MTA1在结肠息肉癌变过程中的表达及意义
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摘要
[目的]研究MTA1在结肠息肉及结肠癌组织中的表达,探讨MTA1在结肠息肉癌变过程中的作用。[方法]应用免疫组织化学法(SABC)检测结肠癌组织104例、结肠息肉组织114例,正常结肠黏膜组织30例中MTA1基因的表达。[结果]正常结肠组织、管状腺瘤、绒毛状腺瘤至结肠癌中MTA1阳性表达率呈逐渐上升趋势(P<0.05);结肠息肉(中重度异型增生)组中MTA1的阳性表达率高于结肠息肉(轻度异型增生)组(P<0.05)。[结论]结肠癌组织中MTA1呈高表达,MTA1参与正常组织、癌前病变、癌组织的发生、发展,在结肠息肉的癌变过程中起着重要的作用。
[Objective]To study the expression of MTA1 in colonic polyp and colorectal carcinoma tissues,and to explore the role of MTA1 in the carcinogenesis of colonic polyps.[Methods]Immunochemical staining was used to detect the expression of MTA1 protein in 104 cases of colorectal carcinoma,114 cases of colonic polyp and 30 cases of normal colorectal mucosa.[Results]The expression rate of MTA1 gradually increased in normal colorectal mucosa,tubular adenoma,villous adenoma to colorectal carcinoma(P <0.05).The expression rate of MTA1 in colonic polyp(middle-severe dysplasia)was higher than that of colonic polyp(mild dysplasia)group(P<0.05).[Conclusion]MTA1is highly expressed in colorectal carcinoma,which is involved in the occurrence and development of normal tissues,precancerous lesions and cancer tissues,playing an important role in the carcinogenesis of colonic polyp.
[Objective]To study the expression of MTA1 in colonic polyp and colorectal carcinoma tissues,and to explore the role of MTA1 in the carcinogenesis of colonic polyps.[Methods]Immunochemical staining was used to detect the expression of MTA1 protein in 104 cases of colorectal carcinoma,114 cases of colonic polyp and 30 cases of normal colorectal mucosa.[Results]The expression rate of MTA1 gradually increased in normal colorectal mucosa,tubular adenoma,villous adenoma to colorectal carcinoma(P <0.05).The expression rate of MTA1 in colonic polyp(middle-severe dysplasia)was higher than that of colonic polyp(mild dysplasia)group(P<0.05).[Conclusion]MTA1is highly expressed in colorectal carcinoma,which is involved in the occurrence and development of normal tissues,precancerous lesions and cancer tissues,playing an important role in the carcinogenesis of colonic polyp.
引文
[1]Ohshiro K,Kumar R.MTA1regulation of ERβpathway in salivary gland carcinoma cells[J].Biochem Biophys Res Commun,2015,464(4):1016-1021.
[2]Yao Y,Feng S,Xiao M,et al.MTA1promotes proliferation and invasion in human gastric cancer cells[J].Onco Targets Ther,2015,8:1785-1794.
[3]Sen N,Gui B,Kumar R.Properties and clinical relevance of MTA1protein in human cancer[J].Cancer Metastasis Rev,2014,33(4):879-889.
[4]Toh Y,Nicolson G L.Properties and clinical relevance of MTA1protein in human cancer[J].Cancer Metastasis Rev,2014,33(4):891-900.
[5]Marzook H,Deivendran S,Kumar R,et al.Role of MTA1in head and neck cancers[J].Cancer Metastasis Rev,2014,33(4):953-964.
[6]Pencil S D,Toh Y,Nicolson G L.Candidate metastasis-associated genes of the rat 13762NF mammary adenocarcinoma[J].Breast Cancer Res Treat,1993,25(2):165-174.
[7]Jang K S,Paik S S,Chung H,et al.MTA1overexpression correlates signicantly with tumor grade and angiogenesis in human breast cancers[J].Cancer Sci,2006,97(5):374-379.
[8]Hofer M D,Kuefer R,Varanlbally S,et al.The role of metastasis-associated protein l in prostate cancer progression[J].Cancer Res,2004,64(3):825-829.
[9]Wang J,Ivanovic M,et al.Targeting prostate cancer angiogenesis through melastasis-associated protein(MTAl)[J].Prostate,2011,71(3):268-280.
[10]Kumar R,Wang R A,Bagheri-Yarmand R.Emerging roles of MTA family members in human cancers[J].Semin Oncol,2003,30(5Suppl 16)∶30-37.
[11]Hofer M D,Menke A,Genze F,et al.Expression of MTA1promotes motility and invasiveness of PANC-1pancreatic carcinoma cells[J].Br J Cancer,2004,90(2)∶455-462.
[2]Yao Y,Feng S,Xiao M,et al.MTA1promotes proliferation and invasion in human gastric cancer cells[J].Onco Targets Ther,2015,8:1785-1794.
[3]Sen N,Gui B,Kumar R.Properties and clinical relevance of MTA1protein in human cancer[J].Cancer Metastasis Rev,2014,33(4):879-889.
[4]Toh Y,Nicolson G L.Properties and clinical relevance of MTA1protein in human cancer[J].Cancer Metastasis Rev,2014,33(4):891-900.
[5]Marzook H,Deivendran S,Kumar R,et al.Role of MTA1in head and neck cancers[J].Cancer Metastasis Rev,2014,33(4):953-964.
[6]Pencil S D,Toh Y,Nicolson G L.Candidate metastasis-associated genes of the rat 13762NF mammary adenocarcinoma[J].Breast Cancer Res Treat,1993,25(2):165-174.
[7]Jang K S,Paik S S,Chung H,et al.MTA1overexpression correlates signicantly with tumor grade and angiogenesis in human breast cancers[J].Cancer Sci,2006,97(5):374-379.
[8]Hofer M D,Kuefer R,Varanlbally S,et al.The role of metastasis-associated protein l in prostate cancer progression[J].Cancer Res,2004,64(3):825-829.
[9]Wang J,Ivanovic M,et al.Targeting prostate cancer angiogenesis through melastasis-associated protein(MTAl)[J].Prostate,2011,71(3):268-280.
[10]Kumar R,Wang R A,Bagheri-Yarmand R.Emerging roles of MTA family members in human cancers[J].Semin Oncol,2003,30(5Suppl 16)∶30-37.
[11]Hofer M D,Menke A,Genze F,et al.Expression of MTA1promotes motility and invasiveness of PANC-1pancreatic carcinoma cells[J].Br J Cancer,2004,90(2)∶455-462.