摘要
[目的]研究MTA1在结肠息肉及结肠癌组织中的表达,探讨MTA1在结肠息肉癌变过程中的作用。[方法]应用免疫组织化学法(SABC)检测结肠癌组织104例、结肠息肉组织114例,正常结肠黏膜组织30例中MTA1基因的表达。[结果]正常结肠组织、管状腺瘤、绒毛状腺瘤至结肠癌中MTA1阳性表达率呈逐渐上升趋势(P<0.05);结肠息肉(中重度异型增生)组中MTA1的阳性表达率高于结肠息肉(轻度异型增生)组(P<0.05)。[结论]结肠癌组织中MTA1呈高表达,MTA1参与正常组织、癌前病变、癌组织的发生、发展,在结肠息肉的癌变过程中起着重要的作用。
[Objective]To study the expression of MTA1 in colonic polyp and colorectal carcinoma tissues,and to explore the role of MTA1 in the carcinogenesis of colonic polyps.[Methods]Immunochemical staining was used to detect the expression of MTA1 protein in 104 cases of colorectal carcinoma,114 cases of colonic polyp and 30 cases of normal colorectal mucosa.[Results]The expression rate of MTA1 gradually increased in normal colorectal mucosa,tubular adenoma,villous adenoma to colorectal carcinoma(P <0.05).The expression rate of MTA1 in colonic polyp(middle-severe dysplasia)was higher than that of colonic polyp(mild dysplasia)group(P<0.05).[Conclusion]MTA1is highly expressed in colorectal carcinoma,which is involved in the occurrence and development of normal tissues,precancerous lesions and cancer tissues,playing an important role in the carcinogenesis of colonic polyp.
引文
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