N-甲基-D-天冬氨酸受体分布与功能研究进展
摘要
N-甲基-D-天冬氨酸(NMDA)受体是由不同亚基组成的异四聚体,它主要参与哺乳动物学习记忆、突触可塑性、兴奋性神经毒性等生理病理过程。当突触内外NMDA受体出现分布及表达异常的情况,会导致神经系统发生严重的功能紊乱。研究NMDA受体分布及表达,探讨其功能变化,将为临床治疗相关疾病提供一个新方向。本文就NMDA受体结构、分布、生理功能等方面对其进行综述。
引文
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[24]ZHANG Y G,JI F C,WANG G M,et al.BDNF activates mTOR to upregulate NR2Bexpression in the rostral anterior cingulate cortex required for inflammatory Pain-Related aversion in rats[J].Neurochem Res,2018,43(3):681-691.
[25]LAUMET G,CHEN S R,PAN H L.NMDA Receptors and Signaling in Chronic Neuropathic Pain[M].New York:Springer,2017:103-119.
[26]TANG B,JI Y P,RICHARD J T.Estrogen alters spinal NMDA receptor activity via a PKA signaling pathway in a visceral pain model in the rat[J].Pain,2008,137(3):540-549.
[27]TU W H,XU X,PENG L S,et al.DAPK1interation with NMDA receptors NR2Bsubmits mediates brain damage in stroke[J].Cell,2010,140(2):222-234.
[28]BA M,KONG M,MA G.Postsynaptic density protein 95-regulated NR2Btyrosine phosphorylation and interactions of Fyn with NR2Bin levodopa-induced dyskinesia rat models[J].Drug Des Devel Ther,2015(9):199-206.
[29]ERIN J K,SOPHIE C,ERIC S,et al.N-methyl-D-aspartate receptor-mediated calcium influx connects amyloid-βoligomers to ectopic neuronal cell cycle reentry in Alzheimer′s disease[J].Alzheimers Dement,2018(14):1302-1312.
[30]NAVARRIA L,ZALTIERI M,LONGHENA F,et al.Alphasynuclein modulates NR2B-containing NMDA receptors and decreases their levels after rotenone exposure[J].Neurochem Int,2015(85/86):14-23.
[2]XU X X,LUO J H.Mutations of N-Methyl-D-Aspartate receptor subunits in epilepsy[J].Neuroscience Bulletin,2018,34(3):549-565.
[3]DING J,ZHOU H H,MA Q R,et al.Expression of NR1and apoptosis levels in the hippocampal cells of mice treated with MK 801[J].Mol Med Rep,2017,16(6):8359-8364.
[4]GARY J L,BRUCE A M,GABRIELA K.Effects of external and internal Ca2+on unitary NMDA receptor properties[J].Biophy J,2015,108(2):285.
[5]BAI N,HAYASHI H,AIDA T,et al.Dock3interaction with aglutamate-receptor NR2Dsubunit protects neurons from excitotoxicity[J].Molecular Brain,2013,6(22):1-11.
[6]LEE J H,WEI Z Z,CHEN D,et al.A neuroprotective role of the NMDA receptor subunit GluN3A(NR3A)in ischemic stroke of adult mice[J].Am J Physiol Cell Physiolo,2015,308(7):C570-577.
[7]LIU H,ZHANG Y,QI D,et al.Downregulation of the spinal NMDA receptor NR2Bsubunit during electro-acupuncture relief of chronic visceral hyperalgesia[J].JPhysiol Sci,2017,67(1):197-206.
[8]THOMAS P,STPHANE H R.Synaptic and extra-synaptic NMDA receptors in the CNS[M].New York:Springer,2017:19-49.
[9]MAHFOOZ K,MARCO S,MARTINEZ-TURRILLAS R,et al.GluN3Apromotes NMDA spiking by enhancing synaptic transmission in Huntington′s disease models[J].Neurobiol Dis,2016(93):47-56.
[10]MATSUNO H,OHI K,HASHIMOTO R,et al.A naturally occurring null variant of the NMDA type glutamate receptor NR3Bsubunit is a risk factor of schizophrenia[J].PLoS One,2015,10(3):e0116319.
[11]YANG Y,JI W G,ZHU Z R,et al.Rhynchophylline suppresses soluble Aβ1-42-induced impairment of spatial cognition function via inhibiting excessive activation of extrasynaptic NR2B-containing NMDA receptors[J].Neuropharmacology,2018(135):100-112.
