SPME-GC-MS筛选肺癌标志物的影响因素综述
|
摘要
综述了近年来基于SPME-GC-MS联用技术在筛选呼出气、血液、尿液等生物样本中挥发性有机化合物(VOCs)作为肺癌标志物的研究进展,总结了在各个关键步骤中对分析结果产生影响的各项因素以及相应的作用,并对GC-MS分析技术在肺癌诊断研究中存在的问题进行了总结和展望。
This paper reviews the recent development in screening volatile organic compounds( VOCs)as lung cancer biomarkers in biological samples such as exhaled breath,blood and urine based on SPME-GC-MS technology. The various factors in the key procedures and corresponding effects influencing the analysis results are summarized. And the current problems and the further trends of the GC-MS analytical technology in the diagnosis of lung cancer are stated.
This paper reviews the recent development in screening volatile organic compounds( VOCs)as lung cancer biomarkers in biological samples such as exhaled breath,blood and urine based on SPME-GC-MS technology. The various factors in the key procedures and corresponding effects influencing the analysis results are summarized. And the current problems and the further trends of the GC-MS analytical technology in the diagnosis of lung cancer are stated.
引文
[1] Chen W Q,Sun K X,Zheng R S,Zhang S W,Zeng H M,Zou X N,He J. China Cancer.,2018,27(1):1陈万青,孙可欣,郑荣寿,张思维,曾红梅,邹小农,赫捷.中国肿瘤,2018,27(1):1
[2] Tirzīte M,Bukovskis M,Strazda G,Jurka N,Taivans I. J. Breath Res.,2017,11(3):36009
[3] Rami-Porta R,Crowley J J,Goldstraw P. Ann. Thorac. Cardiovasc. Surg.,2009,15(1):4
[4] Gordon S M,Szidon J P,Krotoszynski B K,Gibbons R D,O’Neill H J. Clin. Chem.,1985,31(8):1278
[5] Kharitonov S A,Barnes P J. Biomarkers,2002,7(1):1
[6] GuadagniR,Miraglia N,Simonelli A,Silvestre A,Lamberti M,Feola D,Acampora A,Sannolo N. Anal. Chim. Acta,2011,701(1):29
[7] Buszewski B,Ulanowska A,Ligor T,Denderz N,Amann A. Biomed. Chromatogr.,2009,23(5):551
[8] Ligor T,Ligor M,Amann A,Ager C,Bachler M,Dzien A,Buszewski B. J. Breath Res.,2008,2(4):46006
[9] Arthur C L,Pawliszyn J. Anal. Chem.,1990,62(19):2145
[10] Li C X,Zhang P P,Wang L C,Liu H J,Pan Z F,Wang L L. Adv. Anal. Chem.,2014,4:11李彩霞,张佩佩,王利超,刘会君,潘再法,王丽丽.分析化学进展,2014,4:11
[11] King J,Mochalski P,Kupferthaler A,Unterkofler K,Koc H,Filipiak W,Teschl S,Hinterhuber H,Amann A. Physiol.Meas.,2010,31(9):1169
[12] Poli D,Goldoni M,Corradi M,Acampa O,Carbognani P,Internullo E,Casalini A,Mutti A. J. Chromatogr. B.,2010,878(27):2643
[13] Bajtarevic A,Ager C,Pienz M,Amel,Klieber M,Schwarz K,Ligor M,Ligor T,Filipiak W,Denz H,Fiegl M,Hilbe W,Weiss W,Lukas P,Jamnig H,Hackl M,Haidenberger A,Buszewski B,Miekisch W,Schubert J,Amann A. BMC cancer,2009,9(1):348
