自噬基因Beclin1对乳腺癌作用的研究进展
|
摘要
自噬是指胞浆内大分子物质和细胞器在膜包囊泡中大量降解的生物学过程,在维持细胞内稳态、调控细胞分化及对环境应激的应答方面极为关键。Beclin1为重要的自噬相关基因,目前研究发现其对乳腺癌的发生发展起着双向作用。本文对近年来Beclin1对乳腺癌作用的研究进展进行综述。
Autophagy is a process that regulates the degradation of cytoplasmic macromolecular substances and organelles,and its role is crucial in maintaining cell homeostasis,cell differentiation,and response to environmental stress. With the deepening of research,we found Beclin1,which was an important autophagy-related gene,played a bidirectional role in the occurrence and development of breast cancer. We review the research progress on the effect of autophagy-related gene Beclin1 on breast cancer.
Autophagy is a process that regulates the degradation of cytoplasmic macromolecular substances and organelles,and its role is crucial in maintaining cell homeostasis,cell differentiation,and response to environmental stress. With the deepening of research,we found Beclin1,which was an important autophagy-related gene,played a bidirectional role in the occurrence and development of breast cancer. We review the research progress on the effect of autophagy-related gene Beclin1 on breast cancer.
引文
[1] Gamirov R,Komarova L,Khasanov R,et al. Early diagnosis ofbreast cancer:public health and mammographic screening[J].Bionanoscience,2018,8(1):407-411.
[2] Li YJ,Lei YH,Yao N,et al. Autophagy and multidrug resist-ance in cancer[J]. Cancer,2017,36(8):342-351.
[3]王丹丹,陈雪松.细胞自噬及其在乳腺癌中的研究进展[J].现代肿瘤医学,2017,25(22):3704-3707.
[4] Liang XH,Jackson S,Seaman M,et al. Induction of autophagyand inhibition of tumorigenesis by Beclin1[J]. Nature,1999,402(6762):672.
[5] Aita VM,Liang XH,Murty VV,et al. Cloning and genomic organ-ization of Beclin1,a candidate tumor suppressor gene on chromo-some 17q21[J]. Genomics,1999,59(1):59-65.
[6] Du Y,Ji X. Bcl-2 down-regulation by small interfering RNA in-duces Beclin1-dependent autophagy in human SGC-7901 cells[J]. Cell Biol Int,2015,38(10):1155-1162.
[7]吕梦,陆航. Beclin 1基因在SW620细胞自噬和凋亡中作用[J].南方医科大学学报,2017,37(3):373-377.
[8] Gao J,Yu H,Guo W,et al. The anticancer effects of ferulic acidis associated with induction of cell cycle arrest and autophagy incervical cancer cells[J]. Cancer Cell Int,2018,18:102.
[9] Huo Y,Cai H,Teplova I,et al. Autophagyoppo-ses p53-media-ted tumor barrier to facilitate tumo-rigenesis in a model of PALB2-associated heredita-ry breast cancer[J]. Cancer Discov,2013,3(8):894-907.
[10] Morris DH,Yip CK,Shi Y,et al. Beclin 1-Vps34 complex ar-chitecture:Understanding the nuts and bolts of therapeutic targets[J]. Front Biol,2015,10(5):398-426.
[11] Miki Y,Tanji K,Mori F,et al. Alteration of upstream autophagy-re-lated proteins(ULK1,ULK2,Beclin1,VPS34 and AMBRA1)inlewy body disease[J]. Brain Pathol,2016,26(3):359-370.
[12] Mcknight N,Zhong Y,Wold M,et al. Beclin 1 is required for neu-ron viability and regulates endosome pathways via the UVRAG-VPS34complex[J/OL]. PLo S Genet,2014[2018-05-20]. https://www.ncbi. nlm. nih. gov/pubmed/pmid/25275521.
[13] Wang L,Tian Y,Ou JH. HCV induces the expression of Rubi-con and UVRAG to temporally regulate the maturation of autopha-gosomes and viral replication[J/OL]. PLo S Pathog,2015[2018-05-20]. https://www. ncbi. nlm. nih. gov/pubmed/25807108.