[12]NOVYTSKA-USENKO L V,MUSLIN V P,KRYSH-TAFOR A A.Two opposite effects of NMDA-receptors in terms of increased range of pharmacological neuroprotection in acute cerebral ischemia[J].Emerg Med,2016,33(1):24-29.
[13]WANG R,REDDY P H.Role of glutamate and NMDAreceptors in Alzheimer′s disease[J].J Alzheimers Dis,2017,57(4):1041-1048.
[14]WANG Y,CHEN T T,YUAN Z H,et al.Ras inhibitor S-trans,trans-farnesylthiosalicylic acid enhances spatial memory and hippocampal long-term potentiation via upregulation of NMDA receptor[J].Neuropharmacology,2018(139):257-267.
[15]SANHUEZA M,FERNANDEZ G.CaMKII:A master functional and structural molecule in synaptic plasticity and memory[M].New York:Springer,2016:43-66.
[16]HAN Y Y,WANG X D,LIU L,et al.L-type VDCCs participate in behavioral-LTP and memory retention[J].Neurobiol Learn Mem,2017(145):75-83.
[17]LI P,LI Y H,HAN T Z.NR2A-containing NMDA receptors are required for LTP induction in rat dorsolateral striatum in vitro[J].Brain Res,2009(1274):40-46.
[18]BALLESTEROS J J,BUSCHLER A,KHR G,et al.Afferent input selects NMDA receptor subtype to determine the persistency of hippocampal LTP in freely behaving mice[J].Front Synaptic Neurosci,2016(8):33.
[19]HU X Y,YANG J H,SUN Y L,et al.Lanthanum chloride impairs memory in rats by disturbing the glutamateglutamine cycle and over-activating NMDA receptors[J].Food Chem Toxicol,2018(113):1-13.
[20]HOFSTETTER S,ASSAF Y.The rapid development of structural plasticity through short water maze training:a DTI study[J].Neuroimage,2017(155):202-208.
[21]赵宝敏,张楠,程焱.盐酸美金刚对血管性痴呆大鼠N-甲基-D天冬氨酸受体的影响[J].中华老年心脑血管病杂志,2015,17(3):303-306.
[22]WANG D H,JACOBS S A,TSIEN J Z.Targeting the NMDA receptor subunit NR2Bfor treating or preventing age-related memory decline[J].Expert Opin Ther Targets,2014,18(10):1121-1130.
[23]DENG C,GU Y J,ZHANG H,et al.Estrogen affects neuropathic pain through upregulating N-methyl-D-aspartate acid receptor 1expression in the dorsal root ganglion of rats[J].Neural Regeneration Res,2017,12(3):464-469.
[24]ZHANG Y G,JI F C,WANG G M,et al.BDNF activates mTOR to upregulate NR2Bexpression in the rostral anterior cingulate cortex required for inflammatory Pain-Related aversion in rats[J].Neurochem Res,2018,43(3):681-691.
[25]LAUMET G,CHEN S R,PAN H L.NMDA Receptors and Signaling in Chronic Neuropathic Pain[M].New York:Springer,2017:103-119.
[26]TANG B,JI Y P,RICHARD J T.Estrogen alters spinal NMDA receptor activity via a PKA signaling pathway in a visceral pain model in the rat[J].Pain,2008,137(3):540-549.
[27]TU W H,XU X,PENG L S,et al.DAPK1interation with NMDA receptors NR2Bsubmits mediates brain damage in stroke[J].Cell,2010,140(2):222-234.
[28]BA M,KONG M,MA G.Postsynaptic density protein 95-regulated NR2Btyrosine phosphorylation and interactions of Fyn with NR2Bin levodopa-induced dyskinesia rat models[J].Drug Des Devel Ther,2015(9):199-206.
[29]ERIN J K,SOPHIE C,ERIC S,et al.N-methyl-D-aspartate receptor-mediated calcium influx connects amyloid-βoligomers to ectopic neuronal cell cycle reentry in Alzheimer′s disease[J].Alzheimers Dement,2018(14):1302-1312.
[30]NAVARRIA L,ZALTIERI M,LONGHENA F,et al.Alphasynuclein modulates NR2B-containing NMDA receptors and decreases their levels after rotenone exposure[J].Neurochem Int,2015(85/86):14-23.