[14] De L C B,Amann A,Alkateb H,AI-Kateb H,Flynn C,Filipiak W,Khalid T,Osborne D,Ratcliffe N M. J. Breath Res.,2014,8(1):14001
[15] Ligor M,Ligor T,Bajtarevic A,Ager C,Pienz M,Klieber M,Denz H,Fiegl M,Hilbe W,Weiss W,Lukas P,Jamnig H,Hackl M,Buszewski B,Miekisch W,Schubert J,Amann A. Clin. Chem. Lab. Med.,2009,47(5):550
[16] Bianchi F,Riboni N,Carbognani P,Gnetti L,Dalcanale E,Ampollini L,Careri M. J. Pharmaceut. Biomed.,2017,146:329
[17] Gordon S M,Szidon J P,Krotoszynski B K,Gibbons R D,O’Neill H J. Clin. Chem.,1985,31(8):1278
[18] Deng C,Zhang X,Li N. J. Chromatogr. B.,2004,808(2):269
[19] Deng C,Li N,Zhang X. J. Chromatogr. B.,2004,813(1-2):47
[20] Niu Y J,Jiang Y L,Xu C J,Wang X Y,Liu Y R,Zhao H,Han B H,Jiang L Y. Chin. J. Oncol.,2012,15(4):195牛艳洁,江银玲,许长江,王向迎,刘友如,赵珩,韩宝惠,姜丽岩.中国肺癌杂志,2012,15(4):195
[21] Rocha S M,Caldeira M,Carrola J,Santos M,Cruz N,Duarte I F. J. Chromatogr. A.,2012,1252:155
[22] Gallagher M,Wysocki C J,Leyden J J,Spielman A I,Sun X,Preti G. Brit. J. Dermatol.,2008,159(4):780
[23] Sánchez M D N,García E H,Pavón J L,Cordero B M. Anal. Chem.,2012,84(1):379
[24] Zhou X M,He C C,Liu Y M,Zhao Y,Zhao D,Du Y,Zheng W Y,Li J X. Anal. Bioanal. Chem.,2012,404(10):3123
[25] Liu H,Wang H,Li C,Wang L,Pan Z,Wang L. J. Chromatogr. B.,2014,945:53
[26] Yu J,Wang D,Wang L,Wang P,Hu Y J,Ying K J. AIP Conf. Proc.,2009,1137(1):198
[27] Phillips M,Altorki N,Austin J H,MD,Cameron R B,Cataneo R N,Kloss R,Maxfield R A,Munawar M I,Pass H I,Rashid A,Rom W N,Schmit P,Wai J. Clin. Chim. Acta,2008,393(2):76
[28] McWilliams A,Beigi P,Srinidhi A,Lam S,Macaulay C E. IEEE T. Bio-Med. Eng.,2015,62(8):2044
[29] Gaspar E M,Lucena A F,Duro da Costa J,Chaves das Neves H. J. Chromatogr. A.,2009,1216(14):2749
[30] Robroeks C M,van Berkel J J,Jbsis Q,van Schooten F J,Dallinga J W,Wouters E F,Dompeling E. Eur. Respir. J.,2013,42(1):98
[31] Rattray N J,Hamrang Z,Trivedi D K,Goodacre R,Fowler S J. Trends Biotechnol.,2014,32(10):538
[32] Kataoka H,Saito K,Kato H,Masuda K. Bioanalysis,2013,5(11):1443
[33] Poli D,Carbognani P,Corradi M,Goldoni M,Acampa O,Balbi B,Bianchi L,Rusca M,Mutti A. Resp. Res,2005,6(1):71
[34] Wang Y,Hu Y,Wang D,Yu K,Wang L,Zou Y,Zhao C,Zhang X,Wang P,Ying K. Cancer Biomark.,2012,11(4):129
[35] Capuano R,Santonico M,Pennazza G,Ghezzi S,Martinelli E,Roscioni C,Lucantoni G,Galluccio G,Paolesse R,Natale C D,D’Amico A. Sci. Rep.,2015,5:16491
[36] Wedge D C,Allwood J W,Dunn W,Vaughan A A,Simpson K,Brown M,Priest L,Blackhall F H,Whetton A D,Dive C,Goodacre R. Anal. Chem.,2011,83(17):6689