[14]梁冠男,汤红平,张雁瑞,等. beclin-1、LC3及ki67在青年女性乳腺癌中的表达及临床意义[J].临床医学,2017,37(4):90-92.
[15] Tang H,Sebti S,Titone R,et al. Decreased Beclin1 mRNA ex-pression in human breast cancer is associated with estrogen recep-tor-negative subtypes and poor prognosis[J]. EBio Medicine,2015,2(3):255-263.
[16] Pan Y,Yan GU,Shi Y,et al. Correlation research between Bec-lin1 expression level and clinical stage of breast cancer[J]. ClinLab J,2017,6(3):445-447.
[17] Zhou Y,Rucker EB 3rd,Zhou BP. Autophagy regulation in thedevelopment and treatment of breast cancer[J]. Acta BiochemBiophys Sin(Shanghai),2016,48(1):60-74.
[18] Prateep A,Sumkhemthong S,Karnsomwan W,et al. Avicequi-none B sensitizes anoikis in human lung cancer cells[J]. J Bi-omed Sci,2018,25(1):32.
[19] Gomes LR,Vessoni AT,Menck CFM. Microenvironment and au-tophagy cross-talk:Implications in cancer therapy[J]. Pharmaco-logical Res,2016,107:300-307.
[20]焦庆丽,吴爱国,邵国利,等.乳腺癌组织Beclin1和EMT相关分子标志物表达及其临床意义[J].中华肿瘤防治杂志,2015,22(18):1456-1460.
[21]沈刚,沈文香.多西他赛联合噻替哌治疗对乳腺癌组织中上皮间质转化分子标志物及Beclin1表达的影响[J].中国妇幼保健,2017,32(18):4536-4539.
[22] Henson E,Chen Y,Gibson S. EGFR family members'regulationof autophagy is at a crossroads of cell survival and death in cancer[J]. Cancers,2017,9(4):27.
[23] Chen Z,Gao S,Wang D,et al. Colorectal cancer cells are resist-ant to anti-EGFR monoclonal antibody through adapted autophagy[J]. Am J Transl Res,2016,8(2):1190.
[24] Vega-rubín-de-Celis S,Zou Z,FernndezF,et al. Increasedautophagy blocks HER2-mediated breast tumorigenesis[J]. ProcNatl Acad Sci USA,2018,115(16):4176-4181.
[25] Choi J,Jung W,Koo JS. Expression of autophagy-related mark-ers beclin-1,light chain 3A,light chain 3B and p62 according tothe molecular subtype of breast cancer[J]. Histopathology,2013,62(2):275-286.
[26] Rohatgi RA,Janusis J,Leonard D,et al. Beclin1 regulatesgrowth factor receptor signaling in breast cancer[J]. Oncogene,2015,34(42):5352-5362.
[27] Li Q,Kan X,Yin J,et al. Chamaejasmine B induces the anergyof vascular endothelial cells to VEGFA pro-angiogenic signal byautophagic regulation of VEGFR2 in breast cancer[J]. FrontPharmacol,2017,8:963.
[28] Liu H,Zhao WL,Wang JP,et al. EBP50 suppresses the prolif-eration of MCF-7 human breast cancer cells via promoting Beclin-1/p62-mediated lysosomal degradation of c-Myc[J]. Acta Phar-macol Sin,2018,39(8):1347-1358.
[29] Gong C,Bauvy C,Tonelli G et al. Beclin1 and autophagy are re-quired for thetumorigenicity of breast cancer stem-like/progenitorcells[J]. Autophagy,2013,32(18):2261-2272.
[30] Hamurcu Z,Deliba N,Geene S,et al. Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation,survival,migration andinvasion by inhibition of Cyclin-D1 and uPAR/Integrinβ1/Srcsignaling in triple negative breast cancer cells[J]. J Cancer ResClin Oncol,2017,144(3):415-430.
