亚甲基四氢叶酸还原酶基因多态性与妊娠期高血压疾病的关系研究
|
摘要
目的研究亚甲基四氢叶酸还原酶基因多态性与妊娠期高血压疾病的关系。方法选择我院2016年7月～2017年7月收治的无妊娠期高血压患者64例为对照组,选择同期有妊娠期高血压的患者54例为研究组。比较两组患者MTHFR C677T基因检测结果。结果两组患者在MTHFR基因频率TT型、等位基因频率C~*、T~#有统计学意义(P <0.05),两组患者在MTHFR基因频率的AA型、AC型、CC型、等位基因频率A、C上差异无统计学意义(P> 0.05)。结论 MTHFR基因C677T能够作为临床诱发妊娠期高血压的危险因素,在临床上可作为评价患者治疗的指标之一,值得临床进一步研究。
Objective To study the relationship between methylenetetrahydrofolate reductase gene polymorphism and gestational hypertension. Methods 64 patients without gestational hypertension who were admitted and treated in our hospital from July 2016 to July 2017 were selected as the control group and 54 patients with gestational hypertension in the same period were selected as the research objects. The MTHFR C677T gene detection results were compared. Results There no statistically significant difference in MTHFR gene frequency TT type, allele frequency C~* and T~# between two groups(P > 0.05). However, the CC and CT types of the MTHFR gene frequency in the study group were significantly higher than those in the control group. The difference was statistically significant(P < 0.05).There no statistically significant difference in AA type, AC type and CC type of MTHFR gene frequency and allele frequency A and C between two groups(P > 0.05). Conclusion The MTHFR C677T can be as one risk factor for inducing gestational hypertension clinically, which can be used as one of the indexes to evaluate the treatment of patients and is worthy of further clinical study.
Objective To study the relationship between methylenetetrahydrofolate reductase gene polymorphism and gestational hypertension. Methods 64 patients without gestational hypertension who were admitted and treated in our hospital from July 2016 to July 2017 were selected as the control group and 54 patients with gestational hypertension in the same period were selected as the research objects. The MTHFR C677T gene detection results were compared. Results There no statistically significant difference in MTHFR gene frequency TT type, allele frequency C~* and T~# between two groups(P > 0.05). However, the CC and CT types of the MTHFR gene frequency in the study group were significantly higher than those in the control group. The difference was statistically significant(P < 0.05).There no statistically significant difference in AA type, AC type and CC type of MTHFR gene frequency and allele frequency A and C between two groups(P > 0.05). Conclusion The MTHFR C677T can be as one risk factor for inducing gestational hypertension clinically, which can be used as one of the indexes to evaluate the treatment of patients and is worthy of further clinical study.
引文
[1]李俊华.5,10-亚甲基四氢叶酸还原酶基因多态性与妊娠期高血压疾病的相关性研究[J].中国医药导报,2014,11(29):11-14.
[2]陈鹏,史琳,杨红梅,等.妊娠期高血压、子痫前期及子痫与孕前和孕期体质量及其他因素的相关性研究[J].实用妇产科杂志,2017,33(11):848-852.
[3]高文香,徐卫霞,龙丽,等.妊娠期高血压疾病患者血清和肽素水平及临床价值[J].中国妇幼保健,2016,31(5):954-956.
[4]尹维,王建华.妊娠期高血压合并胎儿宫内窘迫的胎儿大脑中动脉血流特征分析及其与缺氧的相关性[J].海南医学院学报,2017,23(1):131-134,138.
[5]石秀霞,马胜辉,李立,等.肾阻力指数对剖宫产术后妊娠期高血压相关性急性肾损伤可逆性诊断的预测价值[J].临床和实验医学杂志,2017,16(7):648-650.
[6]钮慧远,金鑫,张舒,等.内质网氨肽酶2基因rs2549782多态性与妊娠期高血压发病的相关性[J].国际妇产科学杂志,2017,44(6):636-641.
[7]卢潭敏,李爱华.促血管生成素-2与妊娠期高血压疾病的相关性[J].中国妇幼健康研究,2015,26(4):692-694.
[8]周本霞,颜敏.尿β2微球蛋白及D-二聚体与妊娠期高血压肾脏损伤的相关性研究[J].国际检验医学杂志,2017,38(8):1069-1071.