[37] Borges C R,Rehder D S,Boffetta P. Anal. Chem.,2013,85(5):2927
[38] Lu Y,Niu W,Zou X,Shen C,Xia L,Huang C,Wang H,Jiang H,Chu Y. J. Chromatogr. A.,2017,1496:20
[39] Kataoka H,Saito K,Kato H,Masuda K. Bioanalysis,2013,5(11):1443
[40] Amann A,Ligor M,Ligor T,Bajtarevic A,Ager C,Pienz M,Denz H,Fiegl M,Hilbe W,Weiss W,Lukas P,Jamnig H,Hackl M,Haidenberger A,Sponring A,Filipiak W,Miekisch W,Schubert J,Troppmair J,Buszewski B. MEMO,2010,3(3):106
[41] Chen M,Yuan D X,Xu P X,Chang D H. J. Anal. Sci.,2002,18(5):429陈猛,袁东星,许鹏翔,昌敦虎等.分析科学学报,2002,18(5):429
[42] Bojko B,Reyes-Garcés N,Bessonneau V,Goryński K,Mousavi F,Silva E A S,Pawliszyn J. Trac-Trend Anal. Chem.,2014,61:168
[43] Arthur C L,Potter D W,Buchholz K D,Motlagh S,Pawliszyn J. Lc Gc,1992,10(9):656
[44] Górecki T,Yu X,Pawliszyn J. Analyst,1999,124(5):643
[45] Ligor T,Pater,Buszewski B. J. Breath Res.,2015,9(2):27106
[46] Kischkel S,Miekisch W,Sawacki A,Straker E M,Trefz P,Amann A,Schubert J K. Clin. Chim. Acta,2010,411(21-22):1637
[47] Rudnicka J,Walczak M,Kowalkowski T,Jezierski T,Buszewski B. Sensor Actuat. B-Chem.,2014,202:615
[48] Xu G,Shi M G,Wu M H,Liu N,Shi Q H. J Shanghai Univ.(Nat. Sci. Ed.),2013,19(4):368徐刚,史茗歌,吴明红,刘宁,师千惠.上海大学学报(自然科学版),2013,19(4):368
[49] Ulanowska A,Trawińska E,Sawrycki P,Buszewski B. J. Sep. Scie.,2012,35(21):2908
[50] Yang T Z,Luo S Z. Environ. Stud. Monit.,2006,19(1):1杨通在,罗顺忠.环境研究与监测,2006,19(1):1
[51] Li P,Wu L,Feng X,Qiu J P,Ma P. Asia-Pac. Tradit. Med.,2016,12(1):52李盼,吴玲,冯旭,邱骥鹏,马盼.亚太传统医药,2016,12(1):52
[52] Zhou S,Zhao L W,Ma T J,et al. Mod. Sci. Instr.,2006,1(3):14周珊,赵立文,马腾蛟,等.现代科学仪器,2006,1(3):14
[53] Zhou J,Huang Z A,Kumar U,Chen D Y. Clin. Chim. Acta,2017,996:1
[54] Hübschmann H J. Handbook of GC-MS:fundamentals and applications(Third Edition),Hoboken:John Wiley&Sons,2015:85
[55] Hanai Y,Shimono K,Oka H,Baba Y,Yamazaki K,Beauchamp G K. Cancer Cell Int.,2012,12(1):1
[56] Guadagni R,Miraglia N,Simonelli A,Silvestre A,Lamberti M,Feola D,Acampora A,Sannolo N. Clin. Chim. Acta,2011,701(1):29
[57] Hecht S S,Hochalter J B,Carmella S G,Zhang Y,Rauch D M,Fujioka N,Jensen J,Hatsukami D K. Biomarkers,2013,18(2):144
[58] Buszewski B,Ligor T,Jezierski T,Piesik A W,Walczak M,Rudnicka J. Anal. Bioanal. Chem.,2012,404(1):141
[59] Ulanowska A,Kowalkowski T,Trawińska E,Buszewski B. J Breath Res.,2011,5(4):46008
[60] Wang C S,Dong R,Wang X Y,Lian A L,Chi C J,Ke C F,Guo L,Liu S S,Zhao W,Xu G W,Li E Y. Sci. Rep-uk,2014,4(1):7312