[31] Wang MC,Wu AG,Huang YZ,et al. Autophagic regulation of cellgrowth by altered expression of Beclin1 in triple-negative breastcancer[J]. Int J Clin Exp Med,2015,8(5):7049-7058.
[32]王梦川,吴爱国,王日玮,等.转染beclin 1基因诱导自噬对三阴性乳腺癌BT-549细胞生长的影响[J].中华乳腺病杂志(电子版),2013,7(1):12-19.
[33] Ueno T,Saji S,SugimotoM,et al. Clinical significance of the ex-pression of autophagy-associated marker,Beclin1,in breast cancerpatients who received neoadjuvant endocrine therapy[J]. BMCCancer,2016,16(1):230.
[34]郑家芬,谭超.自噬相关基因Beclin1沉默对乳腺癌细胞阿霉素敏感性的影响研究[J].现代预防医学,2017,44(16):2992-2996.
[35] Li JP,Yang YX,Liu QL,et al. Aurora kinase,danusertib,breast cancer[J]. Drug Design Development&Therapy,2015,9(default):1027-1062.
[36] Zhang F,Wang B,Long H,et al. Decreased miR-124-3p expres-sion prompted breast cancer cell progression mainly by targetingBeclin-1[J]. Clin Lab,2016,62(6):1139-1145.
[37] Zhang J,Xu Z,Teng L,et al. Lower Beclin 1 downregulatesHER2 expression to enhance tamoxifen sensitivity and predicts afavorable outcome for ER positive breast cancer[J]. Oncotarget,2016,8(32):52156-52177.
[38] Motawi TK,Abdelazim SA,Darwish HA,et al. Could caffeicacid phenethyl ester expand the antitumor effect of tamoxifen inbreast carcinoma?[J]. Nutrition&Cancer,2016,68(3):435-445.
[39] Luo J,Chen J,He L. mir-129-5p attenuates irradiation-inducedautophagy and decreases radioresistance of breast cancer cells bytargeting HMGB1[J]. Med Sci Monit,2015,21:4122-4129.
[40] He WS,Dai XF,Jin M,et al. Hypoxia-induced autophagy con-fers resistance of breast cancer cells to ionizing radiation[J]. On-col Res,2012,20(5-6):251-258.
[41] Amunjela JN,Tucker SJ,Amunjela JN,et al. Abstract 4124:POPDC1 inhibits breast cancer cell migration and proliferation,and is regulated by EGFR(ErbB1)and c AMP[J]. Cancer Res,2017,77(13 Suppl):4124-4124.
[42] Henson E,Chen Y,Gibson S. EGFR family members'regulationof autophagy is at a crossroads of cell survival and death in cancer[J]. Cancers,2017,9(4):27.
[2] Li YJ,Lei YH,Yao N,et al. Autophagy and multidrug resist-ance in cancer[J]. Cancer,2017,36(8):342-351.
[3]王丹丹,陈雪松.细胞自噬及其在乳腺癌中的研究进展[J].现代肿瘤医学,2017,25(22):3704-3707.
[4] Liang XH,Jackson S,Seaman M,et al. Induction of autophagyand inhibition of tumorigenesis by Beclin1[J]. Nature,1999,402(6762):672.
[5] Aita VM,Liang XH,Murty VV,et al. Cloning and genomic organ-ization of Beclin1,a candidate tumor suppressor gene on chromo-some 17q21[J]. Genomics,1999,59(1):59-65.
[6] Du Y,Ji X. Bcl-2 down-regulation by small interfering RNA in-duces Beclin1-dependent autophagy in human SGC-7901 cells[J]. Cell Biol Int,2015,38(10):1155-1162.
[7]吕梦,陆航. Beclin 1基因在SW620细胞自噬和凋亡中作用[J].南方医科大学学报,2017,37(3):373-377.
[8] Gao J,Yu H,Guo W,et al. The anticancer effects of ferulic acidis associated with induction of cell cycle arrest and autophagy incervical cancer cells[J]. Cancer Cell Int,2018,18:102.
