2005—2014年中日友好医院肺癌发病情况研究
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摘要
目的对比分析2005—2014年中日友好医院住院患者中原发性肺癌患者的病理类型、年龄、性别的差异,以初步了解近10年本院住院肺癌患者的流行病学特征。方法调查2005—2014年在中日友好医院初次住院的原发性肺癌患者的临床资料,对肺癌病理类型构成、发病年龄、性别分布进行统计分析。结果本研究纳入2005—2014年初次住院的原发性肺癌患者共4 114例,明确病理诊断3 183例,临床诊断931例。肺腺癌患者构成比最高,占52.25%(1 663/3 183),男性患者例数是女性的1.98倍(2 734/1 380)。高发年龄为56~75岁,占60.73%(2 499/4 114)。2005—2014年各年病理类型构成比(χ2=27.277,P=0.449)、各年龄段构成比(Z=0.573,P=0.999)比较,差异均无统计学意义。男女患者年龄段构成比比较,差异无统计学意义(χ2=0.152,P=0.879);2005—2014年各年份男女患者构成比比较,差异无统计学意义(χ2=6.446,P=0.695)。Spearman相关分析显示,56~65岁患者构成比与年份呈正相关(rs=0.806,P=0.005)。结论中日友好医院近10年收治住院原发性肺癌患者例数呈逐年增长趋势,腺癌构成比最高,其次是鳞癌、小细胞肺癌。高发年龄段为56~75岁;男性鳞癌比例高于女性。
Objective To make a comparative study on pathological pattern,age and gender of inpatients with primary lung cancer in China- Japan Friendship Hospital from 2005 to 2014, in order to investigate the epidemiologic features of inpatients with lung cancer in the hospital in the past 10 years. Methods We made an investigation on the clinical data of patients with primary lung cancer who were firstly admitted into China- Japan Friendship Hospital from 2005 to 2014. Statistical analysis was made on the pathological types of lung cancer,onset age and gender distribution. Results A total of 4 114 patients with primary lung cancer who were firstly admitted into the hospital from 2005 to 2014 were recruited,with pathological diagnosis for 3 183 and clinical diagnosis for 931 patients. The patients with lung adenocarcinoma accounted for 52. 25%( 1 663 /3 183)with the highest proportion,and the number of males was 1. 98( 2 734 /1 380) times that of females. The peak onset age range was 56- 75,and the patients of this age range accounted for 60. 73%( 2 499 /4 114). The pathological type distribution was not significantly different among different years( χ2= 27. 277, P = 0. 449), and the age distribution was not significantly different among different years( Z = 0. 573,P = 0. 999). Age distribution was not significantly different between males and females( χ2= 0. 152,P = 0. 879),and gender distribution was not significantly different among different years( χ2= 6. 446,P= 0. 695). Rank correlation analysis showed that distribution of 56- 65 age group was positively correlated with year( rs=0. 806,P = 0. 005). Conclusion The number of primary lung cancer patients admitted by China- Japan Friendship Hospital in the past 10 years is increasing,and prevalence is highest in adenocarcinoma,second highest in squamous carcinoma and third highest in small cell lung cancer. The peak onset age range is 56- 75. Males are higher than females in the prevalence of squamous carcinoma.