[9]王国成,麻伟博,李娜,等.妊娠期高血压患者血清同型半胱氨酸水平与幽门螺杆菌感染相关性研究[J].中国实验诊断学,2017,21(4):604-606.
[10]黄漫丰.妊娠期高血压孕妇产程行胎心监护的必要性及异常图形与妊娠结局的相关性[J].国际医药卫生导报,2017,23(7):1003-1005.
[11]陈晓晓,张林,熊明,等.血压变异性联合尿微量白蛋白与妊娠期高血压疾病转归的相关性分析[J].中国医刊,2017,52(10):64-66.
[12]陶斯翠,梁辉,何雪花,等.妊娠期高血压疾病胎儿左心室Tei指数的超声评估及其与胎盘缺氧程度的相关性研究[J].海南医学院学报,2017,23(12):1647-1650.
[13]李天刚,王艺璇,杨磊,等.妊娠期高血压疾病胎儿右心室组织多普勒Tei指数与静脉导管参数的相关性[J].兰州大学学报(医学版),2016,42(6):69-72.
[14]毛红莉.妊娠期高血压疾病患者血清抗心磷脂抗体水平与其妊娠结局的相关性分析[J].齐齐哈尔医学院学报,2017,38(15):1775-1776.
[15]朱毓纯,朱微微,魏玉梅,等.妊娠合并糖尿病与妊娠期高血压疾病的相关性:北京地区15家医院整群分层抽样研究[J].中华糖尿病杂志,2016,8(5):264-267.
[2]陈鹏,史琳,杨红梅,等.妊娠期高血压、子痫前期及子痫与孕前和孕期体质量及其他因素的相关性研究[J].实用妇产科杂志,2017,33(11):848-852.
[3]高文香,徐卫霞,龙丽,等.妊娠期高血压疾病患者血清和肽素水平及临床价值[J].中国妇幼保健,2016,31(5):954-956.
[4]尹维,王建华.妊娠期高血压合并胎儿宫内窘迫的胎儿大脑中动脉血流特征分析及其与缺氧的相关性[J].海南医学院学报,2017,23(1):131-134,138.
[5]石秀霞,马胜辉,李立,等.肾阻力指数对剖宫产术后妊娠期高血压相关性急性肾损伤可逆性诊断的预测价值[J].临床和实验医学杂志,2017,16(7):648-650.
[6]钮慧远,金鑫,张舒,等.内质网氨肽酶2基因rs2549782多态性与妊娠期高血压发病的相关性[J].国际妇产科学杂志,2017,44(6):636-641.
[7]卢潭敏,李爱华.促血管生成素-2与妊娠期高血压疾病的相关性[J].中国妇幼健康研究,2015,26(4):692-694.
[8]周本霞,颜敏.尿β2微球蛋白及D-二聚体与妊娠期高血压肾脏损伤的相关性研究[J].国际检验医学杂志,2017,38(8):1069-1071.
[9]王国成,麻伟博,李娜,等.妊娠期高血压患者血清同型半胱氨酸水平与幽门螺杆菌感染相关性研究[J].中国实验诊断学,2017,21(4):604-606.
[10]黄漫丰.妊娠期高血压孕妇产程行胎心监护的必要性及异常图形与妊娠结局的相关性[J].国际医药卫生导报,2017,23(7):1003-1005.
[11]陈晓晓,张林,熊明,等.血压变异性联合尿微量白蛋白与妊娠期高血压疾病转归的相关性分析[J].中国医刊,2017,52(10):64-66.
[12]陶斯翠,梁辉,何雪花,等.妊娠期高血压疾病胎儿左心室Tei指数的超声评估及其与胎盘缺氧程度的相关性研究[J].海南医学院学报,2017,23(12):1647-1650.
[13]李天刚,王艺璇,杨磊,等.妊娠期高血压疾病胎儿右心室组织多普勒Tei指数与静脉导管参数的相关性[J].兰州大学学报(医学版),2016,42(6):69-72.
[14]毛红莉.妊娠期高血压疾病患者血清抗心磷脂抗体水平与其妊娠结局的相关性分析[J].齐齐哈尔医学院学报,2017,38(15):1775-1776.
[15]朱毓纯,朱微微,魏玉梅,等.妊娠合并糖尿病与妊娠期高血压疾病的相关性:北京地区15家医院整群分层抽样研究[J].中华糖尿病杂志,2016,8(5):264-267.