[61] Chen X,Xu F,Wang Y,Pan Y,Lu D,Wang P,Ying K,Chen E,Zhang W. Cancer,2007,110(4):835
[62] Liu H W. Gas Chromatography Method and Application(Second Edition),Beijing:Chemical Industry Press,2007:38刘虎威.气相色谱方法及应用(第二版),北京:化学工业出版社,2007:38
[63] Ke C F,Zhang T,Wu X Y,Li K. Chin. J. Health Stat.,2014,31(2):357柯朝甫,张涛,武晓岩,李康.中国卫生统计,2014,31(2):357
[64] Van den Berg R A,Hoefsloot H C J,Westerhuis J A,Smilde A K,van der Werf M. Bmc Genomics,2006,7(1):142
[65] Trygg J,Holmes E,Lundstedt T. J. Proteome Res.,2007,6(2):469
[66] A J Y. Chin. J. Clin. Pharmacol. Ther.,2010 15(5):481阿基业.中国临床药理学与治疗学,2010 15(5):481
[2] Tirzīte M,Bukovskis M,Strazda G,Jurka N,Taivans I. J. Breath Res.,2017,11(3):36009
[3] Rami-Porta R,Crowley J J,Goldstraw P. Ann. Thorac. Cardiovasc. Surg.,2009,15(1):4
[4] Gordon S M,Szidon J P,Krotoszynski B K,Gibbons R D,O’Neill H J. Clin. Chem.,1985,31(8):1278
[5] Kharitonov S A,Barnes P J. Biomarkers,2002,7(1):1
[6] GuadagniR,Miraglia N,Simonelli A,Silvestre A,Lamberti M,Feola D,Acampora A,Sannolo N. Anal. Chim. Acta,2011,701(1):29
[7] Buszewski B,Ulanowska A,Ligor T,Denderz N,Amann A. Biomed. Chromatogr.,2009,23(5):551
[8] Ligor T,Ligor M,Amann A,Ager C,Bachler M,Dzien A,Buszewski B. J. Breath Res.,2008,2(4):46006
[9] Arthur C L,Pawliszyn J. Anal. Chem.,1990,62(19):2145
[10] Li C X,Zhang P P,Wang L C,Liu H J,Pan Z F,Wang L L. Adv. Anal. Chem.,2014,4:11李彩霞,张佩佩,王利超,刘会君,潘再法,王丽丽.分析化学进展,2014,4:11
[11] King J,Mochalski P,Kupferthaler A,Unterkofler K,Koc H,Filipiak W,Teschl S,Hinterhuber H,Amann A. Physiol.Meas.,2010,31(9):1169
[12] Poli D,Goldoni M,Corradi M,Acampa O,Carbognani P,Internullo E,Casalini A,Mutti A. J. Chromatogr. B.,2010,878(27):2643
[13] Bajtarevic A,Ager C,Pienz M,Amel,Klieber M,Schwarz K,Ligor M,Ligor T,Filipiak W,Denz H,Fiegl M,Hilbe W,Weiss W,Lukas P,Jamnig H,Hackl M,Haidenberger A,Buszewski B,Miekisch W,Schubert J,Amann A. BMC cancer,2009,9(1):348
[14] De L C B,Amann A,Alkateb H,AI-Kateb H,Flynn C,Filipiak W,Khalid T,Osborne D,Ratcliffe N M. J. Breath Res.,2014,8(1):14001
[15] Ligor M,Ligor T,Bajtarevic A,Ager C,Pienz M,Klieber M,Denz H,Fiegl M,Hilbe W,Weiss W,Lukas P,Jamnig H,Hackl M,Buszewski B,Miekisch W,Schubert J,Amann A. Clin. Chem. Lab. Med.,2009,47(5):550
[16] Bianchi F,Riboni N,Carbognani P,Gnetti L,Dalcanale E,Ampollini L,Careri M. J. Pharmaceut. Biomed.,2017,146:329
[17] Gordon S M,Szidon J P,Krotoszynski B K,Gibbons R D,O’Neill H J. Clin. Chem.,1985,31(8):1278
[18] Deng C,Zhang X,Li N. J. Chromatogr. B.,2004,808(2):269
