIU Y,et al.mi R-148b Functions as a tumor suppressor in pancreatic cancer by targeting AMPK alpha 1[J].Mol Cancer Ther,2013,12(1):83-93.
[23]ZHANG Y Q,SUN Q Q,LOU X X,et al.Molecular mechanisms of Helicobacter pylori infection related mi RNA-148b in proliferation and invasion of gastric cancer cells[J].Chin J Nosocomiol,2017,27(10):2177-2182.
[24]FASSAN M,SARAGGI D,BALSAMO L,et al.Let-7c downregulation in Helicobacter pylori-related gastric carcinogenesis[J].Oncotarget,2016,7(4):4915-4924.
[25]HAYASHI Y,TSUJII M,WANG J,et al.CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylorirelated carcinogenesis[J].Gut,2013,62(11):1536-1546.
[26]SHI Y,DUAN Z,ZHANG X,et al.Down-regulation of the let-7i facilitates gastric cancer invasion and metastasis by targeting COL1A1.[J].Protein&cell,2018.DOI:10.1007/s13238-018-0550-0557.
[27]GAO C,ZHANG Z,LIU W,et al.Reduced micro RNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer[J].Cancer,2010,116(1):41-49.
[28]TIE J,PAN Y,ZHAO L,et al.Mi R-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor[J].PLoS Genet,2010,6(3):e1000879-1000883.
[29]WANG G,FU Y,LIU G,et al.mi R-218 Inhibits proliferation,migration,and EMT of gastric cancer cells by targeting WASF3[J].Oncol Res,2017,25(3):355-364.
[30]WANG L L,WANG L,WANG X Y,et al.micro RNA-218 inhibits the proliferation,migration,and invasion and promotes apoptosis of gastric cancer cells by targeting LASP1[J].Tumour Biol,2016,37(11):15241-15252.
[31]TANG S,WANG D,ZHANG Q,et al.mi R-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2[J].Exp Ther Med,2016,12(6):3837-3842.
[32]ZHOU X,XIA Y,LI L,et al.Mi R-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repression of SOCS2[J].Cancer Biol Ther,2015,16(1):160-169.
[33]HE X P,SHAO Y,LI X L,et al.Downregulation of mi R-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth[J].FEBS J,2012,279(22):4201-4212.
[34]ZHOU X,XIA Y,SU J,et al.Down-regulation of mi R-141 induced by Helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4[J].Cell Physiol Biochem,2014,33(4):1003-1012.
[35]ZHOU X,SU J,ZHU L,et al.Helicobacter pylori modulates cisplatin sensitivity in gastric cancer by down-regulating mi R-141expression[J].Helicobacter,2014,19(3):174-181.
[36]LI N,TANG B,ZHU E D,et al.Increased mi R-222 in H.pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK[J].FEBSLett,2012,586(6):722-728.
[37]TAN X,TANG H,BI J,et al.Micro RNA-222-3p associated with Helicobacter pylori targets HIPK2 to promote cell proliferation,invasion,and inhibits apoptosis in gastric cancer[J].JCell Biochem,2018,119(7):5153-5162.
[38]YANG F,XU Y,LIU C,et al.NF-κB/mi R-223-3p/ARID1Aaxis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression[J].Cell Death Dis,2018,9(1):12.
[39]XIAO B,ZHU E D,LI N,et al.Increased mi R-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis[J].Oncol Rep,2012,27(2):559-566.
[40]GUO J X,TAO Q S,LOU P R,et al.mi R-181b as a potential molecular target for anticancer therapy of gastric neoplasms[J].Asian Pac J Cancer Prev,2012,13(5):2263-2267.
[41]SHAO L,CHEN Z,SOUTTO M,et al.Helicobacter pylori-induced mi R-135b-5p promotes cisplatin resistance in gastric cancer[J].FASEB J,2018,l 9:fj201701456RR.
[42]唐彬.MIR30B在幽门螺旋杆菌诱导的胃上皮细胞自噬调节与持续性感染发生中的机制研究[D].重庆:第三军医大学,2012.
[43]GENG Y,LU X,WU X,et al.Micro RNA-27b suppresses Helicobacter pylori-induced gastric tumorigenesis through negatively regulating Frizzled7[J].Oncol Rep,2016,35(4):2441-2450.