Objective To make a comparative study on pathological pattern,age and gender of inpatients with primary lung cancer in China- Japan Friendship Hospital from 2005 to 2014, in order to investigate the epidemiologic features of inpatients with lung cancer in the hospital in the past 10 years. Methods We made an investigation on the clinical data of patients with primary lung cancer who were firstly admitted into China- Japan Friendship Hospital from 2005 to 2014. Statistical analysis was made on the pathological types of lung cancer,onset age and gender distribution. Results A total of 4 114 patients with primary lung cancer who were firstly admitted into the hospital from 2005 to 2014 were recruited,with pathological diagnosis for 3 183 and clinical diagnosis for 931 patients. The patients with lung adenocarcinoma accounted for 52. 25%( 1 663 /3 183)with the highest proportion,and the number of males was 1. 98( 2 734 /1 380) times that of females. The peak onset age range was 56- 75,and the patients of this age range accounted for 60. 73%( 2 499 /4 114). The pathological type distribution was not significantly different among different years( χ2= 27. 277, P = 0. 449), and the age distribution was not significantly different among different years( Z = 0. 573,P = 0. 999). Age distribution was not significantly different between males and females( χ2= 0. 152,P = 0. 879),and gender distribution was not significantly different among different years( χ2= 6. 446,P= 0. 695). Rank correlation analysis showed that distribution of 56- 65 age group was positively correlated with year( rs=0. 806,P = 0. 005). Conclusion The number of primary lung cancer patients admitted by China- Japan Friendship Hospital in the past 10 years is increasing,and prevalence is highest in adenocarcinoma,second highest in squamous carcinoma and third highest in small cell lung cancer. The peak onset age range is 56- 75. Males are higher than females in the prevalence of squamous carcinoma.
引文
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[14]Proctor RN.The history of the discovery of the cigaretteelung cancer link:evidentiary traditions,corporate denial,global toll[J].Tobacco Control,2012,21(2):87-91.
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[2]Travis WD,Brambila E,Muller-Hermelink GK,et al.World Health Organization classification of tumours,pathology and genetics of tumours of the lung,pleura,thmus and heart[M].Lyon:IARC Press,2004:9-124.
[3]支修益,石远凯,于金明.中国原发性肺癌诊疗规范(2015年版)[J].中华肿瘤杂志,2015,37(1):67.
[4]钱桂生,余时沧.肺癌流行病学最新资料与启示[J].中华结核和呼吸杂志,2012,35(2):87.
[5]Kris.Study using comprehensive genomic tumor testing to match lung cancer patients with targeted therapies transforms care[EB/OL].https://www.mskcc.org/press-releases/study-usingcomprehensive-genomic-tumor-testing-match-lung-patientstargeted-therapies-transforms-care.
[6]Alberg AJ,Brock MV,Ford JG,et al.Epidemiology of lung cancer diagnosis and management of lung cancer,3rd ed:American College of Chest Physicians evidence-based clinical practice guidelines[J].Chest,2013,143(5 Suppl):e1S-29.
[7]de Perrot M,Licker M,Bouchardy C,et al.Sex differences in presentation,management,and prognosis of patients with non-small cell lung carcinoma[J].J Thorac Cardiovasc Surg,2000,119(1):21-26.
[8]Visbal AL,Williams BA,Nichols FC 3rd,et al.Gender differences in non-small-cell lung cancer survival:an analysis of 4618 patients diagnosed between 1997 and 2002[J].Ann Thorac Surg,2004,78(1):209-215;discussion 215.
[9]Nordquist LT,Simon GR,Cantor A,et al.Improved survival in ever-smokers vs.current smokers with primary adenocarcinoma of the lung[J].Chest,2004,126(2):347-351.
[10]Ringer G,Smith JM,Engel AM,et al.Influence of sex on lung cancer histology,stage,and survival in a midwestern United States tumor registry[J].Clin Lung Cancer,2005,7(3):180-182.
[11]王瑞,吴春晓,张杰,等.2002—2005年上海市15~44岁青年人肺癌发病的时间趋势、现况及生存期分析[J].肿瘤,2009,29(12):1146-1152.
[12]Jemal A,Siegel R,Ward E.Cancer stetisfics,2009[J].CA Cancer J Clin,2009,59(4):225-249.
[13]Belani CP,Marts S,Schiller J,et al.Women and lung cancer:epidemiology,tumor biology,and emerging trends in clinical research[J].Lung Cancer,2007,55(1):15-23.
[14]Proctor RN.The history of the discovery of the cigaretteelung cancer link:evidentiary traditions,corporate denial,global toll[J].Tobacco Control,2012,21(2):87-91.
[15]Rivera MP.Lung cancer in women:differences in epidemiology,biology,histology,and treatment outcomes[J].Semin Respir Crit Care Med,2013,34(6):792-801.