[19] Deng C,Li N,Zhang X. J. Chromatogr. B.,2004,813(1-2):47
[20] Niu Y J,Jiang Y L,Xu C J,Wang X Y,Liu Y R,Zhao H,Han B H,Jiang L Y. Chin. J. Oncol.,2012,15(4):195牛艳洁,江银玲,许长江,王向迎,刘友如,赵珩,韩宝惠,姜丽岩.中国肺癌杂志,2012,15(4):195
[21] Rocha S M,Caldeira M,Carrola J,Santos M,Cruz N,Duarte I F. J. Chromatogr. A.,2012,1252:155
[22] Gallagher M,Wysocki C J,Leyden J J,Spielman A I,Sun X,Preti G. Brit. J. Dermatol.,2008,159(4):780
[23] Sánchez M D N,García E H,Pavón J L,Cordero B M. Anal. Chem.,2012,84(1):379
[24] Zhou X M,He C C,Liu Y M,Zhao Y,Zhao D,Du Y,Zheng W Y,Li J X. Anal. Bioanal. Chem.,2012,404(10):3123
[25] Liu H,Wang H,Li C,Wang L,Pan Z,Wang L. J. Chromatogr. B.,2014,945:53
[26] Yu J,Wang D,Wang L,Wang P,Hu Y J,Ying K J. AIP Conf. Proc.,2009,1137(1):198
[27] Phillips M,Altorki N,Austin J H,MD,Cameron R B,Cataneo R N,Kloss R,Maxfield R A,Munawar M I,Pass H I,Rashid A,Rom W N,Schmit P,Wai J. Clin. Chim. Acta,2008,393(2):76
[28] McWilliams A,Beigi P,Srinidhi A,Lam S,Macaulay C E. IEEE T. Bio-Med. Eng.,2015,62(8):2044
[29] Gaspar E M,Lucena A F,Duro da Costa J,Chaves das Neves H. J. Chromatogr. A.,2009,1216(14):2749
[30] Robroeks C M,van Berkel J J,Jbsis Q,van Schooten F J,Dallinga J W,Wouters E F,Dompeling E. Eur. Respir. J.,2013,42(1):98
[31] Rattray N J,Hamrang Z,Trivedi D K,Goodacre R,Fowler S J. Trends Biotechnol.,2014,32(10):538
[32] Kataoka H,Saito K,Kato H,Masuda K. Bioanalysis,2013,5(11):1443
[33] Poli D,Carbognani P,Corradi M,Goldoni M,Acampa O,Balbi B,Bianchi L,Rusca M,Mutti A. Resp. Res,2005,6(1):71
[34] Wang Y,Hu Y,Wang D,Yu K,Wang L,Zou Y,Zhao C,Zhang X,Wang P,Ying K. Cancer Biomark.,2012,11(4):129
[35] Capuano R,Santonico M,Pennazza G,Ghezzi S,Martinelli E,Roscioni C,Lucantoni G,Galluccio G,Paolesse R,Natale C D,D’Amico A. Sci. Rep.,2015,5:16491
[36] Wedge D C,Allwood J W,Dunn W,Vaughan A A,Simpson K,Brown M,Priest L,Blackhall F H,Whetton A D,Dive C,Goodacre R. Anal. Chem.,2011,83(17):6689
[37] Borges C R,Rehder D S,Boffetta P. Anal. Chem.,2013,85(5):2927
[38] Lu Y,Niu W,Zou X,Shen C,Xia L,Huang C,Wang H,Jiang H,Chu Y. J. Chromatogr. A.,2017,1496:20
[39] Kataoka H,Saito K,Kato H,Masuda K. Bioanalysis,2013,5(11):1443
[40] Amann A,Ligor M,Ligor T,Bajtarevic A,Ager C,Pienz M,Denz H,Fiegl M,Hilbe W,Weiss W,Lukas P,Jamnig H,Hackl M,Haidenberger A,Sponring A,Filipiak W,Miekisch W,Schubert J,Troppmair J,Buszewski B. MEMO,2010,3(3):106
[41] Chen M,Yuan D X,Xu P X,Chang D H. J. Anal. Sci.,2002,18(5):429陈猛,袁东星,许鹏翔,昌敦虎等.分析科学学报,2002,18(5):429