[44]FENG Y,WANG L,ZENG J,et al.Fox M1 is Overexpressed in Helicobacter pylori-Induced Gastric Carcinogenesis and Is Negatively Regulated by mi R-370[J].Molecular Cancer Research Mcr,2013,11(8):834-844.
[45]Xiao D,Yun Z,Wu T,et al.Helicobacter pylori infection associated mi R-451 suppressed the proliferation of gastric cancer by targeting CASC4[J].Int.J.Clin.Exp.Path,2016,9(12):12390-12398.
[46]ZHOU X,LI L,SU J,et al.Decreased mi R-204 in H.pylori-associated gastric cancer promotes cancer cell proliferation and invasion by targeting SOX4[J].PloS One,2014,9(7):e101457-104161.
[47]ZHOU X,XU G,YIN C,et al.Down-regulation of mi R-203 induced by Helicobacter pylori infection promotes the proliferation and invasion of gastric cancer by targeting CASK[J].Oncotarget,2014,5(22):11631-11640.
[48]SHEN J,XIAO Z,WU W K,et al.Epigenetic silencing of mi R-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-Induced gastric carcinogenesis[J].Cancer Res,2015,75(4):754-765.
[49]NOTO J M,PIAZUELO M B,CHATURVEDI R,et al.Strainspecific suppression of micro RNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1[J].Am J Physiol Gastrointest Liver Physiol,2013,305(11):786-796.
[50]KANG D W,YANG E S,NOH Y N,et al.Micro RNA-320a and micro RNA-4496 attenuate Helicobacter pylori cytotoxin-associated gene A(CagA)-induced cancer-initiating potential and chemoresistance by targeting-catenin and ATP-binding cassette,subfamily G,member 2[J].J Pathol,2017,241(5):614-625.
[51]MURRAY-STEWART T,SIERRA J C,PIAZUELO M B,et al.Epigenetic silencing of mi R-124 prevents spermine oxidase regulation:implications for Helicobacter pylori-induced gastric cancer[J].Oncogene,2016,35(42):5480-5488.
[52]ZOU M,WANG F,JIANG A,et al.micro RNA-3178 ameliorates inflammationandgastric carcinogenesis promoted by Helicobacter pylori newtoxin,Tip-alpha,by targeting TRAF3[J].Helicobacter,2017,22(2):e12348.
[2]SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics,2018[J].CA Cancer J Clin,2018,68(1):7-30.
[3]樊菡,罗和生.DNA甲基化与胃癌诊治研究进展[J].医学综述,2016,22(3):519-522.
[4]NIWA T,TSUKAMOTO T,TOYODA T,et al.Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells[J].Cancer Res,2010,70(4):1430-1440.
[5]LEE Y,CHIANG T,CHOU C,et al.Association between Helicobacter pylori eradication and gastric cancer incidence:A systematic review and meta-analysis[J].Gastroenterology,2016,150(5):1113-1124.
[6]HUA H B,YAN T T,SUN Q M.mi RNA polymorphisms and risk of gastric cancer in Asian population[J].World J Gastroenterol,2014,20(19):5700-5707.
[7]HAO N B,HE Y F,LI X Q,et al.The role of mi RNA and lnc RNA in gastric cancer[J].Oncotarget,2017,8(46):81572-81582.
[8]兰敏,陈艳,王熙才.mi R-370在肿瘤中的作用及其机制[J].中国肿瘤生物治疗杂志,2016,23(2):291-296.
[9]张自立,王金亮,孟祥朝.mi RNA-183家族在恶性肿瘤中作用的研究[J].天津医药,2017,45(12):1337-1340.
[10]SONG J,BAI Z,ZHANG Z.micro RNAs are implicated in the initiation and progression of gastric cancer[J].Chin Med J(Engl),2014,127(3):554-559.
[11]张欣悦,邱栾,李建雄.micro RNA在胃癌中的作用及临床意义[J].解放军医学院学报,2016,37(12):1301-1303,1307.
[12]CHANG H,NAYOUNG K,HYUN P J,et al.Different Micro R-NA expression levels in gastric cancer depending on Helicobacter pylori infection[J].Gut&Liver,2015,9(2):188-196.
