补脾健脺饮干预2型糖尿病大鼠糖脂代谢的实验研究
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摘要
目的:观察补脾健脺饮对2型糖尿病大鼠糖脂代谢的影响。方法:制成糖尿病大鼠模型,分成正常组、模型组、盐酸吡格列酮组、补脾健脺饮高剂量组、补脾健脺饮中剂量组、补脾健脺饮低剂量组,4周后检测血糖、血脂等。结果:补脾健脺饮对链脲佐菌素致大鼠2型糖尿病模型具有降低葡萄糖耐量和改善血脂的作用。结论:补脾健脺饮对糖尿病大鼠糖脂代谢有明显改善作用。
Objective: To observe clinical effects of Bupi Jiancui Yin( 补 脾 健 脺 饮) on glycolipid metabolism in diabeticⅡ rats.Methods: The diabetic rats model was built. The rats were divided into the normal group, the model group, the PGZ group, Bupi Jiancui Yin high dose group, Bupi Jiancui Yin medium dose group, Bupi Jiancui Yin low dose group. Blood glucose and blood lipid were tested after 4 weeks. Results: Bupi Jiancui Yin can reduced glucose tolerance and improve blood lipid in rats with diabeticⅡcaused by STZ. Conclusion:Bupi Jiancui Yin on glycolipid metabolism in rats with diabeticⅡis effective.
Objective: To observe clinical effects of Bupi Jiancui Yin( 补 脾 健 脺 饮) on glycolipid metabolism in diabeticⅡ rats.Methods: The diabetic rats model was built. The rats were divided into the normal group, the model group, the PGZ group, Bupi Jiancui Yin high dose group, Bupi Jiancui Yin medium dose group, Bupi Jiancui Yin low dose group. Blood glucose and blood lipid were tested after 4 weeks. Results: Bupi Jiancui Yin can reduced glucose tolerance and improve blood lipid in rats with diabeticⅡcaused by STZ. Conclusion:Bupi Jiancui Yin on glycolipid metabolism in rats with diabeticⅡis effective.
引文
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[2]郭学军,邹移海,吴凌.链脲佐菌素诱导SD和Wistar大鼠糖尿病模型的影响因[J].中国实验动物学报,2008,16(4):301-304.
[3]Stumvoll M,Goldstein BJ,van Haeften TW.Pathogenesis of type 2diabetes[J].Endocr Res,2007,32(1-2):19-37.
[4]Muoio DM,Newgard CB.Mechanisms of disease:molecular andmetabolic mechanisms of insulin resistance and beta-cell failure in type 2diabetes[J].Nat Rev Mol Cell Biol,2008,9(3):193-205.
[5]戴鹏,陶枫.近五年“从脾论治”糖尿病常用方药研究概况及对研究方向的思考[J].时珍国医国药,2012,23(3):733-736.