[42] Bojko B,Reyes-Garcés N,Bessonneau V,Goryński K,Mousavi F,Silva E A S,Pawliszyn J. Trac-Trend Anal. Chem.,2014,61:168
[43] Arthur C L,Potter D W,Buchholz K D,Motlagh S,Pawliszyn J. Lc Gc,1992,10(9):656
[44] Górecki T,Yu X,Pawliszyn J. Analyst,1999,124(5):643
[45] Ligor T,Pater,Buszewski B. J. Breath Res.,2015,9(2):27106
[46] Kischkel S,Miekisch W,Sawacki A,Straker E M,Trefz P,Amann A,Schubert J K. Clin. Chim. Acta,2010,411(21-22):1637
[47] Rudnicka J,Walczak M,Kowalkowski T,Jezierski T,Buszewski B. Sensor Actuat. B-Chem.,2014,202:615
[48] Xu G,Shi M G,Wu M H,Liu N,Shi Q H. J Shanghai Univ.(Nat. Sci. Ed.),2013,19(4):368徐刚,史茗歌,吴明红,刘宁,师千惠.上海大学学报(自然科学版),2013,19(4):368
[49] Ulanowska A,Trawińska E,Sawrycki P,Buszewski B. J. Sep. Scie.,2012,35(21):2908
[50] Yang T Z,Luo S Z. Environ. Stud. Monit.,2006,19(1):1杨通在,罗顺忠.环境研究与监测,2006,19(1):1
[51] Li P,Wu L,Feng X,Qiu J P,Ma P. Asia-Pac. Tradit. Med.,2016,12(1):52李盼,吴玲,冯旭,邱骥鹏,马盼.亚太传统医药,2016,12(1):52
[52] Zhou S,Zhao L W,Ma T J,et al. Mod. Sci. Instr.,2006,1(3):14周珊,赵立文,马腾蛟,等.现代科学仪器,2006,1(3):14
[53] Zhou J,Huang Z A,Kumar U,Chen D Y. Clin. Chim. Acta,2017,996:1
[54] Hübschmann H J. Handbook of GC-MS:fundamentals and applications(Third Edition),Hoboken:John Wiley&Sons,2015:85
[55] Hanai Y,Shimono K,Oka H,Baba Y,Yamazaki K,Beauchamp G K. Cancer Cell Int.,2012,12(1):1
[56] Guadagni R,Miraglia N,Simonelli A,Silvestre A,Lamberti M,Feola D,Acampora A,Sannolo N. Clin. Chim. Acta,2011,701(1):29
[57] Hecht S S,Hochalter J B,Carmella S G,Zhang Y,Rauch D M,Fujioka N,Jensen J,Hatsukami D K. Biomarkers,2013,18(2):144
[58] Buszewski B,Ligor T,Jezierski T,Piesik A W,Walczak M,Rudnicka J. Anal. Bioanal. Chem.,2012,404(1):141
[59] Ulanowska A,Kowalkowski T,Trawińska E,Buszewski B. J Breath Res.,2011,5(4):46008
[60] Wang C S,Dong R,Wang X Y,Lian A L,Chi C J,Ke C F,Guo L,Liu S S,Zhao W,Xu G W,Li E Y. Sci. Rep-uk,2014,4(1):7312
[61] Chen X,Xu F,Wang Y,Pan Y,Lu D,Wang P,Ying K,Chen E,Zhang W. Cancer,2007,110(4):835
[62] Liu H W. Gas Chromatography Method and Application(Second Edition),Beijing:Chemical Industry Press,2007:38刘虎威.气相色谱方法及应用(第二版),北京:化学工业出版社,2007:38
[63] Ke C F,Zhang T,Wu X Y,Li K. Chin. J. Health Stat.,2014,31(2):357柯朝甫,张涛,武晓岩,李康.中国卫生统计,2014,31(2):357
[64] Van den Berg R A,Hoefsloot H C J,Westerhuis J A,Smilde A K,van der Werf M. Bmc Genomics,2006,7(1):142
[65] Trygg J,Holmes E,Lundstedt T. J. Proteome Res.,2007,6(2):469
[66] A J Y. Chin. J. Clin. Pharmacol. Ther.,2010 15(5):481阿基业.中国临床药理学与治疗学,2010 15(5):481