[13]ZHANG Z,LI Z,GAO C,et al.mi R-21 plays a pivotal role in gastric cancer pathogenesis and progression[J].Lab Invest,2008,88(12):1358-1366.
[14]IKURA A,SAITO Y,SUZUKI H,et al.W1751 Micro RNA-21plays a critical role in Helicobacter pylori-associated gastric cancer by suppressing Btg2[J].Gastroenterology,2010,138(5):732.
[15]SEKAR D,KRISHNAN R,THIRUGNANASAMBANTHAM K,et al.Significance of micro RNA 21 in gastric cancer[J].Clin Res Hepatol Gastroenterol,2016,40(5):538-545.
[16]LI L,ZHOU L,LI Y,et al.Micro RNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog[J].J Buon,2014,19(1):228-236.
[17]LI C,SONG L,ZHANG Z,et al.Micro RNA-21 promotes TGF-beta1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression[J].Oncotarget,2016,7(41):66989-67003.
[18]ZHANG B G,LI J F,YU B Q,et al.Micro RNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN[J].Oncol Rep,2012,27(4):1019-1026.
[19]LI L,WANG X,LI W,et al.mi R-21 modulates prostaglandin signaling and promotes gastric tumorigenesis by targeting 15-PG-DH[J].Biochem Biophys Res Commun,2018,495(1):928-934.
[20]WANG G,CAO X,LAI S,et al.Altered p53 regulation of mi R-148b and p55PIK contributes to tumor progression in colorectal cancer.[J].Oncogene,2015,34(7):912-921.
[21]LIU G L,LIU X,LX B,et al.mi R-148b functions as a tumor suppressor in non-small cell lung cancer by targeting carcinoembryonic antigen(CEA)[J].Int J Clin Exp Med,2014,7(8):1990-1999.
[22]ZHAO G,ZHANG J G,LIU Y,et al.mi R-148b Functions as a tumor suppressor in pancreatic cancer by targeting AMPK alpha 1[J].Mol Cancer Ther,2013,12(1):83-93.
[23]ZHANG Y Q,SUN Q Q,LOU X X,et al.Molecular mechanisms of Helicobacter pylori infection related mi RNA-148b in proliferation and invasion of gastric cancer cells[J].Chin J Nosocomiol,2017,27(10):2177-2182.
[24]FASSAN M,SARAGGI D,BALSAMO L,et al.Let-7c downregulation in Helicobacter pylori-related gastric carcinogenesis[J].Oncotarget,2016,7(4):4915-4924.
[25]HAYASHI Y,TSUJII M,WANG J,et al.CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylorirelated carcinogenesis[J].Gut,2013,62(11):1536-1546.
[26]SHI Y,DUAN Z,ZHANG X,et al.Down-regulation of the let-7i facilitates gastric cancer invasion and metastasis by targeting COL1A1.[J].Protein&cell,2018.DOI:10.1007/s13238-018-0550-0557.
[27]GAO C,ZHANG Z,LIU W,et al.Reduced micro RNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer[J].Cancer,2010,116(1):41-49.
[28]TIE J,PAN Y,ZHAO L,et al.Mi R-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor[J].PLoS Genet,2010,6(3):e1000879-1000883.
[29]WANG G,FU Y,LIU G,et al.mi R-218 Inhibits proliferation,migration,and EMT of gastric cancer cells by targeting WASF3[J].Oncol Res,2017,25(3):355-364.
[30]WANG L L,WANG L,WANG X Y,et al.micro RNA-218 inhibits the proliferation,migration,and invasion and promotes apoptosis of gastric cancer cells by targeting LASP1[J].Tumour Biol,2016,37(11):15241-15252.
[31]TANG S,WANG D,ZHANG Q,et al.mi R-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2[J].Exp Ther Med,2016,12(6):3837-3842.
[32]ZHOU X,XIA Y,LI L,et al.Mi R-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repression of SOCS2[J].Cancer Biol Ther,2015,16(1):160-169.
[33]HE X P,SHAO Y,LI X L,et al.Downregulation of mi R-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth[J].FEBS J,2012,279(22):4201-4212.
[34]ZHOU X,XIA Y,SU J,et al.Down-regulation of mi R-141 induced by Helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4[J].Cell Physiol Biochem,2014,33(4):1003-1012.