[9] Huo Y,Cai H,Teplova I,et al. Autophagyoppo-ses p53-media-ted tumor barrier to facilitate tumo-rigenesis in a model of PALB2-associated heredita-ry breast cancer[J]. Cancer Discov,2013,3(8):894-907.
[10] Morris DH,Yip CK,Shi Y,et al. Beclin 1-Vps34 complex ar-chitecture:Understanding the nuts and bolts of therapeutic targets[J]. Front Biol,2015,10(5):398-426.
[11] Miki Y,Tanji K,Mori F,et al. Alteration of upstream autophagy-re-lated proteins(ULK1,ULK2,Beclin1,VPS34 and AMBRA1)inlewy body disease[J]. Brain Pathol,2016,26(3):359-370.
[12] Mcknight N,Zhong Y,Wold M,et al. Beclin 1 is required for neu-ron viability and regulates endosome pathways via the UVRAG-VPS34complex[J/OL]. PLo S Genet,2014[2018-05-20]. https://www.ncbi. nlm. nih. gov/pubmed/pmid/25275521.
[13] Wang L,Tian Y,Ou JH. HCV induces the expression of Rubi-con and UVRAG to temporally regulate the maturation of autopha-gosomes and viral replication[J/OL]. PLo S Pathog,2015[2018-05-20]. https://www. ncbi. nlm. nih. gov/pubmed/25807108.
[14]梁冠男,汤红平,张雁瑞,等. beclin-1、LC3及ki67在青年女性乳腺癌中的表达及临床意义[J].临床医学,2017,37(4):90-92.
[15] Tang H,Sebti S,Titone R,et al. Decreased Beclin1 mRNA ex-pression in human breast cancer is associated with estrogen recep-tor-negative subtypes and poor prognosis[J]. EBio Medicine,2015,2(3):255-263.
[16] Pan Y,Yan GU,Shi Y,et al. Correlation research between Bec-lin1 expression level and clinical stage of breast cancer[J]. ClinLab J,2017,6(3):445-447.
[17] Zhou Y,Rucker EB 3rd,Zhou BP. Autophagy regulation in thedevelopment and treatment of breast cancer[J]. Acta BiochemBiophys Sin(Shanghai),2016,48(1):60-74.
[18] Prateep A,Sumkhemthong S,Karnsomwan W,et al. Avicequi-none B sensitizes anoikis in human lung cancer cells[J]. J Bi-omed Sci,2018,25(1):32.
[19] Gomes LR,Vessoni AT,Menck CFM. Microenvironment and au-tophagy cross-talk:Implications in cancer therapy[J]. Pharmaco-logical Res,2016,107:300-307.
[20]焦庆丽,吴爱国,邵国利,等.乳腺癌组织Beclin1和EMT相关分子标志物表达及其临床意义[J].中华肿瘤防治杂志,2015,22(18):1456-1460.
[21]沈刚,沈文香.多西他赛联合噻替哌治疗对乳腺癌组织中上皮间质转化分子标志物及Beclin1表达的影响[J].中国妇幼保健,2017,32(18):4536-4539.
[22] Henson E,Chen Y,Gibson S. EGFR family members'regulationof autophagy is at a crossroads of cell survival and death in cancer[J]. Cancers,2017,9(4):27.
[23] Chen Z,Gao S,Wang D,et al. Colorectal cancer cells are resist-ant to anti-EGFR monoclonal antibody through adapted autophagy[J]. Am J Transl Res,2016,8(2):1190.
[24] Vega-rubín-de-Celis S,Zou Z,FernndezF,et al. Increasedautophagy blocks HER2-mediated breast tumorigenesis[J]. ProcNatl Acad Sci USA,2018,115(16):4176-4181.
[25] Choi J,Jung W,Koo JS. Expression of autophagy-related mark-ers beclin-1,light chain 3A,light chain 3B and p62 according tothe molecular subtype of breast cancer[J]. Histopathology,2013,62(2):275-286.