[35]ZHOU X,SU J,ZHU L,et al.Helicobacter pylori modulates cisplatin sensitivity in gastric cancer by down-regulating mi R-141expression[J].Helicobacter,2014,19(3):174-181.
[36]LI N,TANG B,ZHU E D,et al.Increased mi R-222 in H.pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK[J].FEBSLett,2012,586(6):722-728.
[37]TAN X,TANG H,BI J,et al.Micro RNA-222-3p associated with Helicobacter pylori targets HIPK2 to promote cell proliferation,invasion,and inhibits apoptosis in gastric cancer[J].JCell Biochem,2018,119(7):5153-5162.
[38]YANG F,XU Y,LIU C,et al.NF-κB/mi R-223-3p/ARID1Aaxis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression[J].Cell Death Dis,2018,9(1):12.
[39]XIAO B,ZHU E D,LI N,et al.Increased mi R-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis[J].Oncol Rep,2012,27(2):559-566.
[40]GUO J X,TAO Q S,LOU P R,et al.mi R-181b as a potential molecular target for anticancer therapy of gastric neoplasms[J].Asian Pac J Cancer Prev,2012,13(5):2263-2267.
[41]SHAO L,CHEN Z,SOUTTO M,et al.Helicobacter pylori-induced mi R-135b-5p promotes cisplatin resistance in gastric cancer[J].FASEB J,2018,l 9:fj201701456RR.
[42]唐彬.MIR30B在幽门螺旋杆菌诱导的胃上皮细胞自噬调节与持续性感染发生中的机制研究[D].重庆:第三军医大学,2012.
[43]GENG Y,LU X,WU X,et al.Micro RNA-27b suppresses Helicobacter pylori-induced gastric tumorigenesis through negatively regulating Frizzled7[J].Oncol Rep,2016,35(4):2441-2450.
[44]FENG Y,WANG L,ZENG J,et al.Fox M1 is Overexpressed in Helicobacter pylori-Induced Gastric Carcinogenesis and Is Negatively Regulated by mi R-370[J].Molecular Cancer Research Mcr,2013,11(8):834-844.
[45]Xiao D,Yun Z,Wu T,et al.Helicobacter pylori infection associated mi R-451 suppressed the proliferation of gastric cancer by targeting CASC4[J].Int.J.Clin.Exp.Path,2016,9(12):12390-12398.
[46]ZHOU X,LI L,SU J,et al.Decreased mi R-204 in H.pylori-associated gastric cancer promotes cancer cell proliferation and invasion by targeting SOX4[J].PloS One,2014,9(7):e101457-104161.
[47]ZHOU X,XU G,YIN C,et al.Down-regulation of mi R-203 induced by Helicobacter pylori infection promotes the proliferation and invasion of gastric cancer by targeting CASK[J].Oncotarget,2014,5(22):11631-11640.
[48]SHEN J,XIAO Z,WU W K,et al.Epigenetic silencing of mi R-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-Induced gastric carcinogenesis[J].Cancer Res,2015,75(4):754-765.
[49]NOTO J M,PIAZUELO M B,CHATURVEDI R,et al.Strainspecific suppression of micro RNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1[J].Am J Physiol Gastrointest Liver Physiol,2013,305(11):786-796.
[50]KANG D W,YANG E S,NOH Y N,et al.Micro RNA-320a and micro RNA-4496 attenuate Helicobacter pylori cytotoxin-associated gene A(CagA)-induced cancer-initiating potential and chemoresistance by targeting-catenin and ATP-binding cassette,subfamily G,member 2[J].J Pathol,2017,241(5):614-625.
[51]MURRAY-STEWART T,SIERRA J C,PIAZUELO M B,et al.Epigenetic silencing of mi R-124 prevents spermine oxidase regulation:implications for Helicobacter pylori-induced gastric cancer[J].Oncogene,2016,35(42):5480-5488.
[52]ZOU M,WANG F,JIANG A,et al.micro RNA-3178 ameliorates inflammationandgastric carcinogenesis promoted by Helicobacter pylori newtoxin,Tip-alpha,by targeting TRAF3[J].Helicobacter,2017,22(2):e12348.