[26] Rohatgi RA,Janusis J,Leonard D,et al. Beclin1 regulatesgrowth factor receptor signaling in breast cancer[J]. Oncogene,2015,34(42):5352-5362.
[27] Li Q,Kan X,Yin J,et al. Chamaejasmine B induces the anergyof vascular endothelial cells to VEGFA pro-angiogenic signal byautophagic regulation of VEGFR2 in breast cancer[J]. FrontPharmacol,2017,8:963.
[28] Liu H,Zhao WL,Wang JP,et al. EBP50 suppresses the prolif-eration of MCF-7 human breast cancer cells via promoting Beclin-1/p62-mediated lysosomal degradation of c-Myc[J]. Acta Phar-macol Sin,2018,39(8):1347-1358.
[29] Gong C,Bauvy C,Tonelli G et al. Beclin1 and autophagy are re-quired for thetumorigenicity of breast cancer stem-like/progenitorcells[J]. Autophagy,2013,32(18):2261-2272.
[30] Hamurcu Z,Deliba N,Geene S,et al. Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation,survival,migration andinvasion by inhibition of Cyclin-D1 and uPAR/Integrinβ1/Srcsignaling in triple negative breast cancer cells[J]. J Cancer ResClin Oncol,2017,144(3):415-430.
[31] Wang MC,Wu AG,Huang YZ,et al. Autophagic regulation of cellgrowth by altered expression of Beclin1 in triple-negative breastcancer[J]. Int J Clin Exp Med,2015,8(5):7049-7058.
[32]王梦川,吴爱国,王日玮,等.转染beclin 1基因诱导自噬对三阴性乳腺癌BT-549细胞生长的影响[J].中华乳腺病杂志(电子版),2013,7(1):12-19.
[33] Ueno T,Saji S,SugimotoM,et al. Clinical significance of the ex-pression of autophagy-associated marker,Beclin1,in breast cancerpatients who received neoadjuvant endocrine therapy[J]. BMCCancer,2016,16(1):230.
[34]郑家芬,谭超.自噬相关基因Beclin1沉默对乳腺癌细胞阿霉素敏感性的影响研究[J].现代预防医学,2017,44(16):2992-2996.
[35] Li JP,Yang YX,Liu QL,et al. Aurora kinase,danusertib,breast cancer[J]. Drug Design Development&Therapy,2015,9(default):1027-1062.
[36] Zhang F,Wang B,Long H,et al. Decreased miR-124-3p expres-sion prompted breast cancer cell progression mainly by targetingBeclin-1[J]. Clin Lab,2016,62(6):1139-1145.
[37] Zhang J,Xu Z,Teng L,et al. Lower Beclin 1 downregulatesHER2 expression to enhance tamoxifen sensitivity and predicts afavorable outcome for ER positive breast cancer[J]. Oncotarget,2016,8(32):52156-52177.
[38] Motawi TK,Abdelazim SA,Darwish HA,et al. Could caffeicacid phenethyl ester expand the antitumor effect of tamoxifen inbreast carcinoma?[J]. Nutrition&Cancer,2016,68(3):435-445.
[39] Luo J,Chen J,He L. mir-129-5p attenuates irradiation-inducedautophagy and decreases radioresistance of breast cancer cells bytargeting HMGB1[J]. Med Sci Monit,2015,21:4122-4129.
[40] He WS,Dai XF,Jin M,et al. Hypoxia-induced autophagy con-fers resistance of breast cancer cells to ionizing radiation[J]. On-col Res,2012,20(5-6):251-258.
[41] Amunjela JN,Tucker SJ,Amunjela JN,et al. Abstract 4124:POPDC1 inhibits breast cancer cell migration and proliferation,and is regulated by EGFR(ErbB1)and c AMP[J]. Cancer Res,2017,77(13 Suppl):4124-4124.
[42] Henson E,Chen Y,Gibson S. EGFR family members'regulationof autophagy is at a crossroads of cell survival and death in cancer[J]. Cancers,2017,